ライフサイエンスコーパス: mitochondrially

1 ever, small amounts were also detected extra-mitochondrially.

2 growing hair follicles, particularly in the mitochondrially abundant bulb.

3 responded more effectively to treatment with mitochondrially active ursodeoxycholic acid.

4 redox behavior in plastids and a sub-set of mitochondrially altered lines.

5 Importantly, mitochondrially anchored LRRK2 is much less capable of p

6 Mitochondrially anchored, GTP-bound Rab29 is both a LRRK

7 ction preferentially degraded polyadenylated mitochondrially and non-mitochondrially encoded RNAs ove

8 e cox17 mutants are able to express both the mitochondrially and nuclearly encoded subunits of cytoch

9 lucose transporter 1 (Glut1) and accumulates mitochondrially as ascorbic acid (mtAA).

10 Furthermore, in AD brains, mitochondrially associated APP formed stable approximate

11 APDH-driven mitophagy by phosphorylating the mitochondrially associated GAPDH at threonine 246 follow

12 -type copy of mrp1, additionally require the mitochondrially associated nuclear mutation ptp1-1 for v

13 expression of ARMCX3 increased the amount of mitochondrially associated Sox10.

14 We hypothesized that arginine catabolism via mitochondrially bound arginase augments ureagenesis by s

15 itochondria through incorporation of smaller mitochondrially-bound Drp1 units.

16 ) in the cytoplasm surrounding mitochondria (mitochondrially centered) and (2) traversing the space b

17 Here, we present APOGEE 2, a mitochondrially-centered ensemble method designed to imp

18 The second mitochondrially-centered process involves complex molecu

19 11 specifically activates translation of the mitochondrially coded mRNA for cytochrome c oxidase subu

20 Translation of mitochondrially coded mRNAs in Saccharomyces cerevisiae

21 cAMP levels did not affect the synthesis of mitochondrially coded protein reporters in glucose-grown

22 Leader peptides are relatively unusual in mitochondrially coded proteins: indeed mammalian Cox2p l

23 xidase affect the catalytic functions of its mitochondrially coded subunits.

24 tochondrial function and cell viability in a mitochondrially compromised human cell model.

25 Surprisingly, in mitochondrially defective neurons, but not neuroprogenit

26 At high heteroplasmy, mitochondrially derived acetyl-CoA levels decrease causi

27 eloped two complementary assays sensitive to mitochondrially derived ATP in individual, living hippoc

28 e then show that to meet these energy needs, mitochondrially derived ATP is rapidly dispersed in axon

29 plicated in Leigh disease markedly decreases mitochondrially derived ATP levels in axons, thus inhibi

30 he dependence of synaptic vesicle cycling on mitochondrially derived ATP levels, we developed two com

31 The first is a functional assay for mitochondrially derived ATP that uses the extent of syna

32 ernative to the canonical TCA cycle, wherein mitochondrially derived citrate exported to the cytoplas

33 ACLY produces cytosolic acetyl-CoA from mitochondrially derived citrate.

34 chondrial origin suggests the existence of a mitochondrially derived compartment.

35 unique biological role for an extracellular, mitochondrially derived enzyme and its molecular control

36 These results reveal the critical role of mitochondrially derived formate in mammalian development

37 of yeast Atm1p and is predicted to export a mitochondrially derived metabolite required for cytosoli

38 were identifiable in taxa possessing another mitochondrially derived organelle, the mitosome.

39 sm was found to generate both glycolytic and mitochondrially derived PEP, which triggers K(ATP) closu

40 Mitochondrially derived peptides (MDPs) such as humanin

41 Mitochondrially derived peptides represent a new class o

42 T lymphocytes and generate higher levels of mitochondrially derived reactive oxygen species (ROS).

43 dria are recruited to phagosomes and produce mitochondrially derived reactive oxygen species, which a

44 endogenous antioxidants or the production of mitochondrially derived ROS.

45 l that was independent of other oxidants and mitochondrially derived ROS.

46 anganese-superoxide dismutase (Sod2) removes mitochondrially derived superoxide (O(2)) at near-diffus

47 ese superoxide dismutase supports a role for mitochondrially derived superoxide in 6-hydroxydopamine

48 ts entering the cytoplasmic methyl cycle are mitochondrially derived.

49 Transient increases in mitochondrially-derived reactive oxygen species (ROS) ac

50 ferentially via TRPA1 through the actions of mitochondrially-derived ROS.

51 re converted to their toxic cationic form by mitochondrially directed CYP2D6 and result in neuronal d

52 of the SHR/SST-2 model and the potential of mitochondrially-directed agents to mitigate oxidative st

53 The transcript is mitochondrially encoded and maps to a region upstream of

54 ondrial proteins ACO2, TUFM, IDH3A, CLPP and mitochondrially encoded and synthesized protein mtCO1 we

55 Expression of the mitochondrially encoded ATP6 and ATP8 genes is translati

56 Incorporation of labeled precursors into mitochondrially encoded Atp6, Atp8, Atp9, and Cytb prote

57 drial inner membrane protein that stabilizes mitochondrially encoded ATP6/8 mRNA.

58 ase experiments have enabled us to track the mitochondrially encoded Atp6p, Atp8p and Atp9p subunits

59 o physically interact with newly synthesized mitochondrially encoded Atp9 protein in a posttranslatio

60 Defects in mitochondrially encoded complex I subunits should be add

61 ell line carrying a nonsense mutation in the mitochondrially encoded complex IV subunit 1 gene.

62 As the mitochondrially encoded components are also integral mem

63 ysis to assay the transcript levels of three mitochondrially encoded components of the cytochrome c o

64 electively downregulate transcription of the mitochondrially encoded components of the oxidative phos

65 iogenesis identified Cox1p, one of the three mitochondrially encoded core subunits, in two high-molec

66 ient interaction previously observed for the mitochondrially encoded COX subunits with Oxa1.

67 es the cotranslational membrane insertion of mitochondrially encoded COX subunits, is well documented

68 the respiratory chain subunits that included mitochondrially encoded COX1 (47.5%; P = .004), COX2 (32

69 mutants by restoring normal synthesis of the mitochondrially encoded Cox1p subunit of COX.

70 -encoded COX subunits that interact with the mitochondrially encoded Cox1p.

71 The mitochondrially encoded cytochrome b forms, with cytochr

72 Sequencing of the mitochondrially encoded cytochrome b gene placed these m

73 equence in the 5'-untranslated region of the mitochondrially encoded cytochrome b mRNA in Saccharomyc

74 e ubiquinone reduction site (Qi site) of the mitochondrially encoded cytochrome b, a different site t

75 ficantly increased protein expression of the mitochondrially encoded cytochrome C oxidase I (MTCO1),

76 rahydrofolate (10-formyl-THF) and consequent mitochondrially encoded cytochrome c oxidase II (MT-CO2)

77 Interestingly, expression of the mitochondrially encoded cytochrome c oxidase III and cyt

78 The amino- and carboxy-terminal domains of mitochondrially encoded cytochrome c oxidase subunit II

79 WT included: in striatum, lower VDAC and the mitochondrially encoded cytochrome oxidase subunit I rel

80 cent observations that there appears to be a mitochondrially encoded defect in complex I activity of

81 l DNA and exhibit no activity for the partly mitochondrially encoded enzyme cytochrome c oxidase.

82 ing diabetic insult led to downregulation of mitochondrially encoded F0 component ATP6.

83 nuclear gene PNT1 block the translocation of mitochondrially encoded fusion proteins across the inner

84 deletion in a highly conserved region of the mitochondrially encoded gene for cytochrome c oxidase (C

85 that either a specific sequence element or a mitochondrially encoded gene product is required for pro

86 Both nuclear and mitochondrially encoded gene products of the oxidative p

87 berrant chimera in which portions of several mitochondrially encoded genes are fused to an unknown re

88 uble-strand break repair genes and repressed mitochondrially encoded genes.

89 uridines added or deleted comes from small, mitochondrially encoded guide RNAs (gRNAs).

90 a counterpart of ND1, which is one of seven mitochondrially encoded hydrophobic subunits, and is con

91 self is unstable in the absence of assembled mitochondrially encoded integral membrane proteins of co

92 d that the expression of several nuclear and mitochondrially encoded mitochondrial enzymes was decrea

93 Mutations in the mitochondrially encoded MTATP6 gene typically cause infa

94 A cytosine to adenine transversion in the mitochondrially encoded NADH dehydrogenase subunit 2 (mt

95 We report an unusual molecular defect in the mitochondrially encoded ND1 subunit of NADH ubiquinone o

96 More than half of mitochondrially encoded polypeptides form part of the re

97 equired to terminate the synthesis of all 13 mitochondrially encoded polypeptides, the true physiolog

98 Z(L) could, thus, process both nuclear- and mitochondrially encoded pre-tRNAs.

99 quence evolution among published nuclear and mitochondrially encoded protein-coding loci differ signi

100 Expression of the mitochondrially encoded proteins Cytochrome oxidase subu

101 omparisons here of amino acid sequences from mitochondrially encoded proteins give a single most pars

102 ropose mitomiRs can translationally regulate mitochondrially encoded proteins in spatially distinct m

103 The machinery that inserts mitochondrially encoded proteins into the inner membrane

104 ometry revealed reduced incorporation of the mitochondrially encoded proteins ND6 and ND1 into comple

105 Mitochondrially encoded proteins were differentially aff

106 lity to synthesize low levels of a subset of mitochondrially encoded proteins.

107 Cs displayed features pointing to defects in mitochondrially encoded respiratory chain subunits at ea

108 '-end status, and in vivo stability of major mitochondrially encoded RNA classes.

109 se P RNA-tRNA(Pro) gene cluster, so that the mitochondrially encoded RNA subunit was thought to be co

110 raded polyadenylated mitochondrially and non-mitochondrially encoded RNAs over their non-adenylated c

111 ication of a large number of variants in the mitochondrially encoded rRNA (mt-rRNA) genes, the eviden

112 The mitochondrially encoded substrates interact directly wit

113 sts of nine nuclear encoded subunits and the mitochondrially encoded subunit cytochrome b.

114 nal myoblast cultures, the expression of the mitochondrially encoded subunit I of cytochrome c oxidas

115 Cox18, are required for assembly of Cox2, a mitochondrially encoded subunit of cytochrome c oxidase.

116 ee modules, each containing one of the three mitochondrially encoded subunits and a different subset

117 ression of Atp6p, Atp8p, and Atp9p, the only mitochondrially encoded subunits of ATP synthase.

118 hydrophobic reaction center formed by three mitochondrially encoded subunits with which 9-10 nuclear

119 The key intermediate then accepts the two mitochondrially encoded subunits, stabilized by the addi

120 form a key intermediate that accepts the two mitochondrially encoded subunits.

121 se Afg1 that promotes the degradation of CcO mitochondrially encoded subunits.

122 lated, the mitochondrial DNA is reduced, and mitochondrially encoded transcripts and proteins are als

123 sition of m(5)C at the anticodon loop in the mitochondrially encoded transfer RNA methionine (mt-tRNA

124 es and revealed the unexpected presence of a mitochondrially encoded tRNA (mt-tRNA) that usurps this

125 A mutation hot spot (9821insA) in the mitochondrially encoded tRNA arginine (mt-Tr) locus (tRN

126 ed by mitochondrial DNA are translated using mitochondrially encoded tRNAs and rRNAs.

127 mitochondrial genome, most of them in the 22 mitochondrially encoded tRNAs.

128 tes the insertion of proteins (nuclearly and mitochondrially encoded) into the inner membrane.

129 hat rare variants affecting the nuclear- and mitochondrially-encoded complex I genes show near-mutual

130 so required for the maturation of Rpm1r, the mitochondrially-encoded RNA subunit of the enzyme.

131 Mutations in the mitochondrially-encoded subunits of the complex have bee

132 Although Sirtuin 3 (SIRT3), a mitochondrially enriched deacetylase and activator of fa

133 The mitochondrially enriched electron and free radical scave

134 ionally, we identify Lrpprc mRNA, encoding a mitochondrially enriched protein, as a key direct target

135 abel-free quantitative proteomic analysis of mitochondrially enriched samples isolated from the wild

136 ectrophotometric assay of enzyme activity in mitochondrially-enriched tissue homogenates, requiring a

137 ty of Mip1p and also affects the levels of a mitochondrially-expressed protein, Cox3p.

138 Mitochondrially generated ATP was specifically reduced i

139 housands of dispersed bioenergetic genes via mitochondrially generated high-energy intermediates perm

140 precursor is expressed in S.cerevisiae, the mitochondrially generated mature form is separated by ge

141 nt of alpha-tocopherol in the elimination of mitochondrially generated O2(./-)

142 First, how mitochondrially generated PEP, but not ATP produced abun

143 Mitochondrially generated reactive oxygen species are cr

144 f mitochondrial DNA, and increased levels of mitochondrially generated reactive oxygen species that c

145 mitochondrial function from damage caused by mitochondrially generated ROS during apoptotic induction

146 h it is ER translocated, processed, and then mitochondrially imported.

147 ial range of approximately 10 microm in both mitochondrially labeled fixed cells, and in the membrane

148 built on prior work in which we exploited a mitochondrially localized 3XHA epitope tag (MITO-Tag) fo

149 Here we present evidence that the mitochondrially localized active caspase-9 and -3 result

150 The mitochondrially localized aldehyde dehydrogenase in D. m

151 re we show that exogenously expressed Mcu is mitochondrially localized and increases mitochondrial Ca

152 We confirmed p46Shc to be mitochondrially localized and showed that the major mito

153 interaction with DNAJC11 leads to excessive mitochondrially localized ARMC1 and distinct mitochondri

154 Although neurolastin was only partially mitochondrially localized at steady state, it displayed

155 ism and delivery to cytochrome c oxidase and mitochondrially localized CuZn-superoxide dismutase (Sod

156 Mitochondrially localized cytochrome c-GFP and BFP-Bcl-2

157 cheme, we identified the beta-subunit of the mitochondrially localized electron transfer flavoprotein

158 Messenger RNA expression levels for 198 mitochondrially localized energy production components,

159 Further, we demonstrate that this mitochondrially localized enzymatic activity can be expl

160 ersicum) fruit by altering the expression of mitochondrially localized enzymes of the tricarboxylic a

161 Dihydroorotate dehydrogenase (DHOD), a mitochondrially localized flavoenzyme, catalyzes the rat

162 ough the p46Shc isoform has been known to be mitochondrially localized for 11 years, its function in

163 chondrial ancestry, both by affiliation with mitochondrially localized fungal homologues and by the s

164 We conclude that mitochondrially localized human AGXT2 is able to effecti

165 Mitochondrially localized JNKs but not upstream activato

166 ied libraries of 3' UTR regions from a known mitochondrially localized mRNA by nonhomologous random r

167 Instead, mitochondrially localized NLRP3 potentiated reactive oxy

168 Manganese superoxide dismutase (MnSOD) is a mitochondrially localized primary antioxidant enzyme, kn

169 In most cases, the mitochondrially localized procaspase-9 and -3 are releas

170 may translocate to the mitochondria, or the mitochondrially localized procaspases may be activated b

171 In mammals, mitochondrially localized proteins such as mitochondrial

172 Since the mitochondrially localized Psd1 enzyme provides a major r

173 se 1 (PINK1) or parkin genes, which encode a mitochondrially localized serine/threonine kinase and a

174 Application of LOCL-TL to mitochondrially localized translation revealed that ~20%

175 YGG(C/A)RRC, upstream of the genes encoding mitochondrially localized tRNAs in T. brucei.

176 However, mitochondrially localized tRNAs were much less affected

177 pport the Arabidopsis (Arabidopsis thaliana) mitochondrially localized Type II FAS.

178 oth drugs are activated by a NADH-dependent, mitochondrially localized, bacterial-like, type I nitror

179 orms are proteolytically processed to form a mitochondrially localized, mature PanK2.

180 oxalase II isozyme (GLY1) that appears to be mitochondrially localized.

181 forming in vivo proximity biotinylation with mitochondrially-localized forms of the GTPases.

182 One antibody reacts with a mitochondrially located 45 kDa polypeptide (p45) which c

183 utoimmunity directed against well-identified mitochondrially located autoantigens in individuals with

184 ts of the 2-oxo-acid dehydrogenase family of mitochondrially located enzymes that share a lipoylated

185 monocotyledons and eudicotyledons have twin, mitochondrially located mitochondrial carrier family car

186 cy and autoimmunity specifically directed to mitochondrially located PDC-E2 and subsequent biliary du

187 se a and b double mutant (ntra ntrb) and the mitochondrially located thioredoxin o1 (trxo1) mutant.

188 tions with hexokinase play integral roles in mitochondrially mediated apoptotic signaling.

189 EM011-induced apoptosis has a mitochondrially-mediated component, which was attenuated

190 These, in turn, can be toxic to mitochondrially nonmutant cells that import them to sati

191 tions do not affect expression of either the mitochondrially or nuclearly encoded subunits of the enz

192 o compensate reasonably well for the loss in mitochondrially produced ATP.

193 is augmented in growth conditions requiring mitochondrially produced energy.

194 ggest a positive feedback mechanism in which mitochondrially produced NO induces expression of COX5b,

195 It has been proposed that this mitochondrially produced NO is a component of hypoxic si

196 its cellular NOS isoform, and the effects of mitochondrially produced NO on bioenergetics have been c

197 The effects of mitochondrially produced NO on bioenergetics were studie

198 ulfide bond formation, which is dependent on mitochondrially produced oxidants.

199 low cytometry, showed a dramatic increase in mitochondrially produced reactive oxygen species (ROS) a

200 ted only after a specific threshold level of mitochondrially produced ROS was exceeded, and did not i

201 Small increases in levels of mitochondrially produced superoxide radicals have a prot

202 e, we studied the effect of DEP chemicals on mitochondrially regulated death mechanisms.

203 otective immune response but instead undergo mitochondrially regulated programmed cell death.

204 egradation could be a mechanism by which the mitochondrially released Omi/HtrA2 activates caspases du

205 asitica, was the first virus identified as a mitochondrially replicating virus.

206 s (genus Mitovirus, family Narnaviridae) are mitochondrially replicating viruses that have the simple

207 h glycolytic bloodstream stage parasites and mitochondrially respiring procyclic stage parasites were

208 growth of myeloid progenitors in vitro, and mitochondrially restricted STAT3 and STAT3-Y705F, both t

209 The N-terminal and C-terminal domains of mitochondrially synthesized cytochrome c oxidase subunit

210 Evidence from other organisms suggests that mitochondrially synthesized fatty acids are required for

211 o the inability to generate lipoic acid from mitochondrially synthesized fatty acids.

212 which is clearly implicated in the export of mitochondrially synthesized iron/sulfur clusters.

213 To study in vivo the export of mitochondrially synthesized protein from the matrix to t

214 Thus, mitochondrially synthesized proteins may not have the sa

215 Our objective was to test the mitochondrially targeted agent, MitoQ, alone and in comb

216 We orally administered the mitochondrially targeted anti oxidant MitoQ in order to

217 Calcium chelators act similarly and mitochondrially targeted anti-oxidants also abrogate the

218 mitochondrial electron transport chain and a mitochondrially targeted antioxidant (Mito Q) fully prev

219 other treatments, namely administration of a mitochondrially targeted antioxidant (MitoQ) and inhibit

220 use and human skin, topical application of a mitochondrially targeted antioxidant prevents and mitiga

221 MitoQ, a mitochondrially targeted antioxidant, decreased LPS-indu

222 g was abolished by low concentrations of the mitochondrially targeted antioxidants 10-(6'-ubiquinonyl

223 ROS than normal human lung fibroblasts, and mitochondrially targeted antioxidants attenuated profibr

224 Mitochondrially targeted antioxidants markedly attenuate

225 er transfection of cultured hepatocytes with mitochondrially targeted ApaLI, we found a rapid, direct

226 ing recombinant viral vectors expressing the mitochondrially targeted ApaLI.

227 , expression of ER-targeted Bcl-x(L) but not mitochondrially targeted Bcl-x(L) was required to restor

228 xL-KO cells was restored by re-expression of mitochondrially targeted Bcl-xL.

229 chroman 2-carboxylic acid (TROLOX) or of the mitochondrially targeted but redox-inactive analogs decy

230 f mitochondrial [Ca(2+)] ([Ca(2+)]m) using a mitochondrially targeted Ca(2+) probe (MityCam) and thes

231 Simultaneous expression of mitochondrially targeted catalase to reduce cellular ROS

232 Furthermore, a mitochondrially targeted catalase transgene suppresses B

233 Induction of the mitochondrially targeted catalytic antioxidant, mCAT, in

234 Neurons were cotransfected with a mitochondrially targeted cyan fluorescent protein and an

235 In this study, we show that the mitochondrially targeted CYP2D6 can efficiently catalyze

236 uro-2a cells stably expressing predominantly mitochondrially targeted CYP2D6 were more sensitive to t

237 We therefore designed and synthesized a new mitochondrially targeted CypD inhibitor, JW47, using a q

238 Here we describe the use of mitochondrially targeted deferoxamine (mitoDFO) as a nov

239 oscopy with either hydroethidine (HE) or its mitochondrially targeted derivative Mito-HE (MitoSOX Red

240 ensional reconstruction of fluorescence from mitochondrially targeted DsRed1 or calcein.

241 These data support the view that mitochondrially targeted electron acceptors and SOD mimi

242 use fine mapping to successfully identify a mitochondrially targeted endonuclease gene (MTI1) contro

243 e of cultured hippocampal neurons expressing mitochondrially targeted enhanced yellow fluorescent pro

244 in primary cultures of rat forebrain using a mitochondrially targeted enhanced yellow fluorescent pro

245 itional knockout strategy, we incorporated a mitochondrially targeted fluorescent reporter to facilit

246 dated a chemoptogenetic approach that uses a mitochondrially targeted fluorogen-activating peptide (M

247 two non-AUG, to produce distinct plastid and mitochondrially targeted forms of the protein.

248 Using adenoviral infection, a ratiometric mitochondrially targeted Forster resonance energy transf

249 COX4 translation was studied here using a mitochondrially targeted green fluorescence protein (mtG

250 Although mitochondrially targeted H(2)S donors, such as AP39, hav

251 We have demonstrated previously that mitochondrially targeted human cytochrome P450 2D6 (CYP2

252 red using hydroethidium and signals from the mitochondrially targeted hydroethidine, was increased in

253 Using the mitochondrially targeted inverse pericam indicator Mityc

254 PINK1 is a mitochondrially targeted kinase that regulates multiple

255 We transgenically expressed mitochondrially targeted miniSOG (mito-miniSOG) in Caeno

256 We have developed the first cell-permeable, mitochondrially targeted modulators of the PKCdelta-dF(1

257 Overexpression of the mitochondrially targeted MPG dramatically increased the

258 review historical and recent developments in mitochondrially targeted nuclease technology and the cli

259 However, it was unknown whether mitochondrially targeted p53 has suppressor activities i

260 n chromosome 2L that united a portion of the mitochondrially targeted peptide CG12264 with a segment

261 In contrast, the cell-permeable, mitochondrially targeted PKCdelta-dF(1)F(0) facilitator

262 th 10 nm extracellular concentrations of the mitochondrially targeted PKCdelta-dF(1)F(0) interaction

263 ve-strand RNA synthesis, multiple domains of mitochondrially targeted protein A cooperate to selectiv

264 unia restorer of fertility gene product is a mitochondrially targeted protein that is almost entirely

265 higher expression of mitochondrial genes and mitochondrially targeted proteins (MTPs) involved in oxi

266 A mitochondrially targeted PstI degraded mtDNA harboring P

267 Using a mitochondrially targeted ratiometric sensor (Ro-GFP) in

268 id anti-inflammatory agent, and XJB-5-131, a mitochondrially targeted reactive oxygen species scaveng

269 assay of mitochondrial thiol redox status by mitochondrially targeted redox-sensitive green fluoresce

270 mtDNA by developing a mouse model in which a mitochondrially targeted restriction endonuclease (PstI)

271 se specific mtDNA haplotypes by expressing a mitochondrially targeted restriction endonuclease, ApaLI

272 Using a genetic scheme that expresses a mitochondrially targeted restriction enzyme to induce ti

273 PTEN-induced putative kinase 1 (PINK1) is a mitochondrially targeted serine-threonine kinase, which

274 re discussed in the context of processing of mitochondrially targeted SODs.

275 Glucose-lowering effect of mitochondrially targeted tamoxifen is linked to improvem

276 how that treatment of pre-diabetic mice with mitochondrially targeted tamoxifen, a potential anti-can

277 These findings suggest that early mitochondrially targeted therapeutic interventions may b

278 ividually or simultaneously substituted with mitochondrially targeted transmembrane sequences.

279 This study suggests that mitochondrially targeted variant 3 CYP2C8 may contribute

280 Mitochondrially targeted vitamin E (MitoVit E), a chemic

281 The first step describes how to construct mitochondrially targeted ZFPs (mtZFPs) so that they are

282 Use of the mitochondrially targeted zinc finger-nuclease (mtZFN) re

283 AP39, a mitochondrially targeted, slow-release H(2)S donor, has

284 ed by prenatal exposure of the placenta to a mitochondrially-targeted antioxidant.

285 otes were injected with mRNA encoding either mitochondrially-targeted catalase, which quenches mitoch

286 Depleting mtGSH with mitochondrially-targeted CDNB phenocopied these defects,

287 escribe a new mtDNA mutator model based on a mitochondrially-targeted cytidine deaminase, APOBEC1.

288 against hypoxic injury by a cell-permeable, mitochondrially-targeted deltaPKC-d subunit of F1Fo ATPa

289 Treatments of cells with lipoate and with mitochondrially-targeted lipoate were unsuccessful at co

290 ed mRNAs (RIP-seq) identified mRNAs encoding mitochondrially-targeted proteins.

291 Matrix Ca(2+) levels measured by X-rhod-1 or mitochondrially-targeted ratiometric biosensor 4mtD3cpv,

292 We show that mitochondrially-targeted SOD1 localizes to the IMS, wher

293 COX VIII-3 protein is mitochondrially-targeted, as shown by a fluorescent COX

294 To determine if stress affects mitochondrially transcribed mRNA (mtRNA) expression, we

295 ondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that ar

296 To examine these consequences, mitochondrially transformed cells (cybrids) were created

297 All detectable mtDNA in the mitochondrially transformed cells contained the patholog

298 Activated JNK, and cytosolic and mitochondrially-translocated Bax were increased in P4 bu

299 Mitochondrially transmitted diseases are no exception.

300 a minor histocompatibility Ag composed of a mitochondrially transmitted factor (MTF) and the RT1.Aa