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1 he scrambled pattern of MDSs and IESs of the micronuclear actin I gene has been conserved during evol
2 ht hypotrichs suggests that evolution of the micronuclear actin I gene proceeds by successive additio
3 e manner during species evolution to produce micronuclear actin I genes of increasing structural comp
4 termine the architecture of four loci in the micronuclear and macronuclear genomes of the ciliate Chi
5                                     A single micronuclear C to T transition within the consensus sequ
6              In contrast, condensed inactive micronuclear chromatin is enriched in dephosphorylated d
7 ically, cnj1 and cnj2 fail to condense their micronuclear chromatin prior to each of the three prezyg
8 dine autoradiography, shows that decondensed micronuclear chromatin undergoing active transcription i
9 ermophila ribosomal RNA gene is excised from micronuclear chromosome 1 by site-specific cleavage at c
10                                              Micronuclear chromosome maintenance is also compromised.
11 cterized and each was assigned to a specific micronuclear chromosome or chromosome arm.
12 tion at the homologous site in the recipient micronuclear chromosome.
13                               Concomitantly, micronuclear chromosomes acquire aberrant epigenetic chr
14 or proper mitotic and meiotic segregation of micronuclear chromosomes and for normal chromosome align
15 on, Euplotes crassus precisely fragments its micronuclear chromosomes and synthesizes new telomeres o
16 progressively eroded, suggesting that broken micronuclear chromosomes are not 'healed' by telomerase.
17 acronucleus in the ciliate Euplotes crassus, micronuclear chromosomes are reproducibly broken at appr
18 eplications leading to polytenization of the micronuclear chromosomes before massive DNA elimination,
19 micronuclear genome and (ii) breakage of the micronuclear chromosomes into hundreds of DNA fragments,
20 gs identify a mechanism for fragmentation of micronuclear chromosomes, an important step in generatin
21 entromeric and subtelomeric regions of the 5 micronuclear chromosomes, suggesting that these regions
22                                       In the micronuclear chromosomes, the macronuclear-destined sequ
23 its mitotic engagement with under-replicated micronuclear chromosomes.
24 ous genotoxic stress, destabilizing all five micronuclear chromosomes.
25 lowly and incur rapid deterioration of their micronuclear chromosomes.
26 lations, to uncover the mechanism underlying micronuclear collapse.
27 completely inhibit excision of its Mild-type micronuclear copy through multiple sexual generations.
28                                The germline (micronuclear) copy of this gene is broken into 48 pieces
29                             It also mediated micronuclear disintegrity under hypoxic conditions, link
30 cronuclear locus leads to defective germline micronuclear division and that conjugation of two somati
31 xtra micronuclei, implying faulty control of micronuclear division in the KO cells.
32 ank the 5' ends of macronuclear sequences in micronuclear DNA (12 cases) consist of approximately 50%
33  in the 5' ends of macronuclear sequences in micronuclear DNA are islands of purine richness in which
34 not only recruit cGAS to a major fraction of micronuclear DNA but also activate cGAS in response to t
35 e results establish ER-directed resection of micronuclear DNA by TREX1 as a critical regulator of cyt
36  TREX1 localization to micronuclei, diminish micronuclear DNA damage, and enhance cGAS activation.
37 signal to identify macronuclear molecules in micronuclear DNA during development.
38 generation of the macronuclear rDNA from the micronuclear DNA is proposed.
39 in regulating cGAS activation in response to micronuclear DNA is still poorly understood.
40 Cbs in macronuclear-destined versus flanking micronuclear DNA leads us to propose a model of chromoso
41 genes in the somatic macronucleus results in micronuclear DNA loss and delayed chromosome segregation
42 liminated sequences (IESs) from the germline micronuclear DNA occurs during the differentiation of a
43                                          The micronuclear DNA of Paramecium tetraurelia is estimated
44 f Tlr elements, a family of approximately 30 micronuclear DNA sequences that are efficiently eliminat
45 olecule, but can also reside within flanking micronuclear DNA that is eliminated during macronuclear
46                                  Exposure of micronuclear DNA to innate immune sensors has been propo
47  cGAS activation at micronuclei by degrading micronuclear DNA upon micronuclear envelope rupture.
48                           When NBS1 binds to micronuclear DNA via its fork-head-associated domain, it
49 ntly, ATM stabilizes NBS1's interaction with micronuclear DNA, and CtIP converts DSB ends into single
50 s binding partners prevent cGAS from binding micronuclear DNA, in addition to their classical functio
51  but also activate cGAS in response to these micronuclear DNA.
52 hagosome accumulation in MN and clearance of micronuclear DNA.
53 am regulator that prevents cGAS from binding micronuclear DNA.
54 ese two key events prevent cGAS from binding micronuclear DNA.
55 mutants lose a significant fraction of their micronuclear DNA.
56                                     Aberrant micronuclear envelope behaviors alter communication with
57 ronucleus, with a failure to disassemble the micronuclear envelope encapsulating the chromosomal frag
58                      Rupture of the unstable micronuclear envelope exposes its chromatin to cytosolic
59                             Frequent loss of micronuclear envelope integrity exposes DNA to the cytop
60 lex required for transport (ESCRT)-dependent micronuclear envelope repair by triggering autophagic de
61                                              Micronuclear envelope rupture exposes entrapped chromoso
62 cronuclei by degrading micronuclear DNA upon micronuclear envelope rupture.
63 ough primary nuclei resealing takes minutes, micronuclear envelope ruptures seem to be irreversible.
64 cronuclei(5,6) and subsequent rupture of the micronuclear envelope(7) profoundly disrupt normal histo
65                             Breakdown of the micronuclear envelope, a process associated with chromot
66 one PTMs occur because of the rupture of the micronuclear envelope, whereas others are inherited from
67 e HPV8 E6-induced micronuclei had disordered micronuclear envelopes but retained replication and tran
68  basal bodies (BBs), macronuclear envelopes, micronuclear envelopes, and contractile vacuole pores.
69 e nuclear membrane protein LEMD2, disrupting micronuclear envelopes.
70 can automatically align the macronuclear and micronuclear forms of a gene, outputting the location of
71 olves CIP2A and TOPBP1 proteins, which patch micronuclear fragments to promote their subsequent mitot
72                              The IESs in the micronuclear gene encoding the beta-subunit of the telom
73  after cell mating the IESs are excised from micronuclear genes and the MDSs are spliced in the seque
74                                    Germ line micronuclear genes in ciliated protozoa contain two type
75                                      In some micronuclear genes MDSs are in a scrambled disorder.
76                                     The four micronuclear genes that have been isolated consist of a
77                        IESs are excised from micronuclear genes, and the MDSs are spliced when a micr
78 ate macronucleus-destined segments (MDSs) in micronuclear genes.
79                                   Germ-line (micronuclear) genes in hypotrichous ciliates are interru
80 useful sequence tags for relating macro- and micronuclear genetic, physical, and sequence maps.
81 useful sequence tags for relating macro- and micronuclear genetic, physical, and whole-genome sequenc
82 atic macronuclear genome from their germline micronuclear genome after sexual reproduction.
83 g of macro-nuclear-destined sequences in the micronuclear genome allows for their differential replic
84 ed sequences (IESs) scattered throughout the micronuclear genome and (ii) breakage of the micronuclea
85  which are dispersed in 15,000 copies in the micronuclear genome and completely eliminated during for
86  in transposition of the elements within the micronuclear genome and/or their developmentally regulat
87 ately 5%) of its precursor "silent" germline micronuclear genome by a process of "unscrambling" and f
88 atic (macronuclear) genome, derived from the micronuclear genome by fragmentation, which follows a di
89 nuclear DNA termini and eight regions of the micronuclear genome containing chromosome fragmentation/
90  major repetitive sequence components of the micronuclear genome differ in their chromatin structure
91 mena thermophila removes 34% of its germline micronuclear genome from somatic macronuclei by excising
92                      In conjunction with the micronuclear genome in progress, the O. trifallax macron
93                  Conversion of the germ line micronuclear genome into the genome of a somatic macronu
94 ccurs during the conversion of the germ-line micronuclear genome into the somatic genome of the new m
95             In Euplotes crassus, most of the micronuclear genome is eliminated during formation of a
96 clear genes, and the MDSs are spliced when a micronuclear genome is processed into a macronuclear gen
97 indings identify a new scrambled gene in the micronuclear genome of a spirotrichous ciliate, and sugg
98 nt effectively creates a fragile site in the micronuclear genome, providing the first evidence for a
99                       Genes in the germline (micronuclear) genome of hypotrichous ciliates are interr
100 trahymena possesses two genomes: a germline (micronuclear) genome that follows a Mendelian model of g
101 yzing genome-wide DNA splicing events in two micronuclear genomes of Oxytricha trifallax and Tetrahym
102  to maintain appropriate telomere length and micronuclear genomic stability but does so in a manner d
103 y mapping the genomes of T. thermophila: the micronuclear (germ-line) genome, which is not transcript
104 d by developmental fragmentation of the five micronuclear (germline) chromosomes.
105  ciliates we determined the structure of the micronuclear (germline) gene encoding DNA polymerasealph
106               We report the structure of the micronuclear (germline) gene encoding the large catalyti
107                                        Using micronuclear (germline) transformation, we show that the
108             Mass spectrometric sequencing of micronuclear H3 identified H3K23 trimethylation (H3K23me
109                    Here, we demonstrate that micronuclear H3 phosphorylation occurs at a single site
110 s is attached to H2A.X, is shown to regulate micronuclear H3-S10 phosphorylation.
111 nd inflammation, yet mechanisms safeguarding micronuclear integrity are poorly understood.
112 w that the specificity of the small RNAs for micronuclear-limited sequences increases during conjugat
113 inata and compare the levels of variation in micronuclear-limited sequences to macronuclear destined
114 were used to genetically map 11 junctions to micronuclear linkage groups and macronuclear coassortmen
115  a rapid and dramatic phosphorylation of the micronuclear linker histone, delta, occurs early in the
116         Previous studies have suggested that micronuclear linker histones are phosphorylated by cAMP-
117                                              Micronuclear linker histones of the ciliated protozoan,
118  To investigate the relationship between the micronuclear map and coassortment groups, we systematica
119  continuous segment in a given region of the micronuclear map, with no intervening markers from other
120 genous DNA damage and is required for normal micronuclear meiosis and mitosis and, to a lesser extent
121 ring S phase, which occurs immediately after micronuclear mitosis.
122 istribute their chromosomes correctly during micronuclear mitosis.
123 nue to divide, eventually recapitulating the micronuclear mitotic defects described previously for ra
124 otrich Uroleptus sp., and then pursued their micronuclear organization.
125 s at sites of breakage flanking the germline micronuclear rDNA locus of six additional species of Tet
126             At one end of the T. thermophila micronuclear rDNA locus, a pair of short inverted repeat
127 cronuclei following the programmed arrest of micronuclear replication.
128                                              Micronuclear rupture catalyzes chromosomal rearrangement
129 d chromosome shattering known to result from micronuclear rupture.
130                                     Instead, micronuclear ruptures result in catastrophic membrane co
131 clear polymer is derived from regions of the micronuclear spacer on both the right and the left.
132 the macronuclear polymer is derived from the micronuclear spacer on the right, the spacer at the left
133 demonstrate that excision and elimination of micronuclear-specific DNA occurs independently of endore
134 small RNAs that hybridized preferentially to micronuclear-specific sequences and on the properties of
135 the autophagic receptor p62/SQSTM1 modulates micronuclear stability, influencing chromosome fragmenta
136 coccal nuclease-resistant DNA indicates that micronuclear telomeres are organized into a chromatin st
137 from nongenic, heterogeneous, bidirectional, micronuclear transcripts synthesized at early stages of
138  results argue that Dcl1p processes nongenic micronuclear transcripts to scnRNAs and is required for
139 like enzymes, is required for processing the micronuclear transcripts to scnRNAs.
140  This is the first evidence linking nongenic micronuclear transcripts, scnRNAs, and genome rearrangem
141                        Both macronuclear and micronuclear transformants were recovered.
142                                       In the micronuclear version of the actin I gene intramolecular
143                                          The micronuclear versions of genes in stichotrichous ciliate
144 atin using hybridization probes specific for micronuclear vs. macronuclear sequences indicates that a

 
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