ライフサイエンスコーパス: migrating cell

1 and exocytic membrane flow at the front of a migrating cell.

2 correlated with cellular traction forces in migrating cells.

3 n of Rab13 by DENND2B at the leading edge of migrating cells.

4 sive actin-based structures in spreading and migrating cells.

5 chemokine-dependent strategies used to guide migrating cells.

6 tiffness, but does not increase the speed of migrating cells.

7 re important for locomotion in many types of migrating cells.

8 ation and to provide directional guidance to migrating cells.

9 ments that protrude from the leading edge of migrating cells.

10 rear Cdc42-GTP distribution in directionally migrating cells.

11 native ways of extending the leading edge of migrating cells.

12 of ATX, which redistributes to the front of migrating cells.

13 adients that provide directional signals for migrating cells.

14 ng cells with a morphology characteristic of migrating cells.

15 gl1 are required for proper cell polarity of migrating cells.

16 e adhesion protein and filopodia dynamics in migrating cells.

17 activated both in the front and the rear of migrating cells.

18 and myosin II light chain/actin filaments in migrating cells.

19 and phagocytic cups and the leading edge of migrating cells.

20 d basic machinery, neurons differ from other migrating cells.

21 -bearing proteins present in lamellipodia of migrating cells.

22 ansport Ca-calmodulin to the leading edge of migrating cells.

23 ctin cytoskeleton and focal adhesion (FA) in migrating cells.

24 r, a region corresponding to the lamellum of migrating cells.

25 e formation of lamellipodia and filopodia in migrating cells.

26 measured by increased distance and speed of migrating cells.

27 ransitions between blebs and lamellipodia in migrating cells.

28 otide exchange factor at the leading edge of migrating cells.

29 d for relocalization of DMIB to the front of migrating cells.

30 nitial fuzzy pattern into a compact group of migrating cells.

31 ll protrusions and retract trailing edges of migrating cells.

32 polarity, membrane dynamics, and the rate of migrating cells.

33 dients and to permit direct visualization of migrating cells.

34 myosin II colocalize at the leading edge of migrating cells.

35 ed tails and higher directional stability of migrating cells.

36 wn about the role of Lgl in cell polarity in migrating cells.

37 regulate polarization, speed, and turning of migrating cells.

38 cellular protrusions at the leading edge of migrating cells.

39 the extreme leading edge of lamellipodia of migrating cells.

40 o force-bearing sites at the leading edge of migrating cells.

41 s are transported toward cell protrusions in migrating cells.

42 paxillin and focal adhesion kinase (FAK) in migrating cells.

43 heir intended substrates at leading edges of migrating cells.

44 that governs protrusion-retraction cycles in migrating cells.

45 finding, PhdI located to the leading edge in migrating cells.

46 bling or sliding FAs at the trailing edge of migrating cells.

47 ws and dictates the initial direction of the migrating cells.

48 ocal adhesions mediates their disassembly in migrating cells.

49 2/3, and Myosin-I linker) family proteins in migrating cells.

50 nd overlaps with ARF6 at the leading edge of migrating cells.

51 h colocalize with FAK at the lamellipodia of migrating cells.

52 embly and disassembly in the lamellipodia of migrating cells.

53 atrix-degradative activity to the surface of migrating cells.

54 ation of lamellipodia at the leading edge of migrating cells.

55 e and are restricted to the basal surface in migrating cells.

56 bution, caspase 8 is recruited to lamella of migrating cells.

57 s a core component of gamma-TuRC in neuronal migrating cells.

58 d in the formation of head-to-tail arrays of migrating cells.

59 e distinct distribution of these isoforms in migrating cells.

60 show isoform-specific front-back polarity in migrating cells.

61 al for the establishment of cell polarity in migrating cells.

62 eal activation of PKA at the leading edge of migrating cells.

63 to contribute to the protrusive activity of migrating cells.

64 ted its translocation to the leading edge of migrating cells.

65 gression, which may reduce the population of migrating cells.

66 etween the cytoskeleton and the substrate in migrating cells.

67 ve feedback signal necessary for polarity in migrating cells.

68 redistribution of the actin cytoskeleton in migrating cells.

69 filamentous actin bundles along the base of migrating cells.

70 ons and cell-matrix adhesions at the rear of migrating cells.

71 romote Rac activation at the leading edge of migrating cells.

72 TGalpha6 protein levels are increased in the migrating cells.

73 was found in cloche and scl(mo), possibly in migrating cells.

74 ator of F-actin functional specialization in migrating cells.

75 ronment that presents directional choices to migrating cells.

76 edge including filopodia and lamellipodia of migrating cells.

77 nal data and robust statistical analyses for migrating cells.

78 and dynamic cell-shape changes performed by migrating cells.

79 geometry to predict where blebs will form in migrating cells.

80 that extended into the collagen matrix with migrating cells.

81 he direction, efficiency, and persistence of migrating cells.

82 he direction of actin flow on the surface of migrating cells.

83 n complexes maintain front-rear asymmetry in migrating cells.

84 ures for real-time observation of individual migrating cells.

85 ribution of mitochondria to the periphery of migrating cells.

86 Chemoattractant gradients frequently guide migrating cells.

87 phrin signaling acting positively to pattern migrating cells.

88 nts that drive plasma membrane protrusion in migrating cells.

89 events at the leading edge of directionally migrating cells.

90 wn about their roles in the cell polarity of migrating cells.

91 o macroscopic tracks created in scaffolds by migrating cells.

92 er alignment of contractile stress fibers in migrating cells.

93 e typically smaller than the diameter of the migrating cell(4,5).

94 nocytes was composed largely of pre-existing migrating cells (555.6 +/- 38.1/mm(2)) and to a lesser e

95 In migrating cells, a complex containing phosphorylated CD1

96 (EFs) are able to influence the direction of migrating cells, a process commonly referred to as elect

97 In migrating cells actin remodeling is tightly regulated an

98 In migrating cells, actin polymerization promotes protrusio

99 MT1-MMP was directed to the leading edge of migrating cells along micropatterned fibronectin stripes

100 ike protrusions found at the leading edge of migrating cells and are believed to play a role in direc

101 rated at the leading edge of lamellipodia in migrating cells and axonal growth cones.

102 orm protein complexes at the leading edge of migrating cells and balance patterns of Rac1 and Cdc42 s

103 een the nucleus and the leading edge in many migrating cells and contributes to directional migration

104 enriched in adhesions at the leading edge of migrating cells and depletion of beta2-adaptin by RNAi i

105 hasize Wnt/PCP component localization within migrating cells and discuss how component asymmetry may

106 on of actin filaments in the lamellipodia of migrating cells and exerts significant forces on the sur

107 cells reactivate from dormancy more than non-migrating cells and exhibit differential migration-react

108 oning and cell polarization were impaired in migrating cells and in cells plated on micropatterned su

109 Par3 is recruited at the leading edges of migrating cells and in focal adhesion, where it forms a

110 ed in focal adhesions at the leading edge of migrating cells and inhibition or knockdown of Kir4.2 ca

111 p1 protein is present at the leading edge of migrating cells and interacts directly with cytoskeletal

112 ized distribution toward the leading edge in migrating cells and is clearly distinct from the Myo5a o

113 ls within migrating collectives, and between migrating cells and other cells in the environment, play

114 adients are generated at the leading edge of migrating cells and provide additional insight into the

115 contacts the leader TVC, then 'encases' both migrating cells and provides the inputs maintaining lead

116 isplacement of the front row of collectively migrating cells and reduced the number of migration fing

117 n of 'sticky fingers' at the leading edge of migrating cells and show that an MIT complex drives thes

118 ion dynamics within and between collectively migrating cells and suggest a new model for the role of

119 ositioning is an initial polarizing event in migrating cells and that the positions of the nucleus an

120 egarding the localization of PCP proteins in migrating cells and their impact on the cell biology of

121 ctant stimulation and at the leading edge of migrating cells and this localization is dependent on PI

122 cells but could also cause DNA damage in non-migrating cells and tissues that experience mechanical c

123 genous CIP4 localized to the leading edge of migrating cells and to invadopodia in cells invading gel

124 lized compartment-specific PKA activation in migrating cells and used it to reveal that adhesion-medi

125 iosynthetic exocytic pathway is polarized in migrating cells and whether polarized exocytosis promote

126 ZEB expression measurements in collectively migrating cells) and explains the lack of observed mesen

127 results show that motor neurons are actively migrating cells, and are normally trapped in a static po

128 three GTPases are activated at the front of migrating cells, and biochemical evidence suggests that

129 ned spaces imposes high energetic demands on migrating cells, and cells migrate in the direction of l

130 nonmuscle myosin IIA (NMIIA) to the front of migrating cells, and depletion of NMIIA by RNAi disrupts

131 filopodia and regulate adhesion dynamics in migrating cells, and its expression is correlated with p

132 n of PKL and beta-PIX to the leading edge of migrating cells, and knockdown of Vav2 results in a decr

133 ically interact at the centrosomal region of migrating cells, and PKC-mediated phosphorylation on Thr

134 possibility that in other contexts in which migrating cells appear to breach tissue barriers, they a

135 2D, or 3D environments, we hypothesize that migrating cells are also able to sense the dimension of

136 by which microtubules control FA turnover in migrating cells are beginning to emerge.

137 actin filament array at the leading edge of migrating cells are interdependent and coupled, but the

138 in ciliary axonemes, neuronal processes, and migrating cells are marked by alpha-tubulin acetylation

139 a major reason for treatment failure: these migrating cells are not eliminated in surgical resection

140 rom the extracellular fluid by CCR2-positive migrating cells as they cross the BBB, resulting in decr

141 3 and the upregulation of MCT4 expression in migrating cells at the edge of the wound.

142 and migrating cells reacted to pgp 9.5, and migrating cells, but not the cell clusters, reacted to t

143 indicate that Lgl1 regulates the polarity of migrating cells by controlling the assembly state of NMI

144 by two-photon microscopy and by phenotyping migrating cells by flow cytometry.

145 el regulatory mechanism of NMII in polarized migrating cells by identifying a key molecular determina

146 ymmetric distribution of mitochondria within migrating cells by interfering with mitochondrial fusion

147 complex translocates to the leading edge of migrating cells by membrane trafficking that requires th

148 he mechanism regulating the cell polarity of migrating cells by Scrib, Lgl1, and myosin II.

149 We found that the nucleus in an isolated migrating cell can move forward without any trailing-edg

150 reveal that the type of protrusion formed by migrating cells can be dynamically controlled independen

151 In migrating cells, CARMIL2 is important for cell polarity,

152 nal amplitude and frequency generated by the migrating cells changed over time and these parameters w

153 suggest an "attractive path" model in which migrating cells closely follow a dynamic SDF1a source th

154 In contrast to individually migrating cells, collectively migrating cells maintain c

155 The leading edge of migrating cells contains rapidly translocating activated

156 :6HP formed in the photoreceptors, and these migrating cells could help modulate the inflammation.

157 In migrating cells, cytosolic Ca(2+) pool and Ca(2+) pulses

158 Guidance of individually migrating cells depends critically on subcellularly loca

159 osome orientation toward the leading edge of migrating cells depends on dynein and microtubules (MTs)

160 In migrating cells, depletion of clathrin or Dab2 and ARH i

161 f mean-squared displacement (MSD) curves for migrating cells, describes a motion in which, for increa

162 To investigate how migrating cells detect and respond to mechanical forces,

163 ycling compartment has specific functions in migrating cells discrete from early and recycling endoso

164 eveloping cerebellar white matter, where the migrating cells dispersed widely before entering the int

165 These migrating cells do not replace the entire microglial poo

166 ctyostelium, TORC2 functions at the front of migrating cells downstream of the Ras protein RasC, cont

167 been suggested to be spatially regulated in migrating cells due to its ability to control signaling

168 d pseudopod extension at the leading edge of migrating cells during chemotaxis.

169 y are unconstrained therapeutic transplants, migrating cells during tumor metastasis, or cell populat

170 Most studies have focused on migrating cells equipped with an existing polarity befor

171 turbations, which revealed that individually migrating cells exhibit diminished chemosensitivity.

172 Migrating cells exhibit distinct motility modes and can

173 , which extends from the leading edge of the migrating cell, exploring the cell's neighborhood.

174 Migrating cells extend protrusions, probing the surround

175 In migrating cells, external signals polarize the microtubu

176 actin also localized to the leading front of migrating cells, F-actin polymerization was unstable, an

177 In migrating cells, feedback loops can amplify stochastic f

178 MLC was redistributed to the leading edge of migrating cells following 6 hours of strain on collagen

179 1 (NHE1), which is necessary at the front of migrating cells for polarity and directional motility.

180 in cell transport and delivery that captures migrating cells from the circulating flow.

181 osphere labeling with BrdU, we determined if migrating cells had gone through the S-phase of the cell

182 n, which is expressed along the route of the migrating cells, has an inhibitory role in guiding GnRH

183 This analysis revealed that non-radially migrating cells have a complex pattern of extending and

184 In particular, migrating cells have been shown to sense substrate stiff

185 ominantly accumulates at the leading edge of migrating cells; however, the pathways that link the act

186 an extensive catalog of genes that act in a migrating cell, identify unique molecular functions invo

187 nalyze the co-flux of adhesion components in migrating cells imaged using total internal reflection f

188 the varying nanotopology experienced by the migrating cell in vivo.

189 lipodia and filopodia at the leading edge of migrating cells in association with actin.

190 and high-dynamic-range time-lapse imaging of migrating cells in complex three-dimensional microenviro

191 rity pathway coordinates the polarity of non-migrating cells in epithelial sheets and is required for

192 We also track migrating cells in the developing zebrafish embryo, demo

193 ging of autophagosomes and ATP/ADP levels in migrating cells in the rostral migratory stream of mouse

194 ly CCL4, significantly reduced the number of migrating cells in vitro, indicating their role in the i

195 Addition of DAN reduces the speed of migrating cells in vivo and in vitro, respectively.

196 nal information regarding the role of CaD in migrating cells in vivo.

197 , and phosphocofilin at the leading edges of migrating cells, in wound-healing assays.

198 adless Myo10 in regions of proliferating and migrating cells, including the embryonic ventricular zon

199 wth factor-independent and reorient randomly migrating cells inside the sheet when boundary cells beg

200 In migrating cells, integrin-based focal adhesions (FAs) as

201 Front-rear polarity of migrating cells is determined by local activation of a s

202 On rigid surfaces, the cytoskeleton of migrating cells is polarized, but tissue matrix is norma

203 nals from these chemokines are integrated by migrating cells is poorly understood.

204 ly (adhesion turnover) in the protrusions of migrating cells is regulated by unclear mechanisms.

205 at MLC-dependent activation of myosin IIB in migrating cells is required to form an extended rear, wh

206 In migrating cells, it has been shown that the locations of

207 the disassembly of adhesive cell contacts at migrating cells' lagging ends, immunohistochemical analy

208 results in decreased expression of Cxcr4 in migrating cells, leading to a premature burst of granule

209 We also show that migrating cells leave behind ACA-containing vesicles, li

210 GAP and actin motor protein, in collectively migrating cells led to altered organization of the actin

211 re dynamic constructs at the leading edge of migrating cells, linking them to the extracellular matri

212 crotubules; when microtubules are disrupted, migrating cells lose coherence and frequently fragment i

213 o individually migrating cells, collectively migrating cells maintain cell-cell adhesions and coordin

214 Collectively migrating cells maintain group polarity and interpret ex

215 tribution in response to strain in confluent migrating cells may explain the matrix dependence of the

216 The actin machinery in migrating cells may tune the number of filaments at the

217 In live migrating cells, membrane-associated PKA activity was hi

218 We conduct experiments in which migrating cell monolayers push on carbon fibers as a mod

219 ha5beta1-fn adhesions located at the edge of migrating cell monolayers while also increasing alpha5be

220 Migrating cells move across diverse assemblies of extrac

221 erty that many - perhaps most - collectively migrating cells move as cooperating groups of distinct c

222 oncentration, which was high in the front of migrating cells, MPA density was low in the front and hi

223 A migrating cell must establish front-to-back polarity in

224 metazoan development and metastatic cancer, migrating cells must carry out a detailed, complex progr

225 Migrating cells need to coordinate distinct leading and

226 Migrating cells need to coordinate extension and retract

227 In contrast to single cells, collectively migrating cells need to coordinate with their neighbors

228 Migrating cells need to overcome physical constraints fr

229 Migrating cells of Myxococcus xanthus (MX) in the early

230 Migrating cells often exhibit signal relay, a process in

231 al alterations that reduce the dependence of migrating cells on adhesion-contraction force coupling.

232 onditioned medium and reduced the numbers of migrating cells on injured explants.

233 volution of the strain energy exerted by the migrating cells on their substrate is quasi-periodic and

234 ify enhancing factors, measure the effect of migrating cells on underlying extracellular matrix (ECM)

235 r direct observation of H2O2 accumulation in migrating cells or protrusions.

236 with the lipophilic dye DiI shows that late-migrating cells, originating from the trunk neural tube

237 In contrast to randomly migrating cells, PDGF-induced membrane protrusions have

238 PD, Ca(2+) levels increased within neighbour migrating cells, peaking at ~1 min, suggesting localized

239 study was to assess our hypothesis that the migrating cell population included chondrogenic progenit

240 he correlations observed experimentally in a migrating cell population.

241 retrieval of the distinct migrating and non-migrating cell populations for further analysis.

242 Migrating cells possess intracellular gradients of activ

243 zeta complex by Cdc42 at the leading edge of migrating cells promotes both the localized association

244 h caspase 8 is recruited to the lamella of a migrating cell, promoting cell migration independent of

245 At the leading edge of migrating cells, protrusion of the lamellipodium is driv

246 We find that localized PKA activity in migrating cells rapidly decreases upon inhibition of act

247 Cell clusters and migrating cells reacted to pgp 9.5, and migrating cells,

248 tail, but it has been unclear how individual migrating cells respond to Reelin.

249 Profiling of migrating cells revealed a possible SCF/c-Kit paracrine

250 In randomly migrating cells, RhoA activity is concentrated in a shar

251 We propose that migrating cells sense pressure through Piezo, which medi

252 d by an overall increase in the speed of the migrating cell sheet.

253 igration and overall distance covered by the migrating cell sheets.

254 duced cell detachment and dissemination from migrating cell sheets.

255 Our results indicate that migrating cells show patterns of local matrix deformatio

256 Compared with migrating cells, stationary cells generate stronger, les

257 PHARM have been used to analyze and classify migrating cells, such classification did not exploit SPH

258 directional persistence and polarization in migrating cells, suggesting a coordination between PKL/V

259 assume distinct subcellular distribution in migrating cells suggests that discrete spatiotemporal re

260 In migrating cells, syntaxin clusters polarize to the leadi

261 flects formation of clusters of coordinately migrating cells that are generated further away from the

262 increasingly larger clusters of coordinately migrating cells that move faster with enhanced alignment

263 and adaptation of leading-edge machinery in migrating cells, the invasion of one cell into another d

264 In migrating cells, the majority of PhdB was found at the l

265 ion of focal contacts at the leading edge of migrating cells, the mechanisms and signaling pathways r

266 tracking and quantifying FAK and paxillin in migrating cells, the normalized FAK/Paxillin fluorescenc

267 In migrating cells, the relative importance of myosin II co

268 this invasive migration, acting both in the migrating cells themselves and in the non-migratory pola

269 llective cell migration by acting within the migrating cells themselves, not the surrounding environm

270 tegrin transcytosis from the leading edge of migrating cells thereby inhibiting adequate turnover of

271 ocalize p130Cas to nascent adhesive sites in migrating cells thereby leading to the activation of Rac

272 also regulates actin at the leading edges of migrating cells, therefore coordinating cytoskeleton and

273 fic information that precedes the arrival of migrating cells, thus priming the node for a more effect

274 Proliferative pressure drives migrating cells to attach onto the gap front at which a

275 pithelial migration describes the ability of migrating cells to cross epithelial tissues and occurs d

276 erse polarities, from front-back polarity in migrating cells to dendritic spine morphology in neurons

277 agy and energy consumption act in concert in migrating cells to dynamically regulate the pace and per

278 Thus, PGI2 may act as a "brake" on migrating cells to facilitate cell-cell contact and fusi

279 d adherens junction proteins at the front of migrating cells to locally activate Rac1 in response to

280 hosphorylated Rabaptin-5 toward the front of migrating cells to promote delivery of alphavbeta3 to th

281 One month later, OECs formed an apparent migrating cell tract continuously extending from the inj

282 motility of neuronal growth cones and other migrating cell types by acting as repulsive cues within

283 are interdependent and suggest that distinct migrating cell types can coordinately influence each oth

284 Migrating cells typically form filopodia that extend fro

285 tin turnover in lamellipodia and lamellae of migrating cells, using quantitative Fluorescent Speckle

286 We propose that migrating cells utilize dscam to remodel the developing

287 es to cellular polarization in directionally migrating cells via effects on Rho GTPase activity.

288 tional data for large sample sizes of single migrating cells, we investigated 1) whether cancer cells

289 tanding of actomyosin function in individual migrating cells, we know little about the mechanisms by

290 nitor cytoskeletal and signaling dynamics in migrating cells, we show that peripheral F-actin bundles

291 serially imaged by confocal microscopy, and migrating cells were evaluated for chondrogenic progenit

292 Migrating cells were highly clonogenic and multipotent a

293 orylated CaD is found at the leading edge of migrating cells where dynamic actin filament remodeling

294 se and tensin homolog (Pten) accumulation in migrating cells, whereas Pten overexpression slows ENS p

295 olocalizes with actin at the leading edge of migrating cells, wherein active actin polymerization and

296 induced mislocalized activation of Cdc42 in migrating cells, which coincided with a displacement of

297 One example is the leading edge of migrating cells, which contains filament networks genera

298 al change, RhoA activity, and edge motion in migrating cells with micrometer- and second-scale resolu

299 ndito et al.(2006) reveals that tangentially migrating cells within the ventral telencephalon are ess

300 D44 functions to provide directional cues to migrating cells without affecting the motility apparatus