ライフサイエンスコーパス: microvessel

1 T-shaped bifurcation on the scale of a large microvessel.

2 intermediary step in MV reversion to normal microvessels.

3 vasodilatation in human subcutaneous adipose microvessels.

4 smooth muscle cells to stabilize functional microvessels.

5 GF signalling increases pericyte coverage in microvessels.

6 a velocity of 36 mum/min, 3x faster than in microvessels.

7 also contribute to FIV in human subcutaneous microvessels.

8 perivascular cells to stabilize newly formed microvessels.

9 articles to reversibly occlude blood flow in microvessels.

10 with a VEGF trap reverted MV back to normal microvessels.

11 (LSECs) constitute discontinuous, permeable microvessels.

12 lially to the spatially remote thrombin-free microvessels.

13 rowth of new blood vessels from pre-existing microvessels.

14 ls had impaired rolling on TNF-alpha-treated microvessels.

15 n nutrient delivery through living, perfused microvessels.

16 s embedded in the basement membrane of blood microvessels.

17 ow of deformable red blood cells in stenosed microvessels.

18 platelet aggregate formation within cerebral microvessels.

19 microhemorrhage related to branched dilated microvessels.

20 ocytes with disrupted end-feet juxtaposed to microvessels.

21 flow changes in SMC but not pericyte-covered microvessels.

22 and function of capillary blood vessels and microvessels.

23 vo and lower gelatinase activity in cerebral microvessels.

24 VWF fibers and platelet aggregation in tumor microvessels.

25 tained positively for insulin, glucagon, and microvessels.

26 CD34(+) stem and early progenitor cells with microvessels.

27 s and prevent their accumulation in cerebral microvessels.

28 to the emission of NO by the endothelium of microvessels.

29 aracterized by progressive loss of pulmonary microvessels.

30 proinflammatory, procoagulant state in brain microvessels.

31 nds required for leukocyte rolling in dermal microvessels.

32 bosis, macrophages, smooth muscle cells, and microvessels.

33 cell culture with explicit, endothelialized microvessels.

34 d increase in the permeability of mouse lung microvessels.

35 tes that obstruct/occlude up to 88% of tumor microvessels.

36 ith wild-type (WT) inflamed cremaster muscle microvessels.

37 limiting the delivery effect at or near the microvessels.

38 ression of apelin in arteries and myocardial microvessels.

39 nd techniques that enable the fabrication of microvessels.

40 he cell type through which ASIC1A influences microvessels.

41 claudin-1 is highly expressed in leaky brain microvessels.

42 between the host axons and the transplanted microvessels.

43 atics analysis of laser captured hippocampal microvessels.

44 omatin extraction and shearing from cortical microvessels.

45 f Tuj-positive axons in the direction of the microvessels.

46 jority of participants with branched dilated microvessels (11 of 13) (McNemar Test for equal distribu

47 Based on detection of flow in low-flow microvessels, a new sharp contrast image was derived.

48 nor-derived adventitial and peri-adventitial microvessels after atherogenic diet, suggestive of newly

49 e vasculature, we tested whether PMo protect microvessels against diabetes.

50 an acute spinal cord hemisection injury with microvessels aligned with the rostral-caudal direction.

51 P, and subsequent reversion of GMP to normal microvessels, all without extensive vascular killing.

52 contrast to old mdx mice, displaying marked microvessel alterations, and the functional repercussion

53 the loss of occludin from ischemic cerebral microvessels and a massive BBB leakage at 4.5-hour post-

54 he development of pericyte coverage of tumor microvessels and aPL-induced tumor cell expression of ch

55 Testicular microvessels and blood flow are known to contribute to t

56 ricyte coverage and inflammation in cerebral microvessels and brain tissue paralleling hyperglycemia

57 s a critical factor in persistent leaky lung microvessels and edema formation in the disease.

58 sm of self-regulation of thrombosis in blood microvessels and explains experimentally observed distin

59 formed by the endothelial cells of cerebral microvessels and forms the critical interface regulating

60 chRCC is poorly supported by microvessels and has markably lower glucose uptake than

61 larger size, increasing proliferation, more microvessels and less apoptosis.

62 aracellular BBB permeability in all cerebral microvessels and low levels of vesicle-mediated transpor

63 eceptor expression in isolated preglomerular microvessels and microvascular smooth muscle cells.

64 mic the in vivo spatial relationship between microvessels and nonendothelial cells embedded in extrac

65 s of tumor cell interactions with functional microvessels and provide evidence for a mitosis-mediated

66 N (apelin) and JAG1, to regenerate pulmonary microvessels and reverse pulmonary hypertension.

67 e we show a previously unidentified role for microvessels and their lining endothelial cells in engul

68 environment and induces injury to both tumor microvessels and tumor cells using intrinsic SSRBC-deriv

69 islet grafts stained positively for insulin, microvessels, and a collagen scaffold.

70 oliferation, tube formation and sprouting of microvessels, and drives angiogenesis in mice.

71 damage, i.e. persistent hemorrhage, loss of microvessels, and occurrence of siderophages, (2.) fibro

72 e-dimensional co-culture self-assembled into microvessels, and platelet-derived growth factor had che

73 rehabilitate PAH PAECs, regenerate pulmonary microvessels, and reverse disease.

74 gers photodynamic damage of tumour cells and microvessels, and simultaneously initiates release of XL

75 from pericytes, mural cells associated with microvessels, and that these cells are present in adults

76 Myocardial microvessels appear as strandlike structures on high-spa

77 Cerebral microvessels are formed by endothelial cells (ECs), whic

78 However, normal microvessels are hierarchical and vasoreactive with sing

79 Retinal and cerebral microvessels are structurally and functionally homologou

80 identify mouse-human species differences in microvessel-associated gene expression that may have rel

81 Loss of KRIT1 leads to decreased microvessel barrier function and to the development of t

82 In an in vitro model of 3D microvessels, both tumor-derived and matched normal Line

83 Analysis of microvessel branching patterns revealed that stroke led

84 pecimens contained C5b-9 reactive endomysial microvessels but none of these or other vessels reacted

85 med by the endothelial cells lining cerebral microvessels, but how blood-borne signaling molecules in

86 nts of diameter and flow in individual brain microvessels, calcium imaging and optogenetics allow the

87 s, but unlike cerebral microvessels, retinal microvessels can be noninvasively measured in vivo by re

88 or histocompatibility complex class II), and microvessels (CD31) in plaque and control regions.

89 of endothelial cells, a rarefaction of brain microvessels, cerebral hypoperfusion, a disrupted blood-

90 Microvessel Chaste can be used to build simulations of v

91 process, because EndMT mainly occurs in the microvessels close to these cells, and because megakaryo

92 pericyte alpha-SMA phenotype mediates acute microvessel constriction after SAH possibly by hemoglobi

93 of endothelial progenitor cells (EPCs) into microvessels contributes to the vascularization of endom

94 Further, by comparison of human LCM microvessel data with existing human BMEC transcriptomic

95 espite the presence of heterogeneously leaky microvessels, dense extracellular matrix and high inters

96 ckage to anticancer effects, VEGF levels and microvessel densities (MVD) were quantified.

97 usion CT parameters were correlated with the microvessel density (MVD) count at both corresponding si

98 Microvessel density (MVD), as a derived marker for angio

99 onse was associated with significantly lower microvessel density (P < 0.01) and lower uptake of the p

100 nd MCP-1, along with decreased AR, Ki67, and microvessel density and increased Nkx3.1 expression in t

101 vasive measures reflected a 30% reduction in microvessel density and increased vessel maturation in e

102 s had increased FGF18 expression levels with microvessel density and M2 macrophage infiltration, conf

103 roRNA-126 (miR-126) downregulation decreases microvessel density and promotes the transition from a c

104 in neoplastic mast cells resulted in reduced microvessel density and reduced tumor growth in vivo com

105 tly, miR-126 upregulation in the RV improves microvessel density and RV function in experimental PAH.

106 plantation, as well as significantly reduced microvessel density and secreted VEGF levels.

107 Immunohistochemistry confirmed the lower microvessel density and VEGFR2-positive area fraction in

108 tumors presented significantly more CD31(+) microvessel density but exacerbated hypoxia and tissue n

109 eficient tumors presented significantly less microvessel density but tumor vessels that were more fun

110 by half (P = 0.002) and increased intestinal microvessel density by 80% compared with vehicle control

111 gh-cholesterol mice had significantly higher microvessel density compared with tumors from the other

112 from Ptp4a3-null mice revealed reduced tumor microvessel density compared with wild type controls.

113 Increased microvessel density contributes to abnormal BM and splee

114 Tumor cell density and microvessel density correlated significantly and positiv

115 y revealed increased vessel wall albumin and microvessel density in diseased aortas and especially in

116 ntriguingly, glipizide significantly reduces microvessel density in PC tumor tissues, while not inhib

117 ls, the optical density of TGF-beta, and the microvessel density in the 20-Gy group were significantl

118 sed endothelial stress fibers, and decreased microvessel density in the brain.

119 We also assessed microvessel density in the Bristol (UK) samples, by meas

120 ted with CD11b(+)Gr1(+) cell recruitment and microvessel density in the tumor tissue, with evidence f

121 acellular IL1R2 levels with tumor growth and microvessel density in xenograft mouse models.

122 ural integrity of the endothelium and higher microvessel density increase vascular permeability.

123 ed from these tumors had significantly lower microvessel density than tissue from the other groups as

124 expression were significantly decreased; and microvessel density was increased without changes in ult

125 Microvessel density was inhibited by sorafenib treatment

126 At 72h after microsphere infusion, microvessel density was significantly reduced in tumors

127 Intratumoral microvessel density was studied using CD31 immunohistoch

128 uates in vivo expression of SPARC, increases microvessel density, and enhances drug delivery to the t

129 ascularization activity (microvessel radius, microvessel density, and microvessel type indicator [MTI

130 hological abnormalities (fibrosis, increased microvessel density, and osteosclerosis).

131 lonC-betaKO mice showed a marked decrease in microvessel density, and reduced new vessel formation.

132 activated fibroblasts, collagen deposition, microvessel density, and vascular function.

133 Furthermore, the induction of VEGF protein, microvessel density, decrease of infarct volumes and neu

134 es correlated with advanced stage, increased microvessel density, metastasis, and poor overall surviv

135 genic form and was associated with increased microvessel density.

136 on in tumor growth, proliferating cells, and microvessel density.

137 a-inducible factor expression, and decreased microvessel density.

138 ew more slowly in xenografts, with decreased microvessel density.

139 e while concurrently demonstrating decreased microvessel density.

140 ed higher levels of phospho-Akt, -p44/42 and microvessel density.

141 stratify breast cancer patients with a high microvessel density.

142 MMP-9 release, tumor-infiltrating PMNs, and microvessel density.

143 ize and distinguish individual microvessels, microvessel depth, and the surrounding anatomy.

144 (NOD-SCID) mice resulted in the formation of microvessels derived from human fibroblasts perfused wit

145 for the lumenization of new capillaries and microvessels developing in ischemic muscles to allow suf

146 ase in capillary tortuosity, and widening of microvessel diameter.

147 And hemoglobins significantly reduced the microvessel diameters at pericyte sites, due to the effe

148 Increased F-actin was evident in microvessels directly treated with thrombin and in those

149 Microvessels displaying physiological barrier function a

150 r-shear) vessels, this process in high-shear microvessels does not require fibrin generation or extra

151 A unique morphology of dense microvessels emerged without obvious tip cell guidance a

152 servations were made in cultured human brain microvessel endothelial cells, where ADMA in the presenc

153 dentified several manifestations of cerebral microvessel endothelial dysfunction including blood-brai

154 d an efficient uptake in mouse brain-derived microvessel endothelial, bEnd.3, Madin-Darby canine kidn

155 It was better tolerated by brain microvessel endothelial/neuronal cells, and accumulated

156 bal comparison identified previously unknown microvessel-enriched genes.

157 gh the use of a detailed simulation model of microvessel flow in two principal configurations: a diam

158 Furthermore, D-hydrogels promote hECFC microvessel formation and angiogenesis in vivo.

159 m cells contribute to both encapsulation and microvessel formation.

160 Microvessels formed from cryopreserved dhBMECs show expr

161 epresent important support cells surrounding microvessels found in solid organs.

162 solation from mouse brain cortex that yields microvessel fragments with consistent populations of dis

163 Conversely, treatment of microvessels from CAD patients with the telomerase activ

164 and laser-capture microdissected endoneurial microvessels from four cryopreserved normal adult human

165 Retinal microvessels from streptozotocin-induced diabetic mice a

166 d by 5 mM glucose for four days, and retinal microvessels from streptozotocin-induced diabetic rats i

167 sociations between ambient air pollution and microvessel function measured by peripheral arterial ton

168 Interstitial fluid flow aligned microvessels generated from co-cultures of cerebral-deri

169 nted on infarcted rat hearts, the perfusable microvessel grafts integrate with coronary vasculature t

170 We conclude that MRTF-A promotes microvessel growth (via CCN1) and maturation (via CCN2),

171 and lesion MHC class-II expression, CD31(+) microvessel growth, and media smooth muscle cell loss, c

172 Increased permeability of brain microvessels has the most profound effects as it may lea

173 eloped a novel microfluidic human engineered microvessel (hEMV) platform to enable controlled blood f

174 Ultrasound microvessel imaging (UMI), when applied with ultrafast p

175 model containing a physiologically realistic microvessel in coculture with mammary tumor organoids.

176 nctional permeability properties of the same microvessel in vivo.

177 a unique opportunity to generate endothelial microvessels in a more physiological environment.

178 as observed in rectal mucosal and submucosal microvessels in a preclinical model of radiation proctit

179 diated agonist, thrombin, was instilled into microvessels in a restricted region of isolated blood-pe

180 ormed correlated UM of fluorescently labeled microvessels in cleared brains.

181 The molecular characterization of cerebral microvessels in experimental disease models has been hin

182 Cs after OGD as well as in isolated cerebral microvessels in mice after MCAO.

183 rns revealed that stroke led to a pruning of microvessels in peri-infarct cortex, with very few insta

184 thelial enzymatic changes in skeletal muscle microvessels in response to ET and SIT.

185 e islet endocrine cells, juxtaposed to islet microvessels in T1D.

186 ilatation, by comparing the phenotype of new microvessels in the mesentery during induction of vascul

187 Results SR images revealed microvessels in the rabbit LN, with branches clearly res

188 SI within groups revealed significantly more microvessels in the subepicardium with MR (group 1: P =

189 cent restricted regions increased F-actin in microvessels in the thrombin-treated and adjacent region

190 ascular microhemorrhage and branched dilated microvessels in the tissues lining the clinically health

191 ap could be detected in the branched dilated microvessels in tissues lining the GC.

192 played an enhanced ability of recruiting new microvessels in vivo.

193 retinal endothelial injury, primarily in the microvessels, including vascular tortuosity, obliterated

194 tion in the vasculature and transform normal microvessels into an inflammatory phenotype observed in

195 The study of cerebral microvessels is becoming increasingly important in a wid

196 Thrombin colocalization with microvessels is closely associated with remarkably eleva

197 l cells, the membrane potential along intact microvessels is remarkably uniform.

198 he thrombogenic transcriptome changes in the microvessels is rudimentary.

199 tional assessment of gated individual dermal microvessels is therefore of outstanding interest.

200 Here we explore the transcriptome of retinal microvessels isolated from mouse models of retinal disea

201 erein, we describe an optimized protocol for microvessel isolation from mouse brain cortex that yield

202 achment of astrocytic end-feet from cerebral microvessels, leakage of plasma proteins, reduction in e

203 y to cancer cells by decreasing intratumoral microvessel leakiness.

204 a-knockdown ECs are deficient in assembly of microvessel-like structures.

205 Animal studies reveal networks of microvessels linking brain-meninges-bone marrow.

206 tery, we hypothesize that imaging of thyroid microvessels may be more reliable in the longitudinal vi

207 Hence, metabolically perturbed microvessels may contribute to central nervous system (C

208 Hence HTPCs via control of testicular microvessels may contribute to the regulation of spermat

209 ecisely visualize and distinguish individual microvessels, microvessel depth, and the surrounding ana

210 east cancer cells within a tissue-engineered microvessel model of the tumor microenvironment.

211 extensively, it remains an open question why microvessels need to be so narrow.

212 f the vessel wall consisting of vasa vasorum microvessels, nerves, fibroblasts, immune cells, and res

213 f the vessel wall consisting of vasa vasorum microvessels, nerves, fibroblasts, immune cells, and res

214 oma and is thought to result from mechanical microvessel obstruction and an excessive activation of i

215 Here, we employ engineered microvessels of complex geometry to examine the patholog

216 ranscriptional activity was elevated in skin microvessels of diabetic Akita (Ins2 (+/-) ) mice when c

217 to an inflammatory phenotype observed in the microvessels of diabetic rats.

218 te MP biogenesis and their manifestations in microvessels of diabetic rats.

219 vels of CYP4A12 and 20-HETE in preglomerular microvessels of doxycycline-treated transgenic mice appr

220 gulates gene expression in hippocampal brain microvessels of female mice.

221 These results were confirmed in microvessels of HIV transgenic mice chronically administ

222 o induce the spatially extensive response in microvessels of mice lacking endothelial connexin43, sug

223 amma and GLUT-1 by the bacteria in the brain microvessels of newborn mice causes extensive pathophysi

224 Brain microvessels of S1pr1(iECKO) mice showed altered subcell

225 d glucose transporter expression in cerebral microvessels of the BBB, but it also decreased 2-deoxy-g

226 sistance arteries, as well as recruitment of microvessels of the central and peripheral microcirculat

227 alian eye provides a noninvasive view of the microvessels of the retina, a part of the central nervou

228 elevated in the tumor vasculature and dermal microvessels of VEGF-injected skin in R-Ras knockout mic

229 opositivity is detected only in the ischemic microvessels of wild-type mice and in the cerebrovascula

230 , while reducing endothelial NOX2 content in microvessels of young obese men.

231 n be readily detected from three-dimensional microvessels-on-a-chip and display a more dynamic, less

232 Three-dimensional microvessels-on-a-chip models provide a unique opportuni

233 lated diabetic MPs were perfused into normal microvessels or systemically transfused into normal rats

234 MR severity correlated with percentage of microvessels parasitized in the retina, brain, and nonre

235 sulted in a 2-fold increase in the number of microvessels per square millimeter compared to lipid aft

236 We analyzed cerebroretinal microvessels, performed genetic rescue experiments, vasc

237 Using combined single microvessel perfusion and systemic cross-transfusion app

238 cellular fluid due to leakage of the brain's microvessel permeability barrier, and swelling of astroc

239 helial function in KRIT1-deficient cells and microvessel permeability in Krit1(+/-) mice; however, VE

240 glycocalyx regulate glycocalyx structure and microvessel permeability to both water and albumin.

241 othelial glycocalyx structure and associated microvessel permeability.

242 mediator of angiogenesis and its associated microvessel permeability.

243 -dependent vasoconstriction in preglomerular microvessels, predominantly afferent arterioles.

244 types, we performed RNA sequencing on brain microvessel preparations isolated from snap-frozen human

245 olvement of Piezo1 in sensing increased lung microvessel pressure and mediating endothelial barrier d

246 Increased pulmonary microvessel pressure experienced in left heart failure,

247 1 activation in ECs induced by elevated lung microvessel pressure mediates capillary stress failure a

248 onally in ECs (Piezo1 (iDeltaEC) ), and lung microvessel pressure was increased either by raising lef

249 iness and edema induced by raising pulmonary microvessel pressure were abrogated in Piezo1 (iDeltaEC)

250 n producing thin-walled hyperdilated fragile microvessels prone to bleeding.

251 omarker maps of neovascularization activity (microvessel radius, microvessel density, and microvessel

252 SCA was associated with microvessel rarefaction, decrease in capillary tortuosit

253 the major player in regulating acute dermal microvessel remodeling.

254 -luciferase transcriptional activity in skin microvessels, resulting in improved microvascular functi

255 functionally homologous, but unlike cerebral microvessels, retinal microvessels can be noninvasively

256 othelial cells, as well as occluded rat pial microvessels, showed that luminal but not abluminal LPC

257 horylation of ERK and AKT/eNOS, and promoted microvessel sprouting from an angiogenesis animal model.

258 Similarly, SAD suppressed VEGF-induced microvessel sprouting from rat aortic ring and blood ves

259 AVH and dilatation of dermal microvessels stimulated by vascular endothelial growth f

260 h share a basement membrane and comprise the microvessel structure, remain incompletely characterized

261 mCRP co-localised with CD105 in microvessels suggesting angiogenesis.

262 1 is activated in C4d(+) ECs of interstitial microvessels, supporting the relevance of the cell cultu

263 cantly higher burden of immature intraplaque microvessels than carriers of the ancestral allele, irre

264 tic cancer cells and a functional artificial microvessel that was lined with endothelial cells.

265 all vessel disease is a disorder of cerebral microvessels that causes white matter hyperintensities a

266 very of FGF9 to renal tumors in mice yielded microvessels that were covered by pericytes, smooth musc

267 These microvessels then exhibited augmented permeability respo

268 In the current study, we demonstrated that microvessel thrombin deposition is significantly increas

269 dies in endothelial cells derived from brain microvessels to determine the dose-response and time-cou

270 nt study demonstrates that exposure of brain microvessels to hyperglycemic conditions or advanced gly

271 Here, we evaluate the efficacy of aligned microvessels to induce and control directional axon grow

272 an engineered organotypic model of perfused microvessels to show that activation of the transmembran

273 ial enzymatic changes in the skeletal muscle microvessels to the traditional training methods.

274 activation with sunitinib inhibition reduces microvessel turnover and decreases heterogeneity of the

275 microvessel radius, microvessel density, and microvessel type indicator [MTI]) and oxygen metabolism

276 Mutant brain microvessels, unlike mutant arteries, displayed a signif

277 flow kinetics was performed on single gated microvessels using a free hand tool.

278 the BBB in different categories of cerebral microvessels using ApoM deficient mice (Apom(-/-)).

279 Cs, are the major target of IL-17 within the microvessel wall and that IL-17-activated PCs can modula

280 is capable of increasing the permeability of microvessel walls while also initiating enhanced extrava

281 The fraction of perfused mature tumor microvessels was increased in EpsilonC-betaKO mice sugge

282 The dilation response of microvessels was linear with increasing transmural press

283 esolution, 39 mum) represent intramyocardial microvessels was tested.

284 Analyzing poststroke human and mouse blood microvessels we have identified that claudin-1 is highly

285 thelial phenotype ex vivo using subcutaneous microvessels, we demonstrated that loss of EPCR and TM a

286 The diameters selected microvessels were determined by measuring the full width

287 Sharp images of low-flowing microvessels were enabled by introducing inverse varianc

288 he resulting transcriptome datasets from LCM microvessels were enriched in known brain endothelial an

289 in EpsilonC-betaKO mice suggesting immature microvessels were most sensitive to combined sunitinib a

290 Single perfused rat mesenteric microvessels were perfused with fluorescent endothelial

291 ation of an extensive network of flowing neo-microvessels, which after 14 days structurally resembled

292 targets is the pericytes, the mural cells of microvessels, which regulate microvascular permeability,

293 AVMs arose from enlargement of preexisting microvessels with capillary diameter and blood flow and

294 thod to reproducibly isolate intact cerebral microvessels with consistent cellular compositions and w

295 lar remodeling effect, leading to normalized microvessels with infrequent vascular branches and incre

296 pore architectures and dedicated perfusable microvessels with rapidly degrading porous interfaces in

297 cence from Cy5.5-conjugated dextran in brain microvessels) with adaptive optics to compensate for tis

298 rier (BNB), formed by tight junction-forming microvessels within peripheral nerve endoneurium, exists

299 trast among biological tissues and can treat microvessels without causing collateral damage to the su

300 tentially allowing for long-term dilation of microvessels without substantial changes in cytosolic Ca