ライフサイエンスコーパス: microcalcification

1 oadenoma, or breast cancer (with and without microcalcifications).

2 stortions, and four [67%] of six masses with microcalcifications).

3 ease of matrix vesicles (MVs), precursors of microcalcification.

4 acrophage-derived MVs contribute directly to microcalcification.

5 The benefits were seen for both masses and microcalcification.

6 rary computed tomography cannot assess early microcalcification.

7 metabolism, neuroregulation, thrombosis, and microcalcification.

8 acellular vesicles that act as precursors of microcalcification.

9 ysis, (18)F-fluoride selectively highlighted microcalcification.

10 can distinguish between areas of macro- and microcalcification.

11 to identify pathologically high-risk nascent microcalcification.

12 ng new techniques to predict the presence of microcalcifications.

13 reast cancer, in the absence and presence of microcalcifications.

14 respectively) for diagnosis of lesions with microcalcifications.

15 mosine and isodesmosine cross-linkers in the microcalcifications.

16 ns without, and 0.22 for breast lesions with microcalcifications.

17 e of stereotactic breast needle biopsies for microcalcifications.

18 gital transition, primarily in patients with microcalcifications.

19 mpt the reader to correctly recall masses or microcalcifications.

20 redict the risk of malignancy for suspicious microcalcifications.

21 ular-resolution tool to identify preclinical microcalcifications.

22 of small objects that correspond to typical microcalcifications.

23 lly emerged as marker of benignity in benign microcalcifications.

24 ), 17 manifested as masses and 12 (41%) were microcalcifications.

25 heterogeneous data set containing masses and microcalcifications.

26 s collected from the cleaning pads resembled microcalcifications.

27 d procedure to remove particles mistaken for microcalcifications.

28 icrocalcifications and recurred as DCIS with microcalcifications.

29 raphy screening, 3556 of whom had suspicious microcalcifications.

30 moval of more tissue was helpful with missed microcalcifications.

31 breast, small lesions, small specimens, and microcalcifications.

32 14 (67%) of 21 initially missed lesions, all microcalcifications.

33 Among these, six (54%) had suspicious microcalcifications.

34 masses had multiple associated heterogeneous microcalcifications.

35 ven in the case of a cyst with heterogeneous microcalcifications.

36 distinguish malignant from benign clustered microcalcifications.

37 ost inflammatory reaction with fewer lumenal microcalcifications.

38 was limited to initial identification of the microcalcifications.

39 ty of Orai1-deficient cells to form in vitro microcalcifications.

40 ained thin and pliable with sparse, punctate microcalcifications.

41 hat (18)F-fluoride PET/CT can identify early microcalcifications.

42 g amplification of the PET signal by smaller microcalcifications.

43 ctural distortion, severe neuronal loss, and microcalcifications.

44 can be considered for BI-RADS 4 mammographic microcalcifications.

45 resh biopsy cores and composition of type II microcalcifications.

46 mammographic findings except pure clustered microcalcifications.

47 rs, 2.1 were masses, and 0.1 were masses and microcalcifications.

48 tion clusters, and 17 of 17 were masses with microcalcifications.

49 ues are available for detecting intratumoral microcalcifications.

50 f 28 masses (nine [32%] malignancies) and 26 microcalcifications (10 [38%] malignancies).

51 ncies, 23 (45%) appeared mammographically as microcalcifications, 12 (24%) as masses, four (8%) as ar

52 es and/or microcalcifications (72 masses, 22 microcalcifications, 17 masses with microcalcifications)

53 Lesion types were masses (66%), microcalcifications (25%), parenchymal deformities (6%),

54 egular mass (56.8% [109 of 192]) followed by microcalcifications (25.0% [48 of 192]).

55 benign and malignant masses and clusters of microcalcifications (3.3-7.4 cm in diameter) were then s

56 ne hundred eleven lesions were masses and/or microcalcifications (72 masses, 22 microcalcifications,

57 [1.09-1.19] vs 1.01 [0.94-1.06]; p=0.0004), microcalcification (73% vs 21%, p=0.002), and necrotic c

58 CAD correctly prompted 100% of microcalcifications, 87% of mass lesions, 80% of asymmet

59 ld a classification model that distinguishes microcalcifications according to their overall biochemic

60 multimodal imaging, we assessed the coronary microcalcification activity (18F-sodium fluoride positro

61 sed in each vessel by measuring the coronary microcalcification activity (CMA).

62 )F-NaF uptake was determined by the coronary microcalcification activity (CMA).

63 ch assessments, focusing on inflammation and microcalcification activity, the importance of these pro

64 showed displacement of a few of the targeted microcalcifications adjacent to misplaced marker clips.

65 malignant or patients developed four or more microcalcifications after 3 years, biopsy was performed.

66 accordance, human testicular specimens with microcalcifications also have lower SLC34A2 and a subpop

67 itative assessments of myocardial viability, microcalcification and in patients with cardiac sarcoido

68 High Lp(a) is associated with both microcalcification and macrocalcification of the aortic

69 therapeutic target for ectopic calcification/microcalcification and may clarify the mechanism that un

70 ts without evidence of cancer had testicular microcalcification and one cryptorchidism, risk factors

71 ediated calcification, inflammation precedes microcalcification and results from EV release from macr

72 f Raman spectroscopy to concomitantly detect microcalcifications and diagnose associated lesions, inc

73 e phenotype, in particular, higher levels of microcalcifications and impaired myocardial microvascula

74 so established heritability of the number of microcalcifications and masses at baseline.

75 verall interpretation accuracy, detection of microcalcifications and masses, discrimination between b

76 o systematically evaluate the association of microcalcifications and other mammographic features with

77 (DCIS) cases manifested mammographically as microcalcifications and recurred as DCIS with microcalci

78 ancer screening, where we separately analyze microcalcifications and soft tissue lesions.

79 extracellular vesicles, and the formation of microcalcifications and ultimately large calcification a

80 sses, 22 microcalcifications, 17 masses with microcalcifications) and 21 were architectural distortio

81 diagnosis of breast cancer (with or without microcalcifications) and an overall accuracy of 82.2% fo

82 rval (CI), 48%-67%) for MD, 23% (2%-45%) for microcalcifications, and 13% (1%-25%)] for masses.

83 ding 50 normal tissue sites, 77 lesions with microcalcifications, and 19 lesions without microcalcifi

84 rval decrease in size of lesion or number of microcalcifications, and 4 = no residual mammographic le

85 clerotic plaques is the result of developing microcalcifications, and high surface area in regions of

86 lity of the structures in the image (fibers, microcalcifications, and masses) was evaluated with the

87 jacent to (n = 6) or associated with (n = 1) microcalcifications, and three (30%) were in or adjacent

88 acent to (n = 12) or associated with (n = 1) microcalcifications, and two (13%) were in masses.

89 on mammograms: four masses, two pleomorphic microcalcifications, and two masses with calcifications.

90 stlumpectomy mammography for cases involving microcalcifications; and calls for flexibility in the ap

91 Microcalcifications appear to derive from matrix vesicle

92 Among the latter group, microcalcifications appeared malignant in four breasts,

93 If microcalcifications appeared malignant or patients devel

94 Inflammation and microcalcification are interrelated processes contributi

95 Breast microcalcifications are a common mammographic finding.

96 Microcalcifications are a feature of diagnostic signific

97 guidance of stereotactic breast biopsies for microcalcifications are also discussed.

98 Microcalcifications are an early mammographic sign of br

99 Microcalcifications are an early mammographic sign of br

100 Type I microcalcifications are associated mainly with benign tu

101 Microcalcifications are considered suspicious signs of b

102 Although type II microcalcifications are primarily composed of calcium hy

103 d mainly with benign tumors, whereas type II microcalcifications are produced internally by malignant

104 iopsies and rapid characterization of breast microcalcifications are unmet clinical needs.

105 f lobular neoplasia at core biopsy, residual microcalcifications are viewed in the context of a patie

106 In conclusion, testicular microcalcifications arise secondary to local alterations

107 cium carbonate, an underrated constituent of microcalcifications, as a spectroscopic marker in breast

108 cates new diagnostic potentialities based on microcalcifications assessment.

109 erion to rule out malignancy in mammographic microcalcifications at breast MR imaging.

110 Conclusion The recall rate for suspicious microcalcifications at mammographic screening increased

111 ground Trends in the detection of suspicious microcalcifications at mammography screening and the yie

112 d mass and less likely to manifest noncomedo microcalcifications at mammography than were NLCs with n

113 is of malignancy in lesions that manifest as microcalcifications at mammography.

114 ant factor (P < .001) in failure to retrieve microcalcifications at only 11-gauge vacuum biopsy.

115 ast cancer who had densities masquerading as microcalcifications at the resection margins of the lump

116 roscopy decision algorithms to detect breast microcalcifications, based on fit coefficients (FC) deri

117 nsecutively underwent image-guided biopsy of microcalcifications between November 2001 and October 20

118 carboxyfluorescein-alendronate confirmed the microcalcification binding specificity of alendronate de

119 f malignancy in BI-RADS 3 and 5 mammographic microcalcifications, but can be considered for BI-RADS 4

120 model that includes BI-RADS descriptors for microcalcifications can distinguish between benign and m

121 NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.

122 opsy-proven DCIS corresponding to a unifocal microcalcification cluster or a mass less than 30 mm wer

123 r was used to estimate the likelihood that a microcalcification cluster was due to a malignancy.

124 Overall, 37 of 39 microcalcification clusters (95% sensitivity, 95% confid

125 erpreted by six radiologists who located the microcalcification clusters and rated their conspicuity.

126 mmograms depicting 57 verified masses and 38 microcalcification clusters in 85 positive and 35 negati

127 hile cuing sensitivity affected detection of microcalcification clusters more significantly (P < .01)

128 cm-thick phantoms embedded with 81 simulated microcalcification clusters of three speck sizes (subtle

129 Forty-eight (96.0%) of 50 microcalcification clusters were marked on all three ima

130 erage, 0.5 false-positive rate per view were microcalcification clusters, 2.1 were masses, and 0.1 we

131 lesions detected were masses, 20 of 22 were microcalcification clusters, and 17 of 17 were masses wi

132 four views each), depicting 96 masses and 50 microcalcification clusters, were scanned and analyzed t

133 of breast cancers manifesting as masses and microcalcification clusters, with an acceptable false-po

134 three compression levels for the masses and microcalcification clusters.

135 DBT digital breast tomosynthesis for subtle microcalcification clusters.

136 Outside the clinic, numerous microcalcification compositional metrics (e.g., carbonat

137 Thirteen patients (14 breasts) developed microcalcifications confined to the lumpectomy site afte

138 eight patients (29 breasts [5.7%]) developed microcalcifications confined to the lumpectomy site.

139 Testicular microcalcifications consist of hydroxyapatite and have b

140 0.20 for a 6-cm breast phantom, and the mean microcalcification conspicuities were 16.2 +/- 2.87 and

141 For constant glandular dose, mass and microcalcification conspicuity remained approximately co

142 onstructed images were analyzed for mass and microcalcification conspicuity, or the ratio of the lesi

143 t the composition and structural features of microcalcifications correlate with breast pathology and

144 carcinoma in situ, infiltrating cancer, and microcalcifications correlated with corresponding histop

145 e image-guided breast biopsies performed for microcalcifications deemed suspicious by radiologists we

146 The microcalcification descriptors and categories in BI-RADS

147 To retrospectively evaluate whether microcalcification descriptors and the categorization of

148 cation descriptors and the categorization of microcalcification descriptors in the Breast Imaging Rep

149 In this study, 473 microcalcifications detected on breast biopsy specimens

150 and distinguish benign from malignant breast microcalcifications detected on mammography.

151 spectroscopy to make predictions for breast microcalcification detection.

152 mmography is an option when benign-appearing microcalcifications develop at the lumpectomy site depen

153 it is the primary recommendation when these microcalcifications develop within 3 years after treatme

154 tion mammographic features (density, masses, microcalcifications), differences in the left and right

155 ant differences among the risks suggested by microcalcification distribution descriptors (P = .004) a

156 esticular microlithiasis is common and while microcalcifications do exist in roughly 50% of germ cell

157 nds in recall and outcome of screen-detected microcalcifications during 20 years of mammography scree

158 g that the local microenvironment influences microcalcification features.

159 ical mammogram and hybridized with simulated microcalcifications for use in this study.

160 metal content) are linked to malignancy, yet microcalcification formation is dependent on microenviro

161 tiated before or after the expected onset of microcalcification formation.

162 ssue microenvironments, and how these impact microcalcification formation.

163 The (18)F-fluoride ligand bound to microcalcifications formed by calcifying vascular smooth

164 is of these results, we believe that type II microcalcifications formed in benign ducts typically con

165 Following BiP treatment at any time, microcalcifications formed in vitro were predicted to ha

166 After validation, microcalcifications found in benign and malignant sample

167 e predictive value for recall for suspicious microcalcifications from 51% to 33% (P < .001).

168 The recalls of suspicious microcalcifications from all radiology reports and patho

169 Microcalcifications from malignant samples were generall

170 Microcalcifications geographically target the location o

171 Clinical detection of microcalcifications has been hampered by the lack of ima

172 ystallographic and chemical features of DCIS microcalcifications have been explored.

173 Finally, microcalcifications identified in malignant biopsies, bu

174 In recent years, microcalcifications identified in routine mammograms wer

175 ging platform that can non-invasively detect microcalcification in active unstable atherosclerosis.

176 d annexin V, which contribute to accelerated microcalcification in chronic renal disease.

177 It has recently been shown that active microcalcification in the coronary arteries, one of the

178 The presence of type II microcalcification in the MDA-MB-231 cell line was confi

179 lso revealed extensive areas of fibrosis and microcalcification in which a predominant smooth muscle

180 sts interpreted mammograms showing clustered microcalcifications in 104 patients.

181 teral invasive breast cancer recurrence (179 microcalcifications in 57 patients) were studied.

182 of pixel size on the detection of simulated microcalcifications in a phantom with digital mammograph

183 glial cells and neurons and associated with microcalcifications in all three fatal cases with microc

184 Microcalcifications in atherosclerotic plaques are desta

185 , which are unable to reliably differentiate microcalcifications in benign and malignant breast lesio

186 make accurate and repeatable predictions of microcalcifications in breast tissue using decision algo

187 uate its performance in detecting suspicious microcalcifications in comparison with mammography by us

188 c and ultrastructural characteristics of the microcalcifications in different mammary tumor types.

189 ed high performance for detecting suspicious microcalcifications in ex vivo breast cancer specimens,

190 target to prevent the development of mammary microcalcifications in luminal breast cancer.

191 ive breast cancer--is typically diagnosed as microcalcifications in mammograms.

192 Moreover, the frequent testicular microcalcifications in mice with no functional androgen

193 The (18)F-fluoride ligand labeled microcalcifications in PET-positive, CT-negative regions

194 A) imaging has shown high detection rates of microcalcifications in phantom studies.

195 atheromata and participated in formation of microcalcifications in SMC culture.

196 erformed significantly better on masses than microcalcifications in terms of both the area under the

197 tion was found to have new diffuse bilateral microcalcifications in the breast ducts.

198 that minute (10-mum-diameter) cellular-level microcalcifications in the cap, which heretofore have go

199 rotic plaques has suggested that subcellular microcalcifications in the fibrous cap may promote mater

200 ys had scrotal US, 83 (2%) of whom had TM or microcalcifications in the report.

201 rwent stereotactic core biopsy of suspicious microcalcifications in the upper outer left breast with

202 idance, core needle biopsy fails to retrieve microcalcifications in up to 15% of patients.

203 eatures of a lesion such as typical shape of microcalcifications in x-ray mammography, characteristic

204 The recall rate for microcalcifications increased from 0.1% in 1997-1998 to

205 Early microcalcification is a feature of coronary plaques with

206 macrocalcification confers plaque stability, microcalcification is a key feature of high-risk atherom

207 as performed of 1701 consecutive nonpalpable microcalcification lesions in 1511 women aged 29-92 year

208 orphologic parameter, including nodule size, microcalcification, macrocalcification, halo sign, talle

209 mmographic features such as dense area (MD), microcalcifications, masses, and density change (MDC, cm

210 gs provide novel data on the heritability of microcalcifications, masses, and density change, which a

211 el extracted mammographic features (density, microcalcifications, masses, and left-right breast asymm

212 F-sodium fluoride ((18)F-fluoride) to detect microcalcification may provide insight into disease acti

213 s, and high surface area in regions of small microcalcifications may amplify PET signal.

214 tion, clustering, and shape of nearly 35,000 microcalcifications (microCalcs) >/= 5 microm in the fib

215 s developing fewer than four probably benign microcalcifications more than 3 years after treatment we

216 xisting mineral growth, potentially altering microcalcification morphology and the risk of plaque rup

217 mographic findings other than pure clustered microcalcifications, MR imaging increased the positive p

218 = 16), mass with calcifications (n = 5), and microcalcifications (n = 6; four of these microcalcifica

219 f branching, and associated findings such as microcalcifications, nipple discharge, and interval chan

220 Measurement of aortic valve microcalcification occurring as a healing response to va

221 nostic strategy, we were able to distinguish microcalcifications occurring in benign and malignant du

222 scopy to analyze the chemical composition of microcalcifications occurring in benign and malignant le

223 A 53-year-old woman with right breast microcalcifications of intermediate concern underwent st

224 Microcalcifications offer one such avenue of exploration

225 e in the differential diagnosis of clustered microcalcifications on mammograms.

226 ular cancer after previous identification of microcalcifications on ultrasound generated significant

227 gnant lesions manifested mammographically as microcalcifications only, n = 7) were seen better at con

228 (n = 72 in total) to better detect "grouped microcalcifications" or "architectural distortion" lesio

229 associated with interval change, suspicious microcalcifications, or both warrant biopsy.

230 t differences were found for both masses and microcalcification (P = .037 and .049).

231 imarily because of an effect on detection of microcalcifications (P < .01) and discrimination of mass

232 f 144) of masses and 12.5% (148 of 1,182) of microcalcifications (P <.001); and by number of specimen

233 ography outperformed CT for visualization of microcalcifications (P = .006).

234 minations, particularly when associated with microcalcifications (P = .047).

235 Despite their indisputable value, microcalcifications, particularly of the type II variety

236 Microcalcifications play a major role in destabilizing a

237 Some patterns of calcification such as microcalcification portend increased risk of rupture and

238 d multicentric tumors, diffuse indeterminate microcalcifications, pregnancy, prior irradiation to the

239 Microcalcifications, primarily biogenic apatite, occur i

240 e deposits originate from an early molecular microcalcification process of 2 types: type 1 is calcium

241 affects studies of coronary lesions in which microcalcification processes are targeted.

242 ogists marked cells that included suspicious microcalcifications (referred to as 'positive cell') on

243 ix leading to the formation of destabilizing microcalcifications remain unclear.

244 ralized biological samples, including breast microcalcifications, revealing the local chemical hetero

245 (19 [65%] of 29 masses, seven [88%] of eight microcalcifications, seven [78%] of nine architectural d

246 atment resulted in time-dependent changes in microcalcification size and mineral morphology, dependen

247 Microcalcification size correlated inversely with collag

248 roscopy technique to simultaneously identify microcalcification status and diagnose the underlying br

249 confocal, and electron microscopy to verify microcalcification targeting specificity of DOTA-alendro

250 valuate (64)Cu-DOTA-alendronate as a mammary microcalcification-targeting PET imaging agent, using an

251 masses and less likely to manifest noncomedo microcalcifications than are NLCs with normal E-cadherin

252 lar vesicles participate in the formation of microcalcifications that are implicated in atherosclerot

253 f breast core needle biopsy for detection of microcalcifications that can substantially improve the l

254 ass that changed at 6 months and one case of microcalcifications that changed at 24 months.

255 a(2+)-ATPase, SPCA2, which result in mammary microcalcifications that constitute a prognostic marker

256 light subtle chemical differences in type II microcalcifications that correlate with breast disease.

257 se reflectance spectroscopy for detection of microcalcifications that focuses on variations in optica

258 Recent studies have shown that microcalcifications that form within the fibrous cap of

259 ging was used for assessment of mammographic microcalcifications that were assigned Breast Imaging Re

260 For images of microcalcifications, there were significant differences

261 Of 11 lesions with residual microcalcifications, three (27%) were ADH and one (9%) w

262 fined to address a clinical need to identify microcalcifications using positron emission tomography/c

263 microcalcifications, and 19 lesions without microcalcifications, using a compact clinical system.

264 for the entire group and for distinguishing microcalcifications versus masses and other findings and

265 The whole Raman signature of each microcalcification was then used to build a classificati

266 The false-negative rate for pure clustered microcalcifications was 12% (three of 25 cases) because

267 Finally, we observed that the presence of microcalcifications was associated with increased cardio

268 sions were gone at follow-up, one cluster of microcalcifications was decreased in size, and one fibro

269 One cluster of microcalcifications was gone at follow-up, and one was s

270 aggregation and formation of stress-inducing microcalcifications was imaged via scanning electron mic

271 Failure to retrieve microcalcifications was least common with 11-gauge direc

272 tion to breast cancer (using PRS) and MD and microcalcifications was positive, while for masses this

273 s used in this study, while the detection of microcalcifications was significantly reduced with a com

274 F-fluoride signal amplification derived from microcalcifications was validated against near-infrared

275 s using an omics-inspired approach: For each microcalcification, we define a "biomineralogical signat

276 existence of the hypothesized cellular-level microcalcifications, we examined autopsy specimens of co

277 fibrosis, glomerular congestion, and tubular microcalcification were all greater with CSA (hazard rat

278 ad undergone biopsy for suspicious clustered microcalcifications were analyzed by a computer.

279 nd microcalcifications (n = 6; four of these microcalcifications were associated with a mammographica

280 tion study, we found that a higher number of microcalcifications were associated with increased risk

281 The performances of the BP-ANN on masses and microcalcifications were compared with use of receiver o

282 Microcalcifications were detected in the left and right

283 Type I microcalcifications were diagnosed as benign, whereas ty

284 Five lesions with LCIS and residual microcalcifications were excised.

285 In addition, microcalcifications were extracted from a clinical mammo

286 Pure clustered microcalcifications were followed up for at least 24 mon

287 ing preclinical computed tomography (CT) and microcalcifications were identified using uCT-based 3D X

288 Microcalcifications were initially separated into two ca

289 ght computer-extracted features of clustered microcalcifications were merged by an artificial neural

290 of the specimen were obtained to see whether microcalcifications were retrieved.

291 invasive carcinomas (10 masses, one case of microcalcifications) were detected only mammographically

292 recurrences, 14 (five masses, nine cases of microcalcifications) were detected only mammographically

293 These calcifying EVs form nidi for microcalcification, which can progress to the macrocalci

294 CIS), the most common lesion associated with microcalcifications, which could not be diagnosed using

295 ble approach for detecting suspicious breast microcalcifications with US.

296 aining that TREML4 colocalizes with areas of microcalcification within coronary plaques.

297 Fifteen patients (15 breasts) developed microcalcifications within 3 years of BCT and were follo

298 eceive BCT, those developing probably benign microcalcifications within 3 years of BCT received close

299 biomechanical modeling indicates that small microcalcifications within the plaque fibrous cap can le

300 e.g. hypoechogenicity, irregular borders and microcalcifications) within such thyroid nodules may hav