ライフサイエンスコーパス: microenvironmental

1 The microenvironmental abnormalities are likely a consequenc

2 utility in identifying clinically actionable microenvironmental adaptations in early metastasis.

3 Our findings thus demonstrate that microenvironmental alteration by CSF-1R blockade renders

4 Although microenvironmental alterations have been described in wo

5 tic changes and in neighboring cells through microenvironmental alterations.

6 m to acutely sense and decisively respond to microenvironmental alterations.

7 n driven by specific genetic, epigenetic, or microenvironmental alterations.

8 and navigate biological barriers - systemic, microenvironmental and cellular - that are heterogeneous

9 ally imprinted and modulated by local tissue microenvironmental and inflammatory cues.

10 arding the pathophysiological potential of a microenvironmental and physiological stressor in tumor d

11 Moreover, metastasis is regulated by microenvironmental and systemic processes, such as immun

12 uman patients, Th-MYCN mice develop genomic, microenvironmental, and clinical features reminiscent of

13 to this combination we analysed the genetic, microenvironmental, and immune factors in tumours derive

14 or future studies on the effect of increased microenvironmental bioactive TGFbeta concentrations in m

15 s strategy offers unique insights into tumor microenvironmental biochemistry and should facilitate co

16 Combined analysis of tumor and microenvironmental biomarkers in metastatic biopsies of

17 ect, indicating that targeting a bone marrow microenvironmental cell can lead to a delay in MM tumor

18 Notably, the LNP targets liver microenvironmental cells fivefold more potently than hep

19 or-suppressing role of ANGPTL2 in host tumor microenvironmental cells.

20 Marrow microenvironmental cellular components of the NHD13 BMME

21 (CSF)-filled leptomeninges face substantial microenvironmental challenges, including inflammation an

22 tumor models that recapitulate size-induced microenvironmental changes and, consequently, natural tu

23 MSC production of VEGF and IL-10, suggesting microenvironmental changes from pFUS also increased pote

24 cting against the BBB disruption and related microenvironmental changes in the hippocampus.

25 ac pathological conditions such as ischemia, microenvironmental changes instruct a series of cellular

26 This induces microenvironmental changes that promote spheroid growth.

27 Microglia respond to damage and microenvironmental changes within the central nervous sy

28 n lung cancer, contributing to tumor growth, microenvironmental changes, and metastasis, the epigenet

29 Our results show that microenvironmental changes, such as hypoxia, can affect

30 mor models faithfully represent size-induced microenvironmental changes, such as hypoxic gradients, c

31 nstrate that the nucleodyes are sensitive to microenvironmental changes.

32 layer isolation strategies thus revealed new microenvironmental characteristics of colonic mesenchyma

33 nsitivity suggests that therapies matched to microenvironmental characteristics will be more efficaci

34 c effects through distinct receptors on each microenvironmental compartment of the developing mouse t

35 ggressive experimental tumors has a critical microenvironmental component that involves specific regu

36 oth at initial diagnosis and at relapse) and microenvironmental components as assessed by immunohisto

37 eover, cancer cells also utilize and educate microenvironmental components by reshaping them into acc

38 he phenotypic plasticity of both tumoral and microenvironmental components.

39 analysis enables objective quantification of microenvironmental composition of ovarian tumours.

40 d BBB models is provided, elaborating on the microenvironmental compositions of GBM and BBB, relevant

41 are diverse in their genetic, metabolic and microenvironmental compositions, accounting for their ph

42 l and mechanical properties to determine the microenvironmental conditions (microstructure, degradati

43 e used by PMEIs to inhibit PMEs in different microenvironmental conditions and paving the way to iden

44 Indeed, a number of studies have found that microenvironmental conditions can selectively modify uni

45 lecular mechanism for the synergism of tumor microenvironmental conditions in cancer progression with

46 Altered microenvironmental conditions in lymphoid tissues leadin

47 The microenvironmental conditions in soil exert a major cont

48 competing on a fitness landscape mediated by microenvironmental conditions that dictate their interac

49 tissues, those with viral infection or other microenvironmental conditions that might promote fusion.

50 tissues, those with viral infection or other microenvironmental conditions that might promote fusion.

51 , thus mTORC1 signaling remains active under microenvironmental conditions that potentially promote e

52 Hostile microenvironmental conditions within tumor masses, such

53 stem from an increased resistance to adverse microenvironmental conditions, accumulating evidence ind

54 culture systems in terms of high control of microenvironmental conditions, including accurate pertur

55 conserved mechanism of adaptation to adverse microenvironmental conditions, including limited nutrien

56 erns of tumour-derived sEVs, dictated by the microenvironmental conditions, resulted in specific resp

57 pic traits that permit acclimation to varied microenvironmental conditions.

58 analyses of human and murine samples define microenvironmental consequences of obesity that foster t

59 d for diagnostic approaches addressing these microenvironmental contents-approaches enabling a sensit

60 ypic system that recreates the molecular and microenvironmental context in which squamous carcinogene

61 ne responses in the skin by interpreting the microenvironmental context in which they encounter forei

62 In the appropriate genetic and microenvironmental context, acute deregulation of SOX2 d

63 committed to suppressive function under all microenvironmental contexts.

64 umor biology by focusing through the lens of microenvironmental contributions, namely inflammation, a

65 ounding normal cells as active and essential microenvironmental contributors to early tumour growth t

66 printing platform to study tumorigenesis and microenvironmental control of breast cancer and highligh

67 ovel mechanistic insight into the process of microenvironmental control of cancer.

68 omimetic systems for dynamic multiparametric microenvironmental control of emergent and integrated ce

69 nd/or temporal resolution and limitations on microenvironmental control.

70 This work identifies TGFbeta as a microenvironmental cue that is critical for GC homeostas

71 how that substrate stiffness is an important microenvironmental cue, to which mouse hippocampal neuro

72 or assessing cell quality and the effects of microenvironmental cues and manufacturing processes on c

73 of differentiation and plasticity, including microenvironmental cues and molecular mediators, such as

74 These features are controlled through key microenvironmental cues and regulatory pathways, such as

75 at mediate cancer cell extravasation but the microenvironmental cues and signaling factors that induc

76 o show that NK cell-intrinsic properties and microenvironmental cues are involved in this process, in

77 bit high phenotypic diversity and respond to microenvironmental cues by altering their functional pro

78 dic device design that mimics multiple tumor microenvironmental cues concurrently with biologically r

79 haracteristics responsive to specific tumour microenvironmental cues demonstrate enhanced spatiotempo

80 se to injury and tumor-associated macrophage microenvironmental cues facilitating metastatic cell see

81 successfully demonstrated the importance of microenvironmental cues for proteolytic activity and als

82 equence of prior therapeutic intervention or microenvironmental cues has significant implications for

83 Whether different microenvironmental cues impose invasive or therapy-resis

84 This capability of platelets to mechanosense microenvironmental cues in a growing thrombus or hemosta

85 oles during metastasis; however, the role of microenvironmental cues in the regulation of miRNAs in m

86 ed macrophages (TAM) are exposed to multiple microenvironmental cues in tumors, which collaborate to

87 ineered brain tissue platform by integrating microenvironmental cues of native brain-derived ECMs and

88 ation in tumor predisposition is dictated by microenvironmental cues rather than intrinsic difference

89 ppressive capacity of macrophages, driven by microenvironmental cues such as hypoxia and fibrosis.

90 toll-like receptor 3, together with external microenvironmental cues that drive endothelial cell (EC)

91 PHD3 restrains tumour growth in response to microenvironmental cues through the control of EGFR.

92 ain chemotaxis receptors that can respond to microenvironmental cues to guide cancer cell extravasati

93 However, how platelets transduce microenvironmental cues to mediate contraction and alter

94 In response to microenvironmental cues, embryonic cells form adhesive s

95 lturing human brain cells with physiological microenvironmental cues, human mini-brain models reconst

96 Here we show that microenvironmental cues, including inflammation-mediated

97 d MM cancer stem cells within the context of microenvironmental cues, providing preclinical support f

98 These microenvironmental cues, which include hypoxia, also reg

99 ly change their direction according to other microenvironmental cues, which is important for both nor

100 ribution of NK cell-intrinsic properties and microenvironmental cues.

101 onally distinct subtypes while responding to microenvironmental cues.

102 ncluding light, pH, ligand-binding and other microenvironmental cues.

103 rol various signaling pathways downstream of microenvironmental cues.

104 tional plasticity, both maturation stage and microenvironmental cytokines condition nTreg activities,

105 election at advanced ages in the presence of microenvironmental decline.

106 ges within the concept of their functions in microenvironmental design, focusing in particular on the

107 Hypoxia (low O2) is a fundamental microenvironmental determinant of bone marrow (BM) patho

108 ditions of adipose tissue wasting and review microenvironmental determinants of adipocyte (dys)functi

109 cular changes in tumors and uncovered latent microenvironmental differences between treatment-resista

110 but little is known about the roles of local microenvironmental differences in three-dimensional (3D)

111 at were enriched in grade 3 tumors with high microenvironmental diversity that also substratified pat

112 te the signals a cell receives from specific microenvironmental domains.

113 model has been developed by considering the microenvironmental dynamics of the pesticide in conjunct

114 Yet, how such microenvironmental effects are integrated with direct th

115 cytes is now firmly established, but how the microenvironmental effects of UV radiation influence mel

116 ment and progression via cell autonomous and microenvironmental effects.

117 eased VLA-4 expression in host hematopoietic microenvironmental elements.

118 A microenvironmental exposure model was used to estimate t

119 ns predicted that small perturbations of the microenvironmental extracellular pH (pHe) could invert t

120 ting that intratumoral hypoxia is a critical microenvironmental factor driving cancer progression.

121 Hypoxia is an important microenvironmental factor influencing atherosclerosis pr

122 We identified CCN1 as a microenvironmental factor produced by mesenchymal cells

123 consistent with a role of HIV as a critical microenvironmental factor promoting lymphoma development

124 Hypoxia is a potent microenvironmental factor promoting metastatic progressi

125 ut the response of NP cells to this aberrant microenvironmental factor remains to be fully characteri

126 (+) BM-MSCs in the hypoxic niche, a critical microenvironmental factor that is well known to induce t

127 Hypoxia is a potent microenvironmental factor that promotes tumor metastasis

128 ii) distinguish the contributions of several microenvironmental factors and (iii) test the effects of

129 s into the dynamic interplay between various microenvironmental factors and CAFs in the CSC niche.

130 ta provide a key illustrative example of how microenvironmental factors and cell lineage drive the ge

131 c lymphocytic leukemia (CLL) cells depend on microenvironmental factors for proliferation and surviva

132 C2 responses has advanced, the complexity of microenvironmental factors impacting ILC2s is becoming i

133 ight the temporal dynamics of tumor-secreted microenvironmental factors in inducing tumor migration.

134 plain the zonal pattern suggesting a role of microenvironmental factors in shaping functional ITH.

135 nutrient and oxygen availability, and other microenvironmental factors influence fuel choice.

136 Furthermore, modulation of uptake by microenvironmental factors is largely unstudied.

137 We screened for microenvironmental factors leading to phenotype switchin

138 ties and discuss stem cell tools to identify microenvironmental factors of importance to the developm

139 ferences, we examined the influence of three microenvironmental factors on FDG uptake.

140 be the convergence of genetic, metabolic and microenvironmental factors on mechanisms of epigenetic d

141 Solid tumours are exposed to microenvironmental factors such as hypoxia that normally

142 condary sites, and is strongly influenced by microenvironmental factors such as hypoxia.

143 that integrate many of the (epi-)genetic and microenvironmental factors that contribute to colorectal

144 Targeting microenvironmental factors that foster migratory cell ph

145 ence is the main cause of death from cancer, microenvironmental factors that may influence resistance

146 However, our understanding of microenvironmental factors that modulate the process of

147 iating EMT and stemness, we investigated the microenvironmental factors that promote Notch-Jagged sig

148 To identify microenvironmental factors underlying the resistance of

149 pregulated under hypoxic conditions or other microenvironmental factors), this work calls for a more

150 r tumour response heterogeneity, e.g. due to microenvironmental factors, and quantification of the bi

151 currently undefined interactions with other microenvironmental factors, including extracellular matr

152 Ex vivo added microenvironmental factors, including IL-2, TGFbeta, and

153 cer cell metabolism is heavily influenced by microenvironmental factors, including nutrient availabil

154 ganization events are precisely modulated by microenvironmental factors, which are known to strongly

155 interventions, heterocellular components and microenvironmental factors.

156 nd tumor metabolism and its interaction with microenvironmental factors.

157 nd was independent of prognostic markers and microenvironmental factors.

158 a direct contact with immune cells and local microenvironmental factors.

159 al selection due to a variety of genetic and microenvironmental factors.

160 unologic factors and identification of tumor/microenvironmental features correlating with distant met

161 rectly reconstitute the histomorphologic and microenvironmental features of primary MPNST-like melano

162 h patient, as a result of clone-specific and microenvironmental forces.

163 oes not depend on the space dimension or the microenvironmental geometry.

164 issue of Blood, Jitschin et al demonstrate a microenvironmental glycolytic shift in chronic lymphocyt

165 apitulate the original tumor architecture or microenvironmental gradients and are not designed to ret

166 We developed a quantitative measure of microenvironmental heterogeneity along three spatial dim

167 We propose a clinically relevant role of microenvironmental heterogeneity for advanced breast tum

168 Microenvironmental heterogeneity gives rise to distinct

169 We aimed to assess the degree of microenvironmental heterogeneity in breast cancer and co

170 s, we uncovered a striking link between high microenvironmental heterogeneity measured by EDI and a p

171 e first study to couple unbiased measures of microenvironmental heterogeneity with genomic alteration

172 r understanding the synergistic interplay of microenvironmental heterogeneity with genomic alteration

173 ail to account for intra-tumoral spatial and microenvironmental heterogeneity.

174 xhibit considerable genetic, pathologic, and microenvironmental heterogeneity.

175 on, via localized O2 depletion, resulting in microenvironmental hypoxia and effective inflammatory re

176 These data define microenvironmental IL-1beta as a master cytokine in tumo

177 We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve

178 Thus, a mechanism is presented for microenvironmental influence on tumour growth.

179 ltaneously cultured to explore new facets of microenvironmental influences and CSC biology.

180 zed that epigenetic modifications induced by microenvironmental influences of cytokines can reveal th

181 al common processes-reflecting in part tumor microenvironmental influences-driving cellular behavior

182 ates muTSA as a platform for studying tumour microenvironmental interactions and cancer field effects

183 he recently discovered intrinsic mechanisms, microenvironmental interactions and communication with s

184 and drives expression of genes essential for microenvironmental interactions and lineage ambiguity.

185 f co-mutations on the pathogenesis, biology, microenvironmental interactions and therapeutic vulnerab

186 These findings indicate that microenvironmental interactions are key regulators of AM

187 A wide range of cell-microenvironmental interactions are mediated by membrane

188 mmunologic function is not only modulated by microenvironmental interactions but is also a feature of

189 nsidered to be on the receiving end of these microenvironmental interactions, recent studies show tha

190 gy and therapy, with a focus on genetics and microenvironmental interactions, which contribute to dis

191 on in the context of chemokine signaling and microenvironmental interactions, which may have importan

192 ell-cell and cell-extracellular matrix (ECM) microenvironmental interactions.

193 The lack of clarity regarding microenvironmental lactate highlights the general need f

194 nism of Propionibacterium acidipropionici at microenvironmental levels by analyzing physiological cha

195 boxysomes in cells depend sensitively on the microenvironmental levels of CO(2) and light intensity d

196 mal cells controls leukocyte recruitment and microenvironmental localization in intestine and in the

197 Importantly, their microenvironmental localizations were not different from

198 es convenient real-time imaging, genetic and microenvironmental manipulation and molecular analysis.

199 us, we found that mechanical features of the microenvironmental matrix influence tissue-specific diff

200 ld not be properly accounted for with indoor microenvironmental measurements.

201 hich are anucleate cellular fragments, sense microenvironmental mechanical properties, such as substr

202 ignaling networks that impact autonomous and microenvironmental mechanisms of cancer metastases.

203 etermined by both cancer cell-autonomous and microenvironmental mechanisms, including the contributio

204 roughput investigations of cell-intrinsic or microenvironmental modifiers of metastasis.

205 and in-vehicle exposure was estimated using microenvironmental monitoring data based on field measur

206 ed using subtle morphological differences of microenvironmental myoepithelial cell nuclei without any

207 host cells, which collectively form a tumor microenvironmental network that either suppresses or pro

208 sory neurons and immune cells share a common microenvironmental niche for surveying tissue integrity.

209 ion, which requires a healthy and supportive microenvironmental niche within the bone marrow (BM).

210 f in vivo bone micrometastases regarding the microenvironmental niche, gene expression profile, metas

211 ed to somatic mutations or to changes in the microenvironmental niche.

212 ally colocalize with PD-L1(+) HRS cells in a microenvironmental niche.

213 imilar paradigms in communicating with their microenvironmental "niche" to transition between quiesce

214 PS can reconstruct cellular arrangements and microenvironmental niches as dominated by PPARalpha sign

215 propagating cells (CPCs) within preferential microenvironmental niches has a major part in evading th

216 of lymph nodes (LNs) and establish distinct microenvironmental niches to provide key molecules that

217 and we compared cellular properties between microenvironmental niches, the luminal mucosa and crypts

218 Here we show that HGG growth depends on microenvironmental NLGN3, identify signalling cascades d

219 Therefore, knowledge of microenvironmental nutrient levels is essential to under

220 Transmigrating PMNs rapidly depleted microenvironmental O2 sufficiently to stabilize intestin

221 OX2) are required for the rapid depletion of microenvironmental oxygen and compensatory responses, re

222 ation, it experiences a profound decrease in microenvironmental oxygen levels leading to a state of c

223 tative bacterial oxygen sensor that may link microenvironmental oxygen levels to virulence and antibi

224 Microenvironmental oxygen, glucose, and glutamine are re

225 nsport of NPs and its variation due to tumor microenvironmental parameters have been studied includin

226 pectrum of the trityl probe and assess these microenvironmental parameters within a few microseconds.

227 Using real-time analyses of lumenal microenvironmental parameters, in conjunction with hydro

228 ingle-cell analyses suggested distinct tumor microenvironmental patterns, including cell-to-cell inte

229 udy, we integrate mathematical modeling with microenvironmental perturbation data to investigate inva

230 ate-exposed brains, indicating an underlying microenvironmental perturbation.

231 nce, Vodnala et al. (2019) report that tumor microenvironmental potassium impairs T cell nutrient upt

232 nnate host defences and reveal an additional microenvironmental pressure that selected for a specific

233 ction as a novel and unexpected critical ECM microenvironmental pro-oncogenic regulator of epithelial

234 iscuss the potential of understanding tumour microenvironmental processes to identify biomarkers of c

235 s, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues.

236 No single microenvironmental property was able to predict the loca

237 o-step model of resistance whereby extrinsic microenvironmental proteins FLT3 ligand (FL) and fibrobl

238 reened a library of 297 recombinant-secreted microenvironmental proteins for the ability to confer re

239 is system for the study of tumorigenesis and microenvironmental redirection of breast cancer cells.

240 gent Notch ligand function and combinatorial microenvironmental regulation in liver progenitor fate s

241 rates data from biology and pathology on the microenvironmental regulation of PCa cell behaviour.

242 /niche pairs to advance the understanding of microenvironmental regulation of stem cell function.

243 tants with mislocalized PGCs corroborate the microenvironmental regulation of the cell cycle, except

244 This knowledge of the microenvironmental regulation of the MK lineage could le

245 blish lipid-sensing nuclear receptors in the microenvironmental regulation of tumor progression.

246 esting that Akt dynamics mediates contextual microenvironmental regulation.

247 Extracellular AGR2 (eAGR2) is a microenvironmental regulator of epithelial tissue archit

248 re than 950 GM mouse lines to identify novel microenvironmental regulators of metastatic colonization

249 use lines using an in vivo assay to identify microenvironmental regulators of metastatic colonization

250 Targeted modulation of microenvironmental regulatory pathways may be essential

251 he stage for mechanistic studies deciphering microenvironmental role in brain tumor progression.

252 lic phenotype of tumor cells is plastic, and microenvironmental selection leads to increased tumor gl

253 e escape mechanism that is subject to strong microenvironmental selection pressures later in tumor ev

254 Here we introduce microenvironmental selective plane illumination microsco

255 HBECs to engage EMT machinery in response to microenvironmental (serum/TGF-beta) or oncogenetic (MYC)

256 t extracellular ATP (eATP) could represent a microenvironmental signal potentially affecting virion r

257 t tumors evolve through dynamic responses to microenvironmental signals and development of resistance

258 tream of regulatory processes that integrate microenvironmental signals and directly implicated in fe

259 To assess how selected microenvironmental signals control cancer-associated phe

260 A multidisciplinary study sheds light on microenvironmental signals controlling cancer cell plast

261 ntal approaches allow assessment of critical microenvironmental signals controlling hybrid EMT phenot

262 upon microbial activation in the presence of microenvironmental signals including IL-15, and were cap

263 he ability for cells to sense and respond to microenvironmental signals is influenced by their three

264 Our findings suggest that either microenvironmental signals on the tumor border or differ

265 are hair-like cellular extensions that sense microenvironmental signals surrounding cells.

266 espond to a dynamic set of intercellular and microenvironmental signals that instruct B cell position

267 ts to stemness factors and the nature of the microenvironmental signals that pattern autophagy in dif

268 that venetoclax resistance may be induced by microenvironmental signals that upregulate antiapoptotic

269 Such tissue microenvironmental signals together with epigenetic chan

270 oordinately regulated by cell-autonomous and microenvironmental signals, and establish CAF-derived FG

271 eporters that can nonlinearly amplify tumour microenvironmental signals, permitting the identificatio

272 It is known that microenvironmental signals, such as substrate topography

273 uration, enabling them to respond readily to microenvironmental signals, such as TGFbeta.

274 resident or inflammatory Mphis, depending on microenvironmental signals.

275 diverse extent and quality of adaptation to microenvironmental signals.

276 outcome of a division could be influenced by microenvironmental signals.

277 ET in HPCs can be accelerated in response to microenvironmental stiffening and can be inhibited by so

278 In vivo, however, various microenvironmental stimuli in lymphoid and mucosal tissu

279 quirement for additional mutagenic events or microenvironmental stimuli, including inflammation.

280 heir polarization state in response to local microenvironmental stimuli.

281 associated with tumorigenesis in response to microenvironmental stimuli; however, the regulatory path

282 Cancers can upregulate autophagy to survive microenvironmental stress and to increase growth and agg

283 Hypoxia is a key microenvironmental stress in solid tumors associated wit

284 ed starvation response, has been hijacked by microenvironmental stress signals in melanoma to drive p

285 ed sEV-mediated communication could adapt to microenvironmental stresses.

286 findings suggest that clinical management of microenvironmental stressor-mediated microscopic injury

287 coordination of T cell receptor stimulation, microenvironmental stressors and PD-1 signaling.

288 n tumor progression and response to therapy, microenvironmental (stromal) heterogeneity in TNBC has n

289 elta) mediates B-cell receptor signaling and microenvironmental support signals that promote the grow

290 F-kappaB signaling apparently independent of microenvironmental support.

291 portunities aimed at both cell-intrinsic and microenvironmental targets together with new insights in

292 n is accompanied by increased sensitivity to microenvironmental TGF-beta.

293 In order to analyze the effects of increased microenvironmental TGFbeta concentration in vivo, we dev

294 miR-146a levels were increased in melanoma microenvironmental tissue, and miR-146a(-/-) mice surviv

295 tumoral heterogeneity, and deleterious tumor microenvironmental (TME) crosstalk.

296 Complex tumor microenvironmental (TME) features influence the outcome

297 n preactivated CD8(+) T cells in response to microenvironmental transforming growth factor-beta (TGF-

298 of chemoresistant CSCs is less dependent on microenvironmental tumor structure, while cisplatin show

299 Further, we find that the microenvironmental variable does not strongly affect the

300 eas stem initiation and growth are driven by microenvironmental variables such as light availability