1 re, we have investigated the contribution of
microcephalin 1 (MCPH1), mutated in primary microcephaly
2 Here, we show that the
microcephalin 1/BRCT-repeats inhibitor of hTERT (MCPH1/B
3 Microcephalin-
1 (MCPH1) exists as 2 isoforms that regula
4 candidates for such introgression, including
microcephalin,
a gene influencing brain development.
5 ly, illustrated by the identification of the
Microcephalin,
abnormal spindle in microcephaly and atax
6 It also makes
Microcephalin an attractive candidate locus for studying
7 Indeed, evolutionary analyses of
Microcephalin and ASPM reveal evidence for positive sele
8 ously identified primary microcephaly genes,
microcephalin and ASPM.
9 recent adaptive evolution of either ASPM or
Microcephalin and changes in IQ.
10 these candidates revealed that loss of MCPH1/
microcephalin caused the most robust increase in centrio
11 Here, we examine the evolution of the
microcephalin gene, whose null mutation in humans causes
12 Two primary microcephaly genes, ASPM and
Microcephalin,
have been implicated not only in the adap
13 We show that one genetic variant of
Microcephalin in modern humans, which arose approximatel
14 Additionally,
microcephalin interacts with Chk1.
15 This gene,
microcephalin,
is expressed in the developing cerebral c
16 t the notion that the molecular evolution of
microcephalin may have contributed to brain expansion in
17 al. reported that human genetic variants of
Microcephalin (
MCPH1) and abnormal spindle-like microcep
18 Microcephalin (
MCPH1) and ASPM (abnormal spindle-like mi
19 Mutations of
microcephalin (
MCPH1) can cause the neurodevelopmental d
20 Microcephalin (
MCPH1) is a BRCA1 COOH terminal (BRCT) do
21 Microcephalin (
MCPH1) is one of the causative genes for
22 Microcephalin (
MCPH1) is the first gene identified among
23 The gene
Microcephalin (
MCPH1) regulates brain size and has evolv
24 The gene
microcephalin (
MCPH1) regulates brain size during develo
25 ral, biochemical, and cellular evidence that
Microcephalin (
MCPH1), an early DNA damage response prot
26 Microcephalin (
MCPH1), one of the genes mutated in prima
27 Microcephalin (
MCPH1), the first gene identified as caus
28 ractions with checkpoint kinase 1 (CHK1) and
microcephalin (
MCPH1).
29 Microcephalin/
MCPH1 is one of the causative genes respon
30 genes have been identified: MCPH1, encoding
Microcephalin;
MCPH3, encoding CDK5RAP2; MCPH5, encoding
31 about 45 advantageous amino acid changes in
microcephalin might have fixed during the 25-30 million
32 We show that the evolution of
microcephalin'
s protein sequence is highly accelerated t