ライフサイエンスコーパス: mitochondrial genome

1 e that is responsible for replication of the mitochondrial genome.

2 osphorylation (OXPHOS) system encoded by the mitochondrial genome.

3 st for signals of molecular selection on the mitochondrial genome.

4 on of oxidative damage, in particular in the mitochondrial genome.

5 ting a duplicated sequence in the I. pulchra mitochondrial genome.

6 s the only polymerase known to replicate the mitochondrial genome.

7 ng a need for differential expression of the mitochondrial genome.

8 the 99% nonsynthetic nuclear genome, or the mitochondrial genome.

9 ion of the GR with the control region of the mitochondrial genome.

10 gion of the ATP8 and ATP6 genes of the human mitochondrial genome.

11 of coevolution on the mitoribosome with the mitochondrial genome.

12 e to measure the mutation load of the entire mitochondrial genome.

13 related myxozoan, Myxobolus squamalis, has a mitochondrial genome.

14 flowers are male sterile due to the foreign mitochondrial genome.

15 a G to A mutation at nucleotide 11778 of the mitochondrial genome.

16 scribe epiallelic DNA methylation within the mitochondrial genome.

17 nisms due to shared characteristics with the mitochondrial genome.

18 h mitochondria and with mRNAs encoded by the mitochondrial genome.

19 any thrips species and the ancestral insect mitochondrial genome.

20 n genes encoded by either the nuclear or the mitochondrial genome.

21 romosomal STRs and the control region of the mitochondrial genome.

22 lved in transcription and replication of the mitochondrial genome.

23 ifferent genetic properties than that of the mitochondrial genome.

24 , and base oxidation both in the nuclear and mitochondrial genomes.

25 l for fully automatic annotation of metazoan mitochondrial genomes.

26 d dose of tam drove elimination of defective mitochondrial genomes.

27 on (Mammut americanum), based on 35 complete mitochondrial genomes.

28 caused by mutations in both the nuclear and mitochondrial genomes.

29 ene products encoded in both the nuclear and mitochondrial genomes.

30 gest structure in the canyon, have identical mitochondrial genomes.

31 ell as communication between the nuclear and mitochondrial genomes.

32 organisation in comparison to other metazoan mitochondrial genomes.

33 an DNA, from which we assembled two complete mitochondrial genomes.

34 nits are encoded on both the nuclear and the mitochondrial genomes.

35 of tandem repeats among all the known insect mitochondrial genomes.

36 y but also for segregation of the replicated mitochondrial genomes.

37 d mediates the segregation of the replicated mitochondrial genomes.

38 ty to a large database of publicly available mitochondrial genomes.

39 anslating the few essential mRNAs encoded by mitochondrial genomes.

40 and structural variation in the nuclear and mitochondrial genomes.

41 iogeographical history of the honey bee from mitochondrial genomes.

42 vailable samples of heterotrophic flagellate mitochondrial genomes.

43 ein subunits expressed from both nuclear and mitochondrial genomes.

44 But what of the mitochondrial genome?

45 namics can influence the competition between mitochondrial genomes [14-18], yet little is known about

46 ed the genomes (0.04x-7.25x, mean 2.16x) and mitochondrial genomes (20.8x-1,311.0x, mean 482.1x) of e

47 shrimp Synalpheus microneptunus, a complete mitochondrial genome (22X coverage) assembled from short

48 nnaeus, 1758) transcriptome, nearly complete mitochondrial genomes, 430 unlinked high-quality SNPs sh

49 ith the rapid increase of sequenced metazoan mitochondrial genomes, a detailed manual annotation is b

50 f mitochondrial DNA haplogroup variation and mitochondrial genome abundance in the relationship of PM

51 mitochondrial DNA copy number, a measure of mitochondrial genome abundance, mediated 12% of the asso

52 -tree distance matrix for each of the three- mitochondrial genome alignments and greatly outperformed

53 partitions found in three mid- to large-size mitochondrial genome alignments.

54 in the history of life - the persistence of mitochondrial genomes also creates conditions for geneti

55 Comparison of mitochondrial genomes among the specimens showed a parap

56 By comparing full nuclear and mitochondrial genome ancestries, our data expand our app

57 are mosaics of core subunits encoded by the mitochondrial genome and additional nuclear-encoded prot

58 cluded the complete loss of variation in the mitochondrial genome and along long stretches of the nuc

59 ENs to induce breaks in distinct loci of the mitochondrial genome and found that breaks adjacent to t

60 during replication or possibly repair of the mitochondrial genome and how well it tolerates potential

61 being expressed from an alternate ORF in the mitochondrial genome and inhibiting apoptosis through in

62 of ribosomes comprising rRNAs encoded by the mitochondrial genome and mitochondrial ribosomal protein

63 Using this method, the complete mitochondrial genome and nuclear intergenic and protein-

64 Since the sequencing of the human mitochondrial genome and the discovery of pathogenic mut

65 s, we present 15 newly-sequenced sea anemone mitochondrial genomes and a mitogenome-based phylogeny i

66 ic drift led to the expansion of nuclear and mitochondrial genomes and caused the accumulation of del

67 Here, we review the pathways that safeguard mitochondrial genomes and examine the insights gained fr

68 We use complete ancient mitochondrial genomes and genome-wide nuclear DNA survey

69 the most definitive mutational landscape of mitochondrial genomes and identifies several hypermutate

70 Complete mitochondrial genomes and low-coverage autosomal genomes

71 idimensional, integrated characterization of mitochondrial genomes and related RNA sequencing data.

72 n acts as a stress test for the integrity of mitochondrial genomes and sets the stage for replication

73 r dataset includes 54 previously unpublished mitochondrial genomes and significantly increases the co

74 Therefore, the fragmentation of mitochondrial genomes and the assortment of chromosomes

75 on and sexual antagonism in the evolution of mitochondrial genomes and the mechanisms that suppress s

76 Coordinating gene expression between the mitochondrial genomes and the nuclear genome is imprecis

77 We have analyzed the mitochondrial genomes and transcriptomes of four species

78 e identity and length at CSB 2 amongst human mitochondrial genomes and used in vitro transcription to

79 , the complete chloroplast genome, a partial mitochondrial genome, and a nuclear-ddRAD matrix separat

80 , the myxozoan Henneguya salminicola, has no mitochondrial genome, and thus has lost the ability to p

81 accuracy of gene boundaries and upgrades the mitochondrial genome annotation server MITOS to an even

82 Changes in the gut microbiota and the mitochondrial genome are both linked with the developmen

83 The mitochondrial genomes are linear but, unlike in Hydra, w

84 Thrips mitochondrial genomes are marked by high rates of gene r

85 New analyses suggest that large, gene-rich mitochondrial genomes are more common than previously th

86 al gene retention, suggesting that gene-rich mitochondrial genomes are not a product of their early d

87 Given that mitochondrial genomes are polyploid, cells with advantag

88 rnal inheritance in most animals and plants, mitochondrial genomes are predicted to accumulate mutati

89 Mitochondrial genomes are present in hundreds of copies

90 Because mitochondrial genomes are present in numerous copies per

91 rigenesis, and rare human tumors with mutant mitochondrial genomes are relatively benign.

92 For example, gene-rich mitochondrial genomes are thought to be indicative of an

93 Although mitochondrial genomes are typically thought of as single

94 s sperm formation begins, hundreds of doomed mitochondrial genomes are visualized within the two huge

95 A mutant mitochondrial genome arising amid the pool of mitochondr

96 sms underlying deletion and depletion of the mitochondrial genome as observed in mitochondrial diseas

97 Here we present 90 mitochondrial genomes as well as genome-wide data sets f

98 , a ciliate with high coding capacity of the mitochondrial genome, as the model organism and characte

99 ing model to study adaptive evolution in the mitochondrial genome, as the three extant Old World came

100 This is the first reported mitochondrial genome assembly in the genus Chenopodium.

101 esentative M. musculus sequence (the 16.3 kb mitochondrial genome), at 100%, 100%, and 96.7% consensu

102 eration, the precise exchange of nuclear and mitochondrial genomes between strains, and the assessmen

103 uggest that H. salminicola lost not only its mitochondrial genome but also nearly all nuclear genes i

104 active, long OPA1 forms, which stabilize the mitochondrial genome but do not preserve mitochondrial c

105 s revolutionised our understanding of animal mitochondrial genomes but similar advances have not been

106 n limited to the targeted destruction of the mitochondrial genome by designer nucleases(9,10).Here we

107 DNA transfer and enables modification of the mitochondrial genome by DNA transmitted from a sexually

108 Defects in both the nuclear and mitochondrial genomes cause mitochondrial dysfunction vi

109 Whether the nuclear and mitochondrial genomes coevolved will need a thorough inv

110 Mitochondrial genomes compete for transmission from moth

111 eage-specific MTPTs that have contributed to mitochondrial genome complexity and might cause a putati

112 known to occur in plants, but its impacts on mitochondrial genome complexity and the potential for ca

113 recipitation reveals that Stat3 binds to the mitochondrial genome, consistent with direct transcripti

114 our analyses suggest that both species have mitochondrial genomes consisting of multiple linear frag

115 e genome, our de novo assembled O. nubilalis mitochondrial genomes contained 82 intraspecific substit

116 The larger I. pulchra mitochondrial genome contains both ribosomal genes, 21 t

117 genomes in a species along with nuclear and mitochondrial genomes, contributing to adaptation, diver

118 rovide a robust nexus for nuclear control of mitochondrial genome copy number, since use of common in

119 ation, suggesting that more than half of the mitochondrial genome could be unwound by Twinkle during

120 ch paralogs complicate the interpretation of mitochondrial genome data and confound variant calling.

121 variant calling and annotation do not handle mitochondrial genome data appropriately.

122 view that most humans harbour only identical mitochondrial genomes, deep resequencing has uncovered u

123 By examining the mitochondrial genome diversity and isotopic ratios of 74

124 Complete mitochondrial genomes documented a diversification of ma

125 Additionally, we found evidence of mitochondrial genome duplications allowing replication a

126 MitosRNAs, small ncRNAs derived from the mitochondrial genome, emerged as an interesting group of

127 The mitochondrial genome encodes 22 tRNAs, 2 rRNAs and 11 mR

128 Moreover, the mitochondrial genome encompasses over a thousand nuclear

129 /Cas9 platform, could prompt a revolution in mitochondrial genome engineering and biological understa

130 ly, these data identify a dynamic history of mitochondrial genome evolution including intron gain and

131 , genes within the Ajuga reptans (Lamiaceae) mitochondrial genome exhibit unprecedented intragenomic

132 Here we describe the first mitochondrial genome for Rhyparochromidae: a complete mi

133 Here we report an almost complete mitochondrial genome for the litoptern Macrauchenia.

134 We also present the first complete mitochondrial genome for Vargula tsujii.

135 We obtain 11 mitochondrial genomes for three subspecies in the langur

136 Most hybrids have inherited a mitochondrial genome from a parent other than S. cerevis

137 Mitochondrial aprataxin (APTX) protects the mitochondrial genome from the consequence of ligase fail

138 Bison cf. priscus We extracted and sequenced mitochondrial genomes from both this bison and from the

139 ated the first genome-wide sequence data and mitochondrial genomes from eleven archaeological Guanche

140 tigs, including 21 complete or near-complete mitochondrial genomes from formerly under-sampled phylog

141 Here, we report the recovery of full mitochondrial genomes from four and partial nuclear geno

142 different picture emerges from the 843 whole mitochondrial genomes from modern Finns analyzed here.

143 We present partial mitochondrial genomes from one S. populator sample and t

144 Prior to this study, complete mitochondrial genomes from Order Thysanoptera were restr

145 hondrial genome reduction, we also assembled mitochondrial genomes from picozoans and colponemids and

146 In this study, we sequenced complete mitochondrial genomes from three congeneric Decemunciger

147 A previous comparison of mitochondrial genomes from two different individuals of

148 of nuclear sequence, in addition to complete mitochondrial genomes generated using light-coverage Ill

149 es more than 1,850 described species, but no mitochondrial genome has been sequenced to date.

150 The mitochondrial genome has long been implicated in age-rel

151 The co-evolution of nuclear and mitochondrial genomes has been poorly studied, even thou

152 Deletions in the 16.6 kb mitochondrial genome have been implicated in numerous di

153 Sequences and structural attributes of mitochondrial genomes have played a critical role in the

154 st of its functionalities (i.e., assembly of mitochondrial genomes, heteroplasmic fractions, haplogro

155 Pups receiving the C57BL/6J or BALB/cJ mitochondrial genome (i.e., females crossed with Her2 ma

156 rom ultraconserved elements (UCEs) and whole mitochondrial genomes (i.e., mitogenomes) to explore gen

157 Here we identified the full mitochondrial genome in circulating extracellular vesicl

158 -dependent transcriptional regulation of the mitochondrial genome in vivo and are consistent with pre

159 tablished a Drosophila line transmitting two mitochondrial genomes in a stable ratio enforced by puri

160 the dissimilar intrinsic stabilities of the mitochondrial genomes in A. nidulans and P. anserina.

161 New analysis of rapidly evolving mitochondrial genomes in calcaronean sponges has demonst

162 a population-based resequencing of complete mitochondrial genomes in Europe and the Middle East, in

163 uencing and strand-specific mapping, we show mitochondrial genomes in humans and other animals are st

164 protists defined by one of the most complex mitochondrial genomes in nature, the kinetoplast.

165 The mitochondrial genomes in renal chromophobe and thyroid c

166 expression levels of 14 genes encoded in the mitochondrial genome, including missense variants within

167 We report four complete mitochondrial genomes, including two rearranged mitochon

168 o simultaneously compare how the nuclear and mitochondrial genomes incorporate and remove ribonucleot

169 undance of some mature RNAs derived from its mitochondrial genome increase during culture starvation

170 both between these organelles and within the mitochondrial genome, indicating a history of recombinat

171 irst time in mammals, we identify a complete mitochondrial genome insertion within the nuclear genome

172 ral role of MMEJ in maintenance of mammalian mitochondrial genome integrity and is likely relevant fo

173 nvolved in maintenance and compaction of the mitochondrial genome into nucleoids.

174 This leads to the physical separation of mitochondrial genomes into different mitochondrial fragm

175 Our findings support the hypothesis that the mitochondrial genome is altered greatly as a result of t

176 Faithful replication of the mitochondrial genome is carried out by a set of key nucl

177 This mitochondrial genome is comprised of 16,345 bp, and cont

178 e machinery for replication of the mammalian mitochondrial genome is distinct from that for replicati

179 This is because the mitochondrial genome is placed in a novel nuclear enviro

180 Thus, although functional replacement of the mitochondrial genome is possible, even low levels of het

181 In bilaterian animals, the mitochondrial genome is small, haploid, does not typical

182 sual features, one of which is their complex mitochondrial genome, known as kinetoplast (k) DNA, comp

183 of mitochondrial respiration or ablation of mitochondrial genomes leads to increased death in latent

184 on, stalled replication fork processing, and mitochondrial genome maintenance.

185 Mitochondrial genomes (mitochondrial DNA, mtDNA) encode

186 Mitochondrial genome (mitogenome) plays important roles

187 d the complete plastid genome (plastome) and mitochondrial genome (mitogenome) sequences from three g

188 Currently, complete mitochondrial genomes (mitogenomes) are available from a

189 rogress has suggested that mobile introns in mitochondrial genomes (mitogenomes) can facilitate the r

190 We provide mitochondrial genomes (mitogenomes) from archival type s

191 The first completed mitochondrial genomes (mitogenomes) from parasitic mistl

192 Only six mitochondrial genomes (mitogenomes) have been previously

193 entation, rests in part on expression of the mitochondrial genome (mtDNA) and coordination with expre

194 question is to what extent variation in the mitochondrial genome (mtDNA) contributes to the biologic

195 Acquired human mitochondrial genome (mtDNA) deletions are symptoms and

196 Somatic mutations in the mitochondrial genome (mtDNA) have been linked to multipl

197 tudy, we examine the accumulation of somatic mitochondrial genome (mtDNA) mutations in skin fibroblas

198 >u) editing substitutions which occur in the mitochondrial genome (mtDNA) of a given input plant.

199 We reconstruct the complete mitochondrial genome (mtDNA) of the specimen.

200 o examine the incidence of HGT events in the mitochondrial genome (mtDNA).

201 e two species of the 22 tRNAs encoded by the mitochondrial genome (mtDNA); whether there is tissue-sp

202 Although mitochondrial genomes (mtDNA) accumulate elevated levels

203 Here we analyze 55 complete human mitochondrial genomes (mtDNAs) of hunter-gatherers spann

204 , there is negative selection for pathogenic mitochondrial genome mutations.

205 y identified, suggesting that introns in the mitochondrial genome of annelids may be more widespread

206 zing mtDNA in human breast CSCs; rather, the mitochondrial genome of CSCs displayed an overall decrea

207 nces and successfully assembled the complete mitochondrial genome of Doedicurus sp., one of the large

208 generation sequencing to obtain the complete mitochondrial genome of Nycteria parasites from African

209 ew dozen ~23-kb maxicircles (homologs of the mitochondrial genome of other eukaryotes) and thousands

210 rial genome for Rhyparochromidae: a complete mitochondrial genome of Panaorus albomaculatus (Scott, 1

211 The 15,603 bp long mitochondrial genome of S. microneptunus is AT-rich and

212 ra and Isodiametra pulchra, and the complete mitochondrial genome of the acoel Archaphanostoma ylvae.

213 The complete mitochondrial genome of the eusocial shrimp Synalpheus m

214 Xenikoudakis et al. report a partial mitochondrial genome of the extinct giant beaver Castoro

215 respectively, as well as large parts of the mitochondrial genome of the Forbes' Quarry individual.

216 the kinetoplast, an organelle containing the mitochondrial genome of the parasite (kDNA), with an acc

217 The mitochondrial genome of these hybrids consisted of homog

218 Here we analyse the full mitochondrial genomes of 18 A. mellifera subspecies, bel

219 We sequenced complete mitochondrial genomes of 41 individuals from across the

220 tory of the region, we analyzed the complete mitochondrial genomes of 52 ancient skeletons from prese

221 In addition, mitochondrial genomes of at least some calcaronean spong

222 RNA, 16S rRNA, and tRNA (val) regions of the mitochondrial genomes of daphniids from 186 global sites

223 Overall, the first mitochondrial genomes of ferns show a mix of features sh

224 Here we present the sequences for the mitochondrial genomes of four additional thrips species,

225 sequenced and annotated the nearly complete mitochondrial genomes of four species of each these trib

226 800 years and combined this dataset with 206 mitochondrial genomes of modern Armenians.

227 We sequenced the nuclear and mitochondrial genomes of Paramicrosporidium saccamoebae

228 g that the massively expanded and fragmented mitochondrial genomes of S. noctiflora may have entered

229 The mitochondrial genomes of S. spindale and S. indicum were

230 ledge of the structure and expression of the mitochondrial genomes of these human and animal pathogen

231 We sequenced the mitochondrial genomes of two ceriantharians to see wheth

232 Here, we sequenced the mitochondrial genomes of wild-type or autophagy-deficien

233 eritance at two levels, eliminating paternal mitochondrial genomes or destroying mitochondria deliver

234 ncestral plastid genomes were transferred to mitochondrial genomes over the past 10 million years and

235 umber of mitochondria per cell and number of mitochondrial genomes per mitochondrion, is an indirect

236 Analysis of whole mitochondrial genomes places the three larger species as

237 Our data suggests that the mitochondrial genome plays a role in DNAm-age relationsh

238 ompensate for the deleterious alleles in the mitochondrial genome, presents a potential solution to t

239 lagellate Diplonema papillatum (Euglenozoa), mitochondrial genome rearrangements have resulted in nea

240 To comprehensively examine mitochondrial genome reduction, we also assembled mitoch

241 y on the genes encoding TFAM, which controls mitochondrial genome replication and transcription, and

242 ndicate a direct role for G4 perturbation in mitochondrial genome replication, transcription processi

243 now holds the record for the largest animal mitochondrial genome reported to date.

244 s that aligned to the O. nubilalis reference mitochondrial genome, respectively.

245 ion factor MOC1 and aberrantly expresses the mitochondrial genome, resulting in enhanced photosynthet

246 Analyses of the mitochondrial genomes revealed extensive recombination,

247 mble and interpret a data set of 143 mammoth mitochondrial genomes, sampled from fossils recovered fr

248 Mitochondrial genome sampling is more comprehensive, but

249 provides a generalizable pipeline for whole mitochondrial genome sequence acquisition adaptable to a

250 Additionally, a finished mitochondrial genome sequence of 135,790 bp was obtained

251 In this study we analyse 31 mitochondrial genome sequences from cave lion individual

252 The HmtDB resource hosts a database of human mitochondrial genome sequences from individuals with hea

253 Here we describe mitochondrial genome sequences from the acoels Paratomel

254 We determined the complete circular mitochondrial genome sequences of representatives of 3 d

255 g gDNA derived from P. falciparum Plasmodium mitochondrial genome sequences were subsequently reconst

256 augment standard exome sequencing analysis: mitochondrial genome sequencing analysis, exome sequenci

257 hilst highlighting the necessity of complete mitochondrial genome sequencing in the diagnostic work-u

258 transcription at non-canonical sites in the mitochondrial genome, shedding new light on the importan

259 Tumor mitochondrial genomes show distinct mutational patterns

260 Sequencing of recombinant mitochondrial genomes showed that the noncoding region,

261 , highlights cross-talks between nuclear and mitochondrial genome stability, and shows how strains ha

262 ered in leaf morphology, heat tolerance, and mitochondrial genome stability.

263 Phylogenetic analyses of 63 mitochondrial genomes suggest that porpoises radiated du

264 These evolutionary trends correlate with the mitochondrial genome, suggesting shared underlying mecha

265 Phylogenetic reconstruction based on mitochondrial genomes suggests that Rhyparochromidae is

266 reannotated nine open reading frames in the mitochondrial genome that code for mitoribosomal protein

267 harness naturally occurring mutations in the mitochondrial genome that impair male fertility while ha

268 most AT-rich genomes known save for a single mitochondrial genome that is merely bloated with AT-rich

269 dent evolution between species has generated mitochondrial genomes that are extremely diverse, with t

270 ial diseases is in either the nuclear or the mitochondrial genome, the typical downstream effect is d

271 ing and intergenic areas of both nuclear and mitochondrial genomes, the ability to identify structura

272 eractions between Wolbachia and host nuclear/mitochondrial genomes, the interaction between invasion

273 The dramatically rearranged mitochondrial genomes, the limited set of transcripts, a

274 in products of the trypanosomatid parasites' mitochondrial genomes, the total expressed protein reper

275 and replication might limit options for the mitochondrial genome to escape restriction.

276 The TAC links the single-unit mitochondrial genome to the basal body of the flagellum

277 e transfer of ancestral plastid genomes into mitochondrial genomes to generate mitochondrial plastid

278 of the necessary genes from both nuclear and mitochondrial genomes to produce functional respiratory

279 the evolutionary history of this group using mitochondrial genomes to reconstruct phylogenetic and bi

280 le in both expression and replication of the mitochondrial genome, transcription initiation by mtRNAP

281 findings indicate that random segregation of mitochondrial genomes under uniparental inheritance can

282 We also assemble complete mitochondrial genomes using GetOrganelle.

283 ns and colponemids and re-annotated existing mitochondrial genomes using hidden Markov model gene pro

284 about how the transcriptional regime of the mitochondrial genome varies across individuals and tissu

285 The number of mitochondrial genomes varies depending on the cell's ene

286 Synonymous substitution rates in plant mitochondrial genomes vary by orders of magnitude among

287 The complete mitochondrial genome was obtained with individual reads

288 A canonical fungal mitochondrial genome was recovered from P. saccamoebae t

289 communication exists between the nuclear and mitochondrial genomes, we hypothesized that there are di

290 s, which pair nuclear genomes with different mitochondrial genomes, we previously showed that mitocho

291 apaya chloroplast genome and its nuclear and mitochondrial genomes were sequenced, and no chloroplast

292 Three complete mitochondrial genomes were successfully recovered and an

293 The mitochondrial genome, which consists of 16,569 bp of DNA

294 the 16 nuclear chromosomes, but not for the mitochondrial genome, whose reconstruction still represe

295 er cells with advantageous levels of damaged mitochondrial genomes will selectively proliferate to fa

296 P. mediterranea harbors a highly compact mitochondrial genome with overlapping mitochondrial tRNA

297 itochondrial genome arising amid the pool of mitochondrial genomes within a cell must compete with ex

298 tent with the relatively conserved nature of mitochondrial genomes within annelids.

299 ochondrial genomes, including two rearranged mitochondrial genomes within Haemosporidia.

300 ated a large dataset comprising the complete mitochondrial genomes, Y-chromosome markers, and genotyp