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1 ene combinations not present in the germinal micronucleus.
2 ting to a star strain containing a defective micronucleus.
3 ies of the ATU gene in the diploid germ-line micronucleus.
4 aggard chromosome compartmentalized within a micronucleus.
5 uent reassembly of a single chromatid from a micronucleus.
6 nsive fragmentation of the chromosome in the micronucleus.
7 somatic macronucleus from a diploid germline micronucleus.
8 on of a somatic macronucleus from a germline micronucleus.
9 eous breakage of chromosome 1 in the diploid micronucleus.
10 velops from a mitotic product of the zygotic micronucleus.
11 that DCL1 performs RNA processing within the micronucleus.
12 quentially, but rather are scrambled, in the micronucleus.
13 ptionally active macronucleus and a germline micronucleus.
14 f the somatic macronucleus from the germline micronucleus.
19 ansformation occurred during meiosis for the micronucleus and during anlagen formation for the macron
20 and point mutations were quantified with the micronucleus and hypoxanthine phosphoribosyltransferase
21 mary cells from one patient showed increased micronucleus and nucleoplasmic bridge formation, delayed
23 es of precise loss of some exonic IES in the micronucleus and retention of others in the macronucleus
25 orylated in the SQ motif in both the mitotic micronucleus and the amitotic macronucleus in response t
26 ally distinct nuclei - the silent 'germline' micronucleus and the transcriptionally active macronucle
27 cts are also observed in the diploid mitotic micronucleus, as TIF1 mutants lose a significant fractio
28 phenotype was observed in vivo using the BM micronucleus assay as a measure of chromosome damage.
29 l, fluorescence in situ hybridization (FISH) micronucleus assay attested high levels of genotoxicity
30 This study investigated the potential of the micronucleus assay in peripheral blood reticulocytes (Mn
32 e have used a Chinese hamster V79 cell-based micronucleus assay to further evaluate this hypothesis.
35 omide were examined in the mouse bone marrow micronucleus assay, a significantly (P < .05 to .001) hi
38 unofluorescence and murine cytokinesis-block micronucleus assays confirmed the presence of slight but
41 In parallel, genotoxicity assays (Ames and micronucleus assays) and transcriptional-reporter gene a
42 was clastogenic when examined in vivo in rat micronucleus assays, preventing further development.
43 y localizes to peripheral centromeres in the micronucleus but is absent in the macronucleus during ve
44 th copies of the ATU gene knocked out in the micronucleus but only wild-type genes in the polycopy so
45 ne transformants were made homozygous in the micronucleus by mating to a star strain containing a def
46 everal generations but the chromosome in the micronucleus can also be distributed to daughter nuclei.
47 hat single-chromosome mis-segregation into a micronucleus can directly trigger a broad spectrum of ge
48 rol study, we modified the cytokinesis-block micronucleus (CBMN) assay, an established biomarker for
49 ntric chromosome (DCA) and cytokinesis-block micronucleus (CBMN) assays are well-established biodosim
51 ic chromosome segregation error to produce a micronucleus containing the chromosome to undergo rearra
52 tudy, we have employed the cytokinesis block micronucleus cytome (CBMN-Cyt) assay with WIL2-NS B lymp
53 sis and the results of the cytokinesis block micronucleus cytome (CBMNCyt) assay conducted with respe
54 All IESs are excised and destroyed when a micronucleus develops into a macronucleus after each cel
55 o DSBs induced by chemical agents and in the micronucleus during prophase of meiosis, which occurs in
56 the somatic macronucleus from the germ-line micronucleus during the sexual process of conjugation in
57 e initiated by mitotic errors that produce a micronucleus encapsulating a single chromosome or chromo
59 e growth while there is no expression in the micronucleus except during a brief period following conj
63 show that ZMYND8 is upregulated and inhibits micronucleus formation and DNA damage in breast cancer c
64 0A reduces cellular fitness whilst promoting micronucleus formation and extensive perturbation of tra
65 in chromosome segregation errors, leading to micronucleus formation and increased aneuploidy in daugh
66 -cell genome sequencing, we demonstrate that micronucleus formation can indeed generate a spectrum of
67 romatid breaks and showed modestly increased micronucleus formation compared to cells from wild-type
69 ion of p21(Waf1) as well as the induction of micronucleus formation in bystander cells from confluent
70 ress-inducible signaling pathways as well as micronucleus formation in bystander cells from cultures
71 lesignaling pathways as well as induction of micronucleus formation in bystander cells was investigat
72 breaks in peripheral leukocytes, as well as micronucleus formation in erythroblasts, compared with h
73 higher magnitude of chromosomal breakage and micronucleus formation than the wild-type or Fancg(-/-)
77 the induction of DNA damage (as measured by micronucleus formation) as well as increased Ser-15 phos
78 cells with v-mos resulted in an increase in micronucleus formation, also consistent with the involve
79 oading of prereplication complexes, enhanced micronucleus formation, and attenuated expression and sp
80 and GEN1 exhibit chromosome missegregation, micronucleus formation, and elevated levels of 53BP1-pos
81 p-regulation of p53 and p21(Waf1) as well as micronucleus formation, as evidenced by the inhibition o
82 ollowed by increased levels of apoptosis and micronucleus formation, by loss of nuclear DNA methylati
83 spindle poisons exhibited elevated levels of micronucleus formation, decreased mitotic delay, a failu
84 mosome missegregation lead to aneuploidy and micronucleus formation, which are associated with cancer
92 bF causes robust dose-dependent increases in micronucleus frequency in peripheral blood, indicative o
93 thereby accelerating genome destabilization, micronucleus generation, and cell death under conditions
95 heritable even after the chromosome from the micronucleus has been re-incorporated into a normal daug
96 f the somatic macronucleus from the germline micronucleus in ciliates, chromosome rearrangements occu
97 ps were not significantly different, the BMC micronucleus index, a cytologic indicator of genetic dam
98 cells revealed that 1 causes mitotic arrest, micronucleus induction, centrosome amplification and tub
100 anies differentiation of the silent germline micronucleus into the transcriptionally active somatic m
101 macronucleus from a transcriptionally inert micronucleus is accompanied by the elimination of numero
109 nuclei divide nuclear functions: a germline micronucleus (MIC) is transcriptionally inert during veg
110 The somatic macronucleus (MAC) and germline micronucleus (MIC) of Tetrahymena thermophila differ in
112 nds of nuclei-the silenced germline nucleus (micronucleus [MIC]) and the actively expressed somatic n
114 impaired G2/M checkpoint arrest and elevated micronucleus (MN) formation following exposure to UV and
117 essential features of the in vivo erythroid micronucleus (MN) genotoxicity assay, thus enabling incr
119 d in vivo nongenotoxicity was confirmed with micronucleus (MN), Artemia salina, and Allium cepa assay
121 3 purified from the heterochromatic germline micronucleus of the model organism Tetrahymena thermophi
122 of this study, with published data from the micronucleus of two of these isolates, indicates that C.
123 reveals a strong dependence of the germline micronucleus on centromeric histones for proper chromoso
125 6-well plate-based flow cytometric method of micronucleus scoring that is simple enough for a researc
126 perimentally identified in IESs, that is, in micronucleus-specific DNA, are examined here using the T
129 he chimera derives from a novel locus in the micronucleus that arose by partial duplication of the lo
130 liates have two types of nuclei: a germ line micronucleus that is usually transcriptionally inactive,
133 a DNA fragment or lagging chromosome forms a micronucleus when left behind after the main nucleus is
135 their maintenance of two nuclei: a germline micronucleus, which undergoes conventional mitosis and m
136 ore completion of DNA replication within the micronucleus, with a failure to disassemble the micronuc
137 y show abnormal mitotic segregation of their micronucleus, with most cells eventually losing their mi