ライフサイエンスコーパス: micturition

1 MRI scan was conducted immediately following micturition.

2 e cells may also play a preparatory role for micturition.

3 that either advanced or delayed the onset of micturition.

4 projecting to spinal cord nuclei controlling micturition.

5 lgesia, blood pressure, mating behavior, and micturition.

6 y subtypes that may serve different roles in micturition.

7 chanisms that control urinary continence and micturition.

8 c nerves) to maintain continence or initiate micturition.

9 in the human spinal cord during one cycle of micturition.

10 ns, has an inhibitory function on volitional micturition.

11 ct to neurons in the spinal cord to regulate micturition.

12 affects bladder function and the control of micturition.

13 ivation became synchronized 20-30 s prior to micturition.

14 whose activity modulates hierarchy-dependent micturition.

15 to maintain continence and achieve efficient micturition.

16 erized by incomplete bladder emptying during micturition.

17 dal ventrolateral PAG is essential to permit micturition.

18 orsal caudal PAG is not essential for reflex micturition.

19 pical for the rat, with phasic firing during micturition.

20 s predicts suppression of withdrawals during micturition.

21 M neurons was recorded during continence and micturition.

22 and management of neurological disorders of micturition.

23 lume defecation (9%), increased frequency of micturition (9%), nocturnal enuresis(7%), and encopresis

24 ce of two spinal reflex pathways involved in micturition: a pathway limited to a reflex arc in the pe

25 etwork complexity to reproduce dysfunctional micturition after SCI, and we increased the density and

26 h muscle and striated muscle reflexes during micturition and colorectal distention (CRD) in urethane-

27 could lead to improved voluntary control of micturition and defecation for patients with neurogenic

28 , the internal layer, which provides primary micturition and defecation regulation, and the transvers

29 females, increased intravesical pressure at micturition and downregulations of a major player in bla

30 isengage from ongoing behaviors unrelated to micturition and initiate specific voiding behaviors so t

31 ecting neurons has an inhibitory function on micturition and is a potential therapeutic target for hu

32 prevents the bacteria from being removed by micturition and it triggers bacterial invasion as well a

33 ational and pre-clinical research studies of micturition and LUT function in non-human primates.

34 eurons and their synaptic afferents to study micturition and other pelvic functions.

35 g swimming, walking, scratching, swallowing, micturition and sexual climax, are episodic: even in the

36 rd, which are associated with the control of micturition and sexual reflexes.

37 During both micturition and sleep, OFF cells discharge and sensory r

38 siological and pathophysiological control of micturition and suggest that urothelial pannexin may be

39 %) were associated with rarer causes such as micturition and swallowing.

40 ng realistic computational models of bladder micturition and understanding changes to bladder functio

41 maintain continence and to achieve efficient micturition and when compromised by disease or injury ca

42 in in this region may contribute to impaired micturition and/or constipation in Parkinson disease and

43 o replicate the effects of SCI on control of micturition, and both neuronal and network modifications

44 rized by severe pain, increased frequency of micturition, and chronic inflammation.

45 of the pudendal nerve can elicit or inhibit micturition, and low frequency stimulation of the compou

46 luding hunger for air, thirst, hunger, pain, micturition, and sleep, is discussed with particular ref

47 transition between continence (guarding) and micturition (augmenting) reflexes.

48 computational model of the neural circuit of micturition based on Hodgkin-Huxley equations that repli

49 plays a physiological role in the control of micturition because intravesical perfusion of apyrase or

50 tions of the lateral hypothalamus can switch micturition behavior between high and low TCM, overridin

51 Here, we examine the contribution to micturition behavior of Bar(Crh/Vglut2) neurons relative

52 Micturition behavior, urethral histochemistry and histol

53 the integration center for context-dependent micturition behavior.

54 adder contraction, and when silenced impairs micturition behavior.

55 frequency-dependent effects on void volume, micturition, bowel peristalsis, and sphincter activity j

56 l by 98% and pressure threshold for inducing micturition by 115%, but did not change bladder contract

57 ropin-releasing hormone (Crh) in the pontine micturition center (PMC) is electrophysiologically disti

58 Previous work has revealed that pontine micturition center (PMC) neurons send projections to the

59 ortical micturition circuit from the pontine micturition center (PMC), locus coeruleus (LC) and media

60 e bladder.SIGNIFICANCE STATEMENT The pontine micturition center (PMC), which is a major regulator of

61 ansmitted to the spinal cord via the pontine micturition center (PMC).

62 The pontine micturition center (PMC; i.e., Barrington's nucleus) con

63 bladder neurons were located in the pontine micturition center and external urethral sphincter neuro

64 le-labeled neurons were found in the pontine micturition center and the locus coeruleus or subcoerule

65 ht to determine whether the putative pontine micturition center in the human dorsal pons contains cor

66 ities of fibers originating from the pontine micturition center in the lumbosacral gray matter in the

67 etion of CRF neurons in the putative pontine micturition center may contribute to the severe bladder

68 n of the descending pathway from the pontine micturition center to the sacral spinal cord in the late

69 Neurons of Barrington's nucleus (the pontine micturition center) have been identified which project t

70 Barrington's nucleus, considered the pontine micturition center, in regulation of colonic function.

71 nd the brainstem, in particular, the pontine micturition center.

72 voiding and thereby function as the "pontine micturition center." Lacking detailed information on thi

73 sconnected by spinal injury from the pontine micturition centre, vanilloid-sensitive fibres assume a

74 These results suggest that the changes in micturition characteristics observed in aged rats may in

75 termine the effects of ageing on the in vivo micturition characteristics of male Wistar rats and to a

76 were made within a putative pontine-cortical micturition circuit from the pontine micturition center

77 iding dysfunction characterized by a loss of micturition contractions with overflow incontinence.

78 ed with Barrington's nucleus neurons such as micturition control and pelvic visceral function.

79 ult male mice, confirming the existence of a micturition control center that integrates pro- and anti

80 d reversibly manipulate switching within the micturition control circuitry, to defer voiding and main

81 nd the complex nature of bladder storage and micturition control.

82 control center that integrates pro- and anti-micturition cues.

83 fy spinal neurons that are active during the micturition cycle, and demonstrate that a behaviorally r

84 ractile activity in the filling phase of the micturition cycle.

85 uscle active during the filling phase of the micturition cycle.

86 both the storage and emptying phases of the micturition cycle.

87 rally associated with distinct phases of the micturition cycle.

88 rk that controls pelvic functions, including micturition, defecation, and penile erection, as well as

89 Histologically, the micturition defect is associated with thinning of the ur

90 ne encephalomyelitis (EAE), a MS model, have micturition dysfunction and altered expression of genes

91 yed similar neurological deficits but lesser micturition dysfunction compared to Panx1(+/+) EAE.

92 face of innate defense mechanisms, including micturition, epithelial exfoliation, and the influx of p

93 onist PPADS suggests that bradykinin-induced micturition facilitation may be due in part to increased

94 versus REL+veh improved residual volumes and micturition fractions toward sham levels.

95 rate bother, and a bladder diary documenting micturition frequency (>or=8 micturitions per 24 hours)

96 nt bladder hyperactivity with an increase in micturition frequency and a decrease in bladder capacity

97 treatment results in a temporary increase in micturition frequency and decrease in void volume 4-8 we

98 P/GRP combined with NBQX promote recovery of micturition function following spinal cord injury, likel

99 l layer, which supplements both erectile and micturition function, the internal layer, which provides

100 a behaviorally relevant stimulus (isometric micturition) generated more widespread and greater inten

101 pinal cord to investigate cystometry-induced micturition in awake female and male rats.

102 neurons were also more strongly activated by micturition in females.

103 y cells within the spinal cord that regulate micturition in male cats.

104 fects female sexual behavior, analgesia, and micturition in mammals.

105 hincter EMG also showed phasic firing during micturition in synchrony with EUS activity but, in addit

106 of the pudendal nerve, a period of isometric micturition (induced by ligating the proximal urethra an

107 olorectal distension, a stimulus that delays micturition, inhibited M-inh cells and excited M-exc cel

108 During this pre-micturition interval, a theta oscillation developed in t

109 essing neurons in the PMC control volitional micturition is of critical importance for human voiding

110 C), which is a major regulator of volitional micturition, is neurochemically heterogeneous, and excit

111 trates that PN stimulation also can elicit a micturition-like response and that the response to PN st

112 e response, PN stimulation can also elicit a micturition-like response, and this response is dependen

113 mid-frequency (33 Hz) stimulation produced a micturition-like response, including excitation of the b

114 changes in brain function distributed across micturition loci (e.g., subregions of the salience, sens

115 en the shift in LC-mPFC network activity and micturition may allow time to disengage from ongoing beh

116 However, micturition may be initiated from this region via projec

117 We refer to these micturition modes as, respectively, high and low territo

118 ypothalamic area as a potential modulator of micturition modes.

119 ween noxious stimulus-evoked withdrawals and micturition, movements that are necessary for survival b

120 arrington's nucleus plays a critical role in micturition, MPO projections to Barrington's nucleus may

121 initiate specific voiding behaviors so that micturition occurs in environmentally and socially appro

122 c cells inhibit bladder afferents, advancing micturition onset when M-inh cells are activated and del

123 In animals undergoing isometric micturition or stimulation of Barrington's nucleus, neur

124 d the effects of acute colonic irritation on micturition parameters were assessed.

125 cal instillation of bradykinin activated the micturition pathway.

126 Changes in galanin expression in micturition pathways after SCI may be mediated by changi

127 or TrkB may be involved in reorganization of micturition pathways after SCI.

128 The day-night switch of the micturition pattern is controlled by circadian clocks lo

129 There was a loss of a diurnal rhythm in micturition patterns and a large increase in voided volu

130 effect of olfaction and social hierarchy on micturition patterns in adult male mice, confirming the

131 DSP-4 lesions neither altered micturition patterns nor water intake in the young adult

132 Significant age-related changes in micturition patterns were observed.

133 12 weeks, the urothelium had regenerated and micturition patterns were similar to littermate controls

134 ine context- and social-experience-dependent micturition patterns.

135 ithout incontinence (-3.33 vs -2.54, P=.03), micturitions per 24 hours (-2.54 vs -1.41, P<.001), and

136 ary documenting micturition frequency (>or=8 micturitions per 24 hours) and urgency (>or=3 episodes p

137 s per 24 hours (-2.54 vs -1.41, P<.001), and micturitions per night (-0.59 vs -0.39, P.02).

138 ited an accelerated recovery, with decreased micturition pressure and fewer episodes of detrusor hype

139 tric parameters in both operated groups, and micturition pressure in NRP/GRP rats recovered to normal

140 threshold pressure or bladder capacity, but micturition pressure was elevated compared to control mi

141 urinary bladder and in the inhibition of the micturition reflex by pudendal nerve stimulation (PNS).

142 a human subject with C5 SCI, stimulating the micturition reflex caused AD with exaggerated catecholam

143 e central nervous mechanisms controlling the micturition reflex have also recently attracted attentio

144 eral, spinal and supraspinal segments of the micturition reflex in diseases such as cystitis, bladder

145 he role for this afferent stimulation on the micturition reflex is gradually gaining importance in th

146 The afferent limb of the micturition reflex is often compromised following bladde

147 a consequence of abnormal expression of the micturition reflex or changes in the properties of the s

148 mechanisms controlling the spinobulbospinal micturition reflex pathway.

149 ory modulation of the descending limb of the micturition reflex pathway.

150 of the neuropeptide galanin were examined in micturition reflex pathways 6 weeks after complete spina

151 te cyclase-activating polypeptide (PACAP) in micturition reflex pathways after chronic cystitis induc

152 actors in Trk-mediated signaling cascades in micturition reflex pathways after SCI but may play a rol

153 GAP-43) were examined in lower urinary tract micturition reflex pathways in a chronic model of cyclop

154 and was not due to activation of supraspinal micturition reflex pathways.

155 al cutaneous nerve (PFCN) could modulate the micturition reflex recorded under isovolumetric conditio

156 t high bladder volumes, excites the bladder (micturition reflex) and relaxes the EUS (augmenting refl

157 er afferents which are known to modulate the micturition reflex.

158 d from PMC neurons is thought to mediate the micturition reflex.

159 of bladder afferent pathways controlling the micturition reflex.

160 The lower urinary tract (LUT) and micturition reflexes are sexually dimorphic across mamma

161 dies demonstrate that p75(NTR) expression in micturition reflexes is present constitutively and modif

162 ional significance of p75(NTR) expression in micturition reflexes remains to be determined.

163 In addition to central control, micturition reflexes that govern urination are all initi

164 ation of tyrosine kinase receptors (Trks) in micturition reflexes with urinary bladder inflammation.

165 f the urinary tract and return of functional micturition reflexes, suggesting that this surgical repa

166 nts and DRG (L1, L2, L6, and S1) involved in micturition reflexes.

167 reshold bladder-stretch sensing and urethral micturition reflexes.

168 Normal micturition requires coordinated activation of smooth mu

169 treatment (NBQX&NRP/GRP) had voided volumes/micturition resembling that of normal animals and showed

170 Urine release (micturition) serves an essential physiological function

171 The release of urine, or micturition, serves a fundamental physiological function

172 re capable of carrying diverse pro- and anti-micturition signals, and whose activity modulates hierar

173 ition, whereas most M-inh cells fired before micturition, suggesting that these cells may also play a

174 ed by a suppression of afferent input to the micturition switching circuitry in the pons, whereas the

175 om scale scores, APR patients reported worse micturition symptoms than the SSS group at 1 year (26.9

176 espectively, high and low territory-covering micturition (TCM) and find that the presence of a urine

177 eurons support withdrawal suppression during micturition, the discharge of VMM neurons was recorded d

178 rethral sphincter (EUS) functionality during micturition, the mid-lumbar spinal cord (specifically L3

179 terine contractions (amplitude and rate) and micturition thresholds (MT) assessed by cystometry.

180 Mice lacking the TRPV1 channel have altered micturition thresholds suggesting that TRPV1 channels ma

181 st frequently reported drug-related AEs were micturition urgency (n = 16; 40%), dysuria (n = 16; 40%)

182 Micturition urgency was the most common grade 3-4 study

183 Evaluation of micturition volume in the mid-age multiparous animals af

184 ased the bladder capacity while reducing the micturition volume thus resulting in a marked increase i

185 increase in the ratio of residual volume to micturition volume.

186 In lightly anesthetized rats, micturition was favored, because noxious stimulation nev

187 inhibited (M-inh) or excited (M-exc) during micturition were observed.

188 ing lower urinary tract functions, including micturition, were studied using immunohistochemistry for

189 e between maximum bladder capacity and after micturition when compared to controls (p = 0.013).

190 Although muscimol failed to change reflex micturition when microinjected into the dorsal caudal PA

191 M-exc cells were typically silent before micturition, whereas most M-inh cells fired before mictu

192 ecause noxious stimulation never interrupted micturition, whereas withdrawals were suppressed during

193 s are often accompanied by active urination (micturition), which is considered a mechanism for spatia

194 ic stimulation and noxious paw heat advanced micturition while exciting M-inh cells and inhibiting M-

195 The activation of reflex micturition, with associated detrusor contractions, resu

196 , VMM cells appear to modulate the timing of micturition, with ON cells promoting the initiation of v