ライフサイエンスコーパス: microtubule-organizing center

1 retrograde transport on microtubules to the microtubule organizing center.

2 ules, which appeared to concentrate over the microtubule organizing center.

3 aberrant accumulation of mitochondria at the microtubule organizing center.

4 y cargo away from the plasma membrane to the microtubule organizing center.

5 mplex is associated with microtubules at the microtubule organizing center.

6 it appeared to lie in close proximity to the microtubule organizing center.

7 ear envelope adopts the function as cellular microtubule organizing center.

8 ed for lysosomes to distribute away from the microtubule-organizing center.

9 associated with the trans-Golgi network and microtubule-organizing center.

10 tic concentration of CV membranes around the microtubule-organizing center.

11 at moves cargo on microtubules away from the microtubule-organizing center.

12 olarity is the centrosome, also known as the microtubule-organizing center.

13 ts from a globular structure adjacent to the microtubule-organizing center.

14 ed in the perinuclear region, often near the microtubule-organizing center.

15 ricentriolar material, is the cell's central microtubule-organizing center.

16 in Saccharomyces cerevisiae functions as the microtubule-organizing center.

17 ky-inseminated eggs failed to reconstitute a microtubule-organizing center.

18 les; upon drug removal, EB1 localized to the microtubule-organizing center.

19 ordered arrays in the absence of a dedicated microtubule-organizing center.

20 are initially recruited around the polarized microtubule-organizing center.

21 function in the duplication of a variety of microtubule organizing centers.

22 e show that both Mbo1p and Gfh1p localize to microtubule organizing centers.

23 larity protein PAR-2 in regions distant from microtubule organizing centers.

24 sp in coordinating the nucleation of mitotic microtubule organizing centers.

25 erial, a precursor to full separation of the microtubule organizing centers.

26 r-like structures that dramatically resemble microtubule organizing centers.

27 eated mitotic cells, IAK1 is associated with microtubule organizing centers.

28 independently of either centrosomes or other microtubule organizing centers.

29 of the spindle pole bodies (SPBs), the yeast microtubule organizing centers.

30 e generation of multipolar spindles and free microtubule-organizing centers.

31 t and, in some organisms, for duplication of microtubule-organizing centers.

32 rins are calmodulin-like proteins present in microtubule-organizing centers.

33 ytes and are rarely associated with discrete microtubule-organizing centers.

34 entrioles comprise the heart of centrosomes, microtubule-organizing centers.

35 and muscle, Nin localizes to noncentrosomal microtubule-organizing centers.

36 tubulin ring complexes localized at specific microtubule-organizing centers.

37 ge distances from the cell body and the main microtubule-organizing center?

38 ave shown that Golgi outposts serve as local microtubule-organizing centers [8] and secretory station

39 eased the number of gamma-tubulin-containing microtubule-organizing centers, a phenotype reminiscent

40 is-related abnormalities, including multiple microtubule organizing centers, aberrant mitotic spindle

41 resulted in loss of their ability to restore microtubule-organizing center activity to salt-stripped

42 osomes tightly cluster and act as functional microtubule-organizing centers allowing for increased pe

43 nt PLK1 aggregation that led to acentrosomal microtubule-organizing center (aMTOC) formation and subs

44 n documented to reside in the centrosome, or microtubule-organizing center, an amembranous organelle

45 Third, inhibition of microtubule organizing center and centrosome polarizatio

46 ) vesicles, a recycling compartment near the microtubule organizing center and Golgi apparatus.

47 that cell spreading and polarization of the microtubule organizing center and the actin cytoskeleton

48 Consequently, the relocation of the microtubule organizing center and the Golgi apparatus in

49 aled that AIM2 inflammasomes colocalize with microtubule organizing centers and autophagosomes.

50 eral NK cells, they failed to polarize their microtubule organizing centers and perforin-containing g

51 ion of an actin ring and polarization of the microtubule-organizing center and cytolytic granules to

52 n complex constitutes a key component of the microtubule-organizing center and nucleates microtubule

53 The centrosome functions as the major microtubule-organizing center and plays a vital role in

54 Knockdown of C19ORF5 disrupts the microtubule-organizing center and results in microtubule

55 s then assembled via active transport at the microtubule-organizing center and thereby initiated the

56 before they become competent to function as microtubule-organizing centers and basal bodies.

57 gamma-Tubulin is a conserved component of microtubule-organizing centers and is thought to be invo

58 Centrosomes are microtubule-organizing centers and play a dominant role

59 s in actin accumulation, polarization of the microtubule organizing center, and the convergence of cy

60 Polarization of talin, microtubule-organizing center, and lysosomes occurred on

61 vement of lysosome-related organelles to the microtubule-organizing center, as an early step in the c

62 localization of pM140 to an aggresome-like, microtubule organizing center-associated structure that

63 ites of microtubule overlaps associated with microtubule organizing centers at both interphase and mi

64 is how to organize a bipolar spindle without microtubule organizing centers at the poles.

65 This suppression of activation impacts microtubule organizing center-based cytoskeletal rearran

66 ctively recruited to the cap of CD20 and the microtubule organizing center became polarized toward th

67 ustered in a paranuclear region close to the microtubule organizing center, but different from the Go

68 in target cell-induced reorientation of the microtubule-organizing center, but is required for the s

69 irst travel to the centrosome (the principal microtubule organizing center) by minus-end-directed tra

70 pindle assembly occurs in the absence of the microtubule-organizing centers called centrosomes.

71 recycling endosomes concentrated around the microtubule-organizing center/centrosome.

72 ntracellular calcium and evokes dispersal of microtubule organizing center-clustered WPBs.

73 Centrosomes are microtubule-organizing centers comprised of a pair of ce

74 Postmitotic karyoplasts assembled a microtubule-organizing center containing gamma-tubulin a

75 The accumulation of 6-PGDase at the microtubule-organizing centers could be blocked by colch

76 The reorientation of the microtubule organizing center during cell migration into

77 eation in most cells, lose their function as microtubule organizing centers during neuronal developme

78 , we show here that C19ORF5 localizes to the microtubule-organizing centers during microtubule regrow

79 Equatorial microtubule organizing center (eMTOC) activity was not a

80 TIL do not recruit granzyme B+ granules, the microtubule-organizing center, F-actin, Wiskott-Aldrich

81 -dependent translocation of the virus to the microtubule-organizing center following endosome penetra

82 The APR serves as microtubule-organizing center for the 22 subpellicular m

83 tin polymerization, tubulin multimerization, microtubule organizing center formation, calcium/calmodu

84 er insight into the role of gamma-tubulin in microtubule-organizing center function.

85 ) scaffold required for PCM organization and microtubule-organizing center function.

86 ic extranuclear sites as follows: around the microtubule organizing center in association with the ci

87 ration, the centrosome, which functions as a microtubule organizing center in cardiomyocytes, undergo

88 Centrosomes are the major microtubule organizing center in mammalian cells and est

89 The centrosome is the major microtubule organizing center in mammalian cells.

90 The spindle pole body (SPB) is the microtubule organizing center in Saccharomyces cerevisia

91 C, and cytoskeletal filaments radiate from a microtubule organizing center in the cVAC.

92 The oocyte germinal vesicle serves as a microtubule organizing center in Xenopus oocytes; experi

93 centrosomes are major microtubule organizing centers in animal cells, and they

94 Centrosomes are the principal microtubule organizing centers in eukaryotic cells and c

95 ted for the activity of multiple acentriolar microtubule organizing centers in the oocyte.

96 Centrosomes are the major microtubule-organizing center in animal cells.

97 The centrosome is the dominant microtubule-organizing center in animal cells.

98 cycling compartment (ERC), which is near the microtubule-organizing center in many cell types.

99 female meiotic spindle lacks a centrosome or microtubule-organizing center in many organisms.

100 etected in clusters that colocalize with the microtubule-organizing center in patient cells.

101 ing of late endosomes (LEs)/lysosomes to the microtubule-organizing center in response to stress in m

102 granules move along microtubules toward the microtubule-organizing center in the minus-end direction

103 dles, but chromosomes radiated away from the microtubule-organizing centers in a prometaphase-like pa

104 Centrosomes are the main microtubule-organizing centers in animal cells.

105 Centrosomes are the major microtubule-organizing centers in animals and play funda

106 lization of only a few conserved proteins at microtubule-organizing centers in animals, plants, and f

107 in control neutrophils but is found near the microtubule-organizing centers in cells from pregnant wo

108 g proteins that is an essential component of microtubule-organizing centers in many organisms ranging

109 PDase, undergoes retrograde transport to the microtubule-organizing centers in neutrophils from pregn

110 Centrin is an essential component of microtubule-organizing centers in organisms ranging from

111 ate first the positioning of the centrosome (microtubule organizing center) in the leading process in

112 mma-tubulin-containing structures (potential microtubule-organizing centers) in CACO-2 cells and demo

113 les are the core constituent of centrosomes, microtubule-organizing centers involved in directing mit

114 ontrolling the behavior of the fission yeast microtubule-organizing center (known as the spindle pole

115 ble microtubule arrays without a conspicuous microtubule organizing center like a centrosome.

116 flowering plants lack a structurally defined microtubule-organizing center like the centrosome, organ

117 icity in the absence of structurally defined microtubule-organizing centers like the centrosome.

118 ed peptide-MHC complexes, lytic granules and microtubule organizing center localization into synaptic

119 First, during anaphase, multiple microtubule organizing centers migrated 40 microns or mo

120 Microtubule-organizing centers move from centrosomes to

121 tubulin and microtubules but focuses to the microtubule organizing center (MTOC) after NK cell activ

122 ctin polymerization, and polarization of the microtubule organizing center (MTOC) and cytolytic granu

123 In this study, we report that, whereas the microtubule organizing center (MTOC) and cytosolic granu

124 embryos, which involve reorientation of the microtubule organizing center (MTOC) and Golgi apparatus

125 inant centrosome." This centrosome acts as a microtubule organizing center (MTOC) and remains station

126 through the movement of vesicles toward the microtubule organizing center (MTOC) and translocation o

127 intermediate chain (CDIC) colocalize at the microtubule organizing center (MTOC) around the nucleus

128 y impaired LFA1 polarization, spreading, and microtubule organizing center (MTOC) formation in NK cel

129 ciency induces significant separation of the microtubule organizing center (MTOC) from the nuclear en

130 The centrosome is the major microtubule organizing center (MTOC) in dividing cells a

131 e T cell polarization and recruitment of the microtubule organizing center (MTOC) in HIV-1-infected c

132 Centrosomes act as the main microtubule organizing center (MTOC) in metazoans.

133 The spindle pole body (SPB) is the microtubule organizing center (MTOC) in the yeast Saccha

134 volving cell spreading, translocation of the microtubule organizing center (MTOC) into a trailing uro

135 s were attributed to aberrant release of the microtubule organizing center (MTOC) linker protein, C-N

136 FIB-SEM and microtubule organizing center (MTOC) mapping showed that

137 o the leading edge and, surprisingly, to the microtubule organizing center (MTOC) of migrating fibrob

138 abrogated, including increased calcium flux, microtubule organizing center (MTOC) polarization, phosp

139 , we assessed the location of the centrosome/microtubule organizing center (MTOC) relative to the cel

140 is in animal cells, the centrosome acts as a microtubule organizing center (MTOC) to assemble the mit

141 hat Klarsicht is required for connecting the microtubule organizing center (MTOC) to the nucleus.

142 phocytes (CTL) requires translocation of the microtubule organizing center (MTOC) to the target cell

143 ngle NK cell, signal the polarization of the microtubule organizing center (MTOC) together with cytol

144 ormation of the IS implies relocation of the microtubule organizing center (MTOC) toward the contact

145 mNudE is located in the centrosome or microtubule organizing center (MTOC), and interacts with

146 and furthermore, blocked the movement of the microtubule organizing center (MTOC), granzyme B (a comp

147 The centrosome acts as a microtubule organizing center (MTOC), orchestrating micr

148 pPKCdelta(Thr505) co-localized with two key microtubule organizing center (MTOC)-associated proteins

149 gion (outside the cell nucleus) known as the microtubule organizing center (MTOC).

150 lear migration by linking the nucleus to the microtubule organizing center (MTOC).

151 the capsid moves to and associates with the microtubule organizing center (MTOC).

152 ubulin complex (gamma-TuC), and composes the microtubule organizing center (MTOC).

153 ic leukemia oncogenic domains (PODs) and the microtubule organizing center (MTOC).

154 urrounded by microtubules radiating from the microtubule organizing center (MTOC).

155 p to nucleate microtubules and function as a microtubule organizing center (MTOC).

156 ion of T cells involves reorientation of the microtubule organizing center (MTOC).

157 rliest point, the initiation of the daughter microtubule organizing center (MTOC).

158 LIS1 is a microtubule- (MT) and centrosome- [microtubule organizing center (MTOC)] associated protein

159 whether AurA can stimulate the formation of microtubule organizing centers (MTOC) on its own.

160 due to increased DGAT1 expression leading to microtubule-organizing center (MTOC) amplification.

161 ment site, as judged by reorientation of the microtubule-organizing center (MTOC) and localized actin

162 e parasitophorous vacuole (inclusion) to the microtubule-organizing center (MTOC) and promotes its fu

163 caused swift granule concentration near the microtubule-organizing center (MTOC) and subsequent deli

164 n-dependent lytic granule convergence to the microtubule-organizing center (MTOC) as an early, prereq

165 During apical constriction, a microtubule-organizing center (MTOC) containing the micr

166 ic TIL and cognate tumor cells in vitro, the microtubule-organizing center (MTOC) does not localize t

167 The centrosome acts as the microtubule-organizing center (MTOC) during mitosis in a

168 ding pericentriolar material, is the primary microtubule-organizing center (MTOC) in animal cells.

169 The nucleus is the main microtubule-organizing center (MTOC) in muscle cells due

170 In contrast, reorientation of the T cell microtubule-organizing center (MTOC) is dependent on and

171 The microtubule-organizing center (MTOC) is reoriented betwe

172 ted motor protein, moves cargo away from the microtubule-organizing center (MTOC) on microtubules.

173 stepwise with actin reorganization preceding microtubule-organizing center (MTOC) polarization to the

174 ch as fibroblasts and endothelial cells, the microtubule-organizing center (MTOC) reorients toward th

175 by an apical complex that contains a unique microtubule-organizing center (MTOC) that organizes the

176 In T lymphocytes, polarization of the microtubule-organizing center (MTOC) to the immunologica

177 immunological synapse, translocation of the microtubule-organizing center (MTOC) to the synapse, and

178 Polarization of the T cell microtubule-organizing center (MTOC) toward the antigen-

179 The reorientation of the T cell microtubule-organizing center (MTOC) toward the antigen-

180 ical synapse as well as reorientation of the microtubule-organizing center (MTOC) toward the APC.

181 ormed by the splitting and separation of the microtubule-organizing center (MTOC) well before nuclear

182 e monitored by analyzing the position of the microtubule-organizing center (MTOC), as it moves toward

183 ganelle that can function as an acentrosomal microtubule-organizing center (MTOC), nucleating new mic

184 ns a relatively constant localization at the microtubule-organizing center (MTOC), Nuf is present at

185 he polarization of lytic granules toward the microtubule-organizing center (MTOC).

186 FV capsid assembly takes place near the host microtubule-organizing center (MTOC).

187 ganelle that can function as an acentrosomal microtubule-organizing center (MTOC).

188 zed at Golgi membranes and apparently at the microtubule-organizing center (MTOC).

189 "aggresome", a perinuclear inclusion at the microtubule-organizing center (MTOC).

190 vation, and IL-1beta conversion occur at the microtubule-organizing center (MTOC).

191 as well as on the later polarization of the microtubule-organizing center (MTOC).

192 Moreover, the microtubule-organizing center (MTOC, or centrosome), whi

193 ly at centrosomes, but more diverse types of microtubule organizing centers (MTOCs) also exist, espec

194 Ran and importin beta in the coalescence of microtubule organizing centers (MTOCs) and MI spindle as

195 Non-centrosomal microtubule organizing centers (MTOCs) direct microtubul

196 the poles of the spindle that can persist as microtubule organizing centers (MTOCs) into interphase.

197 Centrosomes, the main microtubule organizing centers (MTOCs) of metazoan cells

198 Regulation of microtubule organizing centers (MTOCs) orchestrates the

199 niversal role in microtubule nucleation from microtubule organizing centers (MTOCs) such as the anima

200 nucleation from noncentrosomal intracellular microtubule organizing centers (MTOCs), although such st

201 centrosome, representing the most prominent microtubule organizing centers (MTOCs), disappeared duri

202 ocess requires enrichment of the Cdc5 PLK to microtubule organizing centers (MTOCs), such as the yeas

203 entriole/kinetosomes, centrosomes, and other microtubule organizing centers (MTOCs), whether by direc

204 and associated proteins present at specific microtubule organizing centers (MTOCs).

205 on with pericentrin and gamma-tubulin within microtubule organizing centers (MTOCs).

206 hese microaggregates were not transported to microtubule organizing centers (MTOCs).

207 and was characterized by the loss of obvious microtubule organizing centers (MtOCs).

208 d microtubules extending from poorly defined microtubule organizing centers (MTOCs).

209 a duplication and separation of centrosomal microtubule organizing centers (MTOCs).

210 known centrosomal proteins with two types of microtubule organizing centers (MTOCs): (1) the central

211 e CM1 protein Mto1 recruits the gamma-TuC to microtubule-organizing centers (MTOCs) [14, 20-22], and

212 mologue of MOZART1, Mzt1/Tam4, is located at microtubule-organizing centers (MTOCs) and coimmunopreci

213 the gamma-TuC becomes active specifically at microtubule-organizing centers (MTOCs) and not more broa

214 In young embryos, hundreds of microtubule-organizing centers (MTOCs) are assembled com

215 Microtubule-organizing centers (MTOCs) are large, multi-

216 shown previously that centrosomes and other microtubule-organizing centers (MTOCs) attach to the api

217 Microtubule-organizing centers (MTOCs) form, anchor, and

218 lta (CK1delta) family members associate with microtubule-organizing centers (MTOCs) from yeast to hum

219 alizes with gamma-tubulin and pericentrin at microtubule-organizing centers (MTOCs) in mouse oocytes

220 HA-tagged GTU1p localizes to four microtubule-organizing centers (MTOCs) in vegetative cel

221 Positioning of microtubule-organizing centers (MTOCs) incorporates bioc

222 that form the mitotic spindle originate from microtubule-organizing centers (MTOCs) located at either

223 Microtubule-organizing centers (MTOCs) nucleate microtub

224 using distinct sites within the cell called microtubule-organizing centers (MTOCs) to build cell-spe

225 In simple epithelial cells, attachment of microtubule-organizing centers (MTOCs) to intermediate f

226 The switch from centrosomal microtubule-organizing centers (MTOCs) to non-centrosoma

227 rives the polarization of lytic granules and microtubule-organizing centers (MTOCs) toward the immune

228 is self-assembled from randomly distributed microtubule-organizing centers (MTOCs) without centriole

229 Microtubule-organizing centers (MTOCs), known as centros

230 at form the core structure of centrosomes or microtubule-organizing centers (MTOCs).

231 yos led to the de novo formation of multiple microtubule-organizing centers (MTOCs).

232 oordinated by specific cellular sites called microtubule-organizing centers (MTOCs).

233 In many asymmetrically dividing cells, the microtubule-organizing centers (MTOCs; mammalian centros

234 ), as the cortical anchor for noncentrosomal microtubule organizing centers (ncMTOCs) in the Drosophi

235 The centrosome is the microtubule organizing center of human cells and facilit

236 Salmonella-containing vacuoles close to the microtubule organizing center of infected epithelial cel

237 The spindle pole body (SPB) is the microtubule organizing center of Saccharomyces cerevisia

238 The microtubule organizing center of stopped cells was posit

239 2 is a core component of the centrosome, the microtubule organizing center of the cell, and functiona

240 The centrosome is the primary microtubule organizing center of the cells and templates

241 component centrioles represent the principal microtubule organizing centers of animal cells.

242 unded by a dense network of proteins, is the microtubule-organizing center of animal cells.

243 The spindle pole body (SPB) is the major microtubule-organizing center of budding yeast and is th

244 The centrosome is the major microtubule-organizing center of most mammalian cells an

245 e spindle pole body (SPB) serves as the sole microtubule-organizing center of the cell, nucleating bo

246 the majority of animals, the centrosome-the microtubule-organizing center of the cell-is assembled f

247 Centrosomes are the microtubule-organizing centers of animal cells that orga

248 trol of the number of centrosomes, the major microtubule-organizing centers of animal cells, is criti

249 organelles that build centrosomes, the major microtubule-organizing centers of animal cells.

250 As the microtubule-organizing centers of most cells, centrosome

251 It is found in microtubule-organizing centers of organisms ranging from

252 Centrosomes are the principal microtubule-organizing centers of the cell, are cellular

253 he K.VP1-2DeltaNLS mutant was blocked at the microtubule organizing center or immediately upstream of

254 at form at pericentriolar sites close to the microtubule organizing center or in specialized nuclear

255 -vesicular structures either adjacent to the microtubule-organizing center or widely distributed in t

256 uf1p) is an essential component of the yeast microtubule organizing center, or spindle pole body (SPB

257 mmon localization of the two proteins in the microtubule organizing center, our results suggest that

258 me, an organelle that functions as the major microtubule-organizing center, plays an essential role i

259 Surprisingly, microtubule organizing center polarity at the IS, which

260 ensable for thymocyte development as well as microtubule organizing center polarization and cytolytic

261 Microtubule organizing center polarization and granule r

262 ion over this range significantly suppressed microtubule organizing center polarization and granzyme

263 lytic granule secretion and by showing that microtubule organizing center polarization is dispensabl

264 zation at the contact site with APC, altered microtubule-organizing center polarization and the IS st

265 d is required for conjugate formation, MTOC (microtubule organizing center) polarization, and NKG2D-d

266 etheless, naive CD8(+) T cells polarized the microtubule organizing center, produced IL-2, proliferat

267 dle is formed through the action of multiple microtubule organizing centers rather than a pair of cen

268 m store release and diacylglycerol-dependent microtubule organizing center reorientation, while deple

269 transiently at the T cell/APC interface, the microtubule organizing center reoriented toward it.

270 Centrosomes are microtubule-organizing centers required for error-free m

271 The basal body is a microtubule-organizing center responsible for organizing

272 complexes that mediate chromosome movement (microtubule organizing centers, spindles, and kinetochor

273 or reasons still speculative, lack the major microtubule organizing centers that most cells use to as

274 Centrosomes are microtubule organizing centers that participate in sever

275 Centrosomes are key microtubule-organizing centers that contain a pair of ce

276 Centrosomes are microtubule-organizing centers that facilitate bipolar m

277 mal structures-distinct from elements of the microtubule-organizing center-that is required for the s

278 duplication of the Saccharomyces cerevisiae microtubule organizing center, the spindle pole body (SP

279 formation is based on the action of multiple microtubule organizing centers, the chromosomes not only

280 Despite the importance of centrosomes as microtubule-organizing centers, the mechanism and regula

281 animal cells states that centrosomes act as microtubule-organizing centers throughout the cell cycle

282 rved role in fenestration to enable a single microtubule organizing center to nucleate both cytoplasm

283 B cell rounding up and translocation of the microtubule organizing center to the region of the B cel

284 Fungal centromeres are clustered near microtubule organizing centers to help adopt the Rabl ch

285 l polarity was indicated by a failure of the microtubule-organizing center to align with the directio

286 h microtubules emanating from the equatorial microtubule-organizing center to position the nuclei awa

287 e that C19ORF5 plays a role in anchoring the microtubule-organizing center to the centrosomes.

288 cell targets and induce reorientation of the microtubule-organizing center to the immunologic synapse

289 raffic determined by the polarization of the microtubule-organizing center to the immunological synap

290 ation of CTLA-4 and the reorientation of the microtubule-organizing center to the site of T-cell rece

291 erization within protrusions remote from the microtubule organizing center triggers actomyosin contra

292 These infected cells did not begin to lose microtubule-organizing centers until 13 hpi.

293 These observations reveal that microtubule organizing centers use minus to plus-end dir

294 i.e., AURKA, PLK1, and gamma-tubulin) to the microtubule-organizing center via the RhoA signaling pat

295 it is shown that a marker protein for plant microtubule organizing centers, which has been shown to

296 case of an unsuccessful polarization of the microtubule-organizing center, which alters the polarity

297 icrotubules is determined in most cells by a microtubule-organizing center, which nucleates microtubu

298 ed by AK301 showed the formation of multiple microtubule organizing centers with Aurora kinase A and

299 ctors and the posterior establishment of the microtubule organizing center within the presumptive ooc

300 s served as a model system for understanding microtubule organizing centers, yet very little is known