ライフサイエンスコーパス: microfilament

1 g of all three Xis protomers to generate the microfilament.

2 clusion of the middle cerebral artery with a microfilament.

3 ll possible inclusions, none associated with microfilaments.

4 tes for accurate characterization of plants' microfilaments.

5 virus (TBSV)], is inhibited by disruption of microfilaments.

6 acin blocked binding between purified B2 and microfilaments.

7 SMA) mRNA and protein and a dense network of microfilaments.

8 y expressed protein and a major component of microfilaments.

9 keletal components, such as microtubules and microfilaments.

10 al mobility is restricted by direct links to microfilaments.

11 mediating crosstalk between microtubules and microfilaments.

12 Dys-ABD alone associated with actin microfilaments.

13 ortical PAR-3 localization depends on intact microfilaments.

14 ent factor C3 and that uptake requires actin microfilaments.

15 dependent, while cortical anchoring required microfilaments.

16 All species were highly contaminated with microfilaments.

17 es was independent of the integrity of actin microfilaments.

18 associated with microtubules and with actin microfilaments.

19 spyA in HeLa cells resulted in loss of actin microfilaments.

20 through preventing cofilin interaction with microfilaments.

21 uence, the opposite was observed for shorter microfilaments.

22 the CH domain interacted directly with actin microfilaments.

23 ingle-fiber recordings of teased dorsal root microfilaments.

24 icrovilli, and proliferative pericanalicular microfilaments.

25 tivity, and requires intact microtubules and microfilaments.

26 olesale depolymerization of microtubules and microfilaments.

27 g filaments had the same dimensions as actin microfilaments.

28 of the par genes and the presence of intact microfilaments.

29 ins that promote formation of actin/spectrin microfilaments.

30 nvolve the assembly and disassembly of actin microfilaments.

31 rt toward the nucleus using microtubules and microfilaments.

32 ct the function of thin muscle filaments and microfilaments.

33 odies (I-LBs) move in association with actin microfilaments.

34 to be primarily mediated by microtubules and microfilaments.

35 5) an association of the receptor with actin microfilaments.

36 contained fine fibers the diameter of actin microfilaments.

37 eraction between a3-containing V-ATPases and microfilaments.

38 oclast-selective a3-subunit of V-ATPase, and microfilaments.

39 subunit of vacuolar H+-ATPase (V-ATPase) and microfilaments.

40 axial strains caused by the sliding of actin microfilaments about the fixed integrin attachments are

41 Microfilaments (actin) and microtubules represent the ex

42 ducts interacting with both microtubules and microfilaments, Actin-related protein 87C; and (3) gene

43 Experimental depolymerization of microfilaments actually prevents retraction rather than

44 Inhibitors of microfilament and microtubule activity resulted in signi

45 , required intracellular calcium, and intact microfilament and microtubule cytoskeletons and were ind

46 Coordinated actin microfilament and microtubule dynamics is required for s

47 the WRAMP proteome, including regulators of microfilament and microtubule dynamics, protein interact

48 coordinates cellular dynamics by regulating microfilament and microtubule function.

49 icating that normal interactions between the microfilament and microtubule systems have been signific

50 ed ATP production by mitochondria and abated microfilament and vesicle motility.

51 iginated mostly from the remodeling of actin microfilaments and adhesion complexes, to less extent fr

52 al proteins are associated with actin in the microfilaments and have a major role in microfilament as

53 inding between the recombinant B-subunit and microfilaments and inhibited osteoclastogenesis in cell

54 Depolymerization of the actin microfilaments and inhibition of the Arp2/3 complex does

55 l injury through disruptive effects on actin microfilaments and microtubule (MT) organization across

56 Shiga toxin also increases the levels of microfilaments and microtubules (MTs) upon binding to th

57 ors of actin and tubulin, we found that both microfilaments and microtubules affect the shape and mot

58 n, although we show that populations of both microfilaments and microtubules are oriented in the dire

59 s may employ unique KCHs to coordinate actin microfilaments and microtubules during cell growth.

60 In this report we examine the role of microfilaments and microtubules during early viral infec

61 its regulatory effect by disorganizing actin microfilaments and microtubules in Sertoli cells so that

62 and suggest that signal integration between microfilaments and microtubules is required for triggeri

63 Depolymerization of microfilaments and microtubules, and disintegration of t

64 Projections depended on microfilaments and microtubules, exhibited meandering tr

65 multidomain protein that can associate with microfilaments and microtubules.

66 cleft progression through regulation of both microfilaments and microtubules.

67 MP structure formation, potentially bridging microfilaments and MVBs.

68 Here we determine the importance of microfilaments and myosins for the sustained intercellul

69 an be used for the assembly of ultraflexible microfilaments and network structures.

70 ons with severely disorganized microtubules, microfilaments and neurofilaments, raising the hypothesi

71 hat was dependent on polymerization of actin microfilaments and on a functional cytoskeleton, as indi

72 volved differently in their requirements for microfilaments and the associated myosin motors, in a ma

73 o diverse mechanical properties of entangled microfilaments and their potential applications.

74 just after GVBD, cortical granules attach to microfilaments and translocate to the cell surface.

75 This results in diverse interactions among microfilaments and with the environment; the differences

76 bunit of vacuolar H(+)-ATPase (V-ATPase) and microfilaments, and also between osteoclast formation an

77 tivation stimulates vesicle association with microfilaments, and is a key regulatory step in the coor

78 ect does not require interactions with actin microfilaments, and it is possible that other actions of

79 s that involves integration of microtubules, microfilaments, and membrane traffic to remove apoptotic

80 nd wortmannin, indicating that microtubules, microfilaments, and signal transduction are required for

81 Vacuolar H(+)-ATPase (V-ATPase) binds microfilaments, and that interaction may be mediated by

82 also indicate that microtubules and cortical microfilaments antagonize each other during the preblast

83 tion of TM1 in breast tumors may destabilize microfilament architecture and confer resistance to anoi

84 the cell by controlling the extent to which microfilaments are bundled.

85 When LIMKs are inhibited, actin microfilaments are disorganized and microtubules are sta

86 addition to periods of high availability of microfilaments are important pathways for contamination.

87 t, but both intermediate filaments and actin microfilaments are involved in dynamic cross-linking org

88 eton with drugs showed that microtubules and microfilaments are involved in the types of mRNA movemen

89 olar material (PCM) fails to assemble, actin microfilaments are not organized into furrows at the syn

90 AJM-1, an apical junction marker, and apical microfilaments are severely affected in the distal sperm

91 protein of muscle thin filaments, and actin microfilaments are the main component of the eukaryotic

92 Microtubules, but not microfilaments, are required for proper MTOC localizatio

93 receptors with F-actin and myosin to form a microfilament array associated with multivesicular bodie

94 These two proteins can generate microfilament arrays that "yield" at a strain amplitude

95 tous nucleation-promoting factor of branched microfilament arrays, is an essential contributor to ske

96 lactide-co-glycolide) copolymer (PLGA) fiber microfilaments as a floating scaffold to generate elonga

97 nuclear envelope motility depended on actin microfilaments as well as tubulin.

98 adaptation required intact microtubules and microfilaments, as well as new protein synthesis, and wa

99 the microfilaments and have a major role in microfilament assembly and function.

100 sperm chromatin is blocked by inhibitors of microfilament assembly or disassembly.

101 shRNA (neither of which alter microtubule or microfilament assembly) causes mesenchymal cells to adop

102 sulted in aberrant distributions of cortical microfilaments associated with abnormal and striking mem

103 opomyosins (TMs), a family of actin-binding, microfilament-associated proteins, is a prominent featur

104 roteins that enhance the depolymerization of microfilaments at their minus, or slow-growing, ends.

105 a suggest that MV homodimerization modulates microfilament attachment at muscular adhesion sites and

106 The primary mechanism of microfilament-based motility does not appear to be throu

107 Transport is dependent on intact microfilaments, because particle movement is inhibited r

108 prion nanoparticles including oligomers and microfilaments bound to lipid vesicles.

109 Both kinases are implicated in microfilament bundle assembly and smooth muscle contract

110 n summary, plastin 3 is a regulator of actin microfilament bundles at the ES in which it dictates the

111 These actin microfilament bundles require rapid debundling to conver

112 entin intermediate filaments, in addition to microfilament bundles, interact with many of the alphavb

113 ce of higher-order actin structures, such as microfilament bundles, is unknown.

114 sed interprocess spacing and haphazard actin microfilament bundles.

115 nisms, while plastid movement is promoted by microfilaments but inhibited by microtubules.

116 nule translocation requires association with microfilaments but not microtubules.

117 s contained disorganized bundles of parallel microfilaments, but anterior F-actin bundles in untreate

118 modification that regulates microtubules and microfilaments, but its effects on intermediate filament

119 be associated with transverse-cortical actin microfilaments, but never with axial actin cables in cot

120 that C. elegans gastrulation requires intact microfilaments, but not microtubules.

121 ters is prevented by the depolymerisation of microfilaments, but not of microtubules.

122 tile granules that are associated with actin microfilaments, but not with microtubules.

123 By contrast, disruption of actin-containing microfilaments by cytochalasin D or microtubules by noco

124 filament rings, and bottleneck suggests that microfilaments can still contract even though they are n

125 Coordinated microtubule and microfilament changes are essential for the morphologica

126 87C; and (3) gene products interacting with microfilaments, chickadee, diaphanous, Cdc42, quail, spa

127 Here we show that plant tracheary microfilaments, collected from Agapanthus africanus and

128 These findings do not support the microfilament-complex model, but instead indicate that t

129 f these complexes is powered by myosin: the "microfilament-complex" model.

130 and animals: a highly sophisticated array of microfilament components, a large family of G-protein-co

131 Therefore, microfilament contamination in snooks are a consequence

132 cles at the nuclear-cytoplasmic junction and microfilament contraction.

133 ere the result of an alteration of the actin microfilaments, converting from their bundled to branche

134 ate that Capu and Spire have microtubule and microfilament crosslinking activity.

135 disrupt the microtubules (thiabendazole) and microfilaments (cytochalasin D and latrunculin B) of the

136 nteraction between both the microtubular and microfilament cytoskeleton and cellular membranes.

137 In response to this cue, the microfilament cytoskeleton polarizes the distribution of

138 In contrast, the microfilament cytoskeleton was enhanced by ROCK II down-

139 g is dependent on the integrity of the actin microfilament cytoskeleton, we sought to determine if ac

140 d actin isoforms that polymerize to form the microfilament cytoskeleton.

141 zation and requires both the microtubule and microfilament cytoskeleton.

142 Uptake was found to be both microtubule and microfilament dependent and required the Rho family of G

143 ug response suggests a maternally inherited, microfilament-dependent organization within the egg cort

144 process involving distinct microtubule- and microfilament-dependent phases and indicate a role for d

145 Finally, the effect of actin microfilament depolymerization on total release is alter

146 olymerizing agent nocodazole, but not to the microfilament-depolymerizing agent cytochalasin B, indic

147 eidispongiolides and sphinxolides are potent microfilament destabilizing agents that represent a prom

148 In contrast, the depolymerization of actin microfilaments did not have any effect on virus binding,

149 dent process, since treatment with the actin microfilament disrupter cytochalasin D prevented iNOS re

150 oxic derivatives, compound 9 did not exhibit microfilament-disrupting activity at 5 microM.

151 rcinoma (HCT-116) cells) but did not exhibit microfilament-disrupting activity at 80 nM.

152 e impaired by microtubule-disrupting but not microfilament-disrupting agents as well as by overexpres

153 Addition of microfilament-disrupting agents led to rapid and extensi

154 association with actin in cells treated with microfilament-disrupting or filament-stabilizing agents

155 e screen, and all compounds were tested in a microfilament disruption assay.

156 ided dramatic protection against PAN-induced microfilament disruption in sense > vector > antisense c

157 roperties with cholesterol removal and actin microfilament disruption.

158 Accurate regulation of microfilament dynamics is central to cell growth, motili

159 ot impede BKV infection, while inhibition of microfilament dynamics with jasplakinolide results in re

160 sibly stabilized microtubules, blocked actin microfilament dynamics, inhibited cell motility in vitro

161 polymeric actin (F-actin) and is involved in microfilament dynamics.

162 Microfilament-engineered cerebral organoids (enCORs) dis

163 after nocodazole washout; in vitro, Mena and microfilaments enhanced GRASP65 oligomerization and Golg

164 quires the formation of filopodia from actin microfilaments (F-actin) and their engorgement with micr

165 ECM, the attached ECs rearrange their actin microfilaments first into peripheral stress fibers and s

166 e dependence of TMV, PVX, and TBSV on intact microfilaments for intercellular movement led us to inve

167 The entry was dependent on microfilaments for internalization and subsequently bruc

168 he same genus as TMV, did not require intact microfilaments for normal spread.

169 ream of Cdc42 in a pathway that may regulate microfilament formation.

170 Agents that impaired microfilament function, including cytochalasin B, cytoch

171 e activity of caldesmon and through this the microfilament functions in cells.

172 binds to free barbed ends, thereby arresting microfilament growth and restraining elongation to remai

173 Inhibition of actin microfilaments had the greatest effect on bulk compressi

174 act, a small peptide with affinity for actin microfilaments has become a gold standard in live cell i

175 ssion induced a substantial rearrangement of microfilaments, implying a bidirectional interaction bet

176 er form that polymerizes into a thin, linear microfilament in cells.

177 ndent potentiation are controlled by PKA and microfilaments in a convergent manner.

178 Furthermore, microfilaments in BMPCs consisted of atypically thick bu

179 ability barrier, causing disruption of actin microfilaments in cell cytosol, perturbing the localizat

180 c interaction between microtubules and actin microfilaments in cotton fibers.

181 Nomofungin disrupts microfilaments in cultured mammalian cells and is modera

182 death, highlighting the importance of actin microfilaments in rituximab/milatuzumab-mediated cell de

183 s study, the involvement of microtubules and microfilaments in the light-driven translocation of arre

184 cells, a shorter CaD isoform co-exists with microfilaments in the stress fibers at the quiescent sta

185 ant transformation, and that TM1 reorganizes microfilaments in the transformed cells.

186 MIPP protein binds to microfilaments in vitro and co-immunoprecipitates with a

187 t- and phototropin-dependent localization to microfilaments in vivo.

188 ed a critical role for microtubules, but not microfilaments, in hTHTR1 trafficking.

189 of CRB3 KD-induced re-organization of actin microfilaments, in which actin microfilaments were trunc

190 tosis via the accumulation of cortical actin microfilaments induced by the ROP2 effector protein RIC4

191 as moving particles, a property inhibited by microfilament inhibitors.

192 on with tropomyosin results in disruption of microfilament integrity leading to inhibition of cell mo

193 Along with microtubules and microfilaments, intermediate filaments are a major compo

194 ide, or colchicine was used to disrupt actin microfilaments, intermediate filaments, or microtubules,

195 tin-dependent manner and to cross-link actin microfilaments into higher-order structures has been cor

196 ither through directed transport along actin microfilaments into one daughter cell or through capture

197 hesized that the ability of TM1 to stabilize microfilaments is crucial for tumor suppression.

198 tood how the interaction of microtubules and microfilaments is mediated in this context.

199 bunit of vacuolar H(+)-ATPase (V-ATPase) and microfilaments is required for osteoclast bone resorptio

200 y that links the centrosome and the cortical microfilaments is unknown.

201 ing mutant, S381E, was incapable of bundling microfilaments, it retains the ability to bind F-actin.

202 Disrupting microtubules but not microfilaments led to reorganization of ENaC clusters an

203 expression of exogenous K-cyclin results in microfilament loss and changes in cell morphology; both

204 The dynamics of microfilament (<5 mm) ingestion were evaluated in three

205 findings suggest that both microtubules and microfilaments may play a role in the effective traffick

206 As microfilament-membrane linkage is critical to this proce

207 bedded in membrane microdomains induce actin-microfilament meshwork formation, anchoring microtubules

208 on, apical recruitment of p150(Glued), actin microfilament meshwork organization, and ultrastructure

209 Both expanded acinar lumina and thickened microfilament meshworks, and both caused homotypic fusio

210 wever, the mechanisms that regulate cortical microfilament (MF) assembly remain poorly understood.

211 Actin microfilament (MF) organization and remodelling is criti

212 at PS1 associates with microtubules (MT) and microfilaments (MF) and that its cytoskeletal associatio

213 ges due to structural modifications in actin microfilaments (MFs) and microtubules (MTs).

214 s elegans, the partitioning proteins (PARs), microfilaments (MFs), dynein, dynactin, and a nonmuscle

215 -bodies and, regardless of size, VRCs, along microfilaments (MFs).

216 bstrate-dependent cultures, entosis requires microfilaments, microtubules and the Golgi complex for c

217 Disruptors of the cytoskeleton (microfilaments, microtubules, and intermediate filaments

218 filaments within the internal cytoskeleton--microfilaments, microtubules, and intermediate filaments

219 We show that microfilaments, microtubules, and the intermediate filam

220 actin and tubulin revealed similar arrested microfilament motility upon challenge.

221 It is clear from endocytosis assays that microfilament motors are functional prior to meiosis, ev

222 chromatin organization, actin filament, and microfilament movement.

223 the presence of an array of bundles of actin microfilaments near the Sertoli cell plasma membrane.

224 With a close examination of the F-actin microfilament network, these findings show that Panx1 ch

225 is accompanied by modifications of the actin microfilament network, with shortened filaments, whereas

226 caused cell retraction and disruption of the microfilament network.

227 N-WASP-mediated actin nucleation of branched microfilament networks is specifically required for the

228 teractions among Cdk1-CycB, microtubule, and microfilament networks.

229 The highest ingestion of microfilaments occurred in the adults, when fishes becam

230 It is built of polygonally bent helical microfilaments of cellulose-based nanostructures coated

231 The ingestion of microfilaments of different colours and sizes was likely

232 he nucleus, endoplasmic reticulum, and actin microfilaments of the cytoskeleton in response to reduct

233 fic and high-affinity binding, it may form a microfilament on DNA similar to that described for the p

234 oocyte, which is unlikely mediated either by microfilaments or by microtubules, markedly decreases be

235 the embryos with agents that disrupt either microfilaments or microtubules has little, if any, effec

236 ukocyte deformability has been attributed to microfilaments or microtubules, but the present studies

237 zation of CteG-2HA was independent of intact microfilaments or microtubules.

238 tochalasin D or latrunculin B to disrupt the microfilament organization selectively slowed only trans

239 D1 plays a central role in the regulation of microfilament organization, consequently controlling cel

240 by depolymerizing actin and disrupting actin microfilament organization.

241 initial uptake of Py, both microtubules and microfilaments play roles in trafficking of the virus to

242 s with cytochalasin E, an inhibitor of actin microfilament polymerisation.

243 rms of the organism induced endothelial cell microfilament rearrangement and subsequent endocytosis.

244 pathway of phosphoinositol 3-kinase controls microfilament rearrangement and translocation of actin-a

245 brane adhesion, probably due to Sertoli cell microfilament redistribution.

246 In summary, CRB3 is an actin microfilament regulator, playing a pivotal role in organ

247 ctivity of CP alpha expand the repertoire of microfilament regulatory mechanisms assigned to CPs.

248 ype also reduce Cdk1-CycB activities and are microfilament-related genes.

249 , whereas completion of the process required microfilament remodeling and ROCK, MLCK, and dynamin II

250 ble actin microfilaments, we show that actin microfilament remodeling is part of fenestra biogenesis

251 The motility of P6 along microfilaments represents an entirely new property for t

252 C4 to promote the assembly of cortical actin microfilaments required for localized outgrowth.

253 omitant to increased polymerization of actin microfilaments resulting in decreased G- to F-actin rati

254 on negatively regulated contractility of the microfilament-rich cell cortex during pronuclear migrati

255 late cellularization allows src64-dependent microfilament ring constriction to drive basal closure.

256 e mutant suggests that src64 is required for microfilament ring contraction even in the absence of Bo

257 Our results suggest that src64-dependent microfilament ring contraction is resisted by Bottleneck

258 controlling contraction of the actin-myosin microfilament ring during this process.

259 craps, a mutation in anillin that eliminates microfilament rings, and bottleneck suggests that microf

260 ted of all, hint at an autonomous process of microfilament self-organization driving the formation of

261 icrotubules or cytochalasin D to disassemble microfilaments simplifies the intermediate scattering fu

262 le (microtubule specific) or cytochalasin D (microfilament specific) prevented the effects of CaM-dep

263 ocytes and in 129 CB3 cells treated with the microfilament stabilizer phalloidin.

264 nism for phospholipid-induced changes in the microfilament structure and cell function and suggest th

265 Cell morphology and the microfilament structure of untreated sense and antisense

266 se channels requires interactions with actin microfilaments subjacent to the plasma membrane.

267 ession of activity at fertilization requires microfilaments, suggesting that the transporters are in

268 arrays after an initial period of intensive microfilament synthesis, followed by array elongation, p

269 leading to a reorganization of the podocyte microfilament system and consequent proteinuria.

270 Actin is the main component of the microfilament system in eukaryotic cells and can be foun

271 ells, suggesting that a dynamic state of the microfilament system is important for Py infectivity.

272 VASP, an important component of the cellular microfilament system, plays a major role in regulating S

273 crotubules as well as a dynamic state of the microfilament system.

274 by both phospholipase D (PLD) and the actin microfilament system.

275 tes from progressive shortening of epidermal microfilaments that are induced by muscle contractions r

276 t, plant and animal cells that confers actin microfilaments their bundled configuration.

277 li cell cytosol, causing truncation of actin microfilament, thereby failing to support the Sertoli ce

278 e that while P6-GFP inclusions traffic along microfilaments, those associated with microtubules appea

279 actin filaments, and their organization with microfilaments to establish and maintain cell polarity d

280 V0domains of V-ATPase through the binding of microfilaments to subunitsBandCand preserving the integr

281 veal that SPATA6 is involved in myosin-based microfilament transport through interaction with myosin

282 The length of microfilaments was also associated with environmental va

283 that rearrangement of both microtubules and microfilaments was necessary for the uptake.

284 f agents that stabilize or disassemble actin microfilaments, we show that actin microfilament remodel

285 ytokinesis defects and disruption of tubulin microfilaments were also observed by immunofluorescence

286 Blue microfilaments were frequently ingested, and appear to h

287 Longer microfilaments were ingested in habitats with greater ri

288 Purple and red microfilaments were more frequently ingested in the lowe

289 ingestion of different colours and sizes of microfilaments were strongly associated with the spatio-

290 tion of actin microfilaments, in which actin microfilaments were truncated, and extensively branched,

291 ed by centrifugal cosedimentation with actin microfilaments, where bound protein is separated from ac

292 large cytoplasmic inclusions associated with microfilaments, whereas the 125-kDa protein formed few s

293 ofilin to stress fibers and disorganizes the microfilaments, whereas wild type TM1 appears to restric

294 attR recombination site to generate a curved microfilament, which promotes assembly of the excisive i

295 a reduction in formation of microtubules and microfilaments, which are necessary for the development

296 Actin microfilaments, which are prominent in pollen tubes, hav

297 Disruption of actin microfilaments, which causes delocalization of Bifocal b

298 n, resulting in the re-organization of actin microfilaments, which rendered them similar to those in

299 icrotubules with colchicine (Colch) or actin microfilaments with cytochalasin D (CD) dramatically red

300 And, microfilaments, with diameters of about 4 nm, transmit m