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1 ore, enzymes that support aECM stability are mislocalized.
2 ation at cell tips even if Mid1 is absent or mislocalized.
3 Golgi, Rh1 is aberrantly glycosylated and is mislocalized.
4 hand side of the cell or two nuclei with one mislocalized.
5 produces bicaudal embryos when oskar mRNA is mislocalized.
6 eased by 25%, and hemidesmosome proteins are mislocalized.
7 audin-3, apical tight-junction proteins, are mislocalized.
8 of membrane proteins in microvilli, is also mislocalized.
9 some other fragments lacking this region are mislocalized.
10 as rhodopsin, arrestin, and transducin, are mislocalized.
11 oteins exhibited reduced expression and were mislocalized.
12 SHORTROOT and SCARECROW are misexpressed or mislocalized.
13 ing NHE1-KRA2 because scaffolding by NHE1 is mislocalized.
14 -)Nrl(-/-) mice was minimal, and opsins were mislocalized.
15 tor, the CD is disorganized and REMPA-YFP is mislocalized.
16 tration-was disrupted, and key proteins were mislocalized.
17 e SH3 domain is overexpressed, paramyosin is mislocalized.
18 ongation zone of twd1 roots, attributable to mislocalized ABCB transporters and suppressed by an auxi
21 with suggestions that AlgL serves to degrade mislocalized alginate that is trapped in the periplasmic
22 of apical-basal polarity, such as ZO-1, were mislocalized along the lateral and basal membranes of fi
23 embrane protein 1 (ROM1), and rhodopsin were mislocalized along the microtubules to the IS, cell body
24 esulting intermicrovillar adhesion links are mislocalized along the microvillar axis rather than enri
25 swollen, but neither opsin nor arrestin was mislocalized, although IFT88 accumulated in the distal r
26 raspeckle function in human diseases because mislocalized amyotrophic lateral sclerosis (ALS)-linked
27 thological feature of ALS is cytoplasmically mislocalized and aggregated TDP-43 protein in >95% of ca
32 e ERM proteins ezrin, radixin, and moesin is mislocalized and found uniformly along the plasma membra
34 5 interact, and in the absence of A34, B5 is mislocalized and not incorporated into extracellular vir
36 cytic adaptors known to bind PI(4,5)P(2) are mislocalized and the defects in FM1-43 dye uptake and ad
37 SENP2, we observe that many nucleoporins are mislocalized and, in some cases, reduced in level when S
41 the absence of INO80, H2A.Z nucleosomes are mislocalized, and H2A.Z levels at promoters show reduced
42 ull mice, PLCbeta2 was undetectable, NHERF-1 mislocalized, and IP3 R3 more intensely stained, along w
43 of JAM-A, other tight junction proteins were mislocalized, and pseudocanaliculi, which form the apica
44 that the STGD3 truncated mutant may generate mislocalized, and therefore toxic, keto intermediates of
48 ed reduced expression of CD103 (Itgae), were mislocalized away from airway epithelia, and demonstrate
49 E6 attenuates repair by causing RAD51 to be mislocalized away from both transient and persistent DSB
50 -eGFP and RhoaCT32-eGFP fusion proteins were mislocalized away from the plasma membrane in embryonic
52 ce of Crumbs or aPKC phosphorylation of Baz, mislocalized Baz recruits adherens junction components a
53 aberrant particles, in which the vRNPs were mislocalized between the CA lattice and the viral lipid
56 rains lacking substrates that are toxic when mislocalized, both LolA and LolB can be completely bypas
58 abnormal anchorage of radial glial endfeet, mislocalized Cajal-Retzius cells, and neuronal overmigra
59 tion of CLASP2 in migrating neurons leads to mislocalized cells in deeper cortical layers, abnormal p
60 n autoimmune pancreatitis (AIP) by restoring mislocalized CFTR protein to the apical ductal membrane.
63 estion, we generated knockin mice expressing mislocalized cytoplasmic FUS and complete FUS knockout m
64 -43 (hTDP-43-WT) to determine the effects of mislocalized cytoplasmic TDP-43 on neuronal viability.
65 ggregation within motor neurons by reducing (mislocalized) cytoplasmic TDP-43, TDP-43 aggregation and
66 s capacity for mesenchymal condensation with mislocalized distributions of chondroitin sulfate proteo
69 In summary, we demonstrate that claudin-7 is mislocalized during the malignant transformation of esop
72 increased expression of aquaporin-2 mRNA but mislocalized expression of aquaporin-2 protein in the cy
74 mplified, mRNA overexpressed, and protein is mislocalized from cell-cell junctions in human breast ca
76 ly expressed and associated, but retromer is mislocalized from neuropil to soma with the Rab7 GTPase.
78 the remaining alpha- and beta-subunits were mislocalized from the light-sensitive outer segment comp
83 and mRNA splicing patterns, indicating that mislocalized FUS results in loss of its normal function.
84 Rock inhibition increased the generation of mislocalized ganglion/amacrine cells at the expense of r
86 y (Mla) pathway has been proposed to extract mislocalized glycerophospholipids from the outer leaflet
92 NA processing, are abnormally aggregated and mislocalized in ALS and FTLD, while the expansion in the
94 eoblast stem cells and progenitor cells were mislocalized in beta1-integrin(RNAi) animals without sig
95 n-1 loss-of-function (lf) mutants, SLO-1 was mislocalized in body-wall muscle but its transcription a
96 likely conserved substrate of fly CCT and is mislocalized in both cct and in dfmr1 mutant embryos.
97 d, an apically localized adaptor protein, is mislocalized in both crb mutant cells and Crb overexpres
98 ronal progenitors, becomes overexpressed and mislocalized in cancer cells from a variety of human tum
103 the key lipid metabolizing enzyme, lipin, is mislocalized in dTorsin-KO cells, and dTorsin increases
107 t germ cell nuclei, nucleoporins (Nups) were mislocalized in large plaques beginning at meiotic entry
108 he nuclear envelope protein emerin, which is mislocalized in Lmna mutant cells and also linked to EDM
112 nd a recently identified Chk1 substrate, was mislocalized in mitotic Chk1(+/-) mammary epithelia.
114 luR localization are also grossly reduced or mislocalized in mtg mutants, including the dPix-dPak-Doc
115 nstrated that viral capsids assemble but are mislocalized in nuclei of cells infected with the mutant
118 ylated rod PDE6 catalytic subunits partially mislocalized in Pde6d(-/-) rods, whereas rhodopsin was u
119 ulator of rhodopsin ciliary trafficking, was mislocalized in photoreceptor cells of rpgrip1 mutants.
125 , endothelial cells with venous identity are mislocalized in the aorta, suggesting that ephrin B2/Eph
126 the cytoskeleton protein betaII spectrin are mislocalized in the axon, and assembly of the node of Ra
131 ochlea in vivo; however, tricellulin becomes mislocalized in the inner ear sensory epithelia of ILDR1
135 Moreover, the tight junction protein ZO-1 is mislocalized in the tal1-deficient endocardium, indicati
138 lar chaperone that is often up-regulated and mislocalized in tumors with abnormal activation of the k
139 ane cell fate regulator, SCRAMBLED (SCM), is mislocalized in ugt80B1 mutants, underscoring the aberra
141 hese transgenic rods without chromophore was mislocalized; in R-opsin's presence, however, S-opsin tr
145 isplay defective cell polarity, resulting in mislocalized junctional complexes and loss of adhesion t
146 Silencing of GPR31 expression partially mislocalized KRAS4B, slowed the growth of KRAS-dependent
148 ress response pathways that are activated by mislocalized lipopolysaccharide may collectively contrib
151 opsins mistrafficked as reported previously, mislocalized M-opsin was degraded whereas mislocalized S
154 , UBQLN1 plays an important role in clearing mislocalized mitochondrial proteins upon cell stimulatio
156 ifically alters EC directional migration and mislocalized MT organizing center (MTOC)/Golgi and myosi
159 ociated with previously characterized matrix-mislocalized-mutant tafazzins to include the rapid degra
160 A activity resulting, in part, from severely mislocalized myospryn and the type II regulatory subunit
162 l or phototransduction defects in cones with mislocalized nuclei, their dark adaptation was impaired,
163 otably, all types of defective spindles have mislocalized NuMA (nuclear mitotic apparatus protein), a
164 topes abolishes binding to the karyopherins, mislocalized NXF1 to the cytoplasm, and significantly co
167 Immunofluorescence correctly identified mislocalized or absent staining in 100% of the discovery
169 So far, little is known about how defective, mislocalized, or abnormally accumulated membrane protein
170 pole plasm posteriorly and in degrading any mislocalized Oskar that results from leaky translational
171 (Psp) stress response system is activated by mislocalized outer-membrane secretin components of prote
174 spadias is a urethral tube defect defined by mislocalized, oversized, or multiple openings of the pen
175 tablishing its function as release factor of mislocalized palmitoylated proteins in the acylation cyc
176 protein thioesterases (APTs) depalmitoylate mislocalized palmitoylated proteins on endomembranes.
179 ed two green fluorescent protein (GFP)-fused mislocalized PGK mutants, the transit peptide deletion m
180 dysregulation of Numb expression results in mislocalized Plk1 and poor centrosomal gamma-tubulin rec
182 ion formation as evidenced by loss of Caspr, mislocalized potassium Kv1.2 channels, and abnormal myel
183 ing to ineffective H2AX dephosphorylation by mislocalized PP4c phosphatase rather than ongoing DNA da
184 the population of prefrontal neurons grossly mislocalized presaccadic stimuli as being closer to the
186 hown to be important in the TRC pathway, the mislocalized protein degradation pathway, and the endopl
187 sults in a specific stabilization of a model mislocalized protein derived from the amyloid precursor
188 d demonstrate the importance of accumulating mislocalized protein per se, rather than specific signal
189 ese data reveal that, in a cellular context, mislocalized protein ubiquitination is the result of a d
190 xposed hydrophobic transmembrane domain of a mislocalized protein, thereby preventing BAG6 recruitmen
193 e that drives the extraction of arrested and mislocalized proteins at the mitochondrial outer membran
195 wn to enhance the proteasomal degradation of mislocalized proteins by selectively promoting their ubi
197 ow that the BAG6-dependent ubiquitination of mislocalized proteins is completely reversible and ident
198 TA actively promotes the deubiquitination of mislocalized proteins that are already covalently modifi
200 ity occurred in cells expressing the nuclear mislocalized PTEN-K62R mutant, whereas elevated cytosoli
201 r subset of cases with an unusual pattern of mislocalized punctate MHC II staining and intermediate l
203 sed NKAalpha mRNA, but due to cotransport of mislocalized rhodopsin and NKAalpha to lysosomes or auto
210 indings thus describe a novel link between a mislocalized RNA binding protein implicated in ALS (RBM4
212 y, mislocalized M-opsin was degraded whereas mislocalized S-opsin accumulated in Lrat(-)(/-) cones be
214 Thus, we demonstrate that high levels of mislocalized SCRIB functions as a neomorph to promote ma
219 n results in unstable dendritic protrusions, mislocalized shaft-synapses, and loss of compartmentaliz
220 m (M)-wavelength opsin was degraded, whereas mislocalized short (S)-wavelength opsin accumulated befo
223 ular basement membrane marker collagen IV is mislocalized, suggesting that ECs fail to recognize the
224 also appear when the septal protein FtsZ is mislocalized, suggesting that peptidoglycan modification
225 upled to pervasive incorporation of H2A.Z by mislocalized SWR-C alters chromatin composition and cont
227 The mitochondrial AAA-ATPase Msp1 removes mislocalized TA proteins from the OMM, but it is unclear
228 r framework for Msp1-dependent extraction of mislocalized TA proteins from the outer mitochondrial me
230 ht promote the extraction and degradation of mislocalized TA proteins to maintain mitochondrial integ
231 Likely as a result of failing to extract mislocalized TA proteins, yeast with combined mutation o
233 ATPase Msp1 is well known for extraction of mislocalized tail-anchored ER proteins from the mitochon
239 ferred into human cells, Bax was found to be mislocalized, thus preventing its characterization in a
240 t SAMHD1 mutants of the cyclin-binding motif mislocalized to a nuclear compartment and had reduced ab
242 abundant in the basolateral membrane and was mislocalized to apical bundles in ap1b1 mutant hair cell
245 -33 and unc-44 mutants, axonal proteins were mislocalized to dendrites and vice versa, suggesting bid
246 percentage of C150S-Rds and cone opsins were mislocalized to different cellular compartments in cones
247 xception was rhodopsin (RHO), which severely mislocalized to inner segments during the initial stage
251 mentia (FTD) cases, and LSD1 is specifically mislocalized to pathological protein aggregates in these
254 ish Clrn1; in contrast, hCLRN1(N48K) largely mislocalized to the cell body with a small amount reachi
256 -DD-overexpressing cells, Dia1 and Dia2 were mislocalized to the contractile ring, and cells exhibite
258 tochemical analysis also showed that p27 was mislocalized to the cytoplasm in the majority of osteosa
261 addition, FSGS-linked ACTN4 mutants not only mislocalized to the cytoplasm, but also lost their abili
262 These results suggest that mutant TDP-43 is mislocalized to the cytoplasm, where it exhibits a toxic
265 oteinopathies, in which this protein becomes mislocalized to the cytoplasm; however, it is unclear wh
269 cases of Alzheimer disease it is cleaved and mislocalized to the cytosol, leading to accumulation.
271 cGAS mutants defective for lipid binding are mislocalized to the cytosolic and nuclear compartments.
272 esynapses of this cholinergic motoneuron are mislocalized to the dendrite at the ventral side: inacti
273 aN13) lacking the first 13 residues was also mislocalized to the endoplasmic reticulum although it re
274 ations present in the stem domain of POMGnT1 mislocalized to the endoplasmic reticulum, highlighting
275 ues) exhibited undetectable activity and was mislocalized to the endoplasmic reticulum, suggesting th
279 he tissues of these mice would be strikingly mislocalized to the nucleoplasm, but this was not the ca
281 ro studies suggest that the mutant CCDC66 is mislocalized to the nucleus relative to wild type CCDC66
284 articularly prominent with OspC mutants that mislocalized to the periplasm or contained C-terminal ep
285 otably, opsin stimulated sprouting only when mislocalized to the plasmalemma of the rod cell body.
289 y injury to other peripheral axons that were mislocalized to the skin, neighboring skin cells, and ma
290 ouse line) exhibited hyperphosphorylated tau mislocalized to the somatodentritic domain of neurons, b
291 D1 (PIN1), PIN2, and AUXIN-RESISTANT1 (AUX1) mislocalized to the vacuolar membrane of the mutant.
292 ubuloreticular and sarcolemmal membranes and mislocalized triads and mitochondria in skeletal muscle
293 DP-25 and TDP-35 and that protection against mislocalized/truncated TDP-43 was observed for HSPB8 in
294 restingly, other transmembrane proteins were mislocalized upon emc1 depletion, providing insight into
296 nnels regulate neuronal excitability and are mislocalized within CA1 pyramidal cells in a rodent mode
297 anGAP protein is enzymatically wild type but mislocalized within cells and, for reasons that remain u
299 which are null for lamins A/C, LAP2alpha is mislocalized within nuclear aggregates, and this is corr