ライフサイエンスコーパス: minisatellite

1 CEB1 is a highly polymorphic human minisatellite.

2 dence for putative coding sequences near the minisatellite.

3 observed for pathogenetic alleles of a human minisatellite.

4 ocus and extending into the beginning of the minisatellite.

5 formed by the C-rich strands of the insulin minisatellite.

6 studies on the C-rich strand of this insulin minisatellite.

7 ntaining a hypervariable array of the DXYS14 minisatellite.

8 of the phenotypes associated with the human minisatellite.

9 s, was confirmed by PCR amplification of M13 minisatellite.

10 tation process compared with highly unstable minisatellites.

11 have been missed in all previous studies of minisatellites.

12 ts in intron 4 and 9, with varying copies of minisatellites.

13 ments very similar to those seen at unstable minisatellites.

14 previous data on the genomic environment of minisatellites.

15 ers of repeat blocks, as seen at other human minisatellites.

16 e structural basis of somatic instability at minisatellites.

17 st a common mutation pathway with some other minisatellites.

18 microsatellite (1- to 8-bp repeat units) and minisatellite (20-bp repeat units) DNA sequences.

19 at the variable number tandem repeat (VNTR) minisatellite 5' of the insulin gene (INS) is associated

20 ole and origin of retrotransposon-associated minisatellites, a computational project to map and physi

21 ol studies have implicated rare length H-ras minisatellite alleles in cancer risk.

22 Two yeast minisatellite alleles were cloned and inserted into a ge

23 system to identify mutations that increased minisatellite alterations specifically in quiescent cell

24 1, MEC1, and RAD53, prevent stationary-phase minisatellite alterations within the quiescent cell subp

25 lysed variant repeat distribution within the minisatellite and combined this with flanking haplotypes

26 Minisatellite and microsatellite are short tandemly repe

27 apid accumulation of population samples from minisatellite and microsatellite loci has resurrected th

28 ing, and compound haplotypes composed of the minisatellite and surrounding substitutional polymorphis

29 -gamma gene contains highly polymorphic GACA minisatellites and 44-bp DNA repeats, giving rise to at

30 hosts, including large blocks of micro- and minisatellites and a high density of Alu repeats.

31 ore, these motifs are found in hypervariable minisatellites and are clustered in the breakpoint regio

32 of simple sequence repeat (SSRs) (micro- and minisatellites and cryptic repeats), which tend to accum

33 of an evolutionary link between TBE-related minisatellites and CTE.

34 Finally, minisatellites and tandem repeats provide exquisitely se

35 However, little is known about minisatellites and the mechanisms by which they mutate i

36 e detected at each of the 12 microsatellite, minisatellite, and single nucleotide polymorphism (SNP)

37 The origin of Alu-derived minisatellites appears to have been mediated by short fl

38 Minisatellites are a class of highly polymorphic GC-rich

39 Minisatellites are highly variable tandem repeats used f

40 However, the origins of minisatellites are less obvious.

41 All three minisatellites are located in GC-rich DNA abundant in di

42 Minisatellites are tandemly repeated DNA sequences found

43 ince the mutation rates and processes of the minisatellite array are known from direct studies, ages

44 For compound haplotypes including the minisatellite array, the network found in a range of wor

45 Within minisatellite arrays, aligned homologs were more similar

46 processes are linked to heterochromatic mo-2 minisatellite arrays, and require MEI4 and ANKRD31 prote

47 suggest human-specific turnover processes at minisatellite arrays.

48 iated factors Klf4 and c-Myc, by the DXPas34 minisatellite associated with the Tsix promoter.

49 s and determined the specific combination of minisatellites at each of the polymorphic sites.

50 AT-rich minisatellites (AT islands) are sites of genomic instabi

51 Human minisatellite B6.7 is a highly variable locus showing ex

52 amental difference in turnover mechanisms at minisatellites between mice and human.

53 The mouse genome also contains authentic minisatellites, but none has yet been found to show high

54 se substitutions and deletions introduced to minisatellites by gene conversion with partially similar

55 es indicate that the unstable end of a human minisatellite can act as a recombination warm-spot, even

56 ange of alleles of the highly unstable human minisatellite CEB1.

57 ethods based on microsatellite-haplotype and minisatellite-code diversity.

58 llite of perfect 36-bp repeats or a yeast Y' minisatellite containing diverged 36-bp repeats.

59 enrichments similar to those noted for micro/minisatellite-containing genes.

60 This provides evidence that minisatellite conversion and crossover arise by a common

61 h level of conservation exhibited by the GPI minisatellite, coupled with the unique location, strongl

62 atistical analyses of extant M. tuberculosis minisatellite data are consistent with Quebec as a sourc

63 Thus expanded alleles of the EPM1 minisatellite demonstrate a mutation rate of 47%, the hi

64 We analyze minisatellites derived from Alu fragments corresponding

65 n ALT-expressing cell lines, indicating that minisatellite destabilization is not universal.

66 Five other hypervariable minisatellites did not show elevated instability in ALT-

67 Unstable minisatellites display high frequencies of spontaneous g

68 add new insights into this hypothesis, MS205 minisatellite diversity has been investigated by Minisat

69 ineages have been estimated using associated minisatellite diversity.

70 We used multilocus minisatellite DNA fingerprinting to examine the local ge

71 Minisatellite DNA has been reported to be involved in re

72 Minisatellite DNA is repetitive DNA with a repeat unit l

73 The internal gene deletion occurs near a minisatellite DNA sequence in intron 8 that removes 1.1

74 enient expansion of repetitive telomeric and minisatellite DNA sequences starting from small syntheti

75 ll population samples, which currently makes minisatellite DNA the most powerful tool for monitoring

76 Repetitive minisatellite DNA tracts are stable in mitotic cells but

77 ats (VNTRs), high-risk variants of the HRAS1 minisatellite do not demonstrate positional polarity.

78 n mouse, the boundary region also contains a minisatellite, Ds-TR, and both Dxz4 and Ds-TR appear to

79 that were due to variation in the length of minisatellite expansions of the central introns of the g

80 egion composed of five distinct, interleaved minisatellite families.

81 Germline instability at human minisatellites frequently involves complex inter-allelic

82 Attempts to transfer minisatellite germline instability to the mouse have fai

83 The insulin minisatellite has been studied intensively due to its as

84 equence analysis of 130 alleles of the HRAS1 minisatellite has demonstrated that breast cancer-associ

85 enomes over evolutionary time and that micro/minisatellites have been recruited to participate in bot

86 nd pike) and corresponds to the insertion of minisatellites having a length of 30 nucleotides.

87 Minisatellite homozygosity did not reduce the frequency

88 ere is also evidence for the presence of the minisatellite in chicken.

89 nucleotide polymorphisms (SNPs) flanking the minisatellite in individuals from six populations, and w

90 te, suggesting that the apparent role of the minisatellite in susceptibility to T1DM may be modified

91 rate, and detailed characterization of known minisatellites in a large, downloaded DNA database, and

92 The expanded FRA16B minisatellites in CEM cells preferentially localize to t

93 rk reports a further characterization of the minisatellites in hTERT.

94 naling components play a role in stabilizing minisatellites in stationary-phase yeast cells.

95 hat the myomaker gene from trout includes 14 minisatellites, indicating that it has an unusual struct

96 ene variable number of tandem repeats (VNTR) minisatellite influences susceptibility to type 1 diabet

97 n analysis of hematopoietic lineage-specific minisatellites initiallyshowed mixed chimerism in CD14(+

98 The insulin minisatellite (INS VNTR) has been intensively analyzed d

99 However, the mouse Stat2 gene harbors a minisatellite insertion that has altered the carboxy-ter

100 tion phenotype, "blebbing," characterized by minisatellite instability during stationary phase.

101 ination initiation complex, and implies that minisatellite instability is a by-product of meiotic rec

102 thyroid gland may be associated with somatic minisatellite instability or microsatellite instability,

103 Minisatellite instability was found in three (18%) tumor

104 underlying two genomic disorders as well as minisatellite instability-implicating PRDM9 as a risk fa

105 story of radiation exposure was positive for minisatellite instability.

106 ve, there are transgenerational increases in minisatellite instability.

107 be related to the palindromic nature of the minisatellite interfering with the generation and/or pro

108 l system by inserting the human Ha-ras/HRAS1 minisatellite into the HIS4 promoter and demonstrated th

109 r 40% of the total genetic variance near the minisatellite is due to differences between Africans and

110 ditionally, a molecular fossil of a TBE-like minisatellite is found in the genome of a modern retroel

111 rom the rapid evolution of a highly unstable minisatellite is integrated with data on the longer-term

112 This minisatellite is located upstream of an antisense transc

113 Furthermore, turnover of repeats at human minisatellites is controlled by intense recombinational

114 Variation in the size of minisatellites is thought to involve homologous recombin

115 cating that B6.7 is one of the most unstable minisatellites isolated to date.

116 g of how the G-quadruplex formation in human minisatellite leads to genetic instability but also addr

117 1 repeats also contain insertions of coding, minisatellite-like sequences, an apparent result of repl

118 gly, whereas other mammalian genomes possess minisatellite-like sequences, hypermutable loci have not

119 be rapidly analyzed as surrogate markers for minisatellite lineage.

120 These haplotypes confirmed that minisatellite lineages defined by variant repeat distrib

121 We have studied the minisatellite located in intron 9 of the human glucose p

122 This polymorphic G-rich minisatellite, located in the promoter region of the hum

123 carcinomas for mutations at three different minisatellite loci (D1S80, D17S30, ApoB), and 27 microsa

124 cies of spontaneous and induced mutations at minisatellite loci allow mutation induction to be evalua

125 he mechanisms of mutation induction at human minisatellite loci are discussed.

126 Germ-line mutation induction at mouse minisatellite loci by acute irradiation with x-rays was

127 the approximately 85 kb interval between the minisatellite loci D16S309 (MS205) and D16S83 (EKMDA2) i

128 Many tandemly repeated minisatellite loci display extreme levels of length vari

129 Germline mutation at eight human minisatellite loci has been studied among families from

130 of germline mutations at human hypervariable minisatellite loci was reported in children born from pa

131 lity of simple tandem repeats, such as human minisatellite loci, has been suggested to arise by gene

132 ne of them exhibiting mutations in all three minisatellite loci, whereas two others showed mutations

133 ted regions of the trypanosome genome, i.e., minisatellite loci.

134 artificially transfected gene and a genomic minisatellite locus 23 cell divisions after the initial

135 PCR has shown that instability at the human minisatellite locus MS205 (D16S309) is largely germline

136 CEB25 is a human minisatellite locus, composed of slightly polymorphic 52

137 The highly polymorphic HRAS1 minisatellite locus, located just downstream from the pr

138 The minisatellite markers show high levels of polymorphism,

139 otypes combining binary, microsatellite, and minisatellite markers were generated for 390 Y chromosom

140 soga, Uganda) using three recently described minisatellite markers.

141 Therefore, while the HRAS1 minisatellite may serve as a reporter for a broad-based

142 g restriction fragment length polymorphisms, minisatellites, microsatellites, YAC-insert termini, exp

143 riving repeat turnover at MS32 and thus that minisatellites might evolve as by-products of localized

144 nstability at one of the most variable mouse minisatellites (MMS80), we used size-enrichment small-po

145 he SCK1/SLI gene contains a record number of minisatellites, most of which are polymorphic and transm

146 ve alleles from different populations at the minisatellite MS205 (D16S309).

147 and is approximately 30 kb from polymorphic minisatellite MS205.

148 traordinary somatic instability in the human minisatellite MS32 (D1S8) in ALT-expressing (ALT+) but n

149 Human minisatellite MS32 (D1S8) shows instability both in the

150 richment strategy was therefore developed at minisatellite MS32 (D1S8) to enable rare abnormal-length

151 that germline and somatic mutation at human minisatellite MS32 occur via distinct pathways, that a m

152 alysis of crossovers adjacent to the GC-rich minisatellite MS32, which is known to mutate by conversi

153 The highly variable human minisatellites MS32 (D1S8), MS31A (D7S21), and CEB1 (D2S

154 t repeat units along the tandem array of one minisatellite, MS42.

155 nal structural analysis of the hypervariable minisatellite, MSY1, has been used to define three major

156 nt highly polymorphic system, the Y-specific minisatellite, MSY1.

157 We present the second human Y-specific minisatellite, MSY2 (DYS440).

158 Mus musculus subspecies suggested that mouse minisatellites mutate at a rate below 10(-3) per gamete

159 MVR data suggest that mouse minisatellites mutate mainly by intra-allelic nonpolar e

160 nia and stem cells, whereas the frequency of minisatellite mutation after postmeiotic irradiation of

161 te a fundamental difference in mechanisms of minisatellite mutation and genome turnover between mice

162 However, somatic minisatellite mutation events are present in a subset of

163 These data suggest that conversion-based minisatellite mutation in sperm is completely germline-s

164 lies from Belarus, suggest that the elevated minisatellite mutation rate can be attributed to post-Ch

165 sperm DNA gives an estimate for the germline minisatellite mutation rate of about 0.05% (95% confiden

166 l3-t mutations grew extremely slowly and had minisatellite mutation rates considerably greater than t

167 g constellations to study de novo mutations, minisatellite mutations, copy-number changes, structural

168 with gap repair must traverse an artificial minisatellite of perfect 36-bp repeats or a yeast Y' min

169 e formed by the G-rich strand of the insulin minisatellite of repeat sequence, (ACAG4TGTG4/TGTC4ACAC4

170 The insulin minisatellite of the insulin-linked polymorphic region (

171 The minisatellites of Mycobacterium tuberculosis are well ch

172 genes, and a second locus, the insulin gene minisatellite on chromosome 11p15 (IDDM2; lambda S = 1.2

173 NS) VNTR (variable number of tandem repeats) minisatellite on chromosome 11p15.

174 Minisatellites, one of the major classes of repetitive D

175 The insulin minisatellite or variable number of tandem repeats locus

176 onger than 5 bp are generally referred to as minisatellite or variable number tandem repeat loci, and

177 ction fragment length polymorphisms, nuclear minisatellite (or variable number tandem repeat) loci an

178 Using an in-situ CHAllenging Minisatellite Payload (CHAMP) density dataset, models de

179 NS-)VNTR (variable number of tandem repeats) minisatellite polymorphism has been reported to be assoc

180 ed to the X-chromosome (DXMit20) utilizing a minisatellite polymorphism in the 5' UTR and by fluoresc

181 n about the processes that mediate bacterial minisatellite polymorphism.

182 ver resolution breakpoints in NID1 avoid the minisatellite, producing a cold spot within the hotspot.

183 Human hypervariable minisatellites provide highly informative loci for analy

184 Minisatellites provide the most informative system for a

185 Minisatellites provide very informative systems for anal

186 While minisatellite recombination is infrequent, crossover rat

187 reporter constructs have shown that the GPI minisatellite region can act to increase transcription f

188 etrotransposon family contains a polymorphic minisatellite region composed of five distinct, interlea

189 motif densities were identified in distinct minisatellite regions (200-1000 base pairs of approximat

190 cells by polymerase chain reaction (PCR) of minisatellite regions.

191 otic crossovers within two different GC-rich minisatellite repeat arrays in humans, both in families

192 not involve expansion of a trinucleotide or minisatellite repeat as has been observed for several of

193 lation variation in the number (3 or 4) of a minisatellite repeat element (MSR1) adjacent to the PRPF

194 ecifically excludes expansion of the AT-rich minisatellite repeat FRA16B fragile site and the CAG tri

195 ty, we isolated mutations that destabilize a minisatellite repeat tract in the ADE2 gene of Saccharom

196 multiple copies of a chromosome 19q-specific minisatellite repeat.

197 ed from each other in the numbers of a 30-bp minisatellite repeat.

198 These TAP-binding elements (TBE) are 15-bp minisatellite repeats that are homologous to the core TA

199 relatively nonrecombining region around the minisatellite revealed a star-shaped phylogeny with line

200 uence polymorphisms immediately flanking the minisatellite reveals no definitive associations with ge

201 olymerase delta) genes on the stability of a minisatellite sequence (20-bp repeats) and microsatellit

202 ctors controlling minisatellite stability, a minisatellite sequence 3' of the human HRAS1 gene was in

203 ability of finding a direct tandem repeat of minisatellite size by chance alone is very low [<4-(10 t

204 characterized checkpoint components maintain minisatellite stability in stationary-phase cells but ar

205 To investigate the factors controlling minisatellite stability, a minisatellite sequence 3' of

206 le is known about the factors that influence minisatellite stability, we isolated mutations that dest

207 possible models by which zinc can influence minisatellite stability.

208 tspot, the NID1 hotspot is associated with a minisatellite, suggesting that hotspots predispose DNA t

209 SPI(-) variant within IGF2 downstream of the minisatellite, suggesting that the apparent role of the

210 show a mild polarity towards one end of the minisatellite, suggesting the possible influence of flan

211 es of several C. thummi populations lack the minisatellites, suggesting their origin in C. piger only

212 such as those present in microsatellites and minisatellites, telomeres, and trinucleotide repeats (li

213 entification of a polymorphic tandem repeats minisatellite (termed MNS16A) in the downstream region o

214 of 5 to 10 bp flanking many yeast and human minisatellites that may be involved in their origins thr

215 We describe the first haploid minisatellite, the human Y chromosome-specific locus, MS

216 The insulin minisatellite therefore appears to evolve by two distinc

217 Mutation at the insulin minisatellite therefore was studied both indirectly from

218 ion and distribution of five Gmr9-associated minisatellites throughout the soybean genome.

219 tterns of variant repeat distribution in the minisatellite to demonstrate that genetic diversity is u

220 in a diploid strain containing heterozygous minisatellite tract alleles differing in length by three

221 Minisatellite tract alterations in blebbing strains cons

222 The minisatellite tract exhibited the same phenotypes in yea

223 Here we demonstrate that meiotic minisatellite tract-length changes are half as frequent

224 n diploid cells harboring heterozygous HRAS1 minisatellite tracts in which the two tracts differ by o

225 that controls specifically the expansion of minisatellite tracts.

226 es when compared to a strain with homozygous minisatellite tracts.

227 mutant specifically affects the stability of minisatellite tracts; microsatellites or simple insertio

228 rated either contraction or expansion of the minisatellite, typically by a single repeat unit.

229 Using minisatellite variant repeat ("MVR") mapping, and compou

230 satellite diversity has been investigated by Minisatellite Variant Repeat (MVR) analysis in a sample

231 e number tandem repeat (VNTR) region using a minisatellite variant repeat (MVR)-PCR approach.

232 us subspecies and in inbred strains by using minisatellite variant repeat mapping (MVR) by PCR to gai

233 We have employed the technique of minisatellite variant repeat mapping by PCR (MVR-PCR), w

234 Indirect evidence using minisatellite variant repeat mapping by PCR in Mus muscu

235 Sperm mutants were further characterized by minisatellite variant repeat mapping using four major po

236 A minisatellite variant repeat PCR (MVR-PCR) system gives

237 binations of both were involved in producing minisatellite variants.

238 nvestigations into the mechanisms underlying minisatellite variation in humans have been performed, r

239 ribe VNTRseek, our software for discovery of minisatellite VNTRs (pattern size >/= 7 nucleotides) usi

240 study is the most comprehensive analysis of minisatellite VNTRs in the human population to date.

241 ets from 2770 individuals in order to detect minisatellite VNTRs, i.e., those with pattern sizes 7 bp

242 first software for genome-wide detection of minisatellite VNTRs.

243 The largest class of events involving the minisatellite was a 3:1 segregation of parental-size all

244 The MS32 minisatellite was also highly unstable in three of eight

245 A total of 63,841 copies of Gmr9-associated minisatellites were recovered from the assembled G. max

246 represented in coding regions and that micro/minisatellites were recruited in genes involved in trans

247 ation frequency at telomeres and at the MS32 minisatellite, which is a marker of ALT.

248 mination of the meiotic events that produced minisatellites with altered lengths.

249 germline mutation at highly unstable GC-rich minisatellites with continuous allele size distributions

250 5 loci revealed the majority to be authentic minisatellites with GC-rich repeat units ranging from 14

251 13 bp but have no effect on the stability of minisatellites with repeat units of 16 or 20 bp.

252 ntaining repetitions of 1-5 nucleotides, and minisatellites, with multiple iterations of approximatel