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1 irectly to that of the bulk, non-transcribed minichromosome.
2 protein required for replication of the SV40 minichromosome.
3 a y+ rescue element on a freely segregating minichromosome.
4 centromere present in the Drosophila Dp1187 minichromosome.
5 of DDX5 enhanced transcription from the HBV minichromosome.
6 ion, but not from the additional copy of the minichromosome.
7 ciate with cellular histone proteins to form minichromosomes.
8 endogenous origins and at origins located on minichromosomes.
9 stones associated with the transcribing SV40 minichromosomes.
10 aplotypes of the two polymorphic loci on the minichromosomes.
11 DNA ends to generate functional macronuclear minichromosomes.
12 epresentation of IS elements, similar to the minichromosomes.
13 undant telomeres due to the presence of many minichromosomes.
14 the mitotic stability of centromere-bearing minichromosomes.
15 s, translocations, and formation of acentric minichromosomes.
17 an be suppressed by the presence of a second minichromosome, a phenomenon termed "trans-suppression."
19 omes are tethered to host histones to form a minichromosome also known as an "episome." Histones, whi
20 osomes, but not the cenRNA from the circular minichromosome, an increase in minichromosome loss was s
21 cription of the Tetrahymena thermophila rDNA minichromosome and are required for cell cycle-controlle
23 cleus of the infected hepatocyte as a stable minichromosome and functions as the viral transcriptiona
25 and their histone tail modifications in SV40 minichromosomes and in the SV40 chromatin found in virio
26 se cellular proteins are recruited to cccDNA minichromosomes and induce the posttranslational modific
27 T1, SMCHD1, and PML were recruited to cccDNA minichromosomes and phenocopied the IFN-alpha-induced po
29 in required for the efficient replication of minichromosomes and the transcriptional regulation of ea
30 in the late direction from what was found in minichromosomes, and the level of modified histones was
31 oresis reveal that sisters of 26 kb circular minichromosomes are held together by catenation as well
32 s easily produced in bacteria, and it formed minichromosomes as HBV cccDNA episome DNA does when it w
33 HPV origin-containing plasmids partition as minichromosomes, attributable to an association of the v
34 HBV covalently closed circular DNA (cccDNA) minichromosome, both in cultured cells in which HBV is r
40 ue DSB could be generated in a non-essential minichromosome, Ch(16), using the Saccharomyces cerevisi
43 iotic centromeric cohesion is compromised in minichromosomes depending on their size and cannot be ma
44 two de novo centromeres on Zea mays (maize) minichromosomes derived from euchromatic sites with high
49 egulation of cenRNAs; an increased loss of a minichromosome; elevated aneuploidy; a down-regulation o
52 fragment taken from the VP1 gene in the SV40 minichromosome has been measured in polyacrylamide gels
54 traps sister DNAs of circular but not linear minichromosomes implies that cohesin functions using a t
56 DNA) of hepadnaviruses exists as an episomal minichromosome in the nucleus of an infected hepatocyte
57 ed with multiple human tumors, persists as a minichromosome in the nucleus of B lymphocytes and induc
59 The 17alpha HAC vectors generated artificial minichromosomes in 32-79% of the HT1080 clones screened,
64 histone H3, a correlate of cohesion, in the minichromosomes in which sister chromatids separated dur
67 ation during the encapsidation of late-stage minichromosomes into virions, we mapped the locations of
68 e found in the regulatory region of the SV40 minichromosome is directed to slide during the formation
69 ive to a normal B chromosome, the progenitor minichromosome is estimated to be at least several megab
71 t minichromosomes or on host chromosomes and minichromosomes, is confirmed using chromosome conformat
73 rapamycin complex 1 (TORC1) by the increased minichromosome loss 1/ GTPase-activating proteins toward
75 nase domain and rad53 null mutants display a minichromosome loss phenotype, Rad53 is important in the
78 the circular minichromosome, an increase in minichromosome loss was still observed, suggesting that
79 elta strains exhibited a modest elevation in minichromosome loss, similar to cbh1Delta or abp1Delta s
83 emporally discrete steps: a double hexameric minichromosome maintenance (MCM) complex is first loaded
87 one mutation corresponds to a subunit of the minichromosome maintenance (MCM) complex of proteins, MC
89 The origin recognition complex, Cdc6 and the minichromosome maintenance (MCM) complex play essential
92 port the identification of the heterohexamic minichromosome maintenance (MCM) complex that interacts
93 requires the recruitment of the six-subunit minichromosome maintenance (Mcm) complex to chromatin th
94 he remaining factor that is necessary as the minichromosome maintenance (MCM) complex, a cellular hel
96 hase, inhibition of chromatin loading of the minichromosome maintenance (Mcm) complex, and a reduced
102 rated for recombinant archaeal homohexameric minichromosome maintenance (MCM) complexes and their yea
108 element (DUE)-binding protein DUE-B and the minichromosome maintenance (MCM) helicase activator Cdc4
109 replication stress presented by a defective minichromosome maintenance (MCM) helicase allele in yeas
110 to replication origins coordinately with the minichromosome maintenance (MCM) helicase and the helica
112 st human genome duplication requires loading minichromosome maintenance (MCM) helicase complexes at m
113 aromyces pombe Mcm4,6,7 complex and archaeal minichromosome maintenance (MCM) helicase from Methanoth
114 auses subunit-specific changes of sumoylated minichromosome maintenance (MCM) helicase in addition to
118 y of a replication origin and recruitment of minichromosome maintenance (MCM) helicase to that origin
121 gins requires the loading of two ring-shaped minichromosome maintenance (MCM) helicases around DNA in
122 The solved atomic structure of an archaeal minichromosome maintenance (MCM) homolog provides insigh
124 rrent models indicate that direct binding to minichromosome maintenance (MCM) plays a role, but the d
125 analysis, we identified components from the minichromosome maintenance (MCM) protein and chromatin-r
138 and Glossina, but we identified a complex of minichromosome maintenance (MCM) proteins that functiona
139 ication are licensed in G1 by recruiting the minichromosome maintenance (MCM) proteins to form a prer
140 th the PBD of Plk1, we identified two of the minichromosome maintenance (MCM) proteins, Mcm2 and Mcm7
141 aracterize the interactions between LANA and minichromosome maintenance (MCM) proteins, members of th
143 s have suggested a two-step binding mode for minichromosome maintenance (MCM) proteins, with transien
147 P(4) reciprocally regulate the expression of minichromosome maintenance (MCM)-2, a protein that is an
148 the origin recognition complex (ORC) and the minichromosome maintenance (MCM)2-7 complex, the replica
149 leads to the assembly of double hexamers of minichromosome maintenance (Mcm2-7) at origin sites.
152 ation is the assembly of the heterohexameric minichromosome maintenance (MCM2-7) helicase complex at
154 xample, the archaeal Sulfolobus solfataricus minichromosome maintenance (SsoMCM) helicase has been sh
155 soDnaG) with the replicative S. solfataricus minichromosome maintenance (SsoMCM) helicase on DNA.
156 Dbf4-dependent kinase (DDK) phosphorylates minichromosome maintenance 2 (Mcm2) during S phase in ye
160 ontaining the cell division cycle 45 (Cdc45)/minichromosome maintenance 2-7 (Mcm2-7)/Go, Ichi, Nii, a
161 egulation of RBR3-type genes, as well as the MINICHROMOSOME MAINTENANCE 2-7 gene family and PROLIFERA
162 roliferating cell nuclear antigen (PCNA) and minichromosome maintenance 4 (MCM4) proteins without cha
163 ion of PGC-1beta decreased the expression of minichromosome maintenance 4 (MCM4), which leads to a de
164 oblasts (MEFs), we show here that NCOA4 is a minichromosome maintenance 7 (MCM7)-interacting protein
165 the presence of a pathogenic variant of the minichromosome maintenance 8 gene (MCM8, c.446C>G; p.P14
167 ies a subunit of the replicative CMG (Cdc45, minichromosome maintenance [MCM] subunits 2-7, and the G
168 A1, origin recognition complex 2 (ORC2), and minichromosome maintenance complex (MCM) association wit
170 nsing mechanisms that prevent loading of the minichromosome maintenance complex (MCM2-7) onto replica
171 ion complex (ORC), Cdc6/Cdc18, Cdt1, and the minichromosome maintenance complex (Mcm2-Mcm7, or Mcm2-7
172 association of the key replication proteins minichromosome maintenance complex component (MCM7) and
173 S-phase kinase-associated protein 2 (SKP2), minichromosome maintenance complex component 4 (MCM4), a
175 between a lactase persistence (LP) SNP, the minichromosome maintenance complex component 6 (MCM6)-rs
176 of HPNE and PDAC cells, and correlated with minichromosome maintenance complex components (MCMs) and
178 Dpb11 stimulates DDK phosphorylation of the minichromosome maintenance complex protein Mcm4 alone an
181 eregulated cells, consistent with a role for minichromosome maintenance complex proteins in initiatio
182 Y600 to increase its association with other minichromosome maintenance complex proteins, thereby pro
183 A replication and compromised loading of the minichromosome maintenance complex, resulting in replica
184 report that mutations in the heterohexameric minichromosome maintenance complex-the DNA replicative h
185 , Ki-67, proliferating cell nuclear antigen, minichromosome maintenance deficient 3, and phosphorylat
186 of 734 residues of this protein also called minichromosome maintenance deficient 5 (MCM5) or cell di
187 ed with G1/S cell-cycle transition including minichromosome maintenance deficient proteins, as well a
188 quence analysis of beta-tubulin, calmodulin, minichromosome maintenance factor, DNA-dependent RNA pol
191 hese reports suggest a critical role for the minichromosome maintenance helicase complex in NK cells
194 ulator of DNA replication through effects on minichromosome maintenance helicase loading and activati
198 Here, we show that Tax associates with the minichromosome maintenance MCM2-7 helicase complex and l
207 n identify colorectal cancer by detection of minichromosome maintenance protein 2 (MCM2) expression i
210 lation sites in the carboxyl terminus of the minichromosome maintenance protein 3 (MCM3), a component
215 damage marker gammaH2AX is upregulated under minichromosome maintenance protein 7 (MCM7) knockdown in
216 We then used our mouse model to identify minichromosome maintenance protein 7 (MCM7), an E2F-indu
217 asmid DNA template by DNA polymerases (pol), minichromosome maintenance protein complex (Mcm), topois
219 regulate DNA replication; are members of the minichromosome maintenance protein complex family; or en
220 be essential to recruit and load MCM2-7, the minichromosome maintenance protein complex, around DNA a
221 etylation and RNR levels, maintains helicase minichromosome maintenance protein complexes (Mcm2-7) on
228 ession of E2F-5, centromere protein A and E, minichromosome maintenance proteins (MCM)-2, -3, -5, -6
229 ognition complex, and the elongation factors minichromosome maintenance proteins (MCM)2-7 and prolife
230 ication, involves the loading of six related minichromosome maintenance proteins (Mcm2-7) into prerep
231 Interestingly, the genes coding for the minichromosome maintenance proteins (MCMs), which consti
232 egulated loading of the replicative helicase minichromosome maintenance proteins 2-7 (MCM2-7) onto re
234 ereplication complex that contains a Mcm2-7 (minichromosome maintenance proteins 2-7) double hexamer.
235 bers, whereas Double-parked protein/Cdt1 and minichromosome maintenance proteins are apparently essen
236 monstrate that uncontrolled DNA unwinding by minichromosome maintenance proteins upon Cdt1 overexpres
237 (origin recognition complex [ORC], Cdc6, and minichromosome maintenance proteins) causes a cell cycle
239 clear antigen, ribonucleotide reductase, and minichromosome maintenance) and of the retinoblastoma-re
241 ryotic DNA replicative helicase, the Mcm2-7 (minichromosome maintenance) complex, is loaded at each o
243 INS (go ichi ni san) complex allows the MCM (minichromosome maintenance) helicase to interact with ke
246 fi1, Dnt1 is required for rDNA silencing and minichromosome maintenance, and both Dnt1 and Net1/Cfi1
247 e-3-phosphate dehydrogenase, proteoglycan 4, minichromosome maintenance, complex component 9, high mo
249 atients identified a variant (c.71-1insG) in minichromosome maintenance-deficient 4 (MCM4) that was p
253 he transgenes would reside on an independent minichromosome, not linked to any endogenous genes; thus
256 n approach is feasible for the generation of minichromosomes of normal A chromosomes by selection of
258 we follow the catenation status of circular minichromosomes of three sizes during the Saccharomyeces
260 ranscription units, whether on two different minichromosomes or on host chromosomes and minichromosom
262 g emulsion PCR (LE-PCR) enables formation of minichromosomes preserving phase information of two poly
264 bstitutes for outer repeats on plasmid-based minichromosomes, promoting de novo CENP-A(Cnp1) and kine
265 d whether incorporation of Sir proteins into minichromosomes regulates early steps of recombinational
267 d-type (WT) chromosomes and de novo circular minichromosomes revealed that meiosis-specific HORMA-dom
268 iz- cells shows that SUMO E3 is required for minichromosome segregation and thus has a positive role
269 SIZ1 and SIZ2 genes we demonstrate that the minichromosome segregation defect and dicentric minichro
270 In addition, our analysis of the plasmid minichromosome shows that T(3)-bound TR disrupts the nor
271 ichromosome segregation defect and dicentric minichromosome stabilization, both characteristic for Sm
273 l centromeres in vivo, using a budding yeast minichromosome system and temperature-sensitive mutation
277 Tetrahymena thermophila ribosomal DNA (rDNA) minichromosome that are required for origin activation.
278 nal regulatory region of the simian virus 40 minichromosome that is being transcribed in the cell is
279 the nucleus of the infected hepatocyte as a minichromosome that serves as the transcription template
280 n-Barr virus (EBV) persists as chromatinized minichromosomes that are replicated by the host replicat
282 ell lines and in larval tissues that contain minichromosomes that have structurally defined centromer
283 ts into cells, where they are assembled into minichromosomes that the cellular machinery replicates a
284 ence of the HBV genome, which forms a stable minichromosome, the covalently closed circular DNA (cccD
285 vely with origin sequences in the 21 kb rDNA minichromosome, the interaction between ORC and the non-
291 st to the hypoacetylated state of NG59, NG59 minichromosomes were hypermethylated at specific lysines
294 can be recapitulated on intracellular human minichromosomes where immunoglobulin 12- and 23-signals
295 plicate through dsDNA intermediates and form minichromosomes which carry the same epigenetic marks as
296 the left side of the enhancer in late-stage minichromosomes while also allowing late transcription.
297 ression of early transcription found in late minichromosomes while likely also repressing late transc