ライフサイエンスコーパス: micromolar

1 gh affinities, ranging from nanomolar to low micromolar.

2 tion equilibrium constants from picomolar to micromolar.

3 th potencies ranging from 470 picomolar to 6 micromolar.

4 ein, Unc119, varies between subnanomolar and micromolar.

5 quilibrium dissociation constants of tens of micromolar.

6 d their already substantial proliferation in micromolar 4-hydroxytamoxifen and fulvestrant/ICI 182,78

7 The new analogues possess micromolar activities against Trypanosoma brucei rhodesi

8 ty (Ki = 38 pM), coupled with a single-digit micromolar activity against Trypanosoma brucei brucei (E

9 activate adenosine receptors (ARs) revealed micromolar activity at serotonin 5HT2B and 5HT2C recepto

10 (CPP) growth, consistently demonstrates low micromolar activity in different in vitro models of VC (

11 irst small-molecule IL-15 inhibitor with sub-micromolar activity.

12 inds to four melanocortin receptors with low micromolar affinities and activates the hMC1R/Gs pathway

13 ide-based inhibitor scaffold that showed sub-micromolar affinities toward collagenase H (ColH) from t

14 t validated LxxIxE motifs bind PP2A:B56 with micromolar affinities, suggesting that additional motifs

15 were discovered, and the most potent had sub-micromolar affinities.

16 s l-cystine, l-cysteine, and d-cysteine with micromolar affinities.

17 ular weight compounds that bind TAR with low micromolar affinity (K(D) values ranging from 3.6 to 22

18 found to bind human IL-12 (hIL-12) with low micromolar affinity and increase hIL-12 bioactivity by m

19 Lipid binding by purified MpPR-1 occurs with micromolar affinity and is saturable in vitro Sterol bin

20 mains are required for binding the NTSD with micromolar affinity and that NTSD binding improves CCSSD

21 motif in noncognate peptides results in low micromolar affinity binding by binding domains from seve

22 ts bind the IL-36R extracellular domain with micromolar affinity but do not detectably bind IL-1RAcP.

23 domains of Myo10 and DdMyo7 bind to MT with micromolar affinity but, surprisingly, their MT binding

24 mor potency and systemic off-tumor toxicity, micromolar affinity CAR T cells demonstrated superior an

25 perior expansion and contraction kinetics of micromolar affinity CAR T cells.

26 ne of these derivatives (DCUK-OEt) displayed micromolar affinity for brain gamma-aminobutyric acid ty

27 region, and show that they all have nano to micromolar affinity for HSA Peptide 40 and nab-paclitaxe

28 e 4-acylpyrrole 6 which shows a single-digit micromolar affinity for the CREBBP bromodomain and a lig

29 Pry1 bound fatty acids with micromolar affinity in vitro, and its function was essen

30 ysine mimetic ligands ranging from mM to low micromolar affinity that were identified using fragment

31 to p97, showing that ataxin3 binds with low-micromolar affinity to both wild-type p97 and mutants li

32 We show that p12 binds with micromolar affinity to the classical PIP-binding pocket

33 valuate the safety and potential efficacy of micromolar affinity tuned CAR T cells against newly diag

34 e of toxicity provides proof-of-concept that micromolar affinity tuned CAR T cells can be used to tar

35 ionally, we show that CASPR2 associates with micromolar affinity with CNTN1 but, under the same condi

36 ch peptide was able to bind DNA and RNA with micromolar affinity, but did not display nuclease activi

37 TOCA1 binds Cdc42 with micromolar affinity, in contrast to the nanomolar affini

38 lene blue-modified aptamers bind to ATP with micromolar affinity, while the reduced form lacks bindin

39 binding guanine-containing dinucleotides in micromolar affinity.

40 ible and disordered, but it binds dsDNA with micromolar affinity.

41 directly to purified TRPML1 proteins with a micromolar affinity.

42 the anticancer drug irinotecan (CPT-11) with micromolar affinity.

43 bound Fe(2+) in detergent solution with low micromolar affinity.

44 M antibodies from patient sera but with only micromolar affinity.

45 es 1255-1452, as interacting with HDAC7 with micromolar affinity.

46 ed ligands that bind to the active site with micromolar affinity.

47 minescens TcdA1 binds to Lewis antigens with micromolar affinity.

48 micking the CTD of P stalk proteins with low micromolar affinity.

49 lion fragments, which revealed another three micromolar agonists unrelated either to 28 or known musc

50 hat evidence pelagic barite precipitation at micromolar ambient sulfate.

51 ar fluorescence turn-on sensors that work at micromolar analyte concentrations that are compatible wi

52 peptide aldehydes Tat-A and Tat-B showed low micromolar anticancer and antifungal activities and syne

53 y congener within this series to demonstrate micromolar antihuman cytomegalovirus (HCMV) potency.

54 (where p-cym=para-cymene) exhibit potent sub-micromolar antiproliferative activity towards human canc

55 ggest that pulsatile stimulation of P2X4 via micromolar ATP may be sufficient to promote TNFalpha pro

56 Five micromolars ATV, within physiologic range, strongly (>95

57 Sub-micromolar binding affinities were obtained by fluoresce

58 d is capable of binding multiple guests with micromolar binding affinities while retaining the abilit

59 imple and label-free method for studying sub-micromolar binding affinities, with potential for extens

60 p of a protein domain; the protein exhibited micromolar binding affinity for the MVCB[8] complex, mat

61 zolidinedione fragment was found to have low micromolar binding affinity to the zinc metalloenzyme ca

62 acidic residues at the P-2 position with low micromolar binding constants.

63 Gelsolin, at both nanomolar and micromolar Ca(2+) concentration, appreciably enhanced ac

64 Our results suggest that micromolar [Ca(2+) ]i , in the submembrane or junctional

65 nic pre-resonant SRS allows detection of sub-micromolar chromophores.

66 e, we show both l- and d-BTZ enantiomers are micromolar competitive betaLIs of all MBL classes in vit

67 they allow the detection of fluoride ions at micromolar concentration by the naked eye, UV-vis absorp

68 elix forms in dilute CH(3)CN solution of the micromolar concentration level, e.g., 5.6 muM from 2D NO

69 st the bacterial challenge was observed at a micromolar concentration of Ceftriaxone or Cefotaxime in

70 ration of GABA and prolonged periods of low, micromolar concentration of the transmitter.

71 The best compound was active in a very low micromolar concentration range against all three transpo

72 promising anti-influenza activity in the low micromolar concentration range and good selectivity.

73 orders of magnitude in the low nanomolar to micromolar concentration range and limit of detection of

74 tion of ciproxifan revealed IC50 values in a micromolar concentration range for human and rat monoami

75 Pt1 strain, 2E,4E-decadienal supplied in the micromolar concentration range led to a nonspecific cell

76 with IC(50) values in the high nanomolar/low micromolar concentration range, and showed antiprolifera

77 vival of multiple cancer cell lines in a low micromolar concentration range.

78 ew methodology to detect and quantify at the micromolar concentration the spatial distribution at mil

79 amide-forming ligation that proceeds at low micromolar concentration under aqueous conditions in the

80 At low micromolar concentration, microalgae fixed all silver in

81 At a low micromolar concentration, PF74 potently inhibited HIV-1

82 n cytomegalovirus (HCMV) replications at low micromolar concentration, with little or no cytotoxicity

83 tivities, ranging from low-nanomolar to high-micromolar concentration.

84 IL-37 monomers also remain monomeric at high micromolar concentrations and that these monomeric IL-37

85 against schistosomula and adult worms at low micromolar concentrations and therefore represent promis

86 y source for biological reactions, for which micromolar concentrations are sufficient, we propose tha

87 Mg(2+) is required at micromolar concentrations as a cofactor for ATP, enzymat

88 e found that 3-NOP indeed inactivates MCR at micromolar concentrations by oxidation of its active sit

89 ed to nitrite, which also inactivates MCR at micromolar concentrations by oxidation of Ni(I).

90 MPs, which may explain why most AMPs require micromolar concentrations for activity, show significant

91 assays by modulation of the phenotype at low micromolar concentrations in both cancer and inflammator

92 actinides can be easily distinguished at low micromolar concentrations in complex salt mixtures.

93 ng oral administration, V565 was detected at micromolar concentrations in ileal fluid from the ileost

94 novel LRAs that reverse viral latency at low micromolar concentrations in multiple cell lines.

95 min) identification of the target opioid at micromolar concentrations in the presence of other cutti

96 These peptides induce autophagy at micromolar concentrations in vitro, have aggregate-clear

97 e detection of multiple illicit drugs at low micromolar concentrations in water and in saliva.

98 Its covalent skeleton renders it stable at micromolar concentrations in water, enabling the fluorom

99 Unexpectedly, at sub-micromolar concentrations MTMs stabilize FLI1-DNA comple

100 Finally, low micromolar concentrations of 7 inhibited 14,15-EET produ

101 ution NMR can reach picomole sensitivity for micromolar concentrations of analyte by combining parahy

102 Micromolar concentrations of Ca(2+) lead to a robust blu

103 ivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultan

104 Caulobacter requires micromolar concentrations of calcium for normal growth a

105 Prior work has indicated that exposure to micromolar concentrations of GABA can both activate the

106 cologically relevant, being sensitive to sub-micromolar concentrations of inorganic phosphate and a r

107 de, requiring the administration of only low micromolar concentrations of IPA, demonstrating that thi

108 The effects of nanomolar versus micromolar concentrations of phloroglucinol differed bot

109 er millimolar concentrations of ornithine or micromolar concentrations of putrescine or by complement

110 of isolated lysosomal membranes showed that micromolar concentrations of Rap and some rapalogs activ

111 Thus, sub-micromolar concentrations of short-chain polyP can accel

112 Moreover, SPCA1a is blocked by micromolar concentrations of the commonly used SERCA1a i

113 This was reversed in the presence of micromolar concentrations of the protein phosphatase inh

114 l forces, Piezo1 is selectively activated by micromolar concentrations of the small molecule Yoda1 th

115 mu-EME salt removal from samples containing micromolar concentrations of the target analytes and 150

116 siva conidia at physiologically relevant low micromolar concentrations that were non-toxic to poplar

117 found that TlpD is selectively sensitive at micromolar concentrations to bleach (hypochlorous acid,

118 In comparison, etomoxir at low micromolar concentrations was sufficient to saturate its

119 n to produce plasmonic gold nanoparticles at micromolar concentrations within 30 min of application u

120 ation, and quantification of analytes at low-micromolar concentrations, provided they can weakly asso

121 ombinant ENO1 and PKM2 at low millimolar and micromolar concentrations, respectively, and inhibited t

122 antioxidant and anti-inflammatory pathway at micromolar concentrations, showing interesting structure

123 hantom images provide sufficient contrast at micromolar concentrations, showing promise for eventual

124 Notably, even at micromolar concentrations, the probe possesses the abili

125 teins also inhibited SOD1 aggregation at low micromolar concentrations, whereas others were ineffecti

126 inhibits human norovirus replication at low-micromolar concentrations.

127 ce bound fluorescent analogs even at tens of micromolar concentrations.

128 suppressing precursor autoprocessing at low micromolar concentrations.

129 en persisted even when ammonium was added to micromolar concentrations.

130 ective HCMV inhibitors, active at sub to low micromolar concentrations.

131 er KDMs, as well as cellular activity at low micromolar concentrations.

132 t substrate inhibition of chain formation at micromolar concentrations.

133 s able to kill Pseudomonas aeruginosa at sub-micromolar concentrations.

134 y against a variety of bacterial taxa at low micromolar concentrations.

135 norketamine mimicked ketamine effects at sub-micromolar concentrations.

136 inhibited pUL89 endonuclease activity at low-micromolar concentrations.

137 mposition, and overall amount of cysteine at micromolar concentrations.

138 were found to block viral replication at low micromolar concentrations.

139 ibits fibrillogenesis of misfolded TTR under micromolar concentrations.

140 it more than 99% of HIV-1 infectivity at low micromolar concentrations.

141 ll growth, and induction of apoptosis at low micromolar concentrations.

142 sive methods for identifying analytes at sub-micromolar concentrations.

143 res residue-specific dynamics measurement at micromolar concentrations.

144 although patrolling becomes more frequent at micromolar concentrations.

145 only a few microliters of protein sample at micromolar concentrations.

146 sitivity for disaccharide lactulose with low micromolar detection and quantification limits.

147 d ribosomes form a one-to-one complex with a micromolar dissociation constant.

148 e that single-stranded RNAs bind to PKR with micromolar dissociation constants and can induce activat

149 ow doses of visible light, and potent at sub-micromolar doses towards 3D multicellular tumor spheroid

150 d endothelial cell viability in vitro at low micromolar doses.

151 Radiation enhancement ratios for 5-10 micromolar drug concentrations ranged from 1.19 to 1.82.

152 activity against all four serotypes with low micromolar EC50 in cell-based assays.

153 ty (selectivity index, SI = 94) along with a micromolar eeAChE inhibition (IC50 = 1.03 muM).

154 , the following IC(50) values were found (in micromolars): >1000 (Ca(V)2.3), 957 (Ca(V)1.3), 656 (Ca(

155 We speculate that micromolar H2O2 is created both biologically and abiotic

156 to the discovery of AMT inhibitors with sub-micromolar half-maximal inhibitory concentrations (IC(50

157 nal topology in a ligand-efficient manner, a micromolar hit identified from a screen of a Pfizer frag

158 h both enantiomers of this compound have sub-micromolar IC(50) values and bind to the enzyme with a t

159 inhibitors of alpha-glucosidase, showing low-micromolar IC(50) values, far lower than that of the ant

160 KDMs - 2A, 2B, 5C, 6A, 7A and 7B - with low micromolar IC(50)s while considerably less active or ina

161 iniums as a promising scaffold with very low micromolar (IC50 approximately 1 muM) NNMT inhibition.

162 6-inducible Axl receptor activation with low micromolar IC50s in cell-based reporter assays, inhibit

163 leukotriene receptors 1 and 2 (CysLT1-2) at micromolar IC50values.

164 trations in healthy animal arteries and ~0.1 micromolar in calcified atherosclerotic arteries owing t

165 Hit compounds in this series display sub-micromolar in vitro activity against the intraerythrocyt

166 The optimized analogues showed low micromolar inhibition against both dynamin I (IC50 = 10.

167 These inhibitors show low- to high-micromolar inhibition in DENV RNA polymerization and cel

168 Four molecules have shown reproducibly low micromolar inhibition of calpain-2.

169 lead series, affording derivatives with sub-micromolar inhibition.

170 ilding on a previously developed nonpeptidic micromolar inhibitor, we determined 22 crystal structure

171 Thus modified compounds are micromolar inhibitors of Rab11A prenylation, simultaneou

172 he approach successfully identified five low-micromolar inhibitors with drug-like properties.

173 decarboxylation/hydrolysis activity with low micromolar K(i) values.

174 using OctetRed instrument, which yielded low micromolar KD against GtfB and nanomolar KD against GtfC

175 molar range for choline and glycine betaine, micromolar Kd for stachydrine and trigonelline and a Kd

176 used for protein-protein interactions in the micromolar KD value range.

177 re Sialic acid derivatives and bind with low micromolar Kd values to Siglec-7.

178 igh affinity binding, characterized by a low micromolar Kd, that is selective for the murine Importin

179 for clinical efficacy of L-asparaginases is micromolar KM for asparagine to allow for complete deple

180 nd pancreatic adenocarcinoma cells generated micromolar level H2O2 during just 1 min of direct CAP tr

181 nexpensive method of detecting Cu(2+) at the micromolar level would be highly desirable.

182 tection of primary alkylamines in water at a micromolar level, based on a cavitary recognition proces

183 ibited the KDM5 members in cells at nano- to micromolar levels and induce a global increase of the H3

184 However, phosphate is generally limited to micromolar levels in the environment because it precipit

185 hat beta-cells have the capacity to detoxify micromolar levels of H(2)O(2) through a thioredoxin redu

186 Inspection revealed that low-micromolar levels of sulfide inhibited the proton-pumpin

187 synthase (iNOS) expression and production of micromolar levels of the free radical nitric oxide in ne

188 on, we found here that beta-cells can remove micromolar levels of this oxidant.

189 rhodesain and falcipain-2, at nanomolar and micromolar levels, respectively.

190 llows obtaining a nitrite/nitrate image with micromolar limit of detection.

191 articularly, four compounds were found to be micromolar LsrK inhibitors (IC(50) ranging between 100 m

192 C50 values from the subnanomolar (NBOMes) to micromolar (mescaline) range.

193 yperpolarization allows DOSY analysis of low-micromolar mixtures, thus reducing the concentration req

194 ism under either millimolar or physiological micromolar Mn(2+) concentration.

195 ytoskeleton that stabilize the initial weak (micromolar) monovalent interaction.

196 we elucidated that they were weak (K (i) low micromolar) mu-opioid agonists, which led to the design

197 ium over a wide concentration range from sub-micromolar (muM) to millimolar (mM).

198 .2% of the total electron flow), even at sub-micromolar O2 concentrations.

199 ides (from both isomeric series) exerted low micromolar or submicromolar in vitro cytostatic activiti

200 This protection requires low micromolar, or iNOS-derived, levels of nitric oxide.

201 at, for sulfate concentrations up to tens of micromolar, organic sulfur would have supported 20 to 10

202 nases resulted in compounds with low- to sub-micromolar potencies.

203 tidine-2-carboxamide analogues that have sub-micromolar potencies.

204 ide, while maintaining sub-micromolar to low micromolar potency against HAdV.

205 ture, telaprevir showed submicromolar-to-low-micromolar potency against several recently circulating

206 covery of 10 new agonist chemotypes with sub-micromolar potency at MT receptors, with compound 21 rea

207 hormone analog, as a lead compound with low micromolar potency.

208 n of a new small-molecule inhibitor with sub-micromolar potency.

209 However, these peptides have only modest (micromolar) potency.

210 situ in the veins of live animals, achieving micromolar precision over many hours without the use of

211 Unfortunately, the required micromolar protein concentration increases the costs and

212 show that domain swapping of FoxP1 occurs at micromolar protein concentrations within hours of incuba

213 can effectively prevent corrosion when only micromolar quantities of H2 are present.

214 NG1B (C-RING1B), with an affinity in the low micromolar range ( approximately 10 muM).

215 All probes exhibited affinities in the low micromolar range (1.6 muM < Kd < 14.6 muM) and had rapid

216 icardipine, nilotinib, and sorafenib) or low micromolar range (abiratone, candesartan, celecoxib, das

217 profilin to the polyproline tracts is in the micromolar range (K (diss) ~ 17 and ~ 31 muM), but bindi

218 SPR519 exhibits an EC(50) of low sub-micromolar range among various tested cancer cell lines

219 3 domain with a dissociation constant in the micromolar range and modifies its tertiary structure lea

220 oducible sensitivity towards H2O2 in the low micromolar range and towards antimalarial compounds at p

221 trations of HOCl and responds to HOCl in the micromolar range by increasing its smooth-swimming behav

222 Micromolar range cysteamine bitartrate treatment in Caen

223 concentrations found in cells (compared with micromolar range dNTP levels).

224 DG and that concentrations of 3,4-DGE in the micromolar range effectively induced iCGRP release from

225 nity of NMS at the allosteric site is in the micromolar range for all receptor subtypes.

226 a pseudotyped infection model was in the low micromolar range for fullerenes with 12 and 36 mannoses.

227 ng potencies in the nanomolar and in the low micromolar range for hMAO B and eeAChE, respectively, we

228 ch as DRI-C21045, activity (IC50) in the low micromolar range has been confirmed in cell assays inclu

229 , with IC(50) and EC(50) values in the lower micromolar range in biochemical and cellular assays.

230 g and an antiproliferative effect in the low micromolar range in KRAS mutant cells.

231 these compounds have IC50 values in the low micromolar range in Pf lines and low toxicity in human A

232 quantifying free P(i) in the subnanomolar to micromolar range in sample volumes <=10 muL.

233 hibited HIV RT-associated RNase H in the low micromolar range in the absence of significant inhibitio

234 on of cell proliferation (GI(50)) in the low micromolar range in the PC3 cell line and were thus sele

235 issues, it can be present in the hundreds of micromolar range in tumors, a concentration compatible w

236 dows selective analyte detection down to the micromolar range on standard instrumentation.

237 and dengue viruses in infected cells in the micromolar range while showing no toxicity for uninfecte

238 wed substantial potency against HIV-1 at low micromolar range while the parent nucleosides were not e

239 icelle concentration (CMC) values in the low micromolar range, 3 orders of magnitude lower than the C

240 iling of DNA with an IC(50) value in the low micromolar range, a species-specificity that resulted in

241 ities to the chromophore in nanomolar to low micromolar range, and high photostability of the protein

242 29) Xe hyperCEST NMR spectroscopy in the low micromolar range, as well as H(2) O(2) produced by HEK 2

243 s maintain mitochondrial pyruvate in the low micromolar range, below cytosolic pyruvate, which means

244 PBS can be used in the micromolar range, equivalent to about 0.1% 1x PBS (150 m

245 nds obtained exhibited MIC values in the low micromolar range, excellent intracellular antimycobacter

246 cy against intracellular bacteria in the low micromolar range, high in vitro solubility and permeabil

247 d RB3 - that penetrate the brain and, in the micromolar range, inhibit phosphorylation of ERK, histon

248 with a reported apparent affinity in the low micromolar range, making it an interesting lead compound

249 ient and binding affinity of proteins in the micromolar range, the implementation of modern detection

250 hat inflicted outer membrane damage at a low micromolar range, whereas measurable bacterial growth in

251 d BTK proteins with IC(50) values in the low micromolar range, with the most active compound at 39 uM

252 mproved compound potency to the double-digit micromolar range.

253 petitive mechanism with potencies in the low micromolar range.

254 alpha7 nAChRs, and alpha3beta2 nAChRs in the micromolar range.

255 curring at much higher concentrations in the micromolar range.

256 ity of chronic myeloid leukemia cells in the micromolar range.

257 rly at therapeutic concentrations in the low micromolar range.

258 trations yielded binding affinity in the low micromolar range.

259 critical micelle concentration (CMC) in the micromolar range.

260 med hits with activities in the nano- to low-micromolar range.

261 of wild-type DAT with affinities in the low micromolar range.

262 iacore analysis, with an affinity in the low micromolar range.

263 bind to both GAGs with affinities in the low-micromolar range.

264 h minimal inhibitory concentrations in a sub-micromolar range.

265 ir minimal effective concentration is in the micromolar range.

266 nd an apparent Kd value estimated in the low micromolar range.

267 o endow it with capsaicin sensitivity in the micromolar range.

268 ilibrium with an association constant in the micromolar range.

269 emarkable activity with IC(50) values in the micromolar range.

270 osides, with affinities in the millimolar to micromolar range.

271 SmSirt2 inhibitors with activity in the low micromolar range.

272 y binds both TMM and PE, but not TDM, in the micromolar range.

273 he initial lead, with K(i) values in the low micromolar range.

274 t has shown PCSK9 inhibitory activity in the micromolar range.

275 -1/Bcl-2 dual inhibitors S1-6 and Nap-1 with micromolar-range affinity.

276 measurement of dissociation constants in the micromolar-range.

277 modality, we designed CAR T cells possessing micromolar rather than nanomolar affinity to ICAM-1 to a

278 Thus, high micromolar S100A1 does alter the CaM/RyR interaction, wi

279 structural states was perturbed only by high micromolar [S100A1], which promoted a shift of bound CaM

280 e substrate of DNMT1, off the protein on sub-micromolar scale, leading for effective enzymatic inhibi

281 nse to NE, good photostability, nanomolar-to-micromolar sensitivities, sub-second kinetics, and high

282 c capable of discriminating nanomolar versus micromolar sensitivity to a cell-permeable GSi (Z-LLNle-

283 BAPTA as a fluorinated Zn-binding probe with micromolar sensitivity, we show that iCEST MRI is able t

284 Thus, coatings characterized by micromolar solubilities give rise to nanomolar soluble c

285 evidenced mass transfer limitations at (sub)micromolar substrate concentrations.

286 of the interfacial hydrophobic molecules at micromolar surfactant concentrations.

287 compound niclosamide, while maintaining sub-micromolar to low micromolar potency against HAdV.

288 This tunability makes weak binding (micromolar to millimolar dissociation constants) difficu

289 put screening to identify molecules with low micromolar to nanomolar affinity to influenza A group 1

290 structures within disease-causing RNAs, with micromolar to nanomolar affinity.

291 atively moderate to high activities with low micromolar to nanomolar potency against all four serotyp

292 ex that causes phototoxicity in the very low micromolar to nanomolar range at clinically relevant 595

293 ta relating to their activity range from low micromolar to sub-nanomolar EC50, the most interesting c

294 C analyzer meant that low concentration (few micromolar to submicromolar), highly turbid subglacial m

295 t concentrations relevant to human exposure (micromolar to subnanomolar).

296 The compounds reach low micromolar to upper nanomolar inhibitory potency in cell

297 The binding affinities reach micromolar values, which are among the highest known val

298 Sestrin2 with a dissociation constant of 20 micromolar, which is the leucine concentration that half

299 ils (Kd values are submillimolar rather than micromolar) yet physiologically relevant because of the

300 that the network structure is unperturbed at micromolar Zn(2+) concentrations, but strong bundle form