ライフサイエンスコーパス: mitochondrial DNA

1 genetic instability in both chromosomal and mitochondrial DNA.

2 amics, telomere fragility and instability of mitochondrial DNA.

3 ng yeast and the signature of aging in human mitochondrial DNA.

4 y have been restricted to short fragments of mitochondrial DNA.

5 atients with visual loss and mutated G11778A mitochondrial DNA.

6 using newly synthesized DNA strands in human mitochondrial DNA.

7 ing short-term viral diseases, which degrade mitochondrial DNA.

8 xygen species production; the NETs contained mitochondrial DNA.

9 cells from ferroptotic death and release of mitochondrial DNA.

10 Given that TLR9 can respond to mitochondrial DNA, a danger signal that is released upon

11 toid dendritic cells activated with oxidized mitochondrial DNA, a distinct class of interferogenic to

12 us, NEIL1 and NEIL2 DNA glycosylases protect mitochondrial DNA against oxidative damage during neural

13 ation promoted excess cytosolic extrusion of mitochondrial DNA along with increased reactive oxygen s

14 sing 143B rho (0) (rho zero) cells devoid of mitochondrial DNA and biochemical assays in UT-SCC-74B c

15 ic morphometrics numerical taxonomy, ancient mitochondrial DNA and direct radiocarbon dating.

16 ualization and sequencing with overall lower mitochondrial DNA and duplicated sequences interference

17 f K. ocellatus along its distribution, using mitochondrial DNA and microsatellites to compare its pat

18 Genetic analyses, based on mitochondrial DNA and microsatellites, revealed consider

19 tudies are now required to determine whether mitochondrial DNA and mitochondrial dysfunction contribu

20 iation with low bronchoalveolar lavage fluid mitochondrial DNA and more severe disease.

21 that such treatment would cause depletion of mitochondrial DNA and provide insight into the consequen

22 e genetic information in their small genome (mitochondrial DNA) and the nucleus.

23 cytotoxic but caused up to 60% depletion of mitochondrial DNA, and a similar reduction in mitochondr

24 lating (c-)microRNAs (miRs), c-proteasome, c-mitochondrial DNA, and cytokines were assessed by real-t

25 prehensive genomic analysis of Y chromosome, mitochondrial DNA, and whole-genome sequence variations

26 orsemeat using just 50 ng of total extracted mitochondrial DNA ( approximately 16660 bp in length) wi

27 es may reveal if the patterns here shown for mitochondrial DNA are also reflected in the nuclear geno

28 Variations in mitochondrial DNA are associated with development of and

29 In this paper, using the D-loop of mitochondrial DNA as a maternally inherited genetic mark

30 We also obtained a mitochondrial DNA-based phylogeny using published genome

31 tero have reduced telomere length, decreased mitochondrial DNA biogenesis and increased oxidative str

32 d oviducts also showed evidence of decreased mitochondrial DNA biogenesis, reduced mtDNA copy number

33 tions showed rich fragmentation patterns for mitochondrial DNA but not for microsatellites, compatibl

34 We show that somatic mutations in mitochondrial DNA can reconstruct cell lineage relations

35 their relationship to circulating cell-free mitochondrial DNA (ccf-mtDNA) in HIV-infected patients a

36 Likewise, circulating, cell-free mitochondrial DNA (ccf-mtDNA) is under similar investiga

37 Here we show that cell-free mitochondrial DNA (cf-mt-DNA) released by senescent cell

38 Cell-free mitochondrial DNA (cfmtDNA) is detectable in almost all

39 ta, dated on the assumption of a "universal" mitochondrial DNA clock are not valid.

40 ear DNA and yet carried different sources of mitochondrial DNA, CMs derived from iPSC and nt-ESCs cou

41 Mitochondrial DNA-CN further improved sensitivity and sp

42 The genes in mitochondrial DNA code for essential subunits of the res

43 central vision associated with mutations in mitochondrial DNA coding for components of complex I.

44 Sequencing of genomic and mitochondrial DNA confirmed the intergeneric hybrid natu

45 impairments were coupled with alterations in mitochondrial DNA content and expression of genes associ

46 We detected reduced mitochondrial DNA content in biopsies of heterotaxy pati

47 d by increased uncoupled oxygen consumption, mitochondrial DNA content, and voltage-dependent anion c

48 idative stress, which can lead to changes in mitochondrial DNA copy number (mtDNAcn).

49 mitochondrial biogenesis and restoration of mitochondrial DNA copy number (p < 0.05).

50 (ETC) coordinated with an increase in tumor mitochondrial DNA copy number and a strong threshold eff

51 septic patients on day 1 (p < 0.05), whereas mitochondrial DNA copy number fell and plasma D-loop inc

52 diation analysis estimated that decreases in mitochondrial DNA copy number, a measure of mitochondria

53 Similarly, cold induced increases in mitochondrial DNA copy number, and the protein content o

54 This was accompanied by lower mitochondrial DNA copy numbers (p < 0.001), mtND1 expres

55 rosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis.

56 sies from patients with DKD showed increased mitochondrial DNA damage associated with glomerular endo

57 Mechanistically, nuclear and mitochondrial DNA damage in SMCs and the subsequent leak

58 Mitochondrial DNA damage was robustly increased in PD pa

59 g, nuclear area enlargement, and genomic and mitochondrial DNA damage, leading to irreversible cell c

60 te poly ADP-ribose polymerase activation and mitochondrial DNA damage.

61 Mitochondrial DNA-depleted RPE cells demonstrated enhanc

62 ucleic acid metabolism may interact with the mitochondrial DNA depletion of MNGIE.

63 could be limited by CGAS or STING knockdown, mitochondrial DNA depletion or mitochondrial outer membr

64 We conclude that ddI-mediated mitochondrial DNA depletion promotes a glycolytic shift

65 Genetic clusters inferred from mitochondrial DNA differed from those based on SNPs and

66 Our findings suggest that MT-ATP6-related mitochondrial DNA disease is best conceptualized as a mi

67 e fossil stem calibrations, we estimated the mitochondrial DNA divergence between cave lions and lion

68 ease in the cellular level of FA can trigger mitochondrial DNA double-strand breaks and dysfunction.

69 a and the lysosome; including instability of mitochondrial DNA due to the lack of the DNA repair nucl

70 g in PERK-deficient MDSCs elicited cytosolic mitochondrial DNA elevation and, consequently, STING-dep

71 In addition, both nuclear- and mitochondrial-DNA encoded oxidative phosphorylation (OxP

72 ssue of Cell, Zhao et al. (2020) reveal that mitochondrial DNA-encoded circRNAs interact with ATP syn

73 The CcO core is formed by mitochondrial DNA-encoded Cox1, Cox2, and Cox3 subunits.

74 disorder subjects showed that the changes in mitochondrial DNA-encoded genes are a feature generalizi

75 ression analysis revealed that in particular mitochondrial DNA-encoded subunits of the oxidative phos

76 Mitochondrial DNA encodes many of the ETC components.

77 chondrial disease caused by mutations in the mitochondrial DNA encoding complex I subunits.

78 nflammatory functions of hepatocyte-derived, mitochondrial DNA-enriched extracellular vesicles, there

79 separately and in combination with published mitochondrial DNA evidence, to assess the relationships

80 e describe the stratigraphy, chronology, and mitochondrial DNA extracted from the sediments in BKC.

81 Concordantly, mitochondrial DNA failed to show meaningful CpG methylat

82 d by accumulation of gammaH2A.X and 53BP1 at mitochondrial DNA foci.

83 depletion of ribosomal RNA for mRNA-seq and mitochondrial DNA for ATAC-seq, our method allows for gr

84 ribosomal DNA 18S-ITS-5.8S, 28S D2/D3 and a mitochondrial DNA fragment flanking cytochrome oxidase g

85 o-date tool to reconstruct and analyze human mitochondrial DNA from NGS data and (iii) the implementa

86 We recover Denisovan mitochondrial DNA from sediments deposited ~100 thousand

87 Morphological analysis of a tooth and mitochondrial DNA from several hominin bone fragments, i

88 Remarkably, mitochondria, and thereby mitochondrial DNA from the parental cells, did not mix u

89 Mitochondrial DNA gene expression is coordinately regula

90 deficient in essential factors required for mitochondrial DNA gene expression, leading to OXPHOS dys

91 Mitochondrial DNA genealogies recover significant region

92 ht to test the hypothesis that variations in mitochondrial DNA haplogroup affect susceptibility to se

93 The 7% of Caucasians belonging to mitochondrial DNA haplogroup clade IWX experienced more

94 We determined each patient's mitochondrial DNA haplogroup using single-nucleotide pol

95 to analyze age-adjusted associations between mitochondrial DNA haplogroups and duration of delirium,

96 males and females; however Y chromosome and mitochondrial DNA haplogroups were not associated with a

97 e we report that bacterial DNA (CpG DNA) and mitochondrial DNA impair phagocytosis and attenuate phag

98 treatment to induce progressive depletion of mitochondrial DNA in differentiated human RPE cells shou

99 ence micrographs, which show the presence of mitochondrial DNA in M. squamalis, but not in H. salmini

100 re significantly lower levels of circulating mitochondrial DNA in recipients receiving EVLP lungs com

101 Experiments on mitochondrial DNA in worms highlight that cheating does

102 icated in the assembly of OM proteins and in mitochondrial DNA inheritance.

103 nt in oxidative environments cause damage to mitochondrial DNA, initiating signaling pathways that li

104 ondrial energy production, oxidative stress, mitochondrial DNA instability, abnormalities in the regu

105 hondrial respiratory capacity and release of mitochondrial DNA into the cytosol.

106 When mitochondrial DNA is depleted from the cells, we observe

107 Expression of human mitochondrial DNA is indispensable for proper function o

108 These findings show that detection of tumor mitochondrial DNA is more sensitive than circulating tum

109 Human mitochondrial DNA is transcribed by POLRMT with the help

110 iasis, HAT), contains a kinetoplast with the mitochondrial DNA (kDNA), comprising of >70% AT base pai

111 Diabetic D2 mice manifested increased mitochondrial DNA lesions (8-oxoguanine) exclusively loc

112 udied the adenocarcinoma cell line A549, its mitochondrial DNA-less derivative A549 rho degrees and c

113 ad geographic range using microsatellite and mitochondrial DNA loci.

114 ded by the nuclear gene TK2, is required for mitochondrial DNA maintenance.

115 l this gap in knowledge, we used nuclear and mitochondrial DNA markers to assess genetic diversity, g

116 digital PCR (ddPCR) method, droplet digital mitochondrial DNA measurement (ddMDM), to measure mtDNA

117 control: 784 +/- 27 compared with 675 +/- 30 mitochondrial DNA molecules per cell; P < 0.05).

118 In 1971, many mitochondrial DNA molecules were found to have a third s

119 Mitochondrial DNA ((mt)DNA), NAD + and ATP levels, and m

120 Mitochondrial DNA (mtDNA) 3243A > G tRNALeu((UUR)) heter

121 Cytosolic mitochondrial DNA (mtDNA) activates cGAS-mediated antivi

122 The combined analysis of nuclear and mitochondrial DNA (mtDNA) allows rapid diagnosis for the

123 of a certain level of rNMPs is tolerated in mitochondrial DNA (mtDNA) although aberrant mtDNA rNMP c

124 arge-scale somatically acquired mutations in mitochondrial DNA (mtDNA) and consecutive respiratory ch

125 UVA irradiation caused greater mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) damage

126 me, CCPAP tumors exhibit severe depletion of mitochondrial DNA (mtDNA) and RNA and high levels of oxi

127 Disease-associated variants in mitochondrial DNA (mtDNA) are frequently heteroplasmic,

128 entified to secrete greater concentration of mitochondrial DNA (mtDNA) compared to noncancer epitheli

129 Mitochondrial DNA (mtDNA) content and telomere length ar

130 verse relationship between AR expression and mitochondrial DNA (mtDNA) content and transcription fact

131 nds crucially on the maintenance of multiple mitochondrial DNA (mtDNA) copies.

132 Low mitochondrial DNA (mtDNA) copy number (CN) is a predicto

133 try in these populations, we first show that mitochondrial DNA (mtDNA) copy number decreases with inc

134 Mitochondrial DNA (mtDNA) copy number in leukocytes has

135 ity ratio, distant pedigree computation, and mitochondrial DNA (mtDNA) copy number inference.

136 Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evol

137 overed that the LRRK2 G2019S mutation causes mitochondrial DNA (mtDNA) damage and is LRRK2 kinase act

138 Despite mitochondrial DNA (mtDNA) damage and nuclear oxidative s

139 Polbeta knockout (KO) had higher endogenous mitochondrial DNA (mtDNA) damage.

140 Mitochondrial DNA (mtDNA) deletions are associated with

141 Clonal expansion of mitochondrial DNA (mtDNA) deletions is an important path

142 We describe a catalogue of 4489 putative mitochondrial DNA (mtDNA) deletions, including their fre

143 can cause mitochondrial toxicity, including mitochondrial DNA (mtDNA) depletion in several cases.

144 Mutations in POLG can cause early childhood mitochondrial DNA (mtDNA) depletion syndromes or later-o

145 Mutations in DGUOK lead to mitochondrial DNA (mtDNA) depletion typically in the liv

146 leading to transplantation, associated with mitochondrial DNA (mtDNA) depletion without accumulation

147 o detect low-frequency, de novo mutations in mitochondrial DNA (mtDNA) directly from oocytes and from

148 Mitochondrial DNA (mtDNA) encodes a subset of genes whic

149 Mitochondrial DNA (mtDNA) encodes cellular machinery vit

150 Mitochondrial DNA (mtDNA) encodes proteins and RNAs that

151 To fill this gap, we analyzed ancient mitochondrial DNA (mtDNA) from Scythians of the North Po

152 uction, are under dual genetic control by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear gen

153 The mitochondrial DNA (mtDNA) genome is indispensable for mi

154 We investigated the association between mitochondrial DNA (mtDNA) haplogroups and the homeostati

155 Although mitochondrial DNA (mtDNA) haplotype variation is often a

156 Heteroplasmy-the presence of multiple mitochondrial DNA (mtDNA) haplotypes in an individual-ca

157 While analysis of 139 bp of mitochondrial DNA (mtDNA) has confirmed that the Indian

158 In recent years mitochondrial DNA (mtDNA) has transitioned to greater pr

159 Mitochondrial DNA (mtDNA) heteroplasmies are associated

160 ation sequencing reveal the crucial roles of mitochondrial DNA (mtDNA) in various pathophysiological

161 ctive oxygen species (ROS), membrane damage, mitochondrial DNA (mtDNA) integrity, morphology, phenoty

162 Mitochondrial stress releases mitochondrial DNA (mtDNA) into the cytosol, thereby trig

163 The synthesis of mitochondrial DNA (mtDNA) is a complex process that invo

164 Mitochondrial DNA (mtDNA) is damaged, the transcription

165 Here, we report that mammalian mitochondrial DNA (mtDNA) is enriched for 6mA.

166 Mitochondrial DNA (mtDNA) is essential for cell viabilit

167 Precise gene editing of mitochondrial DNA (mtDNA) is essential for the generatio

168 ds of evidence question the dogma that human mitochondrial DNA (mtDNA) is inherited exclusively down

169 Mitochondrial DNA (mtDNA) is present at hundreds to thou

170 Although mitochondrial DNA (mtDNA) is prone to accumulate mutatio

171 Mitochondrial DNA (mtDNA) is typically inherited from on

172 the optic nerve associated with one of three mitochondrial DNA (mtDNA) m.3460G>A, m.11778G>A and m.14

173 pyrimidine salvage pathway, is essential for mitochondrial DNA (mtDNA) maintenance.

174 Somatic mitochondrial DNA (mtDNA) mutations accumulate with age

175 Little is known about the spectrum of mitochondrial DNA (mtDNA) mutations across pediatric mal

176 Diseases associated with mitochondrial DNA (mtDNA) mutations are highly variable

177 Furthermore, mitochondrial DNA (mtDNA) mutations associated with NADH

178 Mitochondrial DNA (mtDNA) mutations cause severe congeni

179 Natural mitochondrial DNA (mtDNA) mutations enable the inference

180 Mitochondrial DNA (mtDNA) mutations have been associated

181 Mutations of mitochondrial DNA (mtDNA) often underlie mitochondrial d

182 Selfish or cheater mitochondrial DNA (mtDNA) proliferates within hosts whil

183 ired apurinic/apyrimidinic site (AP site) in mitochondrial DNA (mtDNA) promotes misincorporation of n

184 ssociated with the formation of pathological mitochondrial DNA (mtDNA) rearrangements.

185 pair mitochondrial homeostasis, resulting in mitochondrial DNA (mtDNA) release and activation of cyto

186 which formed mitochondrial pores and induced mitochondrial DNA (mtDNA) release into the cytosol of en

187 Knowledge of the molecular events in mitochondrial DNA (mtDNA) replication is crucial to unde

188 utations in genes encoding components of the mitochondrial DNA (mtDNA) replication machinery cause mt

189 Mitochondrial DNA (mtDNA) replication uses a simple core

190 Three models have been proposed for mitochondrial DNA (mtDNA) replication, and one of the ke

191 Mitochondrial DNA (mtDNA) resides in a high ROS environm

192 Loss of mitochondrial DNA (mtDNA) results in loss of mitochondri

193 Alterations in mitochondrial DNA (mtDNA) sequence and copy number are i

194 Here we use a dataset of mitochondrial DNA (mtDNA) sequences (n = 1327) and nucle

195 Mitochondrial DNA (mtDNA) sequences that are predicted t

196 , we performed whole genome sequencing, deep mitochondrial DNA (mtDNA) sequencing, and tested for mit

197 This was tested using a major mitochondrial DNA (mtDNA) survey and sequencing of two n

198 DNA in infected cells through the release of mitochondrial DNA (mtDNA) to drive the production of cGA

199 ogenic role of mitochondrial dysfunction and mitochondrial DNA (mtDNA) variation in ME/CFS.

200 Here, we investigated the mitochondrial DNA (mtDNA) variation of 545 present-day U

201 Next-generation sequencing of mitochondrial DNA (mtDNA) was performed for 6 affected f

202 ed following incubation of HOS cells lacking mitochondrial DNA (mtDNA) with functional exogenous mito

203 ns of cell-free (cf) nuclear DNA (ncDNA) and mitochondrial DNA (mtDNA) within 24 hours post trauma wi

204 We measured mitochondrial DNA (mtDNA), an indicator of mitochondrial

205 e (reactive oxygen species (ROS) generation, mitochondrial DNA (mtDNA), and nuclear DNA (nDNA) damage

206 ory signature associated with instability of mitochondrial DNA (mtDNA), both corrected by supplementa

207 resource, namely the enzyme that replicates mitochondrial DNA (mtDNA), can alter the selective advan

208 iterature has reported numerous mutations in mitochondrial DNA (mtDNA), further fueling the notion of

209 Base editing within mitochondrial DNA (mtDNA), however, has thus far been hi

210 We targeted the maternally inherited mitochondrial DNA (mtDNA), known to be highly informativ

211 Emerging evidence suggests that mitochondrial DNA (mtDNA), the only form of non-nuclear

212 aired mitophagy, which causes the release of mitochondrial DNA (mtDNA), thereby triggering inflammati

213 We hypothesized that de novo mutations in mitochondrial DNA (mtDNA), which has far less reliable r

214 Circulating mitochondrial DNA (mtDNA), widely studied as a disease b

215 hondrial diseases are caused by mutations in mitochondrial DNA (mtDNA).

216 hondrial diseases and guide the evolution of mitochondrial DNA (mtDNA).

217 anticipated extreme genetic variation within mitochondrial DNA (mtDNA).

218 esponsible for the replication and repair of mitochondrial DNA (mtDNA).

219 ce suggests presence of methylation marks on mitochondrial DNA (mtDNA); but their contribution in can

220 result from a heteroplasmic mutation in the mitochondrial DNA (mtDNA; m.3243A > G) at heteroplasmy l

221 gene transfer (HGT) is common in angiosperm mitochondrial DNAs (mtDNAs), few cases of functional for

222 this, we exploited the unique amenability to mitochondrial DNA mutagenesis of the yeast Saccharomyces

223 The m.3243A > G mitochondrial DNA mutation was originally described in p

224 s associated with the homoplasmic m.14674T>C mitochondrial DNA mutation; however, only ~ 1/100 carrie

225 tween maternal lifetime stress and placental mitochondrial DNA mutational load in an urban multiethni

226 nal lifetime stress in relation to placental mitochondrial DNA mutational load.

227 eyes (LHON group) with different pathogenic mitochondrial DNA mutations (group 11778: 21 eyes; group

228 Brca1KO(smi) mice accumulated mitochondrial DNA mutations and exhibited an altered mit

229 ns of correcting disease-causing nuclear and mitochondrial DNA mutations in gametes or preimplantatio

230 er premature aging caused by accumulation of mitochondrial DNA mutations in Polg(D275A) mice predispo

231 en supported by the detection of nonspecific mitochondrial DNA mutations in these disorders.

232 skeletal muscle function and that increased mitochondrial DNA mutations may represent a potential un

233 Somatically acquired mitochondrial DNA mutations predispose to elevated subch

234 rial disorders are the result of nuclear and mitochondrial DNA mutations that affect multiple organs,

235 t in muscle phenotype and an accumulation of mitochondrial DNA mutations.

236 lage were similar between groups, homozygous mitochondrial DNA mutator mice displayed elevated number

237 ld type mice with that of the PolgA(mut/mut) mitochondrial DNA 'mutator' mouse.

238 cts for HMOX1, NRF1, PPARGC1A, and TFAM, and mitochondrial DNA ND1 and D-loop were measured by quanti

239 Mitochondrial content, measured by mitochondrial DNA/nuclear DNA, was higher in sepsis on d

240 cture enabling mixing of previously discrete mitochondrial DNA nucleoids.

241 Here we analyze the mitochondrial DNA of some of the earliest purported chic

242 guished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ri

243 hese cells display perturbed cholesterol and mitochondrial DNA organization similar to that observed

244 tes mitochondrial bioenergetics, and induces mitochondrial DNA oxidative injury.

245 R-loop is present on thousands of copies of mitochondrial DNA per cell making it potentially the mos

246 Previous mitochondrial DNA phylogenies suggested that it was a hi

247 ferred from the autosomal genomes and mirror mitochondrial DNA phylogenies, indicating replacement of

248 High fidelity human mitochondrial DNA polymerase (Pol gamma) contains two ac

249 fferentially impeded the processivity of the mitochondrial DNA polymerase gamma (Pol gamma) in vitro,

250 ely on the basis of off-target inhibition of mitochondrial DNA polymerase gamma (Polgamma).

251 encodes the catalytic subunit of replicative mitochondrial DNA polymerase gamma.

252 The POLG gene encodes the mitochondrial DNA polymerase that is responsible for rep

253 ratio between POLG (the catalytic subunit of mitochondrial DNA polymerase) and POLGARF synthesized fr

254 ing 5' triphosphates were not substrates for mitochondrial DNA polymerase.

255 demonstrated that DNA synthesis by two known mitochondrial DNA polymerases (Pol gamma, PrimPol) in vi

256 stable hairpins form barriers to nuclear and mitochondrial DNA polymerases delta and gamma, respectiv

257 ription factor, preventing oxidative damage, mitochondrial DNA release, and DNA sensor-STING-dependen

258 extracellular trap (NET) formation, oxidized mitochondrial DNA release, chemotaxis, phagocytosis, deg

259 ntioxidant defence, protein quality control, mitochondrial DNA repair, mitochondrial dynamics, mitoph

260 SSBP1 is an essential protein for mitochondrial DNA replication and maintenance.

261 Pif1 helicase functions in both nuclear and mitochondrial DNA replication and repair processes, pref

262 )-binding proteins (mtSSBs) are required for mitochondrial DNA replication and stability and are gene

263 changes that are beyond its direct effect on mitochondrial DNA replication and transcription.

264 tDNA deletions in patients with mutations in mitochondrial DNA replication factors, and show that the

265 hat genes involved in aerobic respiration or mitochondrial DNA replication were either absent or pres

266 enriched in G-quadruplex regions that impede mitochondrial DNA replication.

267 The clonal reproduction of mitochondrial DNA requires workarounds to avoid mutation

268 We report ancient mitochondrial DNA results of 213 individuals (151 HVS-I

269 observe likely large rare or unique nuclear-mitochondrial DNA segments (mega-NUMTs) transmitted from

270 Specifically, loss of mitochondrial DNA sensing in Casp9(-/-) tumors abolishes

271 sociated DNA fragment procedure [ddRAD]) and mitochondrial DNA sequence data for these samples to rec

272 ect dates for hominin fragments and obtain a mitochondrial DNA sequence for one of them.

273 , we combined data on landscape features and mitochondrial DNA sequence variation for nine codistribu

274 Cytochrome oxidase I (COI) mitochondrial DNA sequences were generated from each lar

275 Eagle mitochondrial DNA sequences were homogeneous and geograp

276 Whole mitochondrial DNA sequencing was performed and mutations

277 e find frequent somatic nuclear transfers of mitochondrial DNA, some of which disrupt therapeutic tar

278 In contrast to genome-wide admixture, mitochondrial DNA stasis supports that this introgressio

279 Hypoxia, mitochondrial DNA stress, and altered redox balance each

280 strongly blocked by representative stable G4 mitochondrial DNA structures, which could be overcome in

281 e for DNA replication in hypoxic conditions, mitochondrial DNA synthesis, and in DNA repair outside t

282 n, whereas p53R2 functions in DNA repair and mitochondrial DNA synthesis.

283 Digital PCR detection of plasma tumor mitochondrial DNA (tmtDNA), an alternative to detection

284 e single-nucleotide polymorphisms (SNPs) and mitochondrial DNA to provide the first genetic assessmen

285 Over time, a rise in mitochondrial DNA tracked with improved respiration.

286 ular energy production, yet understanding of mitochondrial DNA transcription initiation lags that of

287 fficiency and fidelity in the early stage of mitochondrial DNA transcription is crucial for regulatin

288 ever, little information is available on how mitochondrial DNA transcription is regulated.

289 regarding the regulatory events that control mitochondrial DNA transcription, focusing on those invol

290 rstanding of the mechanism and regulation of mitochondrial DNA transcription.

291 tead of apoptotic genomic DNA, tumor-derived mitochondrial DNA triggers intrinsic DNA sensing.

292 Analysis of the mitochondrial DNA variants associated with altered gut m

293 ategy to track cell lineage using endogenous mitochondrial DNA variants in ATAC-seq data.

294 X mice (i.e., same nuclear DNA but different mitochondrial DNA), we showed mt-SNP-dependent increases

295 Using targeted enrichment of mitochondrial DNA, we show that cave sediments represent

296 Modest effects on cell viability and mitochondrial DNA were observed in vitro in a subset of

297 NA accumulation triggers cytosolic escape of mitochondrial DNA, which engages cGAS.

298 replication, organization and expression of mitochondrial DNA, which if compromised can lead to dise

299 ency results in oxidative damage specific to mitochondrial DNA, which triggers a TP53-mediated intrin

300 gs in the implicated gene PCs are encoded in mitochondrial DNA, while others are involved in the host