ライフサイエンスコーパス: mislocalize

1 precursor cells showed that mutant proteins mislocalize.

2 ondria, and the L122P mutant protein did not mislocalize.

3 e SH3 domain is overexpressed, paramyosin is mislocalized.

4 ore, enzymes that support aECM stability are mislocalized.

5 ation at cell tips even if Mid1 is absent or mislocalized.

6 Golgi, Rh1 is aberrantly glycosylated and is mislocalized.

7 hand side of the cell or two nuclei with one mislocalized.

8 produces bicaudal embryos when oskar mRNA is mislocalized.

9 eased by 25%, and hemidesmosome proteins are mislocalized.

10 audin-3, apical tight-junction proteins, are mislocalized.

11 of membrane proteins in microvilli, is also mislocalized.

12 some other fragments lacking this region are mislocalized.

13 as rhodopsin, arrestin, and transducin, are mislocalized.

14 oteins exhibited reduced expression and were mislocalized.

15 SHORTROOT and SCARECROW are misexpressed or mislocalized.

16 tration-was disrupted, and key proteins were mislocalized.

17 ongation zone of twd1 roots, attributable to mislocalized ABCB transporters and suppressed by an auxi

18 n both growth and nuclear segregation due to mislocalized actin assembly.

19 with suggestions that AlgL serves to degrade mislocalized alginate that is trapped in the periplasmic

20 of apical-basal polarity, such as ZO-1, were mislocalized along the lateral and basal membranes of fi

21 embrane protein 1 (ROM1), and rhodopsin were mislocalized along the microtubules to the IS, cell body

22 esulting intermicrovillar adhesion links are mislocalized along the microvillar axis rather than enri

23 We show that SCA5 beta-spectrin dominantly mislocalizes alpha-spectrin and ankyrin-2, components of

24 swollen, but neither opsin nor arrestin was mislocalized, although IFT88 accumulated in the distal r

25 raspeckle function in human diseases because mislocalized amyotrophic lateral sclerosis (ALS)-linked

26 rtain LPS biosynthesis enzymes causes Hap to mislocalize and accumulate in the periplasm, where it is

27 thogenic as they promote wild-type TDP-43 to mislocalize and aggregate acting in a dominant-negative

28 thological feature of ALS is cytoplasmically mislocalized and aggregated TDP-43 protein in >95% of ca

29 tion, the ER enzyme glucosidase I (Gls1) was mislocalized and degraded in the vacuole.

30 Additionally, TFEB is mislocalized and downregulated in human cells expressing

31 In mdx muscle, nNOSbeta was mislocalized and its association with the Golgi complex

32 5 interact, and in the absence of A34, B5 is mislocalized and not incorporated into extracellular vir

33 mutants lacking Schwann cells, the nerve is mislocalized and the axons remain in the epidermis.

34 SENP2, we observe that many nucleoporins are mislocalized and, in some cases, reduced in level when S

35 rin, major slit diaphragm constituents, were mislocalized and/or lost.

36 Ablation of lin-65, but not arle-14, mislocalizes and destabilizes MET-2, resulting in decrea

37 in facilitated exit from mitosis by possibly mislocalizing and functionally inactivating cyclin B1.

38 nded, pseudopodial activity is increased and mislocalized, and chemotaxis is impaired.

39 the absence of INO80, H2A.Z nucleosomes are mislocalized, and H2A.Z levels at promoters show reduced

40 ull mice, PLCbeta2 was undetectable, NHERF-1 mislocalized, and IP3 R3 more intensely stained, along w

41 that the STGD3 truncated mutant may generate mislocalized, and therefore toxic, keto intermediates of

42 a competition-based approach to specifically mislocalize APC-dependent RNAs suggests that localizatio

43 apical domains and terminal cells displayed mislocalized apical proteins.

44 ells overexpressing or depleted of kinastrin mislocalize astrin and show the same mitotic defects as

45 ed reduced expression of CD103 (Itgae), were mislocalized away from airway epithelia, and demonstrate

46 E6 attenuates repair by causing RAD51 to be mislocalized away from both transient and persistent DSB

47 TEM and IF demonstrate mislocalized basal bodies.

48 ce of Crumbs or aPKC phosphorylation of Baz, mislocalized Baz recruits adherens junction components a

49 nteraction and thereby inhibits autophagy by mislocalizing Beclin 1 to the dynein motor complex.

50 aberrant particles, in which the vRNPs were mislocalized between the CA lattice and the viral lipid

51 When Fin1 is mislocalized, bipolar spindles fail to assemble but the

52 Expression of mislocalized Bni1p constructs has a dominant-negative ef

53 at inhibition of acid sphingomyelinase (ASM) mislocalizes both the K-Ras isoforms K-Ras4A and K-Ras4B

54 cause RalA and RalB are equally effective in mislocalizing both murine and human p27, we focus on Ral

55 rains lacking substrates that are toxic when mislocalized, both LolA and LolB can be completely bypas

56 tion of CLASP2 in migrating neurons leads to mislocalized cells in deeper cortical layers, abnormal p

57 n autoimmune pancreatitis (AIP) by restoring mislocalized CFTR protein to the apical ductal membrane.

58 Mislocalized cGAS induces potent interferon responses to

59 estion, we generated knockin mice expressing mislocalized cytoplasmic FUS and complete FUS knockout m

60 -43 (hTDP-43-WT) to determine the effects of mislocalized cytoplasmic TDP-43 on neuronal viability.

61 ggregation within motor neurons by reducing (mislocalized) cytoplasmic TDP-43, TDP-43 aggregation and

62 Cells loose their apical-basal polarity, mislocalize DE-cadherin, and delaminate from the main ep

63 n defective differentiation, nuclear rupture mislocalizes differentiation-relevant MyoD and KU80 (a D

64 s capacity for mesenchymal condensation with mislocalized distributions of chondroitin sulfate proteo

65 unity, with cGAS sensing both pathogenic and mislocalized DNA in the cytoplasm.

66 ds the INM proteome through the clearance of mislocalized ER membrane proteins.

67 an-Cre results in fusion proteins that often mislocalize, exhibit mutant phenotypes, and dramatically

68 increased expression of aquaporin-2 mRNA but mislocalized expression of aquaporin-2 protein in the cy

69 our data indicate a new mechanism, how NPM1c mislocalizes FLT3-TKD and changes its signal transductio

70 mplified, mRNA overexpressed, and protein is mislocalized from cell-cell junctions in human breast ca

71 Pathological TDP-43 is mislocalized from its nuclear location to the cytoplasm,

72 ly expressed and associated, but retromer is mislocalized from neuropil to soma with the Rab7 GTPase.

73 Viable bacteria that are mislocalized from the gut microbiota and metabolically a

74 n telomeres is abrogated, because telomerase mislocalizes from Cajal bodies to nucleoli within the iP

75 We propose that branching begins when mislocalized FtsZ triggers the insertion of inert peptid

76 Aurora B normalization redirects the mislocalized furrow proteins to their proper location, c

77 Aggregation of mislocalized FUS into non-amyloid inclusions is believed

78 and mRNA splicing patterns, indicating that mislocalized FUS results in loss of its normal function.

79 Rock inhibition increased the generation of mislocalized ganglion/amacrine cells at the expense of r

80 ncoded by 44 TetO(7)-orf strains resulted in mislocalized GFP-Nic96.

81 y (Mla) pathway has been proposed to extract mislocalized glycerophospholipids from the outer leaflet

82 al of the C-terminal domain, which partially mislocalizes gp210/Nup210 away from NPCs, efficiently re

83 aseIV), which depletes cellular PI(4,5)P(2), mislocalizes HIV-1 Gag to the cytosol and greatly reduce

84 Mislocalized horizontal cell processes contacted aberran

85 ng Discs Large1, Mud/NuMA, and Canoe/Afadin, mislocalize in dividing Eph mutant neuroepithelial cells

86 Nups were mislocalized in adult intestinal nuclei and in embryos f

87 naptic ribbon protein, was less abundant and mislocalized in adult wud mutants.

88 es different phases of the cell cycle and is mislocalized in affected individuals.

89 NA processing, are abnormally aggregated and mislocalized in ALS and FTLD, while the expansion in the

90 eoblast stem cells and progenitor cells were mislocalized in beta1-integrin(RNAi) animals without sig

91 n-1 loss-of-function (lf) mutants, SLO-1 was mislocalized in body-wall muscle but its transcription a

92 likely conserved substrate of fly CCT and is mislocalized in both cct and in dfmr1 mutant embryos.

93 d, an apically localized adaptor protein, is mislocalized in both crb mutant cells and Crb overexpres

94 ronal progenitors, becomes overexpressed and mislocalized in cancer cells from a variety of human tum

95 a platform for identifying cargoes that are mislocalized in cancer upon CRM1 mutation.

96 Strikingly, OGT is mislocalized in cardiac mitochondria from diabetic rats.

97 the key lipid metabolizing enzyme, lipin, is mislocalized in dTorsin-KO cells, and dTorsin increases

98 xpression is either decreased or the protein mislocalized in human HCC.

99 t germ cell nuclei, nucleoporins (Nups) were mislocalized in large plaques beginning at meiotic entry

100 he nuclear envelope protein emerin, which is mislocalized in Lmna mutant cells and also linked to EDM

101 (NIS; aka SLC5A5), which is upregulated and mislocalized in many human carcinomas.

102 KIF1A cargo is mislocalized in many neurodegenerative diseases, indicat

103 talin (HSPA9/GRP75) is often upregulated and mislocalized in MEK/ERK-deregulated tumors.

104 of the mutants were transport-competent but mislocalized in mouse liver.

105 nstrated that viral capsids assemble but are mislocalized in nuclei of cells infected with the mutant

106 NUP-1 is mislocalized in NUP-2 knockdown cells and vice versa, im

107 Moreover, the KASH protein ZYG-12 was mislocalized in ooc-5 gonads.

108 ulator of rhodopsin ciliary trafficking, was mislocalized in photoreceptor cells of rpgrip1 mutants.

109 Here we demonstrate that NF-E2 is mislocalized in PMF cells and that aberrant NF-E2 locali

110 ich is necessary for basal cell adhesion, is mislocalized in Sac1(ts) retinas.

111 spatial regulator of MSP disassembly, MSP is mislocalized in sperm lacking GSP-3/4.

112 main myristoylated kinases in T cells, were mislocalized in the absence of Nmt activity.

113 the cytoskeleton protein betaII spectrin are mislocalized in the axon, and assembly of the node of Ra

114 These proteins can be mislocalized in the cytosol due to mutations in their ta

115 nts, when tactile stimuli are systematically mislocalized in the direction of the movement.

116 Mutant receptor tyrosine kinases are mislocalized in the endoplasmic reticulum (ER) of AML an

117 ochlea in vivo; however, tricellulin becomes mislocalized in the inner ear sensory epithelia of ILDR1

118 that, in Myo7a-mutant mice, RPE65 is partly mislocalized in the light.

119 isted under this stress, RBPs and mRNAs were mislocalized in the nucleus and cytoplasm.

120 Moreover, the tight junction protein ZO-1 is mislocalized in the tal1-deficient endocardium, indicati

121 weaker to CRM1(E571K), eIF4E-transporter was mislocalized in tumor cells carrying CRM1(E571K).

122 lar chaperone that is often up-regulated and mislocalized in tumors with abnormal activation of the k

123 ane cell fate regulator, SCRAMBLED (SCM), is mislocalized in ugt80B1 mutants, underscoring the aberra

124 Pma1p is mislocalized in vma mutants but remains at the plasma me

125 The mechanism by which rhodopsin mislocalizes in rod photoreceptor neurons is not well un

126 hese transgenic rods without chromophore was mislocalized; in R-opsin's presence, however, S-opsin tr

127 Interestingly, the 26S proteasome is mislocalized into foci, which are colocalized with nucle

128 contraction begins, MYO-3 and UNC-89 become mislocalized into large foci and animals die.

129 However, Vps34-deficient T cells have mislocalized intracellular Eea1, HGF-regulated tyrosine

130 Toxic gain of TBPH did not downregulate or mislocalize its own expression, indicating that a domina

131 Mutations in SLC4A1 that mislocalize its product, the chloride/bicarbonate exchan

132 isplay defective cell polarity, resulting in mislocalized junctional complexes and loss of adhesion t

133 s of L-type calcium channel blockers did not mislocalize K-Ras, suggesting a mechanism that is unrela

134 triterpenoid saponins from Acacia victoriae, mislocalizes K-Ras from the PM and disrupts PM spatial o

135 Silencing of GPR31 expression partially mislocalized KRAS4B, slowed the growth of KRAS-dependent

136 of nodes, disrupted paranodal junctions, and mislocalized Kv1 K(+) channels.

137 ress response pathways that are activated by mislocalized lipopolysaccharide may collectively contrib

138 unction is to prevent lethal accumulation of mislocalized lipoproteins.

139 ficking tasked with protecting the cell from mislocalized lipoproteins.

140 opsins mistrafficked as reported previously, mislocalized M-opsin was degraded whereas mislocalized S

141 , Ubr4 is responsible for the degradation of mislocalized MEC-2 multimers.

142 In Lrat(-/-) mouse model, mislocalized medium (M)-wavelength opsin was degraded, w

143 , UBQLN1 plays an important role in clearing mislocalized mitochondrial proteins upon cell stimulatio

144 lost in the presence of polyglutamine, which mislocalizes MOAG-2/LIR-3 from the nucleus to the cytoso

145 sitioned centrosomes and Golgi apparatus and mislocalized molecules of the slit diaphragm.

146 t somehow compensated, we would consistently mislocalize moving objects behind their physical positio

147 ifically alters EC directional migration and mislocalized MT organizing center (MTOC)/Golgi and myosi

148 Additionally, the mislocalized Muller cells are observed in the photorecep

149 On the other, the mislocalized mutant PTEN results in a significantly decr

150 ociated with previously characterized matrix-mislocalized-mutant tafazzins to include the rapid degra

151 In contrast, defective farnesylation mislocalizes nascent adhesion sites, suggesting that LKB

152 ivo, dysferlin null muscle was found to have mislocalized nuclei and vacuolation.

153 l or phototransduction defects in cones with mislocalized nuclei, their dark adaptation was impaired,

154 topes abolishes binding to the karyopherins, mislocalized NXF1 to the cytoplasm, and significantly co

155 sin-2, a major anterograde IFT motor, causes mislocalized opsin, followed by rapid cell death.

156 t likely results secondarily from binding to mislocalized opsin.

157 Immunofluorescence correctly identified mislocalized or absent staining in 100% of the discovery

158 , localizing to the position of PGCs whether mislocalized or trapped in the endoderm.

159 So far, little is known about how defective, mislocalized, or abnormally accumulated membrane protein

160 pole plasm posteriorly and in degrading any mislocalized Oskar that results from leaky translational

161 Miranda mislocalizes oskar mRNA/Staufen complexes to the oocyte

162 Third, when the RTF2 protein is mislocalized outside the nucleus, it is not able to rest

163 SS2 expression was increased and the protein mislocalized over the entire tumor cell membrane.

164 A Pins S401A mutant mislocalizes over the cell cortex and causes spindle ori

165 spadias is a urethral tube defect defined by mislocalized, oversized, or multiple openings of the pen

166 tablishing its function as release factor of mislocalized palmitoylated proteins in the acylation cyc

167 protein thioesterases (APTs) depalmitoylate mislocalized palmitoylated proteins on endomembranes.

168 Ror2 and Wnt5a mutants with mislocalized PGCs corroborate the microenvironmental reg

169 ed two green fluorescent protein (GFP)-fused mislocalized PGK mutants, the transit peptide deletion m

170 dysregulation of Numb expression results in mislocalized Plk1 and poor centrosomal gamma-tubulin rec

171 Overexpression of Cep152 (1-217) mislocalizes Plk4, but both Cep152 and Plk4 are able to

172 The majority of the mislocalized PMCs in miR-31 KD embryos did not express V

173 ion formation as evidenced by loss of Caspr, mislocalized potassium Kv1.2 channels, and abnormal myel

174 ing to ineffective H2AX dephosphorylation by mislocalized PP4c phosphatase rather than ongoing DNA da

175 the population of prefrontal neurons grossly mislocalized presaccadic stimuli as being closer to the

176 The mechanisms of mislocalized protein (MLP) degradation are unknown.

177 hown to be important in the TRC pathway, the mislocalized protein degradation pathway, and the endopl

178 sults in a specific stabilization of a model mislocalized protein derived from the amyloid precursor

179 d demonstrate the importance of accumulating mislocalized protein per se, rather than specific signal

180 ese data reveal that, in a cellular context, mislocalized protein ubiquitination is the result of a d

181 xposed hydrophobic transmembrane domain of a mislocalized protein, thereby preventing BAG6 recruitmen

182 Mislocalized proteins (MLPs) are protected from aggregat

183 How the Asi complex selectively targets mislocalized proteins and coordinates its activity with

184 e that drives the extraction of arrested and mislocalized proteins at the mitochondrial outer membran

185 Mislocalized proteins bearing a signal sequence that did

186 wn to enhance the proteasomal degradation of mislocalized proteins by selectively promoting their ubi

187 (fs) mutations that encode DNase-active but mislocalized proteins cause disease.

188 ow that the BAG6-dependent ubiquitination of mislocalized proteins is completely reversible and ident

189 TA actively promotes the deubiquitination of mislocalized proteins that are already covalently modifi

190 t, repair, or hydrolyze mutant, damaged, and mislocalized proteins.

191 ity occurred in cells expressing the nuclear mislocalized PTEN-K62R mutant, whereas elevated cytosoli

192 r subset of cases with an unusual pattern of mislocalized punctate MHC II staining and intermediate l

193 id-1 in a forward genetic screen for mutants mislocalizing RBF-1 rabphilin, a RAB-27 effector.

194 sed NKAalpha mRNA, but due to cotransport of mislocalized rhodopsin and NKAalpha to lysosomes or auto

195 Mislocalized rhodopsin causes photoreceptor degeneration

196 On the plasma membrane, mislocalized rhodopsin extracts NKAalpha and sends it to

197 In the absence of the VXPX motif, mislocalized rhodopsin is actively cleared through secre

198 These combined studies suggest that mislocalized rhodopsin leads to photoreceptor dysfunctio

199 ciliary membrane projections that accumulate mislocalized rhodopsin.

200 nism of photoreceptor degeneration caused by mislocalized rhodopsin.

201 indings thus describe a novel link between a mislocalized RNA binding protein implicated in ALS (RBM4

202 We propose that in retinal disease, mislocalized rod opsin gains access to cAMP signaling, w

203 y, mislocalized M-opsin was degraded whereas mislocalized S-opsin accumulated in Lrat(-)(/-) cones be

204 Thus, we demonstrate that high levels of mislocalized SCRIB functions as a neomorph to promote ma

205 serving as a sensor of DNA from pathogens or mislocalized self-DNA.

206 ions and eliminating the need for washout of mislocalized sensor.

207 n results in unstable dendritic protrusions, mislocalized shaft-synapses, and loss of compartmentaliz

208 m (M)-wavelength opsin was degraded, whereas mislocalized short (S)-wavelength opsin accumulated befo

209 also appear when the septal protein FtsZ is mislocalized, suggesting that peptidoglycan modification

210 upled to pervasive incorporation of H2A.Z by mislocalized SWR-C alters chromatin composition and cont

211 The mitochondrial AAA-ATPase Msp1 removes mislocalized TA proteins from the OMM, but it is unclear

212 r framework for Msp1-dependent extraction of mislocalized TA proteins from the outer mitochondrial me

213 AAA+ ATPase Msp1 limits the accumulation of mislocalized TA proteins on mitochondria.

214 ht promote the extraction and degradation of mislocalized TA proteins to maintain mitochondrial integ

215 Likely as a result of failing to extract mislocalized TA proteins, yeast with combined mutation o

216 Mislocalized tail-anchored (TA) proteins of the outer mi

217 ATPase Msp1 is well known for extraction of mislocalized tail-anchored ER proteins from the mitochon

218 The AAA protein Msp1 extracts mislocalized tail-anchored membrane proteins and targets

219 ial membrane, where it is thought to extract mislocalized tail-anchored proteins.

220 In a genetic screen for mutants that mislocalize the dendritic marker human transferrin recep

221 Mutations that alter cell curvature and mislocalize the intermediate filament crescentin cluster

222 Septin mutants mislocalize the leading-edge protein (LEP) complex requi

223 events ATR activation through its ability to mislocalize the MRN complex.

224 epleting each presumed trafficking component mislocalizes the same set of apical membrane molecules b

225 he tumor suppressor p53 in human cells, thus mislocalizing the proteins in the cytosol.

226 Once mislocalized, they are recognized by the Hsp70 chaperone

227 Two distinct truncating mutants were mislocalized throughout the axon and phenocopied the arr

228 ferred into human cells, Bax was found to be mislocalized, thus preventing its characterization in a

229 tic vesicles and active zone proteins mostly mislocalize to dendrites in animals defective for both P

230 his system causes a subset of TA proteins to mislocalize to mitochondria.

231 n-prone RNA-binding proteins that in ALS can mislocalize to the cytoplasm of affected motor neuron ce

232 ail to develop properly, and some OS markers mislocalize to the inner segments and outer nuclear laye

233 t SAMHD1 mutants of the cyclin-binding motif mislocalized to a nuclear compartment and had reduced ab

234 Cx32 was mislocalized to an intracellular location in hepatocytes

235 abundant in the basolateral membrane and was mislocalized to apical bundles in ap1b1 mutant hair cell

236 lls express low levels of E-cadherin that is mislocalized to cytoplasmic vesicles.

237 -33 and unc-44 mutants, axonal proteins were mislocalized to dendrites and vice versa, suggesting bid

238 xception was rhodopsin (RHO), which severely mislocalized to inner segments during the initial stage

239 tissues, Cx43 was found to be pathologically mislocalized to lateral sides of cardiomyocytes.

240 ctors involved in degradation of TA proteins mislocalized to mitochondria.

241 owed both glyphosate sensitivity and FD5-GFP mislocalized to nuclei.

242 mentia (FTD) cases, and LSD1 is specifically mislocalized to pathological protein aggregates in these

243 nucleoporins and mRNA export adaptors, were mislocalized to SGs.

244 During mitosis, Pins is mislocalized to the apical surface in the absence of Par

245 ish Clrn1; in contrast, hCLRN1(N48K) largely mislocalized to the cell body with a small amount reachi

246 ated mimetic mutant failed to bind TNPO3 and mislocalized to the cell cytoplasm.

247 -DD-overexpressing cells, Dia1 and Dia2 were mislocalized to the contractile ring, and cells exhibite

248 tochemical analysis also showed that p27 was mislocalized to the cytoplasm in the majority of osteosa

249 Ect2 is overexpressed and mislocalized to the cytoplasm of NSCLC cells where it bi

250 addition, FSGS-linked ACTN4 mutants not only mislocalized to the cytoplasm, but also lost their abili

251 These results suggest that mutant TDP-43 is mislocalized to the cytoplasm, where it exhibits a toxic

252 W-E) in complex with CDK2 are preferentially mislocalized to the cytoplasm.

253 aroid and nuclear pore complex proteins were mislocalized to the cytoplasm.

254 oteinopathies, in which this protein becomes mislocalized to the cytoplasm; however, it is unclear wh

255 ized to peroxisomes in 4-d-old seedlings but mislocalized to the cytosol in 8-d-old seedlings.

256 CTR1 was similarly mislocalized to the cytosol in the heart of knockin mice

257 cases of Alzheimer disease it is cleaved and mislocalized to the cytosol, leading to accumulation.

258 om the exceedingly minor fraction of protein mislocalized to the cytosol.

259 cGAS mutants defective for lipid binding are mislocalized to the cytosolic and nuclear compartments.

260 esynapses of this cholinergic motoneuron are mislocalized to the dendrite at the ventral side: inacti

261 aN13) lacking the first 13 residues was also mislocalized to the endoplasmic reticulum although it re

262 ations present in the stem domain of POMGnT1 mislocalized to the endoplasmic reticulum, highlighting

263 ues) exhibited undetectable activity and was mislocalized to the endoplasmic reticulum, suggesting th

264 Further, mutant receptors were mislocalized to the inner segments and perinuclear regio

265 ly reduced in diabetic samples, where OGT is mislocalized to the matrix.

266 he tissues of these mice would be strikingly mislocalized to the nucleoplasm, but this was not the ca

267 HDAC4 was mislocalized to the nucleus in PD iPSC-derived dopamine

268 ro studies suggest that the mutant CCDC66 is mislocalized to the nucleus relative to wild type CCDC66

269 ytoplasmic intermediate filament network and mislocalized to the nucleus.

270 In addition, cone opsin mislocalized to the outer nuclear layer and the outer pl

271 articularly prominent with OspC mutants that mislocalized to the periplasm or contained C-terminal ep

272 otably, opsin stimulated sprouting only when mislocalized to the plasmalemma of the rod cell body.

273 We found that rhodopsin mislocalized to the PM is actively internalized and tran

274 The novel GPR161 rare variants mislocalized to the primary cilia, dysregulated Shh and

275 We previously reported that XPA mislocalized to the progerin-induced DNA double-strand b

276 y injury to other peripheral axons that were mislocalized to the skin, neighboring skin cells, and ma

277 ouse line) exhibited hyperphosphorylated tau mislocalized to the somatodentritic domain of neurons, b

278 First, tau mislocalizes to dendritic spines, in a manner that depen

279 HTau-S199-P mislocalizes to dendritic spines, which induces synaptic

280 ot only depleted but the residual PKA-Calpha mislocalizes to heavier cell fractions and is not phosph

281 ciliary basal body, whereas defective TAPT1 mislocalizes to the cytoplasm and disrupts Golgi morphol

282 cated in the nucleus, however, in disease it mislocalizes to the cytoplasm where it aggregates to for

283 eficient Env7C13-15S is also kinase dead and mislocalizes to the cytoplasm.

284 The remaining P23H-hRho-GFP mislocalizes to the inner segment and outer nuclear laye

285 is deficient in the VxPx trafficking signal, mislocalizes to the plasma membrane (PM) of rod photorec

286 Although proteolysis prevents CENP-A from mislocalizing to euchromatin, regulatory factors have no

287 These new tools were used to mislocalize transmembrane and cytoplasmic GFP fusion pro

288 ubuloreticular and sarcolemmal membranes and mislocalized triads and mitochondria in skeletal muscle

289 DP-25 and TDP-35 and that protection against mislocalized/truncated TDP-43 was observed for HSPB8 in

290 restingly, other transmembrane proteins were mislocalized upon emc1 depletion, providing insight into

291 hypersensitive to salt stress and partially mislocalizes vacuolar proteins to the apoplast, indicati

292 Mislocalized Wee1B or Myt1 is not able to maintain meiot

293 Activation of ERSU causes the septin ring to mislocalize, which blocks ER inheritance and cytokinesis

294 -specific proteins (U1-70K, U1A and U1C), co-mislocalize with FUS to the cytoplasm in ALS patient fib

295 4,5)P2 binding, 29KE/31KE, has been shown to mislocalize within the cell, leading to particle assembl

296 nnels regulate neuronal excitability and are mislocalized within CA1 pyramidal cells in a rodent mode

297 anGAP protein is enzymatically wild type but mislocalized within cells and, for reasons that remain u

298 RAD-23 abundance is increased and RAD-23 is mislocalized within motor neurons.

299 PRX lacking O-GlcNAcylation is mislocalized within the myelin sheath of these mutant an

300 sibility that wild-type RNA binding proteins mislocalize without necessarily becoming constituents of