ライフサイエンスコーパス: middle-aged

1 nths) mice is, if anything, stronger than in middle-aged (12-14 months) mice.

2 Middle-aged (12-month old) male C57BL/6 mice.

3 re, randomised controlled trial in young and middle-aged (21-50 years), healthy non-obese (BMI 22.0-2

4 ogress has largely been negated in young and middle-aged (25-49 years) white individuals, and America

5 Among both middle-aged (30-49 years) and older adults (50-75 years)

6 - 3%; Old: 15 +/- 2%; ACh: Young: 63 +/- 2%, Middle Aged: 34 +/- 3%; Old: 23 +/- 3%, P < 0.05).

7 t/obese (Body Mass Index [BMI] >= 28 kg/m2), middle-aged (35-65 years old) men.

8 Higher proportion of younger (34.9%) and middle-aged (36.2%) patients had multiple metastatic sit

9 age-related, reduction (Flow: Y: 65 +/- 3%; Middle Aged: 36 +/- 3%; Old: 15 +/- 2%; ACh: Young: 63 +

10 d over twofold among young (18-39 years) and middle-aged (40-59 years) adults during the study period

11 is observational study was conducted in 5065 middle-aged (44-77 years old) UK Biobank participants wh

12 BMD reduction over a 8-year follow-up of 692 middle-aged (46.7+/-12.3 yrs), low-income BACH/Bone coho

13 Young (18-49 years) and middle-aged (50-64 years) patients were 2 to 8 times mor

14 n SMFAs from Young (27 +/- 2 years, n = 10), Middle Aged (54 +/- 2 years, n = 10) and Old (75 +/- 2 y

15 dolescent (68 days), young adult (143 days), middle-aged (551 days), and old (736 days) C57BL/6 mice

16 Subjects were predominantly middle-aged (64+/-14 years) women (90%).

17 e report exacerbated myelin and axon loss in middle-aged (8-10 months of age) compared with young (6

18 ubregion-dependent tracer distribution in 17 middle aged (9-10 months) and 36 old (22-24 months) mice

19 Middle-aged (9-11 months) transgenic animals (both male

20 restored the vasodilatory response to flow (Middle Aged + Adropin: 59 +/- 3%; Old + Adropin: 47 +/-

21 Old + Adropin: 47 +/- 3%, P < 0.05) and ACh (Middle Aged + Adropin: 59 +/- 3%; Old + Adropin: 49 +/-

22 ly), virtually identical to that reported in middle-aged adult HCM patients (98% and 94%, P=0.23).

23 d obesity in a prospective cohort of Spanish middle-aged adult university graduates.

24 lts (22.22 +/- 2.20 years, 33% males) and 73 middle-aged adults (53.62 +/- 5.18 years, 48% males).

25 A total of 480,940 middle-aged adults (median age of 58 years [range 38-73]

26 escents (n = 21; age = 14 +/- 2.1 years) and middle-aged adults (n = 22; age = 36.6 +/- 5 years) afte

27 The potential benefits of young and middle-aged adults adopting a diet pattern whereby adequ

28 wer risk of developing future diabetes among middle-aged adults after adjusting for body mass index (

29 ity in diabetes risk between black and white middle-aged adults after adjustment for biological, neig

30 ffness in a biracial (black-white) cohort of middle-aged adults aged 32-51 years from the semirural c

31 dent disability could benefit from including middle-aged adults and adding NT-proBNP and IL-6 as inte

32 Similar reductions were found in children to middle-aged adults and in clinically relevant subgroups,

33 a hospitalizations in children and young and middle-aged adults did not vary substantially across low

34 In middle-aged adults free of the disease, we observed that

35 We recruited 569 healthy middle-aged adults from the Fenland Study, an ongoing po

36 This study included 11,715 middle-aged adults in the ARIC (Atherosclerosis Risk In

37 e commute to work could reduce obesity among middle-aged adults in the UK.

38 The proportion of cases in middle-aged adults increased steadily from 41% (55 of 13

39 ood pressure (DBP) <90 mm Hg, in younger and middle-aged adults is increasing in prevalence.

40 ides, organ system diseases) among young and middle-aged adults of all racial groups, with an onset a

41 e ideal aortic valve substitute in young and middle-aged adults remains unknown.

42 Middle-aged adults show few phenotypic signs of aging ye

43 ption and should be considered for young and middle-aged adults undergoing AVR.

44 age of 20%), whereas estimates for young and middle-aged adults varied by country and were potentiall

45 inally, higher baseline amyloid burden among middle-aged adults was related to changes in vocabulary,

46 blastic Leukemia (GRAALL) show that young to middle-aged adults who receive a pediatric-intensive che

47 lthough the 10-year risk is low in young and middle-aged adults who would not be treated according to

48 not been rigorously evaluated for young and middle-aged adults with chronic low back pain.

49 tial overuse of chemotherapy among young and middle-aged adults with colon cancer.

50 We tested 60 healthy middle-aged adults with varying doses of APOE4 - 20 APOE

51 ese previously sedentary, otherwise healthy, middle-aged adults, 2 years of high-intensity exercise t

52 hese previously sedentary, otherwise healthy middle-aged adults, a 2 year programme of high-intensity

53 fficient of Variation in children, young and middle-aged adults, respectively.

54 Among middle-aged adults, we observe a 13-kg gradient in weigh

55 ith a disproportionate increase in young and middle-aged adults.

56 oid dysfunction largely come from studies of middle-aged adults.

57 culties with daily functioning are common in middle-aged adults.

58 on muscle metabolism, mass, and function in middle-aged adults.

59 OPSCC) has been reported predominantly among middle-aged adults.

60 incident CKD in a population-based cohort of middle-aged adults.

61 tive function in a community-based cohort of middle-aged adults.

62 erosclerosis in a population of asymptomatic middle-aged adults.

63 vated BP precedes large-artery stiffening in middle-aged adults.

64 scular disease (CVD) with ISH in younger and middle-aged adults.

65 ight in a cohort of initially normal-weight, middle-aged adults.

66 s regarding the efficacy of GATT in young to middle-aged adults.

67 60 years while increasing at a lower rate in middle-aged adults.

68 h a low-dairy diet (LDD) on BP in overweight middle-aged adults.

69 nd electric remodeling in sedentary, healthy middle-aged adults.

70 ar lean mass (ALM) in a population of 85,750 middle-aged (aged 38-49 years) individuals from the UK B

71 d protein expression in the brains of young, middle aged, aged, and elderly male and female C57BL/6J

72 Obesity in the middle aged and elderly is associated with a reduction i

73 mposition and faecal metabolomic profiles in middle aged and elderly women.

74 Adropin incubation in the Middle Aged and Old SMFAs restored the vasodilatory resp

75 pression with adropin incubation only in the Middle Aged and Old SMFAs; (ii) eNOS blockade ablating b

76 mptomatic H1N1pdm infection, primarily among middle aged and older adult women (5-unit BMI increase O

77 or End-Stage Liver Disease score compared to middle aged and older adults (>=60 years).

78 For middle aged and older adults with obesity there was also

79 ween 1964 and 1973 when the individuals were middle-aged and 1996 and 2015 when participants were in

80 Twenty-six individuals (10 young, 9 middle-aged and 7 older individuals) participated in thi

81 rum bilirubin levels and incident T2D in the middle-aged and elderly adults; instead, direct bilirubi

82 iated with increased risk of incident CHD in middle-aged and elderly Chinese populations.

83 We analysed cross-sectional data from 10,837 middle-aged and elderly Chinese rural adults who complet

84 ip between smoking behaviours and BMI in the middle-aged and elderly Chinese rural population.

85 alth in a population-based cohort of healthy middle-aged and elderly men.

86 c evaluation occur in over 3% of the general middle-aged and elderly population, but are mostly witho

87 f years lived with and without diabetes in a middle-aged and elderly population.

88 ole of these factors in a community-dwelling middle-aged and elderly population.

89 Free thyroxine levels in middle-aged and elderly subjects were positively associa

90 resonance (MR) images in community-dwelling middle-aged and elderly subjects without dementia and wi

91 portance in the prevention of weight gain in middle-aged and elderly women who are initially normal w

92 In this study of middle-aged and elderly women, neither baseline nor time

93 ctric measure of sleep wake cycles in young, middle-aged and old CBA mice, a strain capable of melato

94 ) on lifespan and neurological parameters in middle-aged and old mice.

95 d younger adults (>=17 years), two recruited middle-aged and older adults (>=45 years), and two recru

96 In total, 231 middle-aged and older adults (167 women [72.3%] and 64 m

97 All participants were middle-aged and older adults (aged >/=55 years) who rece

98 Middle-aged and older adults (n = 116; 35 with a history

99 Among middle-aged and older adults in the United States, highe

100 n animals and a short-term clinical trial in middle-aged and older adults support the potential memor

101 OSA) is linked to increased glaucoma risk in middle-aged and older adults.

102 A reductase inhibitor (statin) therapy than middle-aged and older adults.

103 years compared with a dichotomous measure in middle-aged and older adults.

104 rden and cognitive decline was present among middle-aged and older adults.

105 verity of SDB in a community-based cohort of middle-aged and older adults.

106 e development of coronary atherosclerosis in middle-aged and older adults.

107 risk has primarily been shown in studies of middle-aged and older adults.

108 values for RV measurements among principally middle-aged and older adults.

109 ebo-controlled trial of pomegranate juice in middle-aged and older adults.

110 f pomegranate juice on memory in nondemented middle-aged and older adults.

111 ralizable to broader populations, especially middle-aged and older adults.

112 coronary atherosclerosis in athletes who are middle-aged and older and aims to contribute to the unde

113 poral trends in serum PFAS levels among 1257 middle-aged and older California women (ages 40-94) duri

114 IADL disability occurs frequently among middle-aged and older HIV-infected adults on effective a

115 These structural changes in a group of middle-aged and older individuals may represent adaptive

116 However, we observed that middle-aged and older individuals who are carriers of th

117 Conclusions and Relevance: In middle-aged and older individuals with type 2 diabetes,

118 re associated with gray matter changes among middle-aged and older individuals.

119 e arterial stiffness in previously sedentary middle-aged and older men and postmenopausal women.

120 duce the risk of CVD by one-third in healthy middle-aged and older men and women.

121 vascular disease (CVD) prevention in healthy middle-aged and older men and women.

122 major stroke risk factor, blood pressure, in middle-aged and older men from eastern Finland and wheth

123 r disease (AD), and cognitive performance in middle-aged and older men from Eastern Finland.

124 ia thickness and the risk of incident CAD in middle-aged and older men from eastern Finland.

125 egg consumption and risk of incident T2D in middle-aged and older men from eastern Finland.

126 t dementia and with cognitive performance in middle-aged and older men in the prospective, population

127 riathlon are not rare; most have occurred in middle-aged and older men.

128 d for the management of glycaemic control in middle-aged and older people with type 2 diabetes with e

129 f ischemic stroke beyond manifest AF in this middle-aged and older population.

130 s to the variation in the number of teeth in middle-aged and older populations using a population-bas

131 al study tested these hypotheses directly in middle-aged and older suicide attempters representative

132 Blacks have lower NP levels than middle-aged and older white adults.

133 ations of these findings could be limited to middle-aged and older white European populations, our re

134 Recruited were 328 middle-aged and older women from a community health cent

135 associated with increased hospital costs for middle-aged and older women in England across a broad ra

136 ifestyle modification is often difficult for middle-aged and older women living in the community who

137 itive benefit in reducing metabolic risks in middle-aged and older women.

138 ffecting risk of disease and mortality among middle-aged and older women.

139 artery calcification, among athletes who are middle-aged and older.

140 d importantly affects tooth loss in both the middle-aged and the older populations.

141 "younger"), 35% were 55 to 65 years of age ("middle-aged"), and 24% were 66 to 75 years of age ("olde

142 erbils of either sex, divided between young, middle-aged, and old gerbils.

143 m four tissues and one cell type from young, middle-aged, and old mice-yielding 143 high-quality data

144 Younger, middle-aged, and older listeners (10 per group) with goo

145 e was 1.4% for 18- to 49-year-olds, 1.0% for middle-aged, and only 0.4% for >= 60-year-old recipients

146 ge was 1.4% for 18 to 49 year olds, 1.0% for middle-aged, and only 0.4% for >=60-year-old recipients

147 r gp91phox revealed that the upregulation in middle-aged animals occurred primarily in microglia and

148 cal relevance of coronary atherosclerosis in middle-aged athletes and describe strategies for the cli

149 cial disparity in diabetes incidence between middle-aged black and white individuals.

150 FECD affects approximately 5% of middle-aged Caucasians in the United States and accounts

151 Herewith we report an unusual case of a middle-aged clinically and biochemically euthyroid woman

152 med multiplex cytokine analysis in a healthy middle-aged cohort with family history of AD (n = 68) an

153 ndialdehyde immunoreactivity in lesions from middle-aged compared with young mice.

154 sponders (N = 97) of overweight non-diabetic middle-aged Danes to two earlier reported dietary trials

155 PLMS are highly prevalent in our middle-aged European population.

156 Case Report: A middle-aged female patient presenting with a history of

157 We hereby report a case of a middle-aged female who was subsequently diagnosed with l

158 s identified by TPI, between three groups of middle-aged females matched for age: patients with depre

159 eater weight gain and glucose intolerance in middle-aged females than males.

160 t and a wider array of cognitive deficits in middle-aged females than males.

161 a correlated with spatial memory deficits in middle-aged females, but not males.

162 Here, the authors report that middle-aged flies have more elongated, or 'hyper-fused'

163 ors in a well-characterized cohort of 20,625 middle-aged French workers who were followed from the 19

164 e 80+ year olds (n = 21) than in the healthy middle-aged group (n = 18).

165 ng moderate calorie restriction in young and middle-aged healthy individuals, and they offer promise

166 ously acquired resting-state fMRI data in 22 middle-aged healthy subjects.

167 Regular GFJ consumption by middle-aged, healthy postmenopausal women is beneficial

168 e model mimicking the liver Cd deposition in middle-aged human population to determine whether the en

169 nonalcoholic fatty liver disease (NAFLD) in middle-aged human population, but biological evidence is

170 ears or younger than 12 years as compared to middle-aged human subjects.

171 t appears for the first time in the adult or middle-aged individual or even later in life.

172 sms of this impaired exercise response in 20 middle-aged individuals at high risk of developing type

173 Many CVRF-free middle-aged individuals have atherosclerosis.

174 l evidence that chronic smoking in young and middle-aged individuals is associated with significant a

175 Arterial inflammation is highly prevalent in middle-aged individuals with known subclinical atheroscl

176 Middle-aged individuals with physician-diagnosed COPD an

177 levels of 10 mU/L or higher or for young and middle-aged individuals with subclinical hypothyroidism

178 subjects that is distinct from that in young/middle-aged individuals, but also a novel set of taxa co

179 In these middle-aged individuals, HIV infection was independently

180 in around 1% of normal colorectal crypts in middle-aged individuals, indicating that adenomas and ca

181 ns boost non-neutralizing H3N2 antibodies in middle-aged individuals, potentially leaving many of the

182 pnic hypoxia were measured in a cohort of 82 middle-aged individuals.

183 lthy, lean, or slightly overweight young and middle-aged individuals.

184 offsets age-related dendritic retraction in middle-aged (MA) rats.

185 atherosclerosis was highly prevalent in this middle-aged male cohort.

186 sion in the CA1 region of the hippocampus of middle-aged male mice using a viral vector rejuvenates h

187 entially affect the host immune phenotype in middle-aged males and females.

188 ge, condition, and resource holding power as middle-aged males that are in prime physical condition o

189 A middle-aged man with non-Hodgkin lymphoma received chemo

190 study included 150 cognitively normal, late middle-aged (mean [SD] age, 60.7 [5.8] years) adults fro

191 Participants (N=40) were mostly middle-aged (mean age=53 years [SD=9.8]), predominantly

192 dy group, the disease predominantly affected middle aged men.

193 robability of death from vascular disease in middle-aged men (35-69 years) has decreased from 22% in

194 d subclinical atherosclerosis in a cohort of middle-aged men (40 to 59 years of age), underwent carot

195 tients in both study arms were predominantly middle-aged men (mean age 59 years, male 68.9%) with vir

196 to graded, steady-state eucapnic hypoxia in middle-aged men and women (n = 82) with continuous posit

197 ial proportion (41.5%) of apparently healthy middle-aged men and women, more frequently by peripheral

198 both systolic and diastolic BP in overweight middle-aged men and women.

199 Middle-aged men engaged in competitive or recreational l

200 countries, including a high concentration of middle-aged men with alcohol use disorders in China and

201 hickness) in an independent sample cohort of middle-aged men with subclinical cardiovascular disease

202 nd, placebo-controlled trials in unmedicated middle-aged men, one in a hyperlipidemic group (HYL grou

203 Among middle-aged men, recreational marathon training is assoc

204 and coronary artery calcium score (CACS) in middle-aged men.

205 ignificantly associated with increased BP in middle-aged men.

206 ic insults, young C57BL/6 mice (age 3-4 mo), middle-aged mice (age 10-12 mo), and aged mice (age 24-2

207 Conversely, loss of FGF21 function in middle-aged mice accelerated thymic aging, increased let

208 drastically improved the survival outcome of middle-aged mice during both polymicrobial sepsis and st

209 ll populations that produce interleukin-6 in middle-aged mice during systemic inflammation.

210 ducing PERK expression in the hippocampus of middle-aged mice enhances hippocampal-dependent learning

211 tion increased with advancing age, such that middle-aged mice showed much more pronounced differences

212 rom microglia cultures and that treatment of middle-aged mice with indapamide was associated with a d

213 Following lysolecithin demyelination in middle-aged mice, indapamide treatment was associated wi

214 ysolecithin demyelination model in young and middle-aged mice, the latter group developed greater acu

215 Using middle-aged mice, we modeled metabolic disease (obesity/

216 to 60% and improve measures of healthspan in middle-aged mice.

217 oss various ages, i.e., juvenile, adult, and middle-aged mouse groups.

218 Case Report: Our case is of a middle-aged multiparous female who presented with amenor

219 asured physical activity (PA) in a cohort of middle-aged nonathlete participants in the PESA (Progres

220 o determine if dietary NR supplementation in middle-aged, obese, insulin-resistant men affects mitoch

221 indicate that young mice sleep less than do middle-aged or aged mice, especially during the night, w

222 raftable thymic epithelial cells (TECs) to a middle-aged or defective thymus leads to thymic growth a

223 ittle is known about the eczema phenotype in middle-aged or elderly adults.

224 ber of testosterone prescriptions issued for middle-aged or older men with either age-related or obes

225 The study included 5,269 Danish middle-aged or older twins who provided data on the numb

226 bility or postprandial glucose metabolism in middle-aged overweight subjects.

227 present in 10% of this predominantly female, middle-aged, overweight, and deprived population.

228 lly among young participants (aged 7-20) and middle aged participants (25-55 years).

229 Towards this end, 175 late middle-aged participants (mean age 55.9 +/- 5.7 years at

230 med a range of analyses in 367,703 unrelated middle-aged participants of European ancestry from UK Bi

231 ce of CKD in metabolically healthy young and middle-aged participants.

232 [7.6%, 6.5-8.7] of 3652 women; p=0.004) and middle-aged participants.

233 ding 850 younger patients (<50 years), 2,540 middle-aged patients (50-69 years) and 1,542 elder patie

234 Of 954 middle-aged patients (57 +/- 10 years, 63% men) with a m

235 ll predominantly affects relatively young to middle-aged patients and is associated with severe hypox

236 Is of hazard ratios included 1 for young and middle-aged patients compared with older patients for al

237 r health (CVH) on health-related outcomes in middle-aged patients is firmly established.

238 the status of perceived stress in young and middle-aged patients presenting with acute myocardial in

239 In middle-aged patients with COVID-19, FIB-4 may have a pro

240 e risk of progression to critical illness in middle-aged patients with COVID-19.

241 dardized 1-year mortality rates declined for middle-aged patients with heart failure but remained con

242 Middle-aged patients with stage I (odds ratio, 5.04; 95%

243 In addition, middle-aged patients with subclinical hypothyroidism may

244 In this study of middle-aged patients with type 2 diabetes and relatively

245 endophthalmitis were higher for children and middle-aged patients, and for patients with endocarditis

246 Among young and middle-aged patients, higher stress at baseline is assoc

247 Working in Uganda, he noted that middle-aged people (40-60 years old) had a much lower in

248 wer in older persons who are healthy than in middle-aged persons who are healthy.

249 In middle-aged persons without OA, linear intrameniscal sig

250 (idiopathic) etiology, affecting mostly the middle aged population.

251 is a debilitating disease, which affects the middle aged population.

252 rdiovascular prognostic value of TMR in a UK middle-aged population and identify any genetic contribu

253 recordings from 55 222 individuals from a UK middle-aged population undergoing an exercise stress tes

254 bclinical atherosclerosis in an asymptomatic middle-aged population, and investigate interactions amo

255 In a cross-sectional study of a middle-aged population, average LTL and short telomere l

256 associated with cardiovascular risk in a UK middle-aged population, supporting the hypothesis that i

257 enhance risk prediction in a general, white middle-aged population.

258 and extent of subclinical atherosclerosis in middle-aged populations.

259 Study participants were middle-aged, predominantly male with similar cardiometab

260 In young to middle-aged (predominately male) nonsmokers (n = 30) and

261 coincident with the locations of two nearby middle-aged pulsars (Geminga and PSR B0656+14).

262 hysical function impairment was common among middle-aged PWH; greater BMI and physical inactivity are

263 ast 25 years (older trained, OT), and (3) 22 middle-aged (range 35-59 years) untrained women (middle-

264 rontal cortex enhanced memory functions in a middle-aged rat model.

265 CMH among middle-aged smokers represents an early developmental ph

266 We included 8451 middle-aged Spanish university graduates who were initia

267 quency with age, affecting 4-14% of cells in middle-aged subjects who had never smoked.

268 ased risk of future dementia in asymptomatic middle-aged subjects, two decades before dementia onset.

269 AIDE) risk score and longitudinal atrophy in middle-aged subjects.

270 Forty-four middle-aged to older adults (68.45 +/- 7.73 years) perfo

271 le-aged (range 35-59 years) untrained women (middle-aged untrained, MU) as a reference control for th

272 It is estimated that 87% of middle-aged US adults and 95% of individuals >=60 years

273 iles to pollen allergens in the young vs the middle-aged Uzbek population were associated with replan

274 f these on intestinal epithelium of multiple middle-aged versus old-aged mice highlighted the consist

275 dietary intake from 32 AN and 21 RA healthy middle-aged volunteers before screening colonoscopy.

276 omarkers of cancer risk in otherwise healthy middle-aged volunteers.

277 ity-based sample, comprised predominantly of middle-aged white individuals of European descent, bette

278 Participants were mostly middle-aged white men who were taking ART (70%).

279 Most patients were middle-aged white men.

280 Majority surgeons' suicides were middle-aged, White males.

281 e the dietary intake and food consumption of middle-aged women and their female and male adult offspr

282 d structural brain characteristics in 12,021 middle-aged women from the UK Biobank, demonstrating tha

283 , on the health and lifestyle of overweight, middle-aged women in primary care.

284 nd vascular cell adhesion molecule-1) in 524 middle-aged women in the Nurses' Health Study II.

285 e of diverse cardiovascular conditions among middle-aged women with and without prior HDP.

286 se cardiovascular conditions in asymptomatic middle-aged women with prior HDP remains unknown.

287 Among postmenopausal middle-aged women, CHIP was independently associated wit

288 In middle-aged women, cirrhosis incidence increases with to

289 ta Rica among adult men and 10% higher among middle-aged women, despite the several times higher inco

290 ass and strength, but their effectiveness in middle-aged women, or whether there are any additional b

291 In this large prospective cohort of French middle-aged women, participants with greater flavonol, a

292 o be a major public health problem affecting middle-aged women, particularly in less-resourced countr

293 In middle-aged women, poor health can cause unhappiness.

294 autoimmune liver disease that mainly affects middle-aged women.

295 functional muscle power (stair climbing) in middle-aged women.

296 the top 10 leading causes of mortality among middle-aged women.

297 es (ACS) afflicting predominantly younger to middle-aged women.

298 ardiovascular disease risk assessments among middle-aged women.

299 depression and incident cardiac events among middle-aged workers from the GAZEL cohort.

300 performance, and blood pressure in healthy, middle-aged working mothers.