ライフサイエンスコーパス: mislocalization

1 get proteins and results in their controlled mislocalization.

2 ected by motif mutations that caused TbetaRI mislocalization.

3 e protein and induce GEF binding and protein mislocalization.

4 le, ZO1, E-cadherin and N-cadherin and their mislocalization.

5 ium and to investigate the effect of protein mislocalization.

6 G-CSF combined with targeting to correct NE mislocalization.

7 hallmarks of ALS, such as gliosis and TDP-43 mislocalization.

8 olar cells together with correction of opsin mislocalization.

9 anes by bafilomycin A1 treatment caused Gls1 mislocalization.

10 ze nuclear p27 must also prevent cytoplasmic mislocalization.

11 ning of the photoreceptor layer and cellular mislocalization.

12 mreB mutant aberrant morphology due to PBP1 mislocalization.

13 omplete loss of Tyrp2, and significant Vamp7 mislocalization.

14 nism and physiological consequences of Pma1p mislocalization.

15 photoreceptor morphology, and correct opsin mislocalization.

16 essing Ter349Glu rhodopsin exhibited partial mislocalization.

17 al within 327-336 aa further facilitated the mislocalization.

18 he roles of trafficking signals in rhodopsin mislocalization.

19 ephrin-A1 result in protein aggregation and mislocalization.

20 n photoreceptor differentiation secondary to mislocalization.

21 ms of blinding disorders caused by rhodopsin mislocalization.

22 ng disorder frequently manifesting rhodopsin mislocalization.

23 ing to a decrease in a1 protein and cellular mislocalization.

24 of this interaction correlates with channel mislocalization.

25 ic fractions, these findings demonstrate the mislocalization and accumulation of abnormal TDP-43 in t

26 AnxA6 overexpression caused mislocalization and accumulation of Stx6 and integrins i

27 entiation arrest, and was associated with NE mislocalization and activation of the unfolded protein r

28 ive response DNA-binding protein 43 (TDP-43) mislocalization and aggregation are hallmark features of

29 Such mislocalization and aggregation are implicated in ALS pa

30 These studies revealed severe mislocalization and aggregation of NUPs and defective nu

31 Cytoplasmic mislocalization and aggregation of TAR-DNA binding prote

32 Mislocalization and aggregation of the huntingtin protei

33 on of wild-type MLL5 was able to rescue PLK1 mislocalization and aMTOC formation in MLL5-KD cells, wh

34 bition of Aurora B/C kinases results in Kif4 mislocalization and causes anaphase defects.

35 sual pigments, led to alleviation of S-opsin mislocalization and cone degeneration in the knock-in mi

36 ligomerization of mutant CSPalpha causes its mislocalization and consequent loss of its synaptic SNAR

37 ted in shorter photoreceptor outer segments, mislocalization and decrease in visual pigments, decreas

38 orms of cone degeneration because of M-opsin mislocalization and degradation.

39 bsence of LKB1 in the retina caused a marked mislocalization and delay in synapse layer formation.

40 knockdown cause hippocampal pyramidal neuron mislocalization and development of multiple apical dendr

41 Deficiency of ICMT, RAB7, or RAB8 led to mislocalization and diminished processing of NOTCH1-GFP.

42 is dominant-negative and causes IFT protein mislocalization and disrupted ciliogenesis.

43 3A protein may be one of the reasons for its mislocalization and disrupted function in cells of patie

44 ndicate that mutant beta-III spectrin causes mislocalization and dysfunction of mGluR1alpha at dendri

45 ymatic activity of RPE65, causing cone opsin mislocalization and early cone degeneration in the mutat

46 Cytoplasmic mislocalization and elevated half-life is a characterist

47 However, these mutations resulted in mislocalization and enhanced degradation of TRPL after p

48 rations of the basement membrane, led to ESC mislocalization and exhaustion of the ESC pool.

49 either of these two proteins, we found Golgi mislocalization and extensive aberrant dendrite formatio

50 N), and its mutation leads to severe protein mislocalization and growth defects.

51 This mislocalization and its unique C terminus led to increas

52 BAI1 knockdown results in Par3/Tiam1 mislocalization and loss of activated Rac1 and filamento

53 d as an FTLD model, but lack cortical TDP-43 mislocalization and neurodegeneration.

54 nding of the relationships between rhodopsin mislocalization and photoreceptor dysfunction/degenerati

55 Together, the data show that both mislocalization and rod outer segment morphogenesis are

56 harmonin exhibits microvillar protocadherin mislocalization and severe defects in brush border morph

57 creased levels of hnRNP A1 nucleocytoplasmic mislocalization and stress granule formation, both marke

58 Six compounds that caused mislocalization and varying degrees of altered movement

59 n the loss of an interaction or function via mislocalization and/or loss of an essential transmembran

60 ty errors, angle estimate errors, connection mislocalization, and connection topological changes to s

61 C acts as a triage factor to prevent protein mislocalization, and demonstrates how the macromolecular

62 esulting in low protein expression, cellular mislocalization, and reduced functional activity.

63 Low protein expression, protein mislocalization, and reduced G protein binding were iden

64 morphisms demonstrated reduced expression or mislocalization, and these events were associated with e

65 re, we describe a previously uncharacterized mislocalization artifact of Entacmaea quadricolor red fl

66 RNA-processing granules thereby eliminating mislocalization as a cause of defective polyadenylation.

67 Collectively, our results establish ATG9A mislocalization as a key marker of AP-4 deficiency in pa

68 keleton and identify loss of Glu-MTs and RNA mislocalization as common outcomes of ALS pathogenic mut

69 , declined after TDP-43 knockdown and TDP-43 mislocalization as well as in patient-specific motor neu

70 Tyr-Ala-Met-Leu motif is responsible for P0 mislocalization, as its addition is able to restore corr

71 Saccadic mislocalization, by contrast, is robust and resistant to

72 Tactile mislocalizations can depend on the timing of successive

73 Quantifying the size of this mislocalization demonstrates that past lesion-deficit re

74 nd are prone to aggregation, misfolding, and mislocalization during this process.

75 Surprisingly, we found no trace of mislocalization, even for saccades cancelled close to th

76 Using an Rgf3 conditional mutant and mislocalization experiments, we found that Art1 and Rgf3

77 Based on optogenetic protein mislocalization experiments, we propose that the establi

78 CaBP7 depletion induces lysosome mislocalization, extension of intercellular bridge lifet

79 accompanied by rhodopsin and blue cone opsin mislocalization from 6 to 12 months of age with lysosome

80 This results in TbetaRII mislocalization from the basolateral to both the basolat

81 ion in maintaining genomic stability and its mislocalization in cancers, suggests an important role o

82 ein TDP-43, are one cause of ALS, and TDP-43 mislocalization in MNs is a key pathological feature of

83 sensory cortex when observing touch, suggest mislocalization in previous studies, and instead highlig

84 duction of plasma cells in peripheral blood, mislocalization in spleen, and an inability of c-Myb-def

85 ed in colonic Caco-2 cells, similar to ezrin mislocalization in the colon of PTPsigma(-/-) mice follo

86 d to a reduction of TRPL content and partial mislocalization in the dark.

87 oocytes or rice protoplasts showed OsPIP1;3 mislocalization in the endoplasmic reticulum (ER)-like n

88 eneration that was associated with rhodopsin mislocalization in the photoreceptors and reduced cone c

89 Erf2-like human protein, did not rescue Ras1 mislocalization in these cells.

90 e prevalent NPM1c+ mutation that causes NPM1 mislocalization in ~30% of AML patients results in exces

91 the CCC-associated WASH complex causes LDLR mislocalization, increased lysosomal degradation of LDLR

92 FUS mislocalization increases as disease progresses, and mut

93 We found that rhodopsin mislocalization is a facilitated process for which a sig

94 K-Ras4B mislocalization is also recapitulated in ASM-deficient N

95 Rhodopsin mislocalization is associated with blinding diseases cal

96 of 43 kDa (TDP-43), whose nucleo-cytoplasmic mislocalization is characteristically observed in spinal

97 Rhodopsin mislocalization is frequently observed in retinitis pigm

98 If this mislocalization is initiated by saccade preparation, one

99 rod photoreceptor cells triggered by protein mislocalization is likely the mechanism of disease progr

100 We conclude that perisaccadic mislocalization is not a direct consequence of saccade p

101 A similar mislocalization is observed with cerebellar Purkinje neu

102 FUS mislocalization is rescued by the addition of the wild-t

103 1 (ins/ins) retinas have extensive L/M-opsin mislocalization, lack CNGB3 labelling in the L/M-cones,

104 Mice lacking CRALBP exhibited M-opsin mislocalization, M-cone loss, and impaired cone-driven v

105 athological protein and the rescue of TDP-43 mislocalization may be critical for halting or reversing

106 , our findings indicate that cytoplasmic FUS mislocalization not only leads to nuclear loss of functi

107 ffinities for Unc119a and leads to a partial mislocalization of a low affinity mutant of NPHP3.

108 tyrosine (Y20), whose alteration results in mislocalization of a portion of IFITM3 to the cell perip

109 n linked to this predictive remapping is the mislocalization of a stimulus flashed around the time of

110 f metabolism; this resulted in leaky TJs and mislocalization of actin and TJ proteins.

111 The finding that mislocalization of active phosphotransferase is the basi

112 In addition to a mislocalization of AIM1 from the actin cytoskeleton in i

113 F3 mutant proteins in HEK293T cells revealed mislocalization of all but one mutant in the cytoplasm,

114 Silencing SAFB led to marked mislocalization of all RAS isoforms as well as RAP1A but

115 beta1-integrin exhibited down-regulation and mislocalization of alpha3- and alpha5-integrins by immun

116 h, disorganized outer rod segment discs, and mislocalization of and reduction in rhodopsin early in p

117 triglyceride-filled vesicles in enterocytes, mislocalization of apolipoprotein B, and loss of chylomi

118 Mislocalization of APP can promote iron retention, thus

119 ues, perivascular reactive astrogliosis, and mislocalization of astrocyte aquaporin-4 (AQP4).

120 ice led to a reduced scotopic photoresponse, mislocalization of ATP8A2 to the inner segment and cell

121 Mislocalization of axonal proteins can result in misasse

122 d translation, increased degradation, and/or mislocalization of cadherin.

123 ant negative mutant of TRPC6) results in the mislocalization of calpain 1 and 2 and significant downr

124 , depletion of HuR in these neurons led to a mislocalization of CDP(+) neurons in deeper layers of th

125 hibited excessive dendritic arborization and mislocalization of cell bodies in vivo These cellular de

126 in causing inherited disorders manifested by mislocalization of ciliary receptors.SIGNIFICANCE STATEM

127 t disrupting cone LINC complexes resulted in mislocalization of cone nuclei to the basal side of ONL

128 loss of Tmem30a in mouse cone cells leads to mislocalization of cone opsin, loss of photopic electror

129 These defects were associated with mislocalization of cone opsins to the nuclear and synapt

130 s slow photoreceptor degeneration with early mislocalization of cone opsins, features resembling thos

131 Disruption of the BTB coincided with mislocalization of connexin43, which was present through

132 was highly stabilized in a cka2Delta strain, mislocalization of Cse4 was mild, suggesting that Cse4 m

133 hanger regulatory factor-1 resulted in gross mislocalization of cystic fibrosis transmembrane conduct

134 along with impaired endosome morphology and mislocalization of DAF-4/BMPRII to late endosomes and ly

135 showed that these lateral buds resulted from mislocalization of DivIVA, a major determinant in facili

136 and aberrant H3K79 methylation, possibly by mislocalization of DOT1L.

137 Here we demonstrate that in addition to this mislocalization of electron density, a class II IN mutat

138 ion mimics the Weyers cellular phenotype-the mislocalization of EVC-EVC2 within cilia and impaired ac

139 y exhibited cleavage plane displacement with mislocalization of furrow-associated markers, associated

140 uppress the proteotoxicity, aggregation, and mislocalization of FUS and other proteins that aggregate

141 We report nuclear-to-cytoplasmic mislocalization of FUS in both VCP-mutation related ALS

142 ween FUS and Transportin-1, resulting in the mislocalization of FUS in the cytoplasm and formation of

143 rt a two-hit hypothesis, whereby cytoplasmic mislocalization of FUS protein, followed by cellular str

144 ICMT deficiency induced mislocalization of GFP-RAB7 and GFP-RAB8 from endomembra

145 Reduced amounts of RBP-L caused partial mislocalization of glutelin and prolamine RNAs and confe

146 This results in mislocalization of glycosomal enzymes, causing metabolic

147 for parasite metabolism and failure leads to mislocalization of glycosomal enzymes, with fatal conseq

148 protein implicated in aggressive AML causes mislocalization of H3K4me3 at abnormal regions and up-re

149 se activity of this mutant, resulting in the mislocalization of H3K4me3 from the promoter-proximal re

150 The rapid RNase H1-dependent mislocalization of heterodimer proteins P54nrb and PSF t

151 ls of Cse4 and its assembly factor Scm3, and mislocalization of histone H3 at CEN chromatin were obse

152 SERPINH1 that results in destabilization and mislocalization of HSP47 and secondarily has similar eff

153 sts display defective receptor recycling and mislocalization of key muscle proteins, including caveol

154 Loss of DLC2 induces the mislocalization of Kif1B, increased Cdc42 activity and c

155 Furthermore, Commd1 depletion results in mislocalization of LDLR, accompanied by decreased LDL up

156 only in nuclear envelope defects, including mislocalization of LEM domain proteins and extensive inv

157 defects in astral MT dynamics, as well as in mislocalization of LGN and NuMA, leading to misoriented

158 In contrast to the key role in Drosophila, mislocalization of Llgl proteins does not appear to be c

159 Moreover, our analyses demonstrated the mislocalization of lysosomal cathepsins within the cytos

160 letion of the methyltransferase Ezl3p caused mislocalization of meiosis-induced DNA double-strand bre

161 enotypes are partially caused by cytoplasmic mislocalization of Mitf/TFEB, a key transcriptional regu

162 formation by >95% and results in significant mislocalization of multiple tight junction (TJ) proteins

163 dystrophin deficiency causes a decrease and mislocalization of muscle-specific neuronal nitric oxide

164 Muscleblind regulates cytoplasmic mislocalization of mutant FUS and subsequent accumulatio

165 malities in the developing cortex, including mislocalization of mutant huntingtin and junctional comp

166 lines, and additional experiments suggested mislocalization of mutant LEMD2 protein within the nucle

167 al in FUS and thereby facilitate cytoplasmic mislocalization of mutant proteins.

168 ression significantly alleviates cytoplasmic mislocalization of mutant TDP-43.

169 In one, ELANE mutations lead to mislocalization of NE.

170 f Neph1CD in podocytes prevented PAN-induced mislocalization of Neph1.

171 rophy (DMD), loss of dystrophin leads to the mislocalization of nNOSmu from the sarcolemma to the cyt

172 constrictions can cause nuclear rupture and mislocalization of nuclear proteins, but damage to DNA r

173 cytiotrophoblasts results in the subcellular mislocalization of one of the major lactate transporters

174 eceptor outer segment dimensions without any mislocalization of outer segment proteins, whereas photo

175 rdingly, the down-regulation and cytoplasmic mislocalization of p120ctn has been reported in all subt

176 These findings suggest that cytoplasmic mislocalization of p27 despite BCR-ABL1 inhibition by ty

177 lly at T157, thereby promoting the cytosolic mislocalization of p27(KIP1).

178 that mice with diet-induced obesity display mislocalization of Par3, a regulator of cellular junctio

179 was accompanied by the absence of nucleolar mislocalization of paraspeckle protein P54nrb, ablation

180 xpression of the Tmc2a N terminus results in mislocalization of Pcdh15a within hair bundles, together

181 t Msp1, human ATAD1 limits the mitochondrial mislocalization of PEX26 and GOS28, orthologs of Pex15 a

182 along with severe retinal degeneration with mislocalization of phototransduction cascade proteins.

183 ss of PI3K-C2alpha-derived PtdIns3P leads to mislocalization of PRE markers such as TfR and Rab11, re

184 In this model, germline mislocalization of Pten causes inappropriate social beha

185 ing sequence in chemotaxis pathway mRNAs, or mislocalization of Puf118 and its target mRNAs to the ce

186 Conditional mislocalization of PyrKII resulted in decreased transcri

187 5 peptide, into these transgenic rods caused mislocalization of R-opsin and S-opsin to the perinuclea

188 Talpid3 depletion also led to mislocalization of Rab8a, a small GTPase thought to be e

189 ge factors, defects in Rac1 degradation, and mislocalization of Rac signaling components.

190 The mislocalization of RAD51 away from DSBs in cells express

191 recruit importin-alpha and Nup62 and induce mislocalization of RanGap1, Ran, and Nup107, thereby pro

192 s in photoresponse, removal of ARL13B led to mislocalization of rhodopsin, prenylated phosphodiestera

193 s do not form rod outer segments and display mislocalization of rhodopsin, suggesting a role for RPGR

194 orporation, shortening of the kinocilia, and mislocalization of ribeye b clusters.

195 The aggregation and mislocalization of RNA-binding proteins leads to the abe

196 RPN4 transcription is triggered by cytosolic mislocalization of secretory proteins, is mediated by mu

197 Consistent with mislocalization of Serca1 and Ryr1, calcium handling was

198 It also results in mislocalization of several apical (Par6, aPKC, and Pals1

199 nt reduction in the basal pool of PI3P and a mislocalization of several membrane skeleton proteins kn

200 ting SGPL1 mutations resulted in subcellular mislocalization of SGPL1.

201 In vivo, loss of sialylation resulted in mislocalization of slit diaphragm components, whereas po

202 the ALS-causing FUS R495X NLS mutation, and mislocalization of Sm proteins is RRM-dependent.

203 Moreover, mislocalization of SMN disrupts CB integrity and likely

204 udy, we find that FUS inclusions lead to the mislocalization of specific RNAs from fibroblast cell pr

205 nhibitor of trafficking, Retro94, causes the mislocalization of STX5, an altered cVAC morphology, and

206 found that the R383Q mutation resulted in a mislocalization of SV2A from SVs to the plasma membrane,

207 of age and is pathologically associated with mislocalization of TAR DNA/RNA binding protein 43 (TDP-4

208 Our data demonstrate the mislocalization of tau in the somatodendritic compartmen

209 The assumption that mislocalization of tau into the somatodendritic compartm

210 oligomers (Abetao's) for 15 min, we induced mislocalization of tau into the spines under resting con

211 postsynaptic dysfunction associated with the mislocalization of tau to dendritic spines.

212 ibit increased levels of TDP-43, subcellular mislocalization of TDP-43, and decreased cell survival.

213 models of ALS and results in the cytoplasmic mislocalization of TDP-43.

214 letion of TRiC causes loss of TCAB1 protein, mislocalization of telomerase and scaRNAs to nucleoli, a

215 Whereas mislocalization of telomerase by mutation of WDR79 leads

216 R79 leads to critically shortened telomeres, mislocalization of telomerase by Nopp140 KD leads to gra

217 outflow tract myocardialization, leading to mislocalization of the aorta.

218 pendently of each other and independently of mislocalization of the apical determinant Crumbs (Crb).

219 Various RPE defects, including mislocalization of the apical marker ezrin, and disrupte

220 i-saccadic vision is also characterized by a mislocalization of the briefly presented stimulus closer

221 tic spindle and that loss of mtrm results in mislocalization of the catalytically active form of Polo

222 of Ste5 to the plasma membrane due to severe mislocalization of the cellular phosphatidylinositol 4-p

223 densation, loss of centromere stiffness, and mislocalization of the chromosome passenger complex prot

224 We also found mislocalization of the CMA lysosomal receptor LAMP2A and

225 Protein localization defects caused by mislocalization of the cognate mRNA were rescued by intr

226 and latency of corrective saccades, and (2) mislocalization of the corrective (second) saccade in th

227 in several ways, one of which is cytoplasmic mislocalization of the cyclin-dependent kinase inhibitor

228 (4,5)P(2) on aberrant endomembrane vacuoles, mislocalization of the cytokinetic machinery, and extens

229 ning gene molecule interacting with CasL and mislocalization of the Drosophila homolog of the human R

230 In summary, we report widespread mislocalization of the FUS protein in ALS and propose a

231 , which was corroborated by our data showing mislocalization of the gamma subunit.

232 conduction defects were accompanied by overt mislocalization of the gap junction protein connexin43 (

233 t defects in TGN acidification together with mislocalization of the Golgi-enriched vacuolar H(+)-ATPa

234 ider canalicular structures correlating with mislocalization of the junctional protein, cingulin.

235 ed protein phosphatase 2A (PP2A), leading to mislocalization of the lipid kinase PIKfyve.

236 how that loss of AtPH1 function leads to the mislocalization of the metal uptake transporter NRAMP1 t

237 Subcellular mislocalization of the microtubule-associated protein Ta

238 ation by NrasG12D, which was associated with mislocalization of the nonpalmitoylated N-Ras mutant pro

239 Knockdown of either protein causes mislocalization of the other, and endogenous anillin inc

240 The concomitant mislocalization of the PIKfyve product PI(3,5)P2 trigger

241 ing the localization of the mRNA resulted in mislocalization of the protein and vice versa.

242 f the mutated allele in HEK cells revealed a mislocalization of the protein in the cytoplasm, leading

243 dissociation of CENP-A from centromeres and mislocalization of the protein to noncentromeric sites.

244 ding to the absence of the protein in sperm, mislocalization of the protein when injected in mouse GV

245 nges in ion transporter expression or simply mislocalization of the protein.

246 We hypothesized that nuclear-to-cytoplasmic mislocalization of the RNA binding protein fused in sarc

247 ents almost universally display pathological mislocalization of the RNA-binding protein TDP-43 and th

248 Cortical hyperexcitability and mislocalization of the RNA-binding protein TDP43 are hig

249 Immunostaining showed mislocalization of the sarcoplasmic reticulum proteins S

250 alities in the actin cytoskeleton, including mislocalization of the TJ binding protein vasodilator-st

251 in that task but did not alter the classical mislocalization of the visual stimulus.

252 genes required for endocytosis show similar mislocalization of these proteins to dendrites, and stro

253 its trafficking to the photoreceptor OS and mislocalization of this protein likely leads to RP-relat

254 ted in up-regulation of Lmod2 expression and mislocalization of Tmod1.

255 der frontotemporal dementia, is the cellular mislocalization of transactive response DNA-binding prot

256 tochore assembly in mitotic cells due to the mislocalization of two components: Dsn1 and Hec1.

257 We further suggest that the mislocalization of ubH2B to the cytoplasm has additional

258 ition of IN-RNA interactions resulted in the mislocalization of viral ribonucleoprotein complexes out

259 PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid

260 gulatory formins dDAAM and Diaphanous caused mislocalization of Zipper and induced ectopic heart lumi

261 nfected monolayer, and severe disruption and mislocalization of ZO-1 and claudin-1 proteins.

262 As for vision, the mislocalizations of time and space for touch stimuli may

263 R motifs, and determined the impact of SHOC2 mislocalization on ERK signalling.

264 ase in cell curvature, and magnetosome chain mislocalization or complete chain disruption.

265 slation and are incompatible with either the mislocalization or misfolding hypotheses, which require

266 ions we identified in TTC7A result in either mislocalization or reduced expression of TTC7A.

267 We propose that this is due to rescue of the mislocalization phenotype of these two mutants by nitric

268 ce 1 (Oxr1) protein could alleviate cellular mislocalization phenotypes associated with TDP-43 mutati

269 Similar mislocalization phenotypes were observed in Cep290(rd16)

270 ality on RNase H1 cleavage patterns, protein mislocalization phenotypes, activity and toxicity in cel

271 s reduced interaction and enhanced cytosolic mislocalization, prevented the nuclear translocation of

272 f photoreceptor function and that cone opsin mislocalization represents an early step in XLRP caused

273 This mislocalization resulted from the altered membrane prope

274 sters NRF2 and thereby causes its subnuclear mislocalization, resulting in impaired NRF2 transcriptio

275 rto uncharacterized consequence of rhodopsin mislocalization: the activation of the lysosomal pathway

276 ntion in SFPQ transcripts contributes to FUS mislocalization through their direct interaction and nuc

277 Tau mislocalization to dendritic spines and associated posts

278 strain rate deformation alone can induce tau mislocalization to dendritic spines and synaptic deficit

279 Tau mislocalization to dendritic spines depends upon the pho

280 e 5 is required to prevent P301L-induced tau mislocalization to dendritic spines, supporting redundan

281 a and cyclin-dependent kinase 5 prevents tau mislocalization to dendritic spines.

282 In this study, the XPA mislocalization to DSBs occurred at stalled or collapsed

283 CENP-A mislocalization to ectopic sites may disrupt chromatin-b

284 ns) in preventing budding yeast CENP-A(Cse4) mislocalization to euchromatin by mediating its proteoly

285 ndle pole separation as a consequence of its mislocalization to nonkinetochore MTs.

286 pporting redundant pathways that control tau mislocalization to spines.

287 gnificant loss of PLB membrane anchoring and mislocalization to the cytoplasm and nucleus.

288 Our data show pre-mRNA mislocalization to the cytoplasm, where the RNAs are tar

289 essor, can acquire oncogenic activities upon mislocalization to the cytoplasm.

290 n residue with other amino acids resulted in mislocalization to the vacuole and impaired n-glycan pro

291 Remarkably, Cx43 mislocalization was also evident in autopsied left ventr

292 In cultured cells, mislocalization was observed at high expression levels w

293 Examining the downstream effects of ATG9A mislocalization, we found that autophagic flux was intac

294 terestingly, spindle misorientation and NuMA mislocalization were reversed by treatment with a low do

295 The lack of acetaminophen toxicity and Cx32 mislocalization were reversed upon infection with recomb

296 in characteristics of a murine model of Pten mislocalization were used to further evaluate abnormalit

297 nal confers toxicity to rhodopsin and causes mislocalization when the VXPX cilia-targeting motif is a

298 st that SCN disease pathogenesis includes NE mislocalization, which in turn triggers dysfunctional su

299 sA mutants displayed growth defects and raft mislocalization, which were accompanied by reduced neutr

300 ich revealed similar changes in photopigment mislocalization with elevated autophagy levels at 6 days