ライフサイエンスコーパス: microcirculatory

1 dothelial cell P-selectin contributes to the microcirculatory abnormalities in sickle cell disease an

2 matched control subjects and determined the microcirculatory abnormalities in the T1DM and T1DM-MV p

3 Microcirculatory abnormalities of the retina and nail-fo

4 ies, and inflammatory reactions demand local microcirculatory adaption to provide adequate supply.

5 Microcirculatory alterations are associated with adverse

6 Microcirculatory alterations are stronger predictors of

7 ssfully identified a methodology to quantify microcirculatory alterations associated with disease and

8 croTools was used to identify the functional microcirculatory alterations associated with disease con

9 rus disease 2019 patients exhibit sublingual microcirculatory alterations caused by inflammation, coa

10 We studied the prevalence of microcirculatory alterations in a heterogeneous ICU popu

11 We investigated which factors may influence microcirculatory alterations in patients with severe sep

12 The prevalence and significance of microcirculatory alterations in the general ICU populati

13 Modest microcirculatory alterations occur in dengue, are associ

14 Microcirculatory alterations were less severe in the lat

15 s in which a stent has been placed, coronary microcirculatory and epicardial vascular function are no

16 Microcirculatory and macrocirculatory evaluations were m

17 ctive epicardial coronary disease, disturbed microcirculatory and vasomotor function, amongst other i

18 ry distress syndrome and the cardiovascular, microcirculatory, and renal complications of sepsis are

19 significant hemodynamic, blood gas, lactate, microcirculatory, and tissue Pco2 abnormalities were obs

20 potential therapy is linked to the enhanced microcirculatory angiogenesis that results from treatmen

21 culatory targets marks a pivotal moment when microcirculatory assessment becomes essential to guide t

22 hether early wave intensity analysis-derived microcirculatory (backward) expansion wave energy predic

23 e these obstacles using autologous explanted microcirculatory beds (EMBs) as bioscaffolds for enginee

24 to function as an oxygen sensor in mammalian microcirculatory beds and to regulate arteriolar caliber

25 ormability, the parameters influencing their microcirculatory behavior remain unexplored.

26 Hepatic microcirculatory blood flow (MBF) was measured throughou

27 ted by LPR, has a negative relationship with microcirculatory blood flow after cardiovascular surgery

28 nted wound healing murine model enhanced the microcirculatory blood flow and accelerated the wound ti

29 Retinal pericytes regulate microcirculatory blood flow and coordinate neurovascular

30 -leukocyte interactions, leading to improved microcirculatory blood flow and improved survival.

31 Indomethacin restored microcirculatory blood flow and reduced TXA2 .

32 between RBCs and WBCs, resulting in improved microcirculatory blood flow and survival of sickle cell

33 en before the inflammatory stimuli increased microcirculatory blood flow and survival.

34 ce of the local synchronization in the renal microcirculatory blood flow and that it changes dependin

35 Misdistribution of intestinal microcirculatory blood flow at the onset of shock was si

36 wever, no clinical studies have investigated microcirculatory blood flow behavior in hemorrhagic shoc

37 F-alpha) stimulation, and not only increased microcirculatory blood flow but also improved survival o

38 ity of T/HS exchange transfusion to decrease microcirculatory blood flow did not appear to be due to

39 stric and buccal tissue Pco2 with changes in microcirculatory blood flow in a rat model of circulator

40 fely assess for localized recruitment of the microcirculatory blood flow in patients with circulatory

41 Microcirculatory blood flow in small vessels increased (

42 Microcirculatory blood flow in vessels >20 microm was we

43 ere was an early and progressive decrease in microcirculatory blood flow in vessels <20 microm, mostl

44 Sublingual microcirculatory blood flow was assessed by sidestream d

45 Cortical microcirculatory blood flow was markedly reduced after e

46 Microcirculatory blood flow was quantitated with orthogo

47 perioperative anaerobic lactate production, microcirculatory blood flow, and mitochondrial respirati

48 prostaglandin F2alpha (PGF2alpha ), on skin microcirculatory blood flow, as well as to detect its ef

49 that older individuals would exhibit reduced microcirculatory blood flow, interstitial amino acid con

50 damage and vascular tone dysfunction impair microcirculatory blood flow, leading to organ injury and

51 easurements of lactate-pyruvate ratio (LPR), microcirculatory blood flow, plasma tricarboxylic acid c

52 ntly affect systemic oxygen metabolism, skin microcirculatory blood flow, urine output, or splanchnic

53 ubsequent vascular injury and obstruction of microcirculatory blood flow.

54 d that epinephrine reduces cerebral cortical microcirculatory blood flow.

55 ant hemodynamic variables, lactate, LPR, and microcirculatory blood flow.

56 matory trigger of vasoocclusion and improved microcirculatory blood flow.

57 l permeability and microbiome, liver injury, microcirculatory/cardiac dysfunction and muscle damage m

58 n arterial spin tagging was used to estimate microcirculatory CBF in depressed (N = 5) and comparison

59 l intensity ratios corresponding to relative microcirculatory CBF were calculated for four regions on

60 On the superior image, estimates of microcirculatory CBF were statistically significantly lo

61 nks between depression, cardiac disease, and microcirculatory cerebral blood flow (CBF).

62 ect correlation between the observed retinal microcirculatory changes and established plasma markers

63 Microcirculatory changes and oxidative stress have long

64 Microcirculatory changes and tissue oxygenation were inv

65 onance (MR) imaging may be indicators of the microcirculatory changes in patients with nonalcoholic s

66 her goal of the article is to show how these microcirculatory changes may be responsible for the wide

67 ere assessed by cardiac output measurements, microcirculatory changes were investigated by sidestream

68 These effects were associated with microcirculatory collapse due to astrocyte swelling.

69 nitric oxide (NO) bioavailability and brain microcirculatory complications, with a marked decrease i

70 siological evaluation of both epicardial and microcirculatory components of the vasculature, although

71 suction wave caused by relief of myocardial microcirculatory compression-the dominant backward-trave

72 ain ischemia of 30 min duration suggest that microcirculatory compromise develops during recirculatio

73 and endovascular glycocalyx degradation with microcirculatory compromise.

74 PEG-BSA produces improved microcirculatory conditions in the treatment of endotoxe

75 underpin our current understanding of muscle microcirculatory control and place a retrospectroscope o

76 votal role of blood O(2) gradients in muscle microcirculatory control.

77 of a "suction" wave generated by myocardial microcirculatory decompression.

78 Altered cell migration due to microcirculatory deficiencies as well as excessive and p

79 e are no data showing that exercise improves microcirculatory delivery of oxygen and nutrients in pat

80 ndicate that brain hypoxia can be related to microcirculatory derangements and cell edema without evi

81 tion between posttraumatic brain hypoxia and microcirculatory derangements with cell edema, we invest

82 Therapies recruiting the microcirculatory diffusion and convection capacity assoc

83 surement to FFR, especially in patients with microcirculatory disease and impaired maximal hyperemia.

84 ation, microgliosis, oligodendrocyte injury, microcirculatory disease, and interstitial fluid stasis.

85 caused by ischaemia resulting from coronary microcirculatory disorders, coronary vasospasm, and brid

86 g healthy subjects and patients with various microcirculatory disorders-strong correlations were foun

87 ia miltiorrhiza (SM) is widely used to treat microcirculatory disturbance-related diseases; its lipop

88 sion is influenced by the degree of cerebral microcirculatory disturbance.

89 erence)) theoretically normalizes for global microcirculatory disturbances and facilitates interpreta

90 emia-reperfusion (I/R) injury and a range of microcirculatory disturbances contribute to tissue damag

91 ports add to understanding of the control of microcirculatory disturbances in acute pancreatitis, and

92 The microcirculatory disturbances in sepsis have prompted mi

93 ences of portosystemic shunting resulting in microcirculatory disturbances, mild (secondary) periduct

94 d activation of inflammatory pathways and/or microcirculatory disturbances, whereas NO dysregulation

95 is preferentially triggered by mild/moderate microcirculatory disturbances.

96 bnormal radiological features, suggestive of microcirculatory disturbances.

97 sis, diffuse atherosclerotic narrowings, and microcirculatory dysfunction (MCD) contribute to limit m

98 rt: culprit and nonculprit vessel) and acute microcirculatory dysfunction (ST-segment-elevation myoca

99 Hepatic microcirculatory dysfunction and the vasoconstrictive re

100 Antithrombin ameliorates microcirculatory dysfunction and tissue injury in trauma

101 Microcirculatory dysfunction has been well reported in c

102 than vascular remodeling, influence coronary microcirculatory dysfunction in aortic stenosis (AS).

103 rculatory hemodynamic optimization; however, microcirculatory dysfunction is integral to sepsis patho

104 Microcirculatory dysfunction occurs early in cardiovascu

105 s and cirrhosis, marked portal hypertension, microcirculatory dysfunction, an enhanced vasoconstricti

106 ysiology of SA-AKI remains elusive, although microcirculatory dysfunction, cellular metabolic reprogr

107 tic stenosis (AS) is accompanied by coronary microcirculatory dysfunction, demonstrated by an impaire

108 was abnormal (<2.0), suggesting predominant microcirculatory dysfunction.

109 y bypass (C/CPB) is associated with coronary microcirculatory dysfunction.

110 wed by reperfusion for 1, 2 or 4 h, leads to microcirculatory dysfunction.

111 picardial spasm, microvascular spasm, and/or microcirculatory dysfunction.

112 ponse to endothelin-1, and aggravate hepatic microcirculatory dysfunction; these events subsequently

113 This paper describes a self-contained microcirculatory EC culture system that efficiently stud

114 The observed macro- and microcirculatory effects are most likely a result from c

115 rican Americans, pharmacologic correction of microcirculatory endothelial dysfunction in this group i

116 In fact, vessel wall stiffening, and microcirculatory endothelial dysfunction, precedes hyper

117 e system, promoting important changes in the microcirculatory environment.

118 Analysis of microcirculatory events included hepatic ischemia, endot

119 unknown roles for HSCs in the regulation of microcirculatory exchange and its breakdown in chronic l

120 aracteristic analysis, a backward-traveling (microcirculatory) expansion wave threshold of 2.8 W m(-2

121 The backward-traveling (microcirculatory) expansion wave was derived from wave i

122 e infarct-related artery backward-traveling (microcirculatory) expansion wave was inversely correlate

123 a unique series of events characterized with microcirculatory failure and thrombosis progressing from

124 These observations suggest that microcirculatory failure in capillaries appears as an ea

125 hin 4 h of MCAO supports the hypothesis that microcirculatory failure in this region contributes to i

126 insights into septic encephalopathy include: microcirculatory failure precedes changes in evoked pote

127 h mechanisms targeting cell swelling-induced microcirculatory failure.

128 , we found no association between changes in microcirculatory flow and lactate clearance or organ dys

129 urther aggravates ischemia by reducing local microcirculatory flow and oxygenation.

130 Decreases in buccal microcirculatory flow are closely associated with the se

131 morrhagic shock in which systemic and buccal microcirculatory flow are reduced.

132 injury within 24 hours were consistent with microcirculatory flow arrest and collagen preservation (

133 We performed experiments and simulations in microcirculatory flow conditions of viscosity, shear rat

134 and reduced RCD both contribute to decreased microcirculatory flow in severe disease.

135 Despite lower (by approximately 40-45%) microcirculatory flow in the older than in the younger p

136 icant, negative relationship between LPR and microcirculatory flow index ( r = -0.225; beta = -0.037;

137 ; group and time interaction: p = 0.70), and microcirculatory flow index (control: 2.1 +/- 0.6 to 2.4

138 Transfusion of RBC significantly increased microcirculatory flow index (from 2.3 [1.6-2.5] to 2.7 [

139 he primary outcome measure was the change in microcirculatory flow index.

140 ; timely interventions to preserve the renal microcirculatory flow may interrupt the downward spiral

141 cal microcirculatory flow, cerebral cortical microcirculatory flow was fully preserved during cardiog

142 However, cerebral microcirculatory flow was fully preserved.

143 and arterial pressures together with buccal microcirculatory flow, cerebral cortical microcirculator

144 Using this microscope, we visualized microcirculatory flow, fast venous constrictions and neu

145 ed plasma nitrite levels, it did not improve microcirculatory flow, lactate clearance, or organ dysfu

146 ed blood cell deformability (RCD) compromise microcirculatory flow, leading to anaerobic glycolysis.

147 et that can describe the relative quality of microcirculatory flow.

148 Regional mesenteric and microcirculatory flows at jejunal mucosa and serosa were

149 improved regional splanchnic and intestinal microcirculatory flows when compared with mandatory fixe

150 We examined microcirculatory fluid flow via video shearing optical m

151 ea under the curve 98 [SE 14] to 1024 [130]; microcirculatory flux from 5060 [462] to 74,800 [3940])

152 atients demonstrate persistent impairment in microcirculatory function after percutaneous coronary in

153 ly, PTSD is associated with reduced coronary microcirculatory function and greater deterioration over

154 mally invasive evaluation of intramyocardial microcirculatory function and permits assessment of micr

155 Persistent abnormalities in microcirculatory function are associated with poor clini

156 ic roles in the optimization of cellular and microcirculatory function in critical illness and injury

157 ar mathematical models that will investigate microcirculatory function in health and disease.

158 Changes in coronary microcirculatory function in patients with AS after AVR

159 TAVI improves microcirculatory function regardless of the severity of

160 Peripheral microcirculatory function was measured with continuous r

161 Microcirculatory function was not significantly differen

162 nary vasodilator reserve (CVR), a measure of microcirculatory function, after AVR and determine the r

163 ar thrombi, thereby contributing to impaired microcirculatory function, the no-reflow phenomenon, and

164 mia/occlusion is a standard clinical test of microcirculatory function, which has been ascribed to en

165 AS, and coronary perfusion to impairment in microcirculatory function.

166 spasm provocation testing and assessment of microcirculatory function.

167 nt improvement in the parameters of coronary microcirculatory function.

168 s narrowing improves the indexes of coronary microcirculatory function.

169 against CM is associated with improved brain microcirculatory hemodynamics and decreased vascular pat

170 of systemic hemodynamics and restoration of microcirculatory hemodynamics.

171 od, with apparently conflicting data showing microcirculatory hypoperfusion and normal or even increa

172 romise in brain studies; however, high-speed microcirculatory imaging in deep brain remains an open q

173 usion may contribute to progressive cerebral microcirculatory impairment and ischemic neuronal injury

174 Recent studies show that coronary microcirculatory impairment is an independent predictor

175 or in oxygenation pathologies resulting from microcirculatory impairment, including sickle cell disea

176 Microcirculatory impairments have theoretically been pro

177 measured concurrently with determination of microcirculatory indices in buccal and cerebral areas.

178 characterized by endothelial activation with microcirculatory inflammation by monocytes/macrophages a

179 rect mechanistic significance or whether the microcirculatory injury is an epiphenomenon and a manife

180 : Microcirculatory integrity and proper function are the c

181 s of breast milk involve enhanced intestinal microcirculatory integrity via augmentation of nitrate-n

182 culatory parameters identified the number of microcirculatory leukocytes and the capillary-hematocrit

183 ge characteristics of skeletal muscle at the microcirculatory level we tested the hypothesis that, fo

184 chanism of adenosine-induced dilation at the microcirculatory levels.

185 Microcirculatory measurements were obtained either early

186 Microcirculatory morphometric analyses were performed to

187 ry specialization by which generic capillary microcirculatory networks spanning from arteries to vein

188 Impaired microcirculatory (nutritive) blood flow may contribute t

189 rocirculation, through the direct intravital microcirculatory observations after administration of NO

190 e role of decreased nitric oxide (NO) in the microcirculatory obstruction of hepatic sinusoidal obstr

191 of forward (aorta-originating) and backward (microcirculatory-originating) coronary waves were determ

192 No difference was found between the microcirculatory parameters comparing dengue with other

193 During hypothermia, all sublingual microcirculatory parameters decreased significantly toge

194 rs; and 3) quantitative and semiquantitative microcirculatory parameters have a similar performance.

195 er-operating-characteristics analysis of the microcirculatory parameters identified the number of mic

196 oped a new method to monitor and to quantify microcirculatory parameters in the tumor grown in the li

197 The microcirculatory parameters quantified included total ve

198 Semiquantitative and quantitative microcirculatory parameters were determined through the

199 re assessed in combination with conjunctival microcirculatory parameters.

200 parameters but significantly correlated with microcirculatory parameters.

201 ood flow resulting in concomitantly improved microcirculatory perfusion (P = 0.024).

202 Further, we found no association between microcirculatory perfusion and multiple organ dysfunctio

203 17beta-Estradiol improved microcirculatory perfusion and reduced intestinal edema

204 Presently, MCE uses microcirculatory perfusion as the basis to distinguish m

205 sed techniques for bedside or intraoperative microcirculatory perfusion assessment, this article's ob

206 xed, suggest that changes in distribution of microcirculatory perfusion can modulate substrate uptake

207 ings demonstrate the importance of enhancing microcirculatory perfusion in early resuscitation strate

208 haled nitric oxide at 40 ppm did not augment microcirculatory perfusion in patients with sepsis.

209 ent of endothelial adjustment capability and microcirculatory perfusion status, as direct or surrogat

210 nclusion, MCAO induced severe impairments in microcirculatory perfusion within the core ischemic regi

211 It preserves microcirculatory perfusion within the endangered areas i

212 NE affect kidney oxygenation tension, kidney microcirculatory perfusion, and 48-hour kidney function,

213 potentially influences hepatic function and microcirculatory perfusion.

214 bule, improve cell engraftment, and decrease microcirculatory perturbations.

215 t-neutrophil aggregation in vitro and blocks microcirculatory platelet-leukocyte interactions in vivo

216 d saphenous vein grafts is reduced by distal microcirculatory protection using a balloon occlusion an

217 Diabetes mellitus causes microcirculatory rarefaction and may impair the responsi

218 on characteristics, arteriolar constriction, microcirculatory rarefaction, metabolic abnormalities, c

219 THODS AND We established a model of complete microcirculatory regeneration after ischemia-induced obl

220 ells involved in normal vascular repair with microcirculatory regenerative potential and paracrine an

221 ts allocated to control group reached normal microcirculatory reperfusion (myocardial blush grade=3);

222 An incomplete microcirculatory reperfusion might contribute to these s

223 oretical as well as experimental approaches, microcirculatory research belongs within current definit

224 Microcirculatory research represents an example of a 'mi

225 hypothesized that impaired baseline coronary microcirculatory reserve, which reduces the ability to t

226 cular dysfunction, predefined by an index of microcirculatory resistance >20, was observed in 46% of

227 ictive value 92%), contrast-derived index of microcirculatory resistance >47 (area under the curve 0.

228 he number of patients with abnormal index of microcirculatory resistance (>=25) decreased from 12 (57

229 ticagrelor group had lower baseline index of microcirculatory resistance (22.0 [13.0-34.9] versus 27.

230 ticagrelor group had lower post-PCI index of microcirculatory resistance (22.0 [15.0-29.0] versus 27.

231 Index of microcirculatory resistance (IMR) and atherosclerotic bu

232 ta from 6 cohorts that measured the index of microcirculatory resistance (IMR) directly after primary

233 A novel index of microcirculatory resistance (IMR) has been shown in anim

234 valuate the predictive value of the index of microcirculatory resistance (IMR) in patients undergoing

235 picardial stenosis by comparing the index of microcirculatory resistance (IMR) levels in patients bef

236 for periprocedural MI and that the index of microcirculatory resistance (IMR) measured during PCI ca

237 The index of microcirculatory resistance (IMR) of the infarct-related

238 remic mean transit time provides an index of microcirculatory resistance (IMR) that will correlate wi

239 (FFR), coronary flow reserve (CFR), index of microcirculatory resistance (IMR), absolute hyperemic re

240 We compared RRR, index of microcirculatory resistance (IMR), and coronary flow res

241 fractional flow reserve (FFR), the index of microcirculatory resistance (IMR), and coronary flow res

242 microvascular resistance using the index of microcirculatory resistance (IMR), defined as the hypere

243 coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR), exhibit a dynamic pat

244 s study is to determine whether the Index of Microcirculatory Resistance (IMR), measured at the time

245 ion of coronary flow reserve (CFR), index of microcirculatory resistance (IMR), ratio of distal coron

246 coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR).

247 coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR); and intravascular ult

248 with pressure/thermodilution-based index of microcirculatory resistance (r=0.607; P<0.0001) and demo

249 sistance (IMR) that will correlate with true microcirculatory resistance (TMR), defined as the distal

250 thermodilution technique (apparent index of microcirculatory resistance [IMR(app)]).

251 rve, coronary flow reserve, and the index of microcirculatory resistance did not change significantly

252 on optical coherence tomography and index of microcirculatory resistance early posttransplant predict

253 The index of microcirculatory resistance has been shown to have progn

254 at 1 month, as determined with the index of microcirculatory resistance in the infarct-related arter

255 Previous studies demonstrating that microcirculatory resistance is dependent on epicardial s

256 We investigated whether the index of microcirculatory resistance is independent of epicardial

257 Coronary microcirculatory resistance is independent of functional

258 Increasingly, the index of microcirculatory resistance is used as a reference stand

259 reserve, coronary flow reserve, and index of microcirculatory resistance measurements.

260 Recovery of microcirculatory resistance over time was not better in

261 The index of microcirculatory resistance values decreased from 33.35+

262 The primary outcome of index of microcirculatory resistance was not superior in ticagrel

263 20% from baseline) reduction of the index of microcirculatory resistance was observed in 15 (71.4% [9

264 ient male sex, fibrotic plaque, and index of microcirculatory resistance were independent predictors

265 s having microvascular dysfunction (index of microcirculatory resistance, >=25).

266 However, controversy exists over whether microcirculatory resistance, a measure of coronary micro

267 reserve, coronary flow reserve, the index of microcirculatory resistance, and intravascular ultrasoun

268 elated territory as assessed by the index of microcirculatory resistance, and this resulted in a comp

269 nary flow reserve, contrast-derived index of microcirculatory resistance, contrast-derived microvascu

270 The index of microcirculatory resistance, coronary flow reserve, and

271 phy, assessment of coronary flow reserve and microcirculatory resistance, provocative testing for end

272 The index of microcirculatory resistance-a thermodilution-derived mea

273 for collateral flow in their measurement of microcirculatory resistance.

274 sessed using the recently described index of microcirculatory resistance.

275 was the change in the values of the index of microcirculatory resistance.

276 mal absolute coronary blood flow and minimal microcirculatory resistance.

277 sound, fractional flow reserve, and index of microcirculatory resistance.

278 vascular dysfunction assessed using index of microcirculatory resistances at 1 year was also associat

279 results support our hypotheses regarding the microcirculatory response to NO in tumors.

280 placebo controlled, cross-over study of the microcirculatory response to topical application of a ni

281 Cerebral microcirculatory responses consisted of changes in cereb

282 This study sought to determine the cerebral microcirculatory responses to hypoxia, hypotension, hypo

283 Two hours after the intervention, cerebral microcirculatory responses were examined.

284 Vitamin C restores coronary microcirculatory responsiveness and impaired coronary fl

285 e exact locations of occlusive events at the microcirculatory scale remains open.

286 The Microcirculatory Shock Occurrence in Acutely ill Patient

287 sional vasculature structure and determining microcirculatory speeds.

288 ukocytes, activating complement, and causing microcirculatory stasis.

289 irculatory resistance, a measure of coronary microcirculatory status, is dependent on epicardial sten

290 ment, improving point-of-care application of microcirculatory-targeted resuscitation procedures.

291 thus, homeostatic levels of ET-1 to maintain microcirculatory tone.

292 thm to data-mine and identify the sublingual microcirculatory variable changes in response to disease

293 Quantitative and semiquantitative microcirculatory variables displayed similar behaviors.

294 Among microcirculatory variables, proportion of perfused small

295 herapeutic options for recruiting functional microcirculatory variables.

296 value in an integrative model of macro- and microcirculatory variables.

297 ASMase-mediated microcirculatory vasoconstriction after SDRT conferred a

298 Changes in skin microcirculatory volume and flux were measured bilateral

299 ing system can stimulate an increase in both microcirculatory volume and flux.

300 el both in patients with Raynaud's syndrome (microcirculatory volume from mean area under the curve 9