ライフサイエンスコーパス: micromolar concentration

1 tivities, ranging from low-nanomolar to high-micromolar concentration.

2 d GPR35 of all three species at similar, low micromolar concentration.

3 totoxicity against M14 melanoma cells at low micromolar concentration.

4 found to have enzyme inhibition activity at micromolar concentration.

5 an form complexes with coralyne, even at low micromolar concentrations.

6 rupt MAPK and PI3K signaling in cells at low micromolar concentrations.

7 iazines as covalent protein modifiers at low micromolar concentrations.

8 ergic, and neuroprotective properties at low-micromolar concentrations.

9 yprotein synthesis was reduced <50%, even at micromolar concentrations.

10 one hand, assembles in inactive tetramers at micromolar concentrations.

11 ency (use) inhibition of Na+ currents at low micromolar concentrations.

12 th and splice variant AR forms at low to sub-micromolar concentrations.

13 ties of the catalytic core proteasome at low micromolar concentrations.

14 0 K suffice to polymerize 200-mers of RNA in micromolar concentrations.

15 ine inhibited dengue virus infections at low micromolar concentrations.

16 acid, inhibit FAAH activity in vitro at low micromolar concentrations.

17 although patrolling becomes more frequent at micromolar concentrations.

18 effect on different tumor cell lines at low micromolar concentrations.

19 nown to be present in the mammalian brain at micromolar concentrations.

20 nd induced apoptosis in MM cell lines at low micromolar concentrations.

21 only a few microliters of protein sample at micromolar concentrations.

22 ell death during exposure for 24-48 h at low micromolar concentrations.

23 y-five arylstibonic acids showed activity at micromolar concentrations.

24 e., MOMIPP) that can induce methuosis at low micromolar concentrations.

25 f both CCR5- and CXCR4-using isolates at low micromolar concentrations.

26 ase domain to trigger its kinase activity at micromolar concentrations.

27 BG inhibits voltage-gated sodium channels at micromolar concentrations.

28 ining series that blocks this interaction at micromolar concentrations.

29 d transient increases in dopamine (DA) up to micromolar concentrations.

30 colloidal aggregates in aqueous solution at micromolar concentrations.

31 rs and more complex quaternary structures at micromolar concentrations.

32 f the peptide, that occur in response to sub-micromolar concentrations.

33 was significantly inhibited by both drugs at micromolar concentrations.

34 good quality Raman spectra of carbendazim at micromolar concentrations.

35 orophore, also produced photopotentiation at micromolar concentrations.

36 AKT activation and causing apoptosis at low micromolar concentrations.

37 escence reduction is the dominant pathway at micromolar concentrations.

38 nhibited AR expression in LNCaP cells at low micromolar concentrations.

39 from additive to synergistic activity at low micromolar concentrations.

40 nd can be primed with fatty-acyl ACPp at low-micromolar concentrations.

41 plicing both in vivo and in vitro at similar micromolar concentrations.

42 of synaptic activity by Abeta42 oligomers at micromolar concentrations.

43 found to have enzyme inhibition activity at micromolar concentrations.

44 entrations but can form larger assemblies at micromolar concentrations.

45 the substrate APS to inhibit the reaction at micromolar concentrations.

46 tein and RNA expression, was achieved at low micromolar concentrations.

47 report that furamidine inhibits Tdp1 at low micromolar concentrations.

48 a fungal pathogen, Fusarium graminearum, at micromolar concentrations.

49 revented growth of cultured parasites at low micromolar concentrations.

50 inhibits human norovirus replication at low-micromolar concentrations.

51 sn-2-azelaic acid, induced apoptosis at low micromolar concentrations.

52 for label-free DNA detection at picomolar to micromolar concentrations.

53 L. mexicana-infected J774 macrophages at low micromolar concentrations.

54 ranes mimicking bacterial inner membranes at micromolar concentrations.

55 bling to form homooligomeric bundles when in micromolar concentrations.

56 ce bound fluorescent analogs even at tens of micromolar concentrations.

57 suppressing precursor autoprocessing at low micromolar concentrations.

58 en persisted even when ammonium was added to micromolar concentrations.

59 ective HCMV inhibitors, active at sub to low micromolar concentrations.

60 er KDMs, as well as cellular activity at low micromolar concentrations.

61 t substrate inhibition of chain formation at micromolar concentrations.

62 s able to kill Pseudomonas aeruginosa at sub-micromolar concentrations.

63 y against a variety of bacterial taxa at low micromolar concentrations.

64 norketamine mimicked ketamine effects at sub-micromolar concentrations.

65 inhibited pUL89 endonuclease activity at low-micromolar concentrations.

66 res residue-specific dynamics measurement at micromolar concentrations.

67 mposition, and overall amount of cysteine at micromolar concentrations.

68 were found to block viral replication at low micromolar concentrations.

69 ibits fibrillogenesis of misfolded TTR under micromolar concentrations.

70 it more than 99% of HIV-1 infectivity at low micromolar concentrations.

71 ll growth, and induction of apoptosis at low micromolar concentrations.

72 sive methods for identifying analytes at sub-micromolar concentrations.

73 of complexes (0-24 h) in phosphate buffer at micromolar concentrations.

74 urospora crassa and Fusarium graminearum, at micromolar concentrations.

75 o 2-l-fucose (2F-Fuc) reduces root growth at micromolar concentrations.

76 intermediate BrO2(*) indirectly detected at micromolar concentrations.

77 ns to detect cytosolic peptide import at low micromolar concentrations.

78 ta-glucosidase activity in live cells at low-micromolar concentrations.

79 human and mouse breast cancer cells at high micromolar concentrations.

80 also demonstrated antiviral activity at low micromolar concentrations.

81 d selectively inhibiting WNV and DENV at low micromolar concentrations.

82 blastoma cells or primary human neurons with micromolar concentrations (10-100 microM) of D3T for 24

83 Compound 5 was potent at single-digit micromolar concentrations against a panel of cancer cell

84 Each of the aggregators was active at micromolar concentrations against the three GPCRs in cel

85 d in plaques, self-assembles into fibrils at micromolar concentrations and acidic pH.

86 oxidative inactivation by superoxide at low micromolar concentrations and by H 2O 2 at low millimola

87 ow line width, high analytical resolution at micromolar concentrations and enhanced sensitivity to mo

88 ds interrupted cell cycle progression at low micromolar concentrations and induced early and late sta

89 IL-37 monomers also remain monomeric at high micromolar concentrations and that these monomeric IL-37

90 against schistosomula and adult worms at low micromolar concentrations and therefore represent promis

91 ease-activated Ca(2+) (CRAC) currents at low micromolar concentrations and to inhibit them at higher

92 SCRPZ-1 readily dimerizes at micromolar concentrations, and an empirical redesign of

93 ucing both pro-oxidant actions at low (5-20) micromolar concentrations, and antioxidant activity at a

94 opper-loaded dimers exist in solution at low micromolar concentrations, and head-to-head and side-to-

95 nanoparticle is stable upon dilution to low micromolar concentrations, and is cytotoxic at both 37 a

96 unds were obtained that activated RNase L at micromolar concentrations, and structure-activity relati

97 l phenanthroline iridium(III) derivatives at micromolar concentrations are robust catalysts for the p

98 y source for biological reactions, for which micromolar concentrations are sufficient, we propose tha

99 ation of urinary metabolites present at low (micromolar) concentrations are major obstacles.

100 Mg(2+) is required at micromolar concentrations as a cofactor for ATP, enzymat

101 general anesthetics used clinically, acts at micromolar concentrations as an anesthetic and positive

102 lass of small molecules that function at low micromolar concentrations as both beta- and beta,delta-e

103 alene synthase inhibitory activity (at lower micromolar concentrations) as well as a significant anti

104 hat transient calcium increase up to tens of micromolar concentration at the micro/nano domain trigge

105 At low micromolar concentrations, both LTRAs also inhibited cal

106 2-116 markedly enhanced GlyR currents at low micromolar concentrations but had no effects on the clos

107 latelet activation was sGC-dependent only at micromolar concentrations, but sGC-independent at millim

108 oid peptide produces apoptosis in neurons at micromolar concentrations, but the mechanism by which be

109 they allow the detection of fluoride ions at micromolar concentration by the naked eye, UV-vis absorp

110 e found that 3-NOP indeed inactivates MCR at micromolar concentrations by oxidation of its active sit

111 ed to nitrite, which also inactivates MCR at micromolar concentrations by oxidation of Ni(I).

112 At micromolar concentration, Ca(2+) inhibition is nonexclus

113 Methamphetamine at physiologically relevant micromolar concentrations caused apoptosis in NG108-15 c

114 , we report that, at clinically relevant low micromolar concentrations, CCI-779 completely suppressed

115 on of cancer cell growth was demonstrated at micromolar concentrations, comparable to the concentrati

116 nic matter (DOM) can be detected down to low micromolar concentration, depending on the DOM backgroun

117 compounds that inhibited tetramerization at micromolar concentrations, designated PF4 antagonists (P

118 be detected within the same analysis time as micromolar concentrations detected without the use of th

119 cule drug cocaine at near physiological, low micromolar concentrations directly in undiluted, otherwi

120 M, is more efficacious than diazoxide at low micromolar concentrations, directly activates the channe

121 In addition, we discovered that zinc in micromolar concentrations drives ssDNA to a unique, high

122 e latter of which was found to accumulate to micromolar concentrations during simulated solar irradia

123 MPs, which may explain why most AMPs require micromolar concentrations for activity, show significant

124 PR (mFPR) 1 and mouse neutrophils, requiring micromolar concentrations for cell activation.

125 . monocytogenes HMG-CoA reductase, requiring micromolar concentrations for inhibition.

126 GLIC pore is predicted to be blocked at the micromolar concentrations for which inhibition by isoflu

127 At low micromolar concentrations, Grp1 and ARNO are homodimeric

128 bit matriptase activation with IC(50) at low micromolar concentration in both intact-cell and cell-fr

129 es, which inhibit enzymes nonspecifically at micromolar concentrations in aqueous solution.

130 related congeners inhibited melanogenesis at micromolar concentrations in B16 mouse melanoma cells, n

131 tes of the kynurenine pathway are present at micromolar concentrations in blood and are regulated by

132 assays by modulation of the phenotype at low micromolar concentrations in both cancer and inflammator

133 SH-I-048A reached micromolar concentrations in brain tissue, while the unb

134 that prevent HCV infection at nontoxic, low micromolar concentrations in cell culture.

135 actinides can be easily distinguished at low micromolar concentrations in complex salt mixtures.

136 ng oral administration, V565 was detected at micromolar concentrations in ileal fluid from the ileost

137 a key uremic toxin that accumulates to high micromolar concentrations in kidney dialysis patients, b

138 novel LRAs that reverse viral latency at low micromolar concentrations in multiple cell lines.

139 embly of the Vernier complex is efficient at micromolar concentrations in nonpolar solvents, and unde

140 min) identification of the target opioid at micromolar concentrations in the presence of other cutti

141 bited Bacillus anthracis bacterial growth at micromolar concentrations in the presence or absence of

142 eptides that block cellular signaling at low micromolar concentrations in vitro and in vivo.

143 These peptides induce autophagy at micromolar concentrations in vitro, have aggregate-clear

144 e detection of multiple illicit drugs at low micromolar concentrations in water and in saliva.

145 Its covalent skeleton renders it stable at micromolar concentrations in water, enabling the fluorom

146 Both targets are detected at low micromolar concentrations, in seconds, and in a convenie

147 (1)H-(13)C HSQC spectrum of p51 obtained at micromolar concentrations indicates that a significant f

148 nin are also angiogenic factors that, at low micromolar concentrations, induce endothelial cell proli

149 Low micromolar concentrations inhibit Kir7.1, making VU590 t

150 tiomeric excess of several amino alcohols at micromolar concentrations is reported.

151 As the compound inhibits the kinase at micromolar concentrations, it is not known why therapeut

152 elix forms in dilute CH(3)CN solution of the micromolar concentration level, e.g., 5.6 muM from 2D NO

153 egassed aqueous buffer media at pH 7 down to micromolar concentration levels.

154 At micromolar concentrations, lipid-free ApoE exists predom

155 If glutamate were present tonically at low micromolar concentrations, many receptors, especially th

156 At micromolar concentrations, melittin induces stable pores

157 At low micromolar concentration, microalgae fixed all silver in

158 Unexpectedly, at sub-micromolar concentrations MTMs stabilize FLI1-DNA comple

159 When maintained at micromolar concentrations, NAE 18:3 specifically induced

160 get hybridization is selectively detected at micromolar concentrations (nanomoles of target) using re

161 st the bacterial challenge was observed at a micromolar concentration of Ceftriaxone or Cefotaxime in

162 Use of micromolar concentration of dye, which was required to g

163 xcision, and was potently inhibited by a low micromolar concentration of PI(4,5)P(2).

164 residue was complete within minutes at a mid-micromolar concentration of reactants.

165 ration of GABA and prolonged periods of low, micromolar concentration of the transmitter.

166 in transferrin, allowing us to predict a low micromolar concentration of these binding sites in neoco

167 Finally, low micromolar concentrations of 7 inhibited 14,15-EET produ

168 Sub-micromolar concentrations of a novel potent Trk inhibito

169 photons per pixel from cells that contained micromolar concentrations of a Tb(III) complex.

170 imize an enzyme-coupled assay to measure low micromolar concentrations of acetate, coupling acetate p

171 produced cAMP in response to adenosine, and micromolar concentrations of adenosine were measured in

172 ution NMR can reach picomole sensitivity for micromolar concentrations of analyte by combining parahy

173 In this study we report that low micromolar concentrations of arsenite synergistically in

174 Picomolar to micromolar concentrations of ascr#18, the major ascarosi

175 Treatment of parasites with low micromolar concentrations of beta-lactone- or triazole u

176 Spectrin-4.2 binding is amplified by micromolar concentrations of Ca(2+) (but not Mg(2+)) by

177 cell function by responding specifically to micromolar concentrations of Ca(2+) in the presence of a

178 Micromolar concentrations of Ca(2+) lead to a robust blu

179 ivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultan

180 Caulobacter requires micromolar concentrations of calcium for normal growth a

181 and L3.6pL pancreatic cancer cells with low micromolar concentrations of CDDO or CDDO-Me resulted in

182 Low micromolar concentrations of certain compounds blocked t

183 X-linked IAP (XIAP), a recent one found that micromolar concentrations of cIAP1 only weakly inhibit c

184 , evidence for cross-link formation with low micromolar concentrations of copper phenanthroline or io

185 tuted oxazine and can be exploited to detect micromolar concentrations of cyanide in water.

186 Chromatin immunoprecipitations revealed that micromolar concentrations of DIM-C-pPhtBu prevented asso

187 campal slices were cultured and treated with micromolar concentrations of dopamine, with or without d

188 the original membrane was accomplished with micromolar concentrations of EDTA.

189 Here we demonstrate that low micromolar concentrations of extracellular NAD(+) or NAD

190 rated in vitro by stimulating microglia with micromolar concentrations of fibrillar Abeta, a major co

191 human enamel organ, are directly affected by micromolar concentrations of fluoride.

192 of Ca(2+)-dependent phospholipid binding at micromolar concentrations of free Ca(2+), suggesting tha

193 Prior work has indicated that exposure to micromolar concentrations of GABA can both activate the

194 In addition, superfusion of low micromolar concentrations of glutamate had no effect on

195 e damage that depends on the synergy between micromolar concentrations of GzmA and sublytic perforin

196 Low micromolar concentrations of H2O2 completely blocked the

197 Brief exposure of T cells to micromolar concentrations of Hg(2+) leads to physiologic

198 We show that on addition of micromolar concentrations of hyaluronic acid, the result

199 susceptible to oxidation to sulfenic acid by micromolar concentrations of hydrogen peroxide.

200 We further show that micromolar concentrations of imatinib abrogate multiple

201 cologically relevant, being sensitive to sub-micromolar concentrations of inorganic phosphate and a r

202 spond jointly to membrane depolarization and micromolar concentrations of intracellular Ca2+ ions, ar

203 de, requiring the administration of only low micromolar concentrations of IPA, demonstrating that thi

204 or use in plants are monopartate and require micromolar concentrations of ligand for activation of th

205 Intriguingly, low micromolar concentrations of long chain fatty acyl-CoAs

206 ition of purified rabbit muscle PFK-1 by low micromolar concentrations of long chain fatty acyl-CoAs

207 In contrast, application of micromolar concentrations of lysophosphatidylcholine (LP

208 for AMTr-AuNPs in the presence of less than micromolar concentrations of melamine.

209 mately 10 and are the predominant species at micromolar concentrations of metallothionein in cells.

210 olated transgenic keratinocytes to show that micromolar concentrations of MFQ attenuated increased ma

211 Although the NH(4)Cl solution contains micromolar concentrations of NH(3) at pH 7.4, our eviden

212 Here we show that micromolar concentrations of nicotinamide adenine dinucl

213 from nitrate and resulted in accumulation of micromolar concentrations of nitric oxide during denitri

214 hat had undergone a more chronic exposure to micromolar concentrations of nitric oxide showed an appr

215 onsequence (gravitropism), were inhibited by micromolar concentrations of NPPB that did not affect gr

216 Micromolar concentrations of octreotide and NISAs are ne

217 The effects of nanomolar versus micromolar concentrations of phloroglucinol differed bot

218 ked Hcy, whereas cow milk and whey contained micromolar concentrations of protein N-linked Hcy.

219 reaction provides a modest driving force at micromolar concentrations of protein.

220 er millimolar concentrations of ornithine or micromolar concentrations of putrescine or by complement

221 Specifically, micromolar concentrations of pyrene in methanol/water so

222 in, a linear dynamic range from nanomolar to micromolar concentrations of R6G with a limit of detecti

223 of isolated lysosomal membranes showed that micromolar concentrations of Rap and some rapalogs activ

224 y refolded in an aerobic solution containing micromolar concentrations of reduced PDI and nanomolar l

225 Surprisingly micromolar concentrations of S1P activated the wild type

226 Thus, sub-micromolar concentrations of short-chain polyP can accel

227 f unlabeled NAADP or 5N(3)-NAADP, but not by micromolar concentrations of structurally related nucleo

228 Micromolar concentrations of the bile salt deoxycholate

229 Thus, at the low micromolar concentrations of the cellular environment an

230 Moreover, SPCA1a is blocked by micromolar concentrations of the commonly used SERCA1a i

231 MP could only be demonstrated at hundreds of micromolar concentrations of the dinucleotide, and it ha

232 ulated >2-fold but potently inhibited by low micromolar concentrations of the oxidizing reagent coppe

233 f QDs that is compatible with neutral pH and micromolar concentrations of the peptide target.

234 This was reversed in the presence of micromolar concentrations of the protein phosphatase inh

235 At micromolar concentrations of the receptor, sedimentation

236 l forces, Piezo1 is selectively activated by micromolar concentrations of the small molecule Yoda1 th

237 mu-EME salt removal from samples containing micromolar concentrations of the target analytes and 150

238 In comparison, activation of mFPR2 requires micromolar concentrations of the two peptides.

239 Addition of high nanomolar to low micromolar concentrations of these inhibitors to cancer

240 we show that arsenicals bind tightly to low micromolar concentrations of these unfolded proteins wit

241 te (EGCG), but effects were observed only at micromolar concentrations of unclear clinical relevance.

242 he rate of folding of SOD in the presence of micromolar concentrations of zinc demonstrates a signifi

243 rat hippocampal slices, we observed that low micromolar concentrations of zinc depress NMDAR synaptic

244 in cultured cells have demonstrated that low micromolar concentrations of zinc stimulate the endocyto

245 Plasma pH levels and micromolar concentrations of Zn(2+) inhibit WT Cx26 hemi

246 orters that are predominantly inward-facing, micromolar concentrations of Zn(2+) markedly potentiated

247 1 activity in the presence of physiological (micromolar) concentrations of Ca(2+) ions, as long as Mg

248 ibitors showed antibacterial activity at low micromolar concentration on Gram-positive and Gram-negat

249 At a low micromolar concentration, PF74 potently inhibited HIV-1

250 At micromolar concentrations, pioglitazone increased mitoch

251 At low micromolar concentrations, polyunsaturated fatty acids (

252 ation, and quantification of analytes at low-micromolar concentrations, provided they can weakly asso

253 The best compound was active in a very low micromolar concentration range against all three transpo

254 promising anti-influenza activity in the low micromolar concentration range and good selectivity.

255 orders of magnitude in the low nanomolar to micromolar concentration range and limit of detection of

256 chitooligosaccharides with Kd values in the micromolar concentration range and that the binding ener

257 The initial steps in the micromolar concentration range follow apparent sigmoidal

258 tion of ciproxifan revealed IC50 values in a micromolar concentration range for human and rat monoami

259 ompounds 11 and 36 were effective in the low micromolar concentration range in a cellular assay syste

260 Pt1 strain, 2E,4E-decadienal supplied in the micromolar concentration range led to a nonspecific cell

261 with IC(50) values in the high nanomolar/low micromolar concentration range, and showed antiprolifera

262 showed selective detection of glucose in the micromolar concentration range, with a detection limit o

263 essel and lymphatic endothelial cells in the micromolar concentration range.

264 otoxic to Neuro2a neuroblastoma cells in the micromolar concentration range.

265 alcohols, with dissociation constants in the micromolar concentration range.

266 cient probing of fluoride and cyanide in the micromolar concentration range.

267 vival of multiple cancer cell lines in a low micromolar concentration range.

268 ombinant ENO1 and PKM2 at low millimolar and micromolar concentrations, respectively, and inhibited t

269 Extracellular GsMTx4 at micromolar concentrations reversibly inhibited approxima

270 0.1) and cooperative substrate inhibition at micromolar concentrations ([S](1/2) = 740 +/- 240 nm; n

271 antioxidant and anti-inflammatory pathway at micromolar concentrations, showing interesting structure

272 hantom images provide sufficient contrast at micromolar concentrations, showing promise for eventual

273 e show that zinc binds unaggregated hIAPP at micromolar concentrations similar to those found in the

274 On the contrary, at higher (micromolar) concentrations, tapentadol elicited proneuro

275 its the growth of melanoma cell lines at low micromolar concentrations that are clinically attainable

276 siva conidia at physiologically relevant low micromolar concentrations that were non-toxic to poplar

277 ew methodology to detect and quantify at the micromolar concentration the spatial distribution at mil

278 At low micromolar concentrations, the domain is predominantly m

279 Notably, even at micromolar concentrations, the probe possesses the abili

280 seleninic acid (MSA), inactivated PKC at low micromolar concentrations through a redox modification o

281 found that TlpD is selectively sensitive at micromolar concentrations to bleach (hypochlorous acid,

282 AS-6 was cytotoxic when added at micromolar concentrations to cultures of three different

283 hibiting antioxidant character were able, at micromolar concentration, to slow down the photoinduced

284 amide-forming ligation that proceeds at low micromolar concentration under aqueous conditions in the

285 ex 2 is active when compared to cisplatin at micromolar concentrations using the MTT and cell invasio

286 ular-signal-regulated kinase (ERK) whereas a micromolar concentration was ineffective.

287 In comparison, etomoxir at low micromolar concentrations was sufficient to saturate its

288 that c-di-GMP can form G-quadruplexes at low micromolar concentrations when aromatic molecules such a

289 teins also inhibited SOD1 aggregation at low micromolar concentrations, whereas others were ineffecti

290 kamides F and H inhibited HIV-1 entry at low micromolar concentrations while their linear counterpart

291 ma and MCF-7 breast carcinoma cell growth in micromolar concentration with the ability to arrest canc

292 tes able to inhibit virus replication at low micromolar concentrations with no significant toxicity t

293 ion of a specific target protein in vitro at micromolar concentration, with a readout scheme that red

294 n cytomegalovirus (HCMV) replications at low micromolar concentration, with little or no cytotoxicity

295 n GABA(A) receptor function at nanomolar and micromolar concentrations, with maximum potentiation com

296 j and 7s were found to inhibit Mtb growth at micromolar concentrations, with MIC values of 1.4 and 1.

297 n to produce plasmonic gold nanoparticles at micromolar concentrations within 30 min of application u

298 omponents, heroin, noscapine and morphine at micromolar concentration without any separation or pretr

299 At low micromolar concentrations, XN acutely increased uncouple

300 eta cells or intact pancreatic islets at low micromolar concentrations, ZIMIR labeled cells rapidly,