ライフサイエンスコーパス: microcytic

1 identify the causative mutation in mice with microcytic anaemia (mk).

2 ure can be preceded by diabetes mellitus and microcytic anaemia, which are considered to be early man

3 encing of arhgef3 in Danio rerio resulted in microcytic and hypochromic anemia.

4 % CI: -7.5, -1.1% points) and nonthalassemic microcytic anemia (-1.7% points; 95% CI: -3.3, -0.1% poi

5 ted with higher odds of anemia, particularly microcytic anemia (asthma: 1.61; 1.09-2.38; P = .02; ecz

6 9 nmol/L]), leukocytosis (13 800/mm(3)), and microcytic anemia (hemoglobin level, 7.2 g/dL).

7 Microcytic anemia (mk) mice and Belgrade (b) rats have s

8 notype are similar to those reported for the microcytic anemia (mk) mutation in the mouse.

9 hianti (cia) mutant manifests a hypochromic, microcytic anemia after the onset of embryonic circulati

10 ere 343 mild anemic males in whom 47.8% were microcytic anemia and 3,323 non-anemic males for the ana

11 Mice lacking Pcbp1 exhibited microcytic anemia and activation of compensatory erythro

12 ted with lower probability of nonthalassemic microcytic anemia and better adequacy of dietary iron in

13 ns or deletions may be a cause of refractory microcytic anemia and bone marrow iron depletion in pati

14 It is characterized by microcytic anemia and by iron loading, and can be treate

15 tants associated with human diseases such as microcytic anemia and Charcot-Marie-Tooth are unable to

16 entified in a female with severe hypochromic microcytic anemia and iron overload.

17 Mice that lack IRP2 develop microcytic anemia and neurodegeneration associated with

18 bdh2 null mice developed microcytic anemia and tissue iron overload, especially i

19 The mutation, zinfandel, has a hypochromic microcytic anemia as an embryo, but later recovers in ad

20 deficiency anemia patients, who present with microcytic anemia caused by hyperhepcidinemia, and of qu

21 These animals exhibit hypochromic microcytic anemia due to impaired intestinal iron absorp

22 cythemia in heterozygotes and a hypochromic, microcytic anemia in homozygotes.

23 yses reveal a mild, congenital, hypochromic, microcytic anemia intrinsic to the hematopoietic system

24 athogenesis of a new recessive, hypochromic, microcytic anemia mouse mutant, nm1054.

25 ient with a history of a 6-month hypochromic microcytic anemia of unknown cause.

26 a genetic locus not previously implicated in microcytic anemia or iron phenotypes.

27 lobin level, i.e. 10.9 g/dL with hypochromic microcytic anemia pattern seen in complete blood count (

28 e normal recipients of HBD marrow obtained a microcytic anemia similar to the donor.

29 and alpha2-globulin and more frequently had microcytic anemia than those without such deposits (P =

30 ene symbol hbd) is characterized by a severe microcytic anemia that is inherited in an autosomal-rece

31 A hypochromic, microcytic anemia was present from birth, and platelet c

32 The Rac1(-/-);Rac2(-/-) mice developed microcytic anemia with a hemoglobin drop of about 20% an

33 Homozygous sublytic mice develop hypochromic microcytic anemia with reduced osmotic fragility of RBCs

34 ice alters actin assembly in RBCs and causes microcytic anemia with reticulocytosis, implicating Rac

35 yndrome (joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced childhood-on

36 rized by joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystroph

37 (cdy), a zebrafish mutant with hypochromic, microcytic anemia, and positioned the mutant gene on lin

38 duction, whereas those who lack IRP2 develop microcytic anemia, believed to result from iron deficien

39 ome akin to typhoid fever with splenomegaly, microcytic anemia, extramedullary erythropoiesis, and in

40 nhibition of mTORC1 results in macrocytic or microcytic anemia, respectively.

41 These Tf-deficient mice have severe microcytic anemia, tissue iron overload, and hepcidin de

42 d-specific ALA synthase 2 (ALAS2) gene cause microcytic anemia, whereas mitochondrial DNA deletions a

43 Chronic turpentine treatment led to microcytic anemia, which was prevented by concurrent adm

44 d individuals included liver dysfunction and microcytic anemia, while one had fatal cardiomyopathy wi

45 moderately severe, congenital, hypochromic, microcytic anemia, with an elevated red cell zinc protop

46 nduction, iron deficiency and a hypochromic, microcytic anemia.

47 ssive loss of body (but not facial) hair and microcytic anemia.

48 Heterozygous gammabeta(0) mice suffer from microcytic anemia.

49 ion by red blood cells leads to hypochromic, microcytic anemia.

50 -/- mice represent a new paradigm of genetic microcytic anemia.

51 Hypochromic, microcytic anemias are typically the result of inadequat

52 plinary guidelines on the management of rare microcytic anemias due to genetic disorders of iron meta

53 derstanding of the pathogenesis of inherited microcytic anemias has gained from the identification of

54 nd transferrin saturation, the appearance of microcytic anisocytotic red blood cells, and decreases i

55 drome [ATMDS]) characterized by hypochromic, microcytic, anisopoikilocytic red blood cells with hemog

56 st cases, the red cells were hypochromic and microcytic, consistent with abnormalities in hemoglobin

57 the sla mutation develop moderate to severe microcytic hypochromic anaemia.

58 esults in iron deficiency and eventually the microcytic hypochromic anemia or iron deficiency anemia

59 HNF1A(-/-) mice displayed microcytic hypochromic anemia with reticulocytosis that

60 s process in iron/heme deficiency results in microcytic hypochromic anemia, the most prevalent anemia

61 Homozygous mk/mk mice have microcytic, hypochromic anaemia due to severe defects in

62 The zebrafish mutant sauternes (sau) has a microcytic, hypochromic anaemia, suggesting that haemogl

63 Belgrade rats exhibit microcytic, hypochromic anemia and systemic iron deficie

64 cit (hbd) mouse mutant, which suffers from a microcytic, hypochromic anemia apparently due to defecti

65 rat has an autosomal recessively inherited, microcytic, hypochromic anemia associated with abnormal

66 These mice exhibited microcytic, hypochromic anemia, as did lethally irradiat

67 e (median hemoglobin, 7.1 g/dL) and markedly microcytic (median mean corpuscular volume, 62.0 fL).

68 volume, as well as increased hypochromic and microcytic RBC fractions.

69 mice developed thrombocytopenia and altered microcytic red blood cell counts.