ライフサイエンスコーパス: microtubule dynamics

1 ells, forming pools that fundamentally drive microtubule dynamics.

2 y of cancers due to their ability to perturb microtubule dynamics.

3 known, as is the effect of this interplay on microtubule dynamics.

4 tion as network hubs to coordinate actin and microtubule dynamics.

5 ns-acting GTP into a computational model for microtubule dynamics.

6 ng agent vinblastine, which acts to suppress microtubule dynamics.

7 diversity is exploited to modulate intrinsic microtubule dynamics.

8 dent of its previously studied regulation of microtubule dynamics.

9 8 protein, Kif18B, in the control of mitotic microtubule dynamics.

10 ue platform for novel approaches to studying microtubule dynamics.

11 edback mechanism that couples furrowing with microtubule dynamics.

12 ed to neuronal axons, binds to and regulates microtubule dynamics.

13 lational modifications of tubulin also alter microtubule dynamics.

14 e coordination between furrow ingression and microtubule dynamics.

15 ty light to spatially and temporally control microtubule dynamics.

16 The TUBB mutations also have an impact on microtubule dynamics.

17 Bs end-tracking behavior and their effect on microtubule dynamics.

18 -tubulin assembly and maintenance to support microtubule dynamics.

19 nation independently of its global impact on microtubule dynamics.

20 growth retardation syndrome and function in microtubule dynamics.

21 alpha-tubulin 4 and shows aberrant cortical microtubule dynamics.

22 1 mutant is hypersensitive to alterations in microtubule dynamics.

23 lecular basis of the roles of p150(glued) in microtubule dynamics.

24 sregulating DP-EB1 interactions and altering microtubule dynamics.

25 implicated in regulating several aspects of microtubule dynamics.

26 unbound M1 or M87 mutant spastins increased microtubule dynamics.

27 cently found to bind microtubules and affect microtubule dynamics.

28 tabilizing protein whose depletion increases microtubule dynamics.

29 ha/beta-tubulin heterodimers is critical for microtubule dynamics.

30 can be rapidly modulated to control cellular microtubule dynamics.

31 erging as interesting mechanisms to regulate microtubule dynamics.

32 vasive procedure that may interfere with the microtubule dynamics.

33 nd function of the pronucleus by fine-tuning microtubule dynamics.

34 romotes intracellular transport and controls microtubule dynamics.

35 These proteins are crucial regulators of microtubule dynamics.

36 ts its antiproliferative action by dampening microtubule dynamics.

37 eleases the FH2 domain to modulate actin and microtubule dynamics.

38 telet production, particularly by regulating microtubule dynamics.

39 ol of the subcellular cytoskeleton including microtubule dynamics.

40 ibuted significantly to our understanding of microtubule dynamics.

41 e chromatin spring in response to changes in microtubule dynamics.

42 with microtubules and the impact of MAP20 on microtubule dynamics.

43 signaling node that controls both actin and microtubule dynamics.

44 ends in the form of comet tails and regulate microtubule dynamics.

45 the pericentric chromatin upon reduction of microtubule dynamics.

46 ffect through a previously unknown effect on microtubule dynamics.

47 way and by promoting interference of MP with microtubule dynamics.

48 ve been recently identified as regulators of microtubule dynamics.

49 ulates tubulin mRNA stability via changes in microtubule dynamics.

50 tion is one of the least understood steps of microtubule dynamics.

51 ors could also have effects on intracellular microtubule dynamics.

52 ciated protein that has a role in regulating microtubule dynamics.

53 portant for the regulatory roles of MAP2c in microtubule dynamics.

54 role in controlling organelle transport and microtubule dynamics.

55 nal complex whose activity is fundamental to microtubule dynamics.

56 pecific but is more responsive to changes in microtubule dynamics.

57 overexpressed gene (TOG) domains to modulate microtubule dynamics.

58 deling of the cytoskeleton including altered microtubule dynamics.

59 microtubule-based stepping and regulation of microtubule dynamics.

60 e, and define a target for the modulation of microtubule dynamics.

61 anding how tubulin isoform composition tunes microtubule dynamics.

62 MAP2c also may regulate processes other than microtubule dynamics.

63 nomenon regulated by molecules that modulate microtubule dynamics [3-6], as well as by limiting cytop

64 l focus on changes in proteins that regulate microtubule dynamics [5-8], the contribution of the spin

65 teractions regulate EB1-dependent effects on microtubule dynamics [7], we propose that EB1-APC intera

66 ion deficit could be related to cardiac cell microtubule dynamics alterations.

67 rstanding of how cellular effectors modulate microtubule dynamics, analysis of the relationship betwe

68 ling that drives 1) presynaptic Futsch/MAP1b microtubule dynamics and 2) postsynaptic Frizzled nuclea

69 ng hypomyelination phenotypes showed altered microtubule dynamics and acted through a dominant toxic

70 llular NKCC1 trafficking by interfering with microtubule dynamics and associated motor proteins.

71 nto the microtubule network where they alter microtubule dynamics and can reduce kinesin localization

72 mouse oocytes, including key factors such as microtubule dynamics and chromosome movement.

73 lysine 40 (K40) amino acid residue regulates microtubule dynamics and controls a wide range of cellul

74 f linc00899, upregulation of TPPP/p25 alters microtubule dynamics and delays mitosis.

75 ted to drive CIN in HGSC, including elevated microtubule dynamics and DNA replication stress that can

76 controlled by Arp2/3-mediated regulation of microtubule dynamics and Dynein-generated forces on the

77 uble mutants indicated that F-actin enhances microtubule dynamics and enables reorientation.

78 cells in vitro However, our understanding of microtubule dynamics and functions in vivo, in different

79 etyrosination of alpha-tubulin is crucial to microtubule dynamics and functions, and defects have bee

80 rowing plus-ends of microtubules to regulate microtubule dynamics and functions.

81 Increased microtubule dynamics and global neuronal stabilization w

82 How temperature specifically affects microtubule dynamics and how these lead to changes in mi

83 ERG affects several parameters of microtubule dynamics and inhibits effective drug-target

84 ommonly found in tumor stromal cells, affect microtubule dynamics and interphase cell polarity.

85 bule-associated phosphoprotein tau regulates microtubule dynamics and is involved in neurodegenerativ

86 igated the role of RSK2 in the regulation of microtubule dynamics and its potential implication in ca

87 otic phenotypes described above by affecting microtubule dynamics and kinetochore function.

88 eacetylating alpha-tubulin, which suppresses microtubule dynamics and leads to cell cycle arrest and

89 These +TIPs control microtubule dynamics and microtubule interactions with o

90 ulations reveals a direct effect of Myo10 on microtubule dynamics and microtubule-cortex interactions

91 functions as a mitotic kinase necessary for microtubule dynamics and mitosis.

92 ty, as shown using drugs that interfere with microtubule dynamics and myosin II activity.

93 brain tubulin tyrosination and alteration of microtubule dynamics and neuron physiology.

94 -responsive scaffold protein AKAP9 regulates microtubule dynamics and nucleation at the Golgi.

95 undwork for a more complete understanding of microtubule dynamics and of the viscoelastic properties

96 tive and inactive conformations and roles in microtubule dynamics and organelle transport is not well

97 are driven by changes in actin filament and microtubule dynamics and organisation.

98 xonal growth and regeneration by controlling microtubule dynamics and organization in the growth cone

99 tein that plays a central role in regulating microtubule dynamics and organization.

100 icrotubule-associated protein that regulates microtubule dynamics and planar cell polarity in multi-c

101 Microtubule dynamics and polarity stem from the polymeri

102 n two related Xenopus frog species influence microtubule dynamics and spindle length.

103 Measurements of microtubule dynamics and spindle ultrastructure can prov

104 show that B1 regulates indirectly endogenous microtubule dynamics and stability while its loss leads

105 lead to the fine-tuning of the regulation of microtubule dynamics and stability.

106 port of SCG10, which is necessary for proper microtubule dynamics and subsequent axon extension.

107 Thus, we examined microtubule dynamics and synaptic density in primary cor

108 atforms for essential proteins that regulate microtubule dynamics and their interactions with cellula

109 In this review, we discuss how microtubule dynamics and their rotational movement drive

110 eletions of kinesin-like proteins to perturb microtubule dynamics and used high-resolution and time-l

111 e investigated direct effects of profilin on microtubule dynamics and whether ALS-linked mutations in

112 inked mutations in PFN1 may perturb cellular microtubule dynamics and/or the coordination between the

113 Centromere positioning, microtubule dynamics, and bipolar spindle formation can

114 How growth, microtubule dynamics, and cell-cycle progression are coo

115 ver, chimera levels fluctuate in response to microtubule dynamics, and disruption of microtubules lea

116 eveloping arbors have extensive acentrosomal microtubule dynamics, and here, we report an unexpected

117 participate in signaling cascades, modulate microtubule dynamics, and preferentially inhibit kinesin

118 XPO5 suppression reduces miR-122, increases microtubule dynamics, and results in tumor development a

119 r mitotic arrest in conditions of suppressed microtubule dynamics, and the duration of mitotic arrest

120 Furthermore, anaphase Stu2-dependent microtubule dynamics are critical for separation of long

121 Microtubule dynamics are critically important for plant

122 Intact microtubules and microtubule dynamics are required for RRV trafficking to

123 We show that microtubule dynamics are required for the recruitment an

124 Microtubule dynamics are thought to play an important ro

125 Small molecule inhibitors of microtubule dynamics are widely used as cell biology res

126 u functions, which include the regulation of microtubules dynamics, are dependent on its phosphorylat

127 ings highlight the regulation of cytoplasmic microtubule dynamics as a role of the IFT54 protein beyo

128 und that the B1-KD cells exhibited increased microtubule dynamics as compared with parental A549 cell

129 ubule-severing enzyme complex that regulates microtubule dynamics as well as ciliary functions.

130 This interaction is functionally relevant to microtubule dynamics, as mouse embryonic fibroblasts der

131 putational model using a multi-MAP, in vitro microtubule dynamics assay to reconstitute robust plus-e

132 ges of these labels to visualize and analyze microtubule dynamics at any given time.

133 have suggested that AKAP350 is important for microtubule dynamics at both locations, but how this sca

134 gs suggest that the Ndc80 complex influences microtubule dynamics at kinetochores in vivo.

135 COMA/CENP-H/I kinetochore complex regulates microtubule dynamics at kinetochores.

136 Mechanisms controlling microtubule dynamics at the cell cortex play a crucial r

137 Microtubule dynamics at the growth cone are mediated by

138 QW-296 disturbed the microtubule dynamics at the nanomolar concentration in A

139 CH-3-8 disrupted microtubule dynamics at the nanomolar concentration in M

140 g cell morphology, likely through regulating microtubule dynamics at the posterior end of the cell.

141 ry useful genetic tool to record intrabundle microtubule dynamics at the subdiffraction level.

142 r data support the notion that by decreasing microtubule dynamics, ATIP3 controls the ability of micr

143 The observed adverse effects on microtubule dynamics, axonal transport, endoplasmic reti

144 th microtubules, resulting in an increase in microtubule dynamics because of the activation of tubuli

145 he spindle poles, where it regulates mitotic microtubule dynamics, bipolar spindle formation, and sub

146 We identify a chTOG mutant that regulates microtubule dynamics but accumulates erroneous kinetocho

147 axonal growth requires alterations in axonal microtubule dynamics, but the signalling mechanisms invo

148 addition to severing, these enzymes modulate microtubule dynamics by accelerating the conversion of m

149 p150(Glued) alters microtubule dynamics by binding both to microtubules and

150 at dynein plays a primary role in regulating microtubule dynamics by destabilizing microtubules.

151 acilitating mechanisms such as regulation of microtubule dynamics by diffusible gradients, spatially

152 ubulin; the other holds that stathmin alters microtubule dynamics by directly destabilizing growing m

153 duced c-Jun N-terminal kinase (JNK) controls microtubule dynamics by enhancing both microtubule growt

154 s suggest that the coordination of actin and microtubule dynamics by FHDC1 is required for normal Gol

155 TACC3 promotes axon outgrowth and regulates microtubule dynamics by increasing microtubule plus end

156 mitotically in neurons to suppress dendritic microtubule dynamics by inhibiting nucleation.

157 esults demonstrate that phosphoregulation of microtubule dynamics by MNB/DYRK1a is critical for dendr

158 EB1 and EB3 together can regulate microtubule dynamics by promoting microtubule growth and

159 Interestingly, control of cortical microtubule dynamics by the severing enzyme KATANIN beca

160 Our results demonstrate how microtubule dynamics can be modulated to achieve a dynam

161 Thus, increased microtubule dynamics can delay short-term injury-induced

162 l chromatin-chromatin tethers, together with microtubule dynamics, can mobilize the genome in respons

163 lular processes, including the regulation of microtubule dynamics, cell migration, and intracellular

164 es and recapitulates the effects of ATIP3 on microtubule dynamics, cell proliferation, and migration.

165 Dysregulated microtubule dynamics characterized by differential alpha

166 ing dynamic micropatterns, and modulation of microtubule dynamics, confirmed that centrosome repositi

167 otubule regulation and suggests that altered microtubule dynamics contribute to CFEOM1 pathogenesis.

168 little is known about how the regulation of microtubule dynamics contributes to this process.

169 Our results suggest that microtubule dynamics coordinate the cytoskeletal changes

170 ylation and has been implicated in promoting microtubule dynamics, could play a role in this process.

171 Current models for microtubule dynamics do not account for GDP-to-GTP excha

172 ion of KIFC3 or CAMSAP2 results in increased microtubule dynamics during dendritic development.

173 rtant player in the regulation of centrosome/microtubule dynamics during mitosis and found to be dere

174 with chTOG required for spindle assembly and microtubule dynamics during mitotic cell division.

175 ver, little is known about the regulation of microtubule dynamics during synaptic development and fun

176 mediates the fidelity of MII by maintaining microtubule dynamics during the rapid formation of the M

177 , GAR22beta interacted with the regulator of microtubule dynamics end-binding protein 1 (EB1) via a n

178 In addition to defects in microtubule dynamics, ER organization is also defective

179 Microtubule dynamics facilitate neurite growth and estab

180 cell signaling, cytoskeletal transport, and microtubule dynamics for axon growth and guidance.

181 tubule depolymerases, which tightly regulate microtubule dynamics for many cellular processes.

182 axonal growth and regeneration by promoting microtubule dynamics for reorganization at the neuronal

183 R+ cells to assess the effects on individual microtubule dynamics for RNA interference-mediated deple

184 Extraction and computational analysis of microtubule dynamics from EB3-GFP time-lapse image seque

185 include roles in the regulation of plus-end microtubule dynamics, gene regulation, and mitotic and c

186 However, inhibition of microtubule dynamics has no effect on BDNF/TrkB motility

187 bona fide nucleation factors also regulating microtubule dynamics have challenged this notion.

188 studying mitochondrial, membrane, Golgi, and microtubule dynamics in cells and calcium activity in ne

189 Microtubule dynamics in cells are regulated by associate

190 ctivates kinesin-1's function of controlling microtubule dynamics in cells, demonstrating that these

191 However, profilin also influences microtubule dynamics in cells, which may be mediated in

192 tive approach to study spatial regulation of microtubule dynamics in cells.

193 l micro-enclosures as a means to investigate microtubule dynamics in cytoplasmic volumes of defined s

194 However, the mechanisms regulating microtubule dynamics in dendrites and spines remain uncl

195 Concomitant with stabilization, microtubule dynamics in dendrites increased.

196 to recruit ectopic gammaTub-GFP and increase microtubule dynamics in dendrites.

197 ndent role of ERI complexes in modulation of microtubule dynamics in differentiated keratinocytes.

198 ins that have a conserved role in regulating microtubule dynamics in diverse cell types.

199 at high density, enabling video recording of microtubule dynamics in interphase and mitotic cells.

200 F1A is a key regulator in the fine tuning of microtubule dynamics in interphase cells and proper Golg

201 led that PP1beta-MYPT1 phosphatase regulates microtubule dynamics in late cytokinesis and de-phosphor

202 nvestigating spatial and temporal control of microtubule dynamics in live cells is critical to unders

203 Using this method, we demonstrated imaging microtubule dynamics in living cells with a time resolut

204 rosome biogenesis in progenitor cells and in microtubule dynamics in migrating neurons.

205 This fact together with a key role of microtubule dynamics in neurite outgrowth led to the con

206 s show decreased survival and dysfunction in microtubule dynamics in neurons from Tubb4a(D249N/D249N)

207 Regulation of microtubule dynamics in neurons is critical, as defects

208 Microtubule dynamics in neurons play critical roles in p

209 er, we found that the severity of defects in microtubule dynamics in spr1 eb1b mutant hypocotyl cells

210 ivation and F-actin remodeling and decreased microtubule dynamics in the AIS.

211 inks transport of SCG10 to the regulation of microtubule dynamics in the axon growth cone and enhance

212 idence suggests that regulators of actin and microtubule dynamics in the growth cone might serve as a

213 pha-tubulin isoforms indicative of increased microtubule dynamics in the hippocampus of naive Sprague

214 of how microtubule-associated proteins tune microtubule dynamics in trans, we have yet to understand

215 We characterise microtubule dynamics in two-dimensional systems by chron

216 ly tagged end-binding proteins have revealed microtubule dynamics in vitro and in non-mammalian model

217 Here, we reconstituted microtubule dynamics in vitro to investigate the influen

218 To test its potential role as a modulator of microtubule dynamics in vitro, an engineered homodimeric

219 a stable kinesin-5 dimer and reconstituting microtubule dynamics in vitro, we demonstrate that kines

220 opus tropicalis, have surprisingly different microtubule dynamics in vitro.

221 Our approach allows measurement of microtubule dynamics in vivo and ex vivo in peripheral n

222 new data indicating these activities enhance microtubule dynamics in vivo via repair or removal of al

223 iation in vitro and causes severe defects in microtubule dynamics in vivo.

224 rmly support a structural plasticity view of microtubule dynamics in which microtubule lattice confor

225 t plus-end coupling during several rounds of microtubule dynamics, in the absence of any specialized

226 Interestingly, E7130 not only is a novel microtubule dynamics inhibitor but can also increase int

227 ster chromatids to the spindle and transduce microtubule dynamics into chromosome movement.

228 Microtubule dynamics involves the polymerization and dep

229 The precise regulation of microtubule dynamics is essential during cell division.

230 Proper regulation of microtubule dynamics is essential for cell functions and

231 matical model shows that spastin's effect on microtubule dynamics is essential for this nucleation-li

232 Indeed, the regulation of microtubule dynamics is essential to the integrity and f

233 The spatial and temporal control of microtubule dynamics is fundamentally important for prop

234 Our study shows that proper control of microtubule dynamics is important for axon elongation in

235 G protein dynamics and their contribution to microtubule dynamics is important for understanding the

236 owever, the mechanism by which they regulate microtubule dynamics is not well understood.

237 Microtubule dynamics is regulated by plus end-tracking p

238 In cells, microtubule dynamics is regulated by stabilizing and des

239 Coordinated actin microfilament and microtubule dynamics is required for salivary gland deve

240 ecent work studying effects of kinesin-8s on microtubule dynamics, it remains unclear whether the kin

241 ds and has seemingly antagonistic effects on microtubule dynamics: it induces catastrophes, and it in

242 Although PAK1 regulates cytoskeleton and microtubule dynamics, its role in controlling the functi

243 l suggests that kinesin-8-induced effects on microtubule dynamics, kinetochore attachment stability,

244 -like motor proteins that directly attenuate microtubule dynamics make key contributions to this cont

245 Growing evidence suggests that altered microtubule dynamics may also underlie or contribute to

246 We provide evidence that these effects on microtubule dynamics may be explained in part by changes

247 Thus increased microtubule dynamics might serve as a general indicator

248 Regulation of microtubule dynamics, motor proteins, microtubule crossl

249 Actin and microtubule dynamics must be precisely coordinated durin

250 The alterations in microtubule dynamics observed in the presence of mutated

251 e that Aurora A kinase regulates kinetochore-microtubule dynamics of metaphase chromosomes, and we id

252 , whether this modification alters intrinsic microtubule dynamics or affects extrinsic associations w

253 served protein involved in the regulation of microtubule dynamics orchestrates NLRP3 inflammasome act

254 CUL7 depletion results in altered microtubule dynamics, prometaphase arrest, tetraploidy,

255 The changes in microtubule dynamics promote microtubule regrowth so tha

256 e, including regulators of microfilament and microtubule dynamics, protein interactions, and enzymati

257 tate stochastic models that seek to describe microtubule dynamics purely in terms of the biochemical

258 nsistent with kinesin-8s being regulators of microtubule dynamics rather than cargo transporters.

259 Here, we demonstrate that spatially distinct microtubule dynamics regulate amoeboid cell migration by

260 le plus end-tracking proteins, in specifying microtubule dynamics required for directional tip growth

261 n primary neurons, they enable regulation of microtubule dynamics resolved to subcellular regions wit

262 e generally attributed to the suppression of microtubule dynamics resulting in defects in cell divisi

263 s cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene expre

264 ct as a microtubule depolymerase, regulating microtubule dynamics, spindle assembly and chromosome co

265 pounds cellular growth arrest phenotypes and microtubule dynamics suggest that the antiproliferative

266 The DYT4 mutation had no impact on microtubule dynamics suggesting a distinct mechanism of

267 Current in vitro optical studies of microtubule dynamics tend to rely on fluorescent labelin

268 Schizosaccharomyces pombe, depend on astral microtubule dynamics that drag the nucleus through the z

269 , spastin is an ATP-independent regulator of microtubule dynamics that slows shrinkage and increases

270 Although degranulation depends crucially on microtubule dynamics, the molecular machinery that coupl

271 enotypes are consequences of their effect on microtubule dynamics, their well-established motor activ

272 tor (BDNF)-TrkB complexes and also regulates microtubule dynamics through a separable, non-motor micr

273 hese results indicate that the regulation of microtubule dynamics through KLP10A plays a critical rol

274 ting proteins (Rho GAPs), controls actin and microtubule dynamics through negative regulation of Rac.

275 ting attachment stability, Aurora B controls microtubule dynamics through phosphorylation of the Ndc8

276 rough its extracellular domain and regulates microtubule dynamics through RUVBL proteins at its intra

277 iwaki and Goshima reconstitute all phases of microtubule dynamics through the inclusion of five key r

278 is pathway, Rac1 serves as a hub to modulate microtubule dynamics through two different routes: 1) ph

279 l division requires that kinetochores couple microtubule dynamics to chromosome movement.

280 tanding of how the 'tubulin code' influences microtubule dynamics to generate complex cellular struct

281 ommodate the changing tension resulting from microtubule dynamics to maintain a stable metaphase spin

282 ow that Plk1 activity suppresses kinetochore-microtubule dynamics to stabilize initial attachments in

283 , thereby enabling accurate control over the microtubule dynamics to treat various pathologies.

284 shown to contribute to the heterogeneity of microtubule dynamics: tubulin isoform composition [9, 10

285 HDAC6 might function as a MAP that regulates microtubule dynamics under certain conditions.

286 Our study establishes a mechanism governing microtubule dynamics via the separase-dependent activati

287 , dendrite stabilization was suppressed when microtubule dynamics was dampened, which was achieved by

288 Increased dendritic microtubule dynamics was independent of dual leucine zip

289 r chemicals that interact with regulators of microtubule dynamics, we identified Pyr1, a cell permeab

290 By slowing down microtubule dynamics, we reveal such a mechanism by show

291 Using computational modeling of microtubule dynamics, we show that these mechanisms coul

292 Microtubule-bound mutant M1 decreased microtubule dynamics, whereas unbound M1 or M87 mutant s

293 y and chromosome segregation rely on precise microtubule dynamics, which are governed in part by the

294 cal nucleus depends on a critical balance of microtubule dynamics, which is regulated by the chromati

295 (Glued) in nonpolarized cells does not alter microtubule dynamics, while depletion of p150(Glued) in

296 underscoring an additional cause of altered microtubule dynamics with impact on neuronal function an

297 dynein-NCAM180 interaction, or dampening of microtubule dynamics with low dose nocodazole all result

298 llar granule cells in the context of altered microtubule dynamics, with profound neurodevelopmental d

299 or low concentrations of drugs that suppress microtubule dynamics without affecting the amount of mic

300 it is an open question how tau can regulate microtubule dynamics without impeding microtubule-depend