ライフサイエンスコーパス: microvesicle

1 stases and analyzed tumor cells, stroma, and microvesicles.

2 et cells to which they are trafficked within microvesicles.

3 y resolved in animals cranially grafted with microvesicles.

4 triggering their secretion by extracellular microvesicles.

5 rrestin domain-containing protein 1-mediated microvesicles.

6 matrix metalloprotease (MT1-MMP) to shedding microvesicles.

7 ells adopt an amoeboid phenotype and release microvesicles.

8 tes TCR sorting and release in extracellular microvesicles.

9 to generate T-cell antigen receptor-enriched microvesicles.

10 cancers, are often packaged within secreted microvesicles.

11 lar signals in response to isolated synaptic microvesicles.

12 Vif in lysosomes and by secretion of Vif in microvesicles.

13 ss caused by circulating erythrocyte-derived microvesicles.

14 the miRNA content of the macrophage-derived microvesicles.

15 te the binding of circulating leukocytes and microvesicles.

16 sms, including tunnelling nanotubes and host microvesicles.

17 ct, but relied on engulfment within secreted microvesicles.

18 nd promotes novel membrane TNF signaling via microvesicles.

19 regulated in senescent endothelial cells and microvesicles.

20 embrane in a Ca(2+)-dependent manner, namely microvesicles.

21 Neutrophil microvesicles accumulate at disease-prone regions of art

22 s support a scenario by which T cell-derived microvesicles act as intercellular carriers of functiona

23 ggest that the neuroprotective properties of microvesicles act through a trophic support mechanism th

24 e analysis of the content and the surface of microvesicles allow conclusions about the cells they are

25 Exosomes and related microvesicles also aid cells in exporting less-needed mo

26 h the release of a soluble growth factor and microvesicles, alter the type of particles engulfed by n

27 bound extracellular vesicles (EVs; exosomes, microvesicles and apoptotic bodies) containing proteins,

28 cellular vesicles (EVs), including exosomes, microvesicles and apoptotic bodies, are lipid-bound vesi

29 ys for protein delivery with both eukaryotic microvesicles and bacterial surface secretion systems.

30 ield (n = 30), respectively; (2) circulating microvesicles and blood cells; and (3) lungs from a mono

31 trated that the proinflammatory potential of microvesicles and directly isolated mitochondria were dr

32 moted the biogenesis of onco-miR-221(hi) CAF microvesicles and established stromal CSC niches in expe

33 reviews the current knowledge on the role of microvesicles and exosomes from various cellular origins

34 lar vesicles (EVs), sometimes referred to as microvesicles and exosomes, to transfer immune modulatin

35 racellular vesicles (EVs): apoptotic bodies, microvesicles and exosomes.

36 losion of novel functions: the biogenesis of microvesicles and exosomes; plasma membrane wound repair

37 Here, we characterized macrophage-derived microvesicles and explored their role in the differentia

38 ioactive products, including adipocytokines, microvesicles and gaseous messengers, with a wide range

39 cellular vesicles (EVs) include exosomes and microvesicles and have been shown to have roles in the C

40 cells are able to switch between the use of microvesicles and invadopodia to facilitate invasion thr

41 ence of the kinin B1 receptor on endothelial microvesicles and its contribution to the inflammatory p

42 racellular vesicles (EVs), such as exosomes, microvesicles and large oncosomes, are involved in this

43 Furthermore, tumor microvesicles and miR-21 require c-Jun N-terminal kinase

44 Extracellular vesicles (exosomes, microvesicles, and apoptotic bodies) are ubiquitous in h

45 rious extracellular vesicles (EVs; exosomes, microvesicles, and apoptotic bodies) that differ in biog

46 ther submicron particles including exosomes, microvesicles, and bacteria.

47 icles (EVs), which include apoptotic bodies, microvesicles, and exosomes, have emerged as important p

48 rbed matrix, producing secreted proteins and microvesicles, and expressing membrane-bound factors.

49 tracellular vesicles (EVs) such as exosomes, microvesicles, and large oncosomes are involved in tumor

50 ial effects by release of paracrine factors, microvesicles, and transfer of mitochondria, all of whic

51 ous report, the majority of peripheral blood microvesicles are derived from platelets, while mononucl

52 Thus, complement-coated RBC-derived microvesicles are elevated in HUS patients and induced i

53 report that levels of circulating neutrophil microvesicles are enhanced by exposure to a high fat die

54 Exosomes and microvesicles are extracellular nanovesicles released by

55 Tumor-derived microvesicles are heterogeneous membrane-bound sacs that

56 Microvesicles are membrane-bound vesicles released from

57 We conclude that tau and APP in CSF microvesicles are promising biomarkers which could direc

58 Microvesicles are small membrane-bound particles compris

59 Microvesicles are small membranous particles generated d

60 omain-containing protein 1 (ARRDC1)-mediated microvesicles) are extracellular vesicles that bud direc

61 lular vesicles (EVs), including exosomes and microvesicles, are 30-800 nm vesicles that are released

62 ellular vesicles (EVs), namely, exosomes and microvesicles, are important mediators of intercellular

63 Extracellular vesicles, including microvesicles, are increasingly recognized as important

64 lular vesicles (EVs), including exosomes and microvesicles, are present in a variety of bodily fluids

65 Cancers have adapted the exosome and related microvesicles as a pathway by which neoplastic cells com

66 les, suggesting that they may be specific to microvesicles as opposed to exosomes.

67 The functional roles of sCTLA-4 and microvesicle-associated Tm-CTLA-4 warrant further invest

68 ion via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and the micro

69 sed on our observations, we hypothesize that microvesicles bind to and activate target cells.

70 e describe Rho-mediated pathways involved in microvesicle biogenesis through the regulation of myosin

71 Despite growing understanding of microvesicle biogenesis, function and contents, mechanis

72 sferrin-positive endosomes and synaptic-like microvesicles but not in insulin-containing large dense

73 ophil chemotaxis, and the reduction of these microvesicles by C1-inhibitor should be explored as a po

74 rst demonstration that C. neoformans-derived microvesicles can facilitate cryptococcal traversal acro

75 these studies demonstrate the importance of microvesicle cargo sorting in matrix degradation and dis

76 s, the v-SNARE, VAMP3, regulates delivery of microvesicle cargo such as the membrane-type 1 matrix me

77 here, by membrane invagination, intraluminal microvesicles carrying membranal bioactive FasL and TRAI

78 mation and atherogenesis through delivery of microvesicles carrying miR-155 to disease-prone regions.

79 In addition to infectious microvesicles, CD9-positive exosomes released from PV-in

80 Recently, cytochalasin B-induced microvesicles (CIMVs) were shown to be effective drug de

81 s study, we found that C. neoformans-derived microvesicles (CnMVs) can enhance the traversal of the b

82 owed broader size-distribution likely due to microvesicle co-precipitation and had the least dispersi

83 rum, Stx2 induced the release of RBC-derived microvesicles coated with C5b-9, a process that was inhi

84 release of B1 receptor-positive endothelial microvesicles compared with normal plasma, an effect sig

85 pCRP*-microvesicle complexes lead to enhanced recruitment of l

86 hed MSC secreted factor profiles and altered microvesicle composition.

87 mean 72% decrease (P = 0.01) in C4d+/CD144+ microvesicle concentration compared with pretreatment va

88 We studied microvesicle concentration in the plasma of 95 kidney tr

89 by comparing interleukin 6 concentration and microvesicle concentration.

90 Mitochondria and mitochondria embedded in microvesicles constitute a major subset of extracellular

91 Previously, we showed that plasma microvesicles contain microRNAs (miRNAs).

92 response to iron restriction and that these microvesicles contain mycobactin, which can serve as an

93 Microvesicles contain proteins and nucleic acids.

94 ensional architecture of secreted infectious microvesicles containing both virions and a unique morph

95 , extracellular vesicles (EVs), exosomes and microvesicles, containing cargo mediators, such as prote

96 C4d+/AVB+ microvesicles correlated with AMR biopsy severity.

97 These microvesicles deliver transcellular signals across antig

98 It is unknown how exosomes/microvesicles deliver transmembrane proteins such as PMC

99 ivergent secretory organelles (synaptic-like microvesicles, dense-core vesicles, lysosomes, exosomes

100 nd functional studies reveal that IGF-1- and microvesicle-dependent communication between macrophages

101 MT1-MMP delivery to nascent microvesicles depends on the association of VAMP3 with t

102 Recently, we have shown that microvesicles derived from activated T cells (mvT*s) can

103 It has recently been shown that microvesicles derived from activated T cells can stimula

104 orting this hypothesis, by demonstrating how microvesicles derived from cancer-associated fibroblasts

105 Proteomic analysis of microvesicles derived from JAK2V617F erythrocytes identi

106 Myeloperoxidase inhibition in microvesicles derived from JAK2V617F erythrocytes suppre

107 rent Plasmodium strains are known to produce microvesicles derived from the infected red blood cells

108 s from wild-type cells, B1 receptor-positive microvesicles derived from transfected human embryonic k

109 ton, followed by shedding of plasma membrane microvesicles, disassembly and remodeling of the microtu

110 ic cells produce and release CrkI-containing microvesicles (distinct from exosomes and apoptotic bodi

111 igh levels of C3- and C9-bearing RBC-derived microvesicles during the acute phase, which decreased af

112 Endothelial microvesicles (EMVs) are elevated in patients with tradi

113 gger the release of infectious extracellular microvesicles (EMVs) that contain viral material.

114 Exosomes, also known as microvesicles (EMVs), are nano-sized membranous particle

115 Extracellular vesicles, including exosomes/microvesicles (EMVs), have been described as sensitive b

116 s and ICAM-1 induce budding of extracellular microvesicles enriched in functional TCR, defined here a

117 cesses, including formation of extracellular microvesicles, enveloped virus budding, and the abscissi

118 d, we found full-length IL-6R on circulating microvesicles, establishing microvesicle release as a no

119 Exosomes and other extracellular microvesicles (ExMVs) have important functions in interc

120 extracellular RNAs (exRNAs) associated with microvesicles, exosomes (collectively called EVs), and r

121 it with extracellular fractions enriched in microvesicles, exosomes and ribonucleoprotein complexes.

122 RECENT FINDINGS: Microvesicles, exosomes, apoptotic bodies, lipoproteins,

123 mata and the presence of TDP-43 oligomers in microvesicles/exosomes and show that microvesicular TDP-

124 MiR-126 was secreted in microvesicles/exosomes, and inhibition of their release

125 eview how exosomes and related extracellular microvesicles facilitate the progression and metastases

126 Suppression of RhoA signaling blocks microvesicle formation but enhances the formation of inv

127 ne (an antidepressant agent known to inhibit microvesicle formation by interfering with membrane-asso

128 to each organism such as adherence proteins, microvesicle formation, toxin production and the propens

129 allooning was closely followed by a surge in microvesicle formation, which was absent when synchrony

130 were able to identify miR-155 in circulating microvesicles from both individuals with MBL and patient

131 Extracellular microvesicles from GBV-C E2-expressing cells contained E

132 ) and control plasma (n=6) on the release of microvesicles from glomerular endothelial cells.

133 Importantly, microvesicles from patients with HTR metastatic disease

134 ls were significantly reduced in circulating microvesicles from patients with PAH and the lungs of th

135 RBCs and/or RBC-derived microvesicles from patients with STEC-HUS (n = 25) were

136 rotein sorting 4 (VPS4) mediates scission of microvesicles from the T-cell plasma membrane.

137 arrying JAK2V617F and by erythrocyte-derived microvesicles from transgenic mice.

138 Compared with microvesicles from wild-type cells, B1 receptor-positive

139 sites, infected red blood cell (RBC)-derived microvesicles, gametocytes, and uninfected RBCs.

140 - and MAPK-dependent apoptosis and apoptotic microvesicle generation.

141 Microvesicles have a variety of cellular functions from

142 Therefore, CSF microvesicles have been suggested to be promising target

143 (EVs), which include exosomes and ectosomes/microvesicles, have emerged as important intercellular r

144 We determined that CAF-derived microvesicles horizontally transferred miR-221 to tumor

145 Exosomes and microvesicles (i.e., extracellular vesicles: EVs) have b

146 Thus, new and improved strategies for microvesicle identification, isolation, and capture will

147 dly higher levels of circulating endothelial microvesicles, identified by flow cytometry analysis, an

148 Consequently, the results revealed a role of microvesicles in iron acquisition in M. tuberculosis, wh

149 sess the evidence for a role of exosomes and microvesicles in normal cardiovascular physiology, as we

150 fic and readily differentiates exosomes from microvesicles in samples containing 1000-fold excess of

151 d platelet-derived MPs are the most abundant microvesicles in the circulation.

152 Microvesicles in the CSF of 15 patients with Alzheimer's

153 les, an effect abrogated by reduction of the microvesicles in the perfused samples.

154 However, the contribution of microvesicles in this process is poorly understood.

155 we identify multiple components in secreted microvesicles, including mature PV virions; positive-sen

156 Similarly, neutrophil microvesicles increase miR-155 and enhance NF-kappaB at

157 (ICAM1) is released from senescent cells by microvesicles independently of ADAM17.

158 patient samples, we show that tumor-derived microvesicles induce apoptosis of skeletal muscle cells.

159 Furthermore, we find that microvesicles induce the differentiation of macrophages.

160 Microvesicles induced the upregulation of several cluste

161 ong these, IL24 appeared to be a hallmark of microvesicle-induced activation.

162 Production of IL-24 is a unique feature of microvesicle-induced MC activation because its productio

163 The aim of this study was to characterize microvesicle-induced MC expression patterns.

164 osphocholine)-hexane), which blocks the pCRP-microvesicle interactions, abrogates these proinflammato

165 internalization of activated T cell-derived microvesicles into human MCs occurred within 24 hours.

166 portantly we show that TRAILshort is shed in microvesicles into the cellular microenvironment and the

167 lease nanoparticles, including extracellular microvesicles, into the maternal blood during pregnancy.

168 Microvesicles, introduced onto a dedicated microfluidic

169 A subgroup of such microvesicles is called exosomes and is described in blo

170 increase in macrophage content by neutrophil microvesicles is dependent on miR-155.

171 tools indicates that the optimal release of microvesicles is dependent upon the PAF receptor.

172 Finally, we describe functionally similar microvesicles isolated from bodily fluids of ovarian can

173 nse was reproduced in WT mice by circulating microvesicles isolated from patients carrying JAK2V617F

174 ated monocytic cells, as well as circulating microvesicles isolated from volunteers receiving low-dos

175 The ability of small secretory microvesicles known as exosomes to influence neuronal an

176 motaxis, an effect decreased by reduction of microvesicle levels and by blocking the B1 receptor.

177 metastases of cancers and describe how these microvesicles may affect clinical care.

178 Thus, B1 receptor-positive endothelial microvesicles may contribute to chronic inflammation by

179 We investigated whether neutrophil-derived microvesicles may influence arterial pathophysiology.

180 For example, microvesicle-mediated genetic transfer can regulate the

181 Overall, our results illuminate how microvesicle-mediated horizontal transfer of genetic mat

182 The hypothesis that microvesicle-mediated miRNA transfer converts noncancer

183 EVs (that comprise exosomes and microvesicles/microparticles) have a size ranging from 4

184 lular vesicles are classified into exosomes, microvesicles/microparticles, or apoptotic bodies, origi

185 cultures exhibit distinct compositions, with microvesicles most closely reflecting cellular transcrip

186 ound that acid exposure induced a remarkable microvesicle (MV) release from lung epithelium as detect

187 Because microvesicles (MV) are biomarkers of endothelial dysfunc

188 Exosomes and microvesicles (MV) are cell membranous sacs originating

189 Microvesicles (MV) are shredded plasma membrane componen

190 med small RNA sequencing of exosomes (EXOs), microvesicles (MVs) and source cells from 14 cancer cell

191 latelets, and tissue factor-positive (TF(+)) microvesicles (MVs) are all potential factors that alone

192 Microvesicles (MVs) are anuclear fragments of cells rele

193 described cerebrospinal fluid (CSF) myeloid microvesicles (MVs) as a marker of microglia activation

194 The prognostic value of microvesicles (MVs) for midterm graft patency has never

195 Accurate analysis of specific microvesicles (MVs) from biofluids is critical and chall

196 used this system to investigate the role of microvesicles (MVs) in promoting self-renewal properties

197 Our recent evidence indicates that microvesicles (MVs) released by microglia enhance the me

198 L-1b); (2) platelet-derived IL-1b-containing microvesicles (MVs) that increase vascular permeability;

199 ssential for sorting of selected miRNAs into microvesicles (MVs), a main type of EVs generated by out

200 cells derived from the ICM generate and shed microvesicles (MVs), a major class of extracellular vesi

201 We examine the cellular origin of plasma microvesicles (MVs), a type of ectocytosis-derived EV, t

202 describe how a specific class of EVs, called microvesicles (MVs), activates VEGF receptors and tumour

203 ar vesicles (EVs), specifically exosomes and microvesicles (MVs), are presumed to play key roles in c

204 Microvesicles (MVs), but not exosomes (Exos) or apoptoti

205 lular vesicles (EVs), including exosomes and microvesicles (MVs), by cells has emerged as a form of i

206 llular vesicles, including exosomes and shed microvesicles (MVs), can be internalized by recipient ce

207 18) and their respective fraction carried by microvesicles (MVs), CCL20 and TREM1.

208 lular vesicles (EVs), including exosomes and microvesicles (MVs), have emerged as a major form of int

209 s phosphatidylserine is a major component of microvesicles (MVs), this study also examined the conseq

210 n, ATP packages membrane TNF (26 kDa) within microvesicles (MVs).

211 o smoke extract (TSE) induces the release of microvesicles (MVs; or microparticles) with proteolytic

212 change was neither observed in the number of microvesicles nor in the expression of the other antigen

213 e-positive, oligodendrocyte-derived enriched microvesicles (OEMVs), followed by fluorescent nanoparti

214 The levels of tau and APP were reduced in microvesicles of Alzheimer's disease patients.

215 o the distribution of miRNAs among different microvesicles of breast cancer cells, normal cells relea

216 Exosomes are microvesicles of endocytic origin constitutively release

217 Microvesicles of other cellular origins had no effect.

218 result of shedding from the plasma membrane (microvesicles, oncosomes and apoptotic bodies).

219 nal varicosities in which no electron-lucent microvesicles or synaptic membrane thickenings were visi

220 cytokines, chemokines, proteases, exosomes, microvesicles, or therapeutic agents, play important and

221 studies describe a novel mechanism involving microvesicle particles by which a metabolically labile b

222 Of note, burn injury-stimulated microvesicle particles do not carry appreciable protein

223 ytes to disperse bioactive substances is via microvesicle particles, which are subcellular bodies rel

224 explants ex vivo, and mice in vivo generate microvesicle particles.

225 These findings suggest that the microvesicle pathway and P2X7R could represent exploitab

226 ndothelial injury and C4d deposition, plasma microvesicles positive for endothelial (CD144) marker an

227 discovered that Tm-CTLA-4 is associated with microvesicles produced by the activated cells.

228 ings indicate that M. tuberculosis increases microvesicle production in response to iron restriction

229 ng that influenza virions form by subverting microvesicle production.

230 sturbed flow, we demonstrate that neutrophil microvesicles promote inflammatory gene expression by de

231 Extracellular microvesicles provide local signals (eg, autocrine and p

232 Quantification of plasma C4d+ microvesicles provides information about presence of AMR

233 Storage lesion-induced, red cell-derived microvesicles (RBC-MVs) propagate coagulation by support

234 using leukoreduced RBC units to isolate RBC microvesicles (RBC-MVs), they document that RBC-MVs acti

235 R on circulating microvesicles, establishing microvesicle release as a novel mechanism for sIL-6R gen

236 Notably, firm matrices do not support microvesicle release, whereas compliant matrices are not

237 n of growth factors and their receptors, and microvesicle release.

238 ubsequent surge in procoagulant activity and microvesicle release.

239 , MSC-derived exosomes (MSC-Exos), a type of microvesicle released from MSCs, were thought to carry f

240 both mitochondria directly isolated from and microvesicles released by LPS-activated monocytic cells,

241 cells failed to express HIF-1alpha, and the microvesicles released by these cells failed to carry HI

242 cellular vesicles (EVs) such as exosomes and microvesicles released from cells are potential biomarke

243 esicles, this study examined M. tuberculosis microvesicles released under iron limitation, a common c

244 esicles (sEVs), including exosomes and small microvesicles, represent an understudied form of interce

245 d plasma membrane origin called exosomes and microvesicles, respectively.

246 ecent advances in the study of tumor-derived microvesicles reveal new insights into the cellular basi

247 the first evidence that cranial grafting of microvesicles secreted from hNSC affords similar neuropr

248 In contrast, their larger cousins, microvesicles, seem to have generally detrimental effect

249 Tau and APP in microvesicles separated patients with Alzheimer's diseas

250 Exosomes and microvesicles share a number of similar characteristics,

251 endothelial cells through the absorption of microvesicles shed from tumor cells.

252 on and actomyosin contractility required for microvesicle shedding.

253 racellular vesicles (EVs), exosomes and shed microvesicles (sMVs), which differ in size distribution

254 Syncytiotrophoblast extracellular microvesicles (STEVs) are being studied for their diagno

255 Microvesicles such as exosomes secreted from the iPSC-de

256 determined that exosomes, secreted membrane microvesicles, suppressed the hypoxic pulmonary influx o

257 cantly more B1 receptor-positive endothelial microvesicles than control samples, an effect abrogated

258 -independent cellular process that generates microvesicles that are distinct from exosomes and which,

259 Exosomes are secreted microvesicles that are emerging as potent mediators of c

260 Exosomes are small extracellular microvesicles that are secreted by cells when intracellu

261 identify annexin A1 as a specific marker for microvesicles that are shed directly from the plasma mem

262 are located on the surface of extracellular microvesicles that bud at the immunological synapse cent

263 Neutrophils deploy extracellular microvesicles that can arrest the growth of bacteria.

264 n is present in the cell membrane and within microvesicles that can be secreted from the cell and tak

265 f endothelial cell-derived microparticles or microvesicles that contain microRNAs which can promote v

266 plasma membrane and mediates the release of microvesicles that contain TSG101, ARRDC1, and other cel

267 t T cells release NADPH oxidase 2-containing microvesicles that inhibit TCR activation by elevating R

268 Exosomes are cell-secreted microvesicles that play important roles in epithelial ov

269 Oncosomes are tumor-derived microvesicles that transmit signaling complexes between

270 sonized particles initiated the formation of microvesicles that were able to impair bacterial growth.

271 w cytometry analysis, and significantly more microvesicles that were positive for the kinin B1 recept

272 maturation and shedding of membrane-derived microvesicles, the two key structures involved in invasi

273 In addition, microvesicle tissue factor activity and interleukin-8 le

274 association between plasma interleukin-8 and microvesicle tissue factor activity measured on admissio

275 lation measured on ICU day 1, only increased microvesicle tissue factor activity was significantly as

276 Microvesicle tissue factor activity, thrombin-antithromb

277 Tumour-derived microvesicles (TMVs) comprise a class of extracellular v

278 -loaded extracellular vesicles, called tumor microvesicles (TMVs), which are released directly from t

279 a significantly reduced the ability of these microvesicles to induce type I IFN and TNF-dependent gen

280 ontribution of microRNAs (miRs) delivered by microvesicles to MC activation.

281 Microvesicle treatment was found to attenuate neuroinfla

282 from the cell surface, including viruses and microvesicles, typically have a unique membrane protein

283 nstrate that pCRP by binding to cell-derived microvesicles undergoes a structural change without disr

284 otic cells was reduced whereas engulfment of microvesicles was increased.

285 e antibacterial effect of neutrophil-derived microvesicles was independent of production of toxic oxy

286 ubjects with AMR, the density of C4d+/CD144+ microvesicles was on average 11-fold (P = 0.002) higher

287 t the exosome fraction of EVs and not larger microvesicles was responsible for induction of TNF-alpha

288 ties of C4d+ and C4d+/annexin V+ (C4d+/AVB+) microvesicles were also increased in AMR patients compar

289 Neutrophil-derived microvesicles were detected in the serum of healthy dono

290 T cell-derived microvesicles were labeled with PKH67 to allow visualiza

291 olecules contained in the macrophage-derived microvesicles were transported to target cells, includin

292 ene 101 (TSG101) sorts TCRs for inclusion in microvesicles, whereas vacuolar protein sorting 4 (VPS4)

293 Oviductosomes ((OVS), exosomes/microvesicles), which deliver the Ca(2+) efflux pump, pl

294 lular vesicles including structures known as microvesicles, which are known to alter the extracellula

295 s of exosomes, membrane-enclosed subcellular microvesicles, which have immunosuppressive effects on c

296 the discoveries that (a) they fragment into microvesicles, whose resorption facilitates considerable

297 Macrophages also released microvesicles, whose uptake by epithelial cells was enha

298 solated neutrophilic granulocytes to release microvesicles with different biologic properties.

299 onocytic cells release free mitochondria and microvesicles with mitochondrial content as demonstrated

300 combinant NspA expressed in Escherichia coli microvesicles, with each dose being separated by 3 weeks