ライフサイエンスコーパス: microvillar

1 ical domain, which transects the rootlets of microvillar actin bundles.

2 irected translation of apical membrane along microvillar actin bundles.

3 uld have a role in linking CD9 to the oocyte microvillar actin core.

4 However, the microvillar actin filaments are sparse and lack the char

5 ctin filaments, has been shown to bundle the microvillar actin filaments.

6 Photoactivation experiments indicate that microvillar actin is mobilized at the lamellipodium, all

7 Through its F-actin-severing activity, the microvillar actin-binding protein villin drives both api

8 port that triple knockout mice lacking these microvillar actin-bundling proteins suffer from growth d

9 397)FAK and cortical actin without affecting microvillar actin.

10 with focal adhesions, nonmuscle myosin, and microvillar adapter proteins of the ezrin-radixin-moesin

11 E can regenerate, but lacks the non-neuronal microvillar and Bowman's gland support cells.

12 eins that are orthologous to transporters in microvillar and ciliary opsin trafficking.

13 icroscopy to demonstrate the independence of microvillar and membrane receptor patch scanning.

14 al differentiation, including formation of a microvillar apical membrane and lateral desmosome adhesi

15 lar model of WASp(I294T), displayed abnormal microvillar architecture, associated with an increase in

16 de a molecular atlas for the construction of microvillar assemblies and illustrate the critical effec

17 tion of mutations in MYO5B and disruption of microvillar assembly and polarity in enterocytes.

18 tematically show that EBP50 is necessary for microvillar assembly and requires that EBP50 has both a

19 However, the mechanisms controlling microvillar assembly remain poorly understood.

20 r the F-BAR domain protein PACSIN2 in normal microvillar assembly.

21 or PKC phosphorylation are nonfunctional in microvillar assembly.

22 ar adhesion links are mislocalized along the microvillar axis rather than enriched at the distal tips

23 ociate with the curved membrane found at the microvillar base.

24 n PT ion transport thought to be mediated by microvillar bending.

25 proteins in microvilli and is necessary for microvillar biogenesis.

26 lays a fundamental role in chemokine-induced microvillar breakdown in human T lymphocytes.

27 to apical junctions and positioned below the microvillar brush border, which suggests a protective in

28 nucleation, growth of microvilli, joining of microvillar bundles into modules, assembly of modules in

29 like these other immune cells we showed with microvillar cartography (MVC) that key signaling protein

30 It is unknown, however, whether microvillar cells also mediate the deficits observed in

31 xperiments demonstrate that the non-neuronal microvillar cells and Bowman's glands are exclusively de

32 tal basal cells (HBCs), which repopulate all microvillar cells and Bowman's glands during OE regenera

33 itors that are lineage-committed strictly to microvillar cells and Bowman's glands, and highlight the

34 mRNA in mouse OE is exclusively localized in microvillar cells and CFTR immunofluorescence is coassoc

35 ether, these data strengthen the notion that microvillar cells in the OE play a key role in maintaini

36 The importance of CFTR in microvillar cells was further underscored by decreased t

37 eyes of Bilateria are often classified into microvillar cells with rhabdomeric opsin and ciliary cel

38 Microvillar cells, a specialized OE cell-subtype, have b

39 be in the neurons and in some non-neuronal (microvillar) cells of unperturbed rat olfactory epitheli

40 between closely apposed surface microvilli (microvillar channels) in hormone-stimulated steroidogeni

41 control Sf9 cells do not express SR-BI, show microvillar channels, or internalize CEs.

42 hly plastic photoreceptor cell type of mixed microvillar/ciliary organization.

43 estor, with an apical cilium surrounded by a microvillar collar, that structurally resembled modern s

44 collar complex, a flagellum surrounded by a microvillar collar.

45 aling pathway at SC tips gives rise to these microvillar component-enriched "caps" and influences the

46 Thus, the linking of relatively stable microvillar components can be mediated by surprisingly d

47 ve observed that SCs reorganize and polarize microvillar components, such as the ezrin-binding phosph

48 ing a pastiche of occupancies that vary from microvillar contact to contact.

49 In the absence of the glycocalyx or when microvillar contact-size is increased by enhancing CD2 e

50 ated that conventional CARs hyper-stabilized microvillar contacts relative to TCRs.

51 in-1 directs unallocated actin monomers into microvillar core bundles during enterocyte differentiati

52 found ER clusters to be less abundant at the microvillar cortex when compared to wild type oocytes.

53 icators, we determined that, unlike in their microvillar counterparts, photostimulation of ciliary ce

54 Although many microvillar cytoskeletal components have been identified

55 r tyrosine phosphorylation in modulating the microvillar cytoskeleton in vivo by villin in response t

56 may be involved in the rearrangement of the microvillar cytoskeleton.

57 t the bacteria effect a fourfold increase in microvillar density over the first 4 days of the associa

58 st to previous reports suggesting lymphocyte microvillar density to be reduced on lymphocytes from Wi

59 that furrow ingression controls the rate of microvillar depletion.

60 n of SR-BI in this manner suggests that this microvillar domain is a way station for cholesterol traf

61 native SLLP1 co-localized with SAS1B to the microvillar domain of ovulated M2 oocytes.

62 HERF1 and PDZK1, are expressed in the apical microvillar domain of rat small intestine enterocytes.

63 ATPase was due to a combination of a smaller microvillar domain, a taller lateral domain, and more ba

64 Actin staining showed that microvillar domains were smaller and that lateral membra

65 plicity of receptor binding sites normalized microvillar dynamics and synapse resolution, and effecto

66 armacologically inhibited displayed impaired microvillar dynamics, morphological polarization, and ch

67 s targeted to CL4 cell microvilli and caused microvillar elongation, whereas espin with the c.2469del

68 Myo1a-TH1 are both required for steady state microvillar enrichment.

69 ed SR-BI in patches or clusters primarily on microvillar extensions of the plasma membrane.

70 iary vertebrate rods and cones or protostome microvillar eye photoreceptors, that have specialized st

71 AP, ARHGAP18, is localized by binding active microvillar ezrin, and this interaction enhances ARHGAP1

72 turbations, we show that exocytosis promotes microvillar F-actin assembly, while furrow ingression co

73 n assembly, while furrow ingression controls microvillar F-actin disassembly.

74 ns in the assembly and organization of actin microvillar filaments.

75 NHE3-DPPIV complex was predominantly in the microvillar fraction in which NHE3 is active.

76 tro kinase assays on isolated microvilli and microvillar fractions enriched in the putative signal tr

77 Immunoblotting of p185(neu)-containing microvillar fractions revealed the presence in each of s

78 cosediment with megalin in brush border and microvillar fractions.

79 e tyrosine kinase activity with STP-enriched microvillar fractions.

80 vide insight into a mechanism that regulates microvillar growth during epithelial differentiation and

81 ded for BB assembly and sufficient to induce microvillar growth using a mechanism that requires funct

82 trachomatis serovar L2 did not display such microvillar hypertrophy following exposure to L2 EBs, wh

83 Ultrastructural studies revealed a transient microvillar hypertrophy that was dependent upon C. trach

84 e G-proteins G(beta) and G(alphail-3) at the microvillar layer, the presumed site of signal tranducti

85 the vomeronasal sensory neurons but not the microvillar layer.

86 on bundles and an absence of labeling in the microvillar layer.

87 ng electron micrographs, we find that median microvillar length and surface density range from 0.3 to

88 fer insight on how epithelial cells minimize microvillar length variability.

89 amics consistent with actin treadmilling and microvillar lifetimes.

90 ns, are required for RTP localization in the microvillar light-gathering organelle, the rhabdomere.

91 egulated transcripts by blood feeding were a microvillar-like protein (LuloMVP3), a trypsin like prot

92 pregulated transcripts such as four distinct microvillar-like proteins (LuloMVP1, 2, 4 and 5), two pe

93 uded down regulated transcripts such as four microvillar-like proteins (LuloMVP1,2, 4 and 5), a Chymo

94 onal histopathologies, including a POU2F3(+) microvillar-like state.

95 SI), a transmembrane disaccharidase found in microvillar lipid rafts, was missing from the brush bord

96 Microvillar localization of CLIC-5A was retained after T

97 Additionally, the tails promote different microvillar localizations for EBP50 and E3KARP, which lo

98 to Rac1 (but not Rac2, Rho, or Cdc42) blocks microvillar loss induced by the chemokine stromal cell-d

99 d expressing dominant-active Arf6 results in microvillar loss.

100 ays of velocity sedimentation fractions from microvillar lysates in the presence and absence of the e

101 ers, myosin-1a (myo1a) powers the sliding of microvillar membrane along core actin bundles.

102 Finally, we directly track the microvillar membrane and see it move along the cell surf

103 Microfilaments are associated with the microvillar membrane in the 13762 ascites rat mammary ca

104 lding of the microvilli and incorporation of microvillar membrane into the furrow.

105 ire conformational interactions with BinB or microvillar membrane lipids to bind to its intracellular

106 Among these are defects in microvillar membrane morphology, distinct changes in bru

107 Microfilaments associate with the microvillar membrane of 13762 ascites mammary adenocarci

108 ar proteins in vivo indicated that ezrin and microvillar membrane proteins had dynamics consistent wi

109 ressing furrow regulate the utilization of a microvillar membrane reservoir.

110 were examined in patches of light-sensitive microvillar membrane screened for the exclusive presence

111 We found CD9 is localized to the oocyte microvillar membrane using transmission electron microsc

112 n of Myo1a depends on its ability to bind to microvillar membrane, an interaction mediated by a C-ter

113 les retain the right side out orientation of microvillar membrane, contain catalytically active brush

114 uctural basis for rhodopsin alignment in the microvillar membrane.

115 insulin binding site was identified in renal microvillar membranes by chemical cross-linking procedur

116 near retinal chromophores in the cylindrical microvillar membranes for light capture.

117 ered-lipid nanodomains preferentially occupy microvillar membranes, contrasting with localization of

118 ve reduced fusion ability, and found altered microvillar morphology by SEM and TEM.

119 erwise indistinguishable in their apical and microvillar morphology, the microvilli of both cell type

120 endocytic machinery could explain defects in microvillar morphology, we examined the impact of PACSIN

121 s, this molecule plays a role in controlling microvillar morphology.

122 s and photokinetic experiments revealed that microvillar motility is driven by actin assembly at the

123 Thus, microvillar motility represents a previously unrecognize

124 lus, leading to feedback between binding and microvillar motion.

125 The distinctness of TCR patch movement from microvillar movement extends to many other receptors tha

126 To investigate changes in the microvillar myosin population that may limit the Myo1a K

127 Immunofluorescence localized SAS1B to the microvillar oolemma of M2 oocytes.

128 As in larger flies, we found that the microvillar orientation of the distal photoreceptor R7 c

129 ctral sensitivities, but mutually orthogonal microvillar orientations.

130 uring intestinal epithelial differentiation, microvillar packing and organization are driven by cadhe

131 adhesion molecule CDHR2 in the regulation of microvillar packing via the formation of adhesion comple

132 ce of antigen-presenting cells using dynamic microvillar palpation and movements as well as by having

133 rates exceeding approximately 150% of total microvillar phosphoinositides per second.

134 Phototransduction in Drosophila microvillar photoreceptor cells is mediated by a G prote

135 We suggest that microvillar photoreceptors became predominant in most in

136 Because illumination of microvillar photoreceptors cells leads to PIP2 break-dow

137 Phototransduction in microvillar photoreceptors is mediated via G protein-cou

138 Phototransduction in invertebrate microvillar photoreceptors is thought to be mediated by

139 -dependent channels in melanopsin-expressing microvillar photoreceptors of early chordates.

140 , a photopigment related to the rhodopsin of microvillar photoreceptors of invertebrates, evolved in

141 Microvillar photoreceptors of the primitive chordate amp

142 by which Ca2+ regulates light adaptation in microvillar photoreceptors remain poorly understood.

143 In microvillar photoreceptors the pivotal role of phospholi

144 ibited the light response of voltage-clamped microvillar photoreceptors, but were ineffective in cili

145 parations confirmed PKCalpha localization in microvillar photoreceptors, preferentially confined to t

146 s activate a G-protein signalling pathway in microvillar photoreceptors.

147 The microvillar photosensitive membrane is consistent in str

148 s suggest that ERM proteins are required for microvillar positioning of L-selectin and that this is i

149 L-selectin occurred preferentially from the microvillar processes of the plasma membrane rather than

150 support diverse cellular processes including microvillar projections and filopodial extensions.

151 receptor patches within the membrane and on microvillar projections is random prior to antigen detec

152 ace, delays the appearance of the primordial microvillar projections, and subsequently leads to malfo

153 Loss of Palisade or the microvillar protein Cad99C results in abnormal uptake in

154 Selective cadherin, claudin, and microvillar protein expression as the UB matures likely

155 , E-cadherin) and the subapical cytoskeletal/microvillar protein ezrin.

156 We find that EPI64, an apical microvillar protein with a Tre-2/Bub2/Cdc16 (TBC) domain

157 Our analysis of the dynamics of microvillar proteins in vivo indicated that ezrin and mi

158 e barrier function of the gut (peritrophins, microvillar proteins, glutamine synthase), digestive phy

159 of Usher syndrome lacking harmonin exhibits microvillar protocadherin mislocalization and severe def

160 The cytoplasmic domains of microvillar protocadherins interact with the scaffolding

161 of actin-bundling proteins is not to enable microvillar protrusion, as has been assumed, but to conf

162 est that the binding of the PT to the oocyte microvillar region and its removal from the sperm nucleu

163 in the perivitelline space as well as on the microvillar region of the egg plasma membrane.

164 recombinant fertilin alpha-EC) binds to the microvillar region of zona pellucida (ZP)-free eggs, the

165 proteomics and kinase inhibition reveal that microvillar remodeling is regulated by p21-activated kin

166 ment of this pathogen, resulting in distinct microvillar reorganization throughout the cell surface a

167 th prokaryotes and eukaryotes, prevented the microvillar response to and internalization of the P+ Op

168 articipation in ERM dephosphorylation and in microvillar retraction.

169 in (Arr2) translocates from cell body to the microvillar rhabdomere down a diffusion gradient created

170 ent (disc outer segments in vertebrates, and microvillar rhabdomeres in insects), whose primary role

171 ve intestinal tissue sections, we found that microvillar rootlets are decorated with the severing pro

172 lso lost from their normal localization near microvillar rootlets.

173 The microvillar scaffolding protein EBP50 (ERM-binding phosp

174 D/Na(+)-H(+) exchanger regulatory factor), a microvillar scaffolding protein with two PDZ domains fol

175 cytometry provided strong evidence that the microvillar selective localization of signaling proteins

176 ate circadian receptors display no hint of a microvillar specialization and show an extremely low lig

177 ool of subapical vesicles and an increase in microvillar structure, cellular changes consistent with

178 skeletal subdomains and that EPI64 regulates microvillar structure.

179 m (ER), which accumulates in clusters at the microvillar subcortex during oocyte maturation.

180 e ommatidial acceptance angles and increased microvillar surface area for light capture in the rhabdo

181 truct (released with thrombin), bound to the microvillar surface of murine eggs.

182 AG human deafness mutation showed defects in microvillar targeting and elongation.

183 retical framework to explore the motion of a microvillar tip above an antigen-presenting surface when

184 at actin incorporation was restricted to the microvillar tip and that bundles continued to undergo ac

185 te the molecular basis of IMAC enrichment at microvillar tips and hold important implications for und

186 nd mucin-like protocadherin, which target to microvillar tips and interact to form a trans-heterophil

187 te fusibility and the radius of curvature of microvillar tips on CD9 wild-type oocytes was found to b

188 Upon reaching microvillar tips, membrane is "shed" into solution in th

189 leads to the shedding of small vesicles from microvillar tips, suggesting that microvilli may functio

190 by measuring the radius of curvature at the microvillar tips.

191 motes the accumulation of IMAC components at microvillar tips.

192 and myosin-7b, which promote localization to microvillar tips.

193 ced numbers of microvilli and defects in the microvillar ultrastructure, with membranes lifting away

194 omputer simulations to show that the average microvillar velocity varies in a ligand-dependent manner

195 Together, these results suggest that microvillar vesicle shedding represents a novel mechanis