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1 lagen-activated NPY-rich platelets were more mitogenic (~2-fold vs. ~1.6-fold increase) for human mic
2 rb14 as a physiological repressor of insulin mitogenic action in the liver and further supports that
3 retinoic acid, correlated with sustained pro-mitogenic action of PACAP beyond the developmental switc
7 or tyrosine kinases (RTKs) and/or downstream mitogenic activation is almost ubiquitous; thus tailored
9 activity of FGF1 can be dissociated from its mitogenic activity and is mediated predominantly via FGF
11 the increase in tumor engraftment and serum mitogenic activity in mice pretreated with a chemotherap
12 val of mice after partial hepatectomy, FGF19 mitogenic activity is associated with liver carcinoma.
13 and protein assays, we further show that the mitogenic activity of TWEAK on primary astrocytes requir
15 endent of its protease activity, FXII exerts mitogenic activity with implications for angiogenesis.
16 stigating factors that limit YAP's postnatal mitogenic activity, we found that the CM-enriched TEAD1
18 s with the capacity to withstand an aberrant mitogenic activity, with a profound impact on the geneti
19 we demonstrate that-in contrast to its known mitogenic activity-Rspo3 induces differentiation of basa
27 receptor substrates 1 and 2 (IRS1/2) mediate mitogenic and antiapoptotic signaling from insulin-like
28 y as a C-terminal fragment homologous to the mitogenic and bactericidal region in human lacritin, sug
29 demonstrate that tropoelastin elicits strong mitogenic and cell-attractive responses, both as an immo
30 syndecan-1 binding is necessary for lacritin mitogenic and cytoprotective activities, TGM2 cross-link
31 sic 1-10 nM dose optimum, the same domain is mitogenic and cytoprotective for epithelia via a syndeca
32 ERalpha-mediated gene expression involved in mitogenic and developmental processes in MCF7 breast can
33 scaffold proteins that interact with various mitogenic and developmental signals, the genetic role of
34 3, dedicated hubs integrate the antagonistic mitogenic and DNA damage signals, regulating the stoichi
37 hedgehog (HH) pathway is well known for its mitogenic and morphogenic functions during development,
38 propose that the potent, growth factor-like mitogenic and motogenic abilities of tropoelastin are bi
42 ayers and growth factors alone, we sustained mitogenic and osteogenic signals with these growth facto
47 We assessed functional T cell responses to mitogenic and viral antigenic stimulation by the express
48 s studies, we find that E-peptide signaling, mitogenic, and motogenic effects are dependent upon IGF-
49 renal ischemia-reperfusion injury, mainly by mitogenic, angiogenic, and anti-inflammatory mechanisms.
50 ture of murine CD3epsilon complexed with the mitogenic anti-CD3epsilon antibody 2C11 enabled the firs
53 ased upregulation of the CSF1R-dependent pro-mitogenic cascade, correlating with disease severity.
55 rs (GEFs) of the Dbl family are activated by mitogenic cell surface receptors and activate the Rho fa
58 these data suggest mTOR signaling-dependent, mitogenic conditioning of AECII is a determinant of host
61 rexpression of Dsg2 increased EV release and mitogenic content including epidermal growth factor rece
62 t-ratio silica microrods loaded with soluble mitogenic cues and coated with liposomes of defined comp
63 ed via the fluid, synthetic membranes, while mitogenic cues are released slowly from the microrods.
69 between in vivo and in vitro studies on the mitogenic effect of estrogen and raises questions regard
71 endent of keratinocyte proliferation and the mitogenic effect of FGF signalling, which are only requi
72 c cell types offers new understanding of the mitogenic effect of IL-17 on tissue repair and cancer.
75 the WNT signaling pathway is known to have a mitogenic effect on cells, but relatively little is know
76 l properties against 11 human pathogens, and mitogenic effect on hamster spleen lymphocytes were also
78 tumors and cell lines, leading to a similar mitogenic effect through activation of the MAP kinase pa
80 y smooth muscle cell proliferation, and this mitogenic effect was greatly pronounced in PAH-pulmonary
83 ese findings provide evidence that insulin's mitogenic effects are mediated by a subpopulation of IRs
85 three members of the MAPK family mediate the mitogenic effects of catecholoestradiols in the endothel
90 n of direct from indirect and motogenic from mitogenic effects of genes and molecules affecting wound
91 ration, and clinical trials that exploit the mitogenic effects of IL-7 have achieved success in treat
98 analogs like alfacalcidol had rapid, potent mitogenic effects on embryonic and adult cardiomyocytes
99 se BPA exerted c-Myc-dependent genotoxic and mitogenic effects on ERalpha-negative mammary cells.
100 producing IL-22 and IL-17, which have direct mitogenic effects on hepatocytes and promote a regenerat
101 Neuregulin1 (Nrg1), previously shown to have mitogenic effects on mammalian cardiomyocytes, is sharpl
103 iferation, we investigated whether insulin's mitogenic effects result from activation of Ca(2+)-signa
104 olypeptide hormones with potent anabolic and mitogenic effects that regulate cell growth and differen
105 ough E-cadherin, which prevents secretion of mitogenic epidermal growth factors (EGFs) by repressing
106 (q/11) proteins and preferentially inhibited mitogenic ERK signaling rather than canonical phospholip
108 s strains have genes encoding IgA proteases, mitogenic factor deoxyribonucleases, nickel/cobalt uptak
109 wth factor (EGF) is a potent chemotactic and mitogenic factor for epidermal keratinocytes, and these
112 moattractant protein-1 and hypoxia-inducible mitogenic factor, in the murine model of hypoxic pulmona
114 ascades lead to the downstream production of mitogenic factors and the proliferation of neighboring s
117 f fenestrations and expression of growth and mitogenic factors, leading to proliferative changes and
119 s and skeletal muscle satellite cells and is mitogenic for both cell types under normal conditions.
129 lation of which is stimulated in response to mitogenic, growth, and nutritional stimuli, and proteins
130 insulin-sensitizing action for exogenous non-mitogenic human FGF1 with therapeutic potential for the
131 subthreshold TCR signaling in the context of mitogenic IL-2 signals, thereby rendering CD8 T cells ex
132 lls, suggesting that integration of multiple mitogenic inputs may alter the minimal requirement for T
133 mechanism responsible for the generation of mitogenic IR-A and provides a novel interplay between IR
134 ntrol of ENaC activity and the activation of mitogenic kinase pathways; (b) provide evidence for a Cy
135 s a proximal target for EET-activated ERK1/2 mitogenic kinases, (c) characterize a mechanistic common
136 ed by activation of Sestrin2, which impaired mitogenic mammalian target of rapamycin (mTOR) signaling
138 tor through early endosomes are accelerated, mitogenic MAPK-ERK1/2 signals are rapidly terminated, an
140 ur data demonstrate that IL-1 functions as a mitogenic mediator of encephalitogenic Th17 cells rather
141 LOX12) expression and elevated levels of its mitogenic metabolite, 12-(S)-hydroxy-5,8,10,14-eicosatet
143 tant roles of the TNF-alpha ligand Eiger and mitogenic molecules in mediating these interactions duri
144 atocyte growth factor, Met signaling confers mitogenic, morphogenic, and motogenic activity to variou
146 ) SCLC cells, an increased expression of the mitogenic neuropeptide receptors for gastrin-releasing p
149 iferation through a novel extracellular cAMP mitogenic pathway and further support MRP4 inhibition as
150 axon guidance; 2) some very highly expressed mitogenic pathway genes (e.g., Map2k1, Igf1r, Rara, Runx
151 ctor Receptor (PDGFR) signaling is a central mitogenic pathway in development, as well as tissue repa
153 by converting a transcriptional repressor of mitogenic pathways into a transcriptional activator.
154 tion 5a (Stat5a), factors that influence key mitogenic pathways that regulate normal mammary gland de
157 of adrenomedullin (Adm, gene; AM, protein)-a mitogenic peptide hormone required for normal cardiovasc
158 for producing active endothelin-1 (ET-1), a mitogenic peptide implicated in the aetiology of a numbe
162 tion of furin reduces IRA maturation and its mitogenic potential without altering the insulin effects
164 al mediator of FGF19 action on metabolic and mitogenic programs; thus, the involvement of mTORC1 in F
167 reased hepatocyte proliferation; however, no mitogenic response in hepatocytes to T3 was evident in t
169 demonstrate that neuronal activity elicits a mitogenic response of neural progenitor cells and OPCs,
170 ily of Ca(2+)-regulated PDEs, also induced a mitogenic response to AVP in NHK cells, similar to the e
171 We have identified T3-induced hepatocyte mitogenic response to be mediated by PKA-dependent beta-
173 y reflect the requirement for an exceptional mitogenic response to growth factor signalling in the af
174 re rapid VEGFR2 clustering and a more potent mitogenic response triggered by VEGF-A in respect to gre
179 weakly acting phytoestrogen that mimics the mitogenic responses produced by E2 in an ERalpha-depende
180 cholinergic neurons, revealing an important mitogenic role for the planarian hh signaling molecule i
181 rn of events given the pathway's established mitogenic role, and they show that Hedgehog pathway atte
184 phingolipids ceramide and sphingosine to the mitogenic S1P, thereby determining the susceptibility of
185 port that the ER-transiting and functionally mitogenic secreted proenzyme (pCatD) form of cathepsin D
186 Previously, we found that PACAP was an anti-mitogenic signal from embryonic day 13.5 (E13.5) onward
190 kinase impaired ERBB3 (HER3) create a potent mitogenic signal, but the phosphorylation of ERBB2 in th
191 gulated and extended the transduction of the mitogenic signal, whereas silencing of LNK produced the
194 broblasts function cooperatively to activate mitogenic signaling activities and to induce their trans
195 y reported that, in cancer cells, heightened mitogenic signaling allows TGF-beta-activated Smad3 to i
196 e-independent timer to limit the response to mitogenic signaling and aberrant cycling in terminally d
197 , we propose that cilia decapitation induces mitogenic signaling and constitutes a molecular link bet
198 Cav-1 may provide a mechanism for regulating mitogenic signaling and modulating the cell-surface pres
201 how IL-17-mediated inflammatory response and mitogenic signaling are exploited to equip its cancer-pr
203 cell proliferation by induction of paracrine mitogenic signaling between heterogeneous malignant cell
206 nockdown or small-molecule targeting reduced mitogenic signaling in non-small cell lung cancer cell l
208 y in the G(1) cell cycle phase, we find that mitogenic signaling is temporally integrated throughout
210 expression activates PI3K, a key node in the mitogenic signaling network known to promote malignancie
211 hinery is a major recipient of the principal mitogenic signaling networks involving Raf-ERK1/2 and ph
212 ction as a tumor suppressor and regulator of mitogenic signaling networks such as the Ras/rac, Akt, a
213 ry of knowledge for beta-cell researchers on mitogenic signaling pathways and to emphasize how little
214 findings show that an important activity of mitogenic signaling pathways is to inactivate the growth
215 increased hHSC proliferation through several mitogenic signaling pathways such as EGFR, PI3K and p38.
216 contain known binding sites for effectors of mitogenic signaling pathways such as Yorkie and Notch.
217 nduces hHSC fibrogenic activity via multiple mitogenic signaling pathways, and is upregulated in muri
219 as a signaling hub that negatively regulates mitogenic signaling pathways, like the ERK1/2 MAP kinase
220 cell proliferation, tissue growth, and many mitogenic signaling pathways; we investigated its role i
221 Taken together, these results indicate that mitogenic signaling regulates the miRNA effector machine
223 cellular desmosomal adhesion, Dsg2 regulates mitogenic signaling that may promote cancer development
225 ling, contraction, intracellular Ca(2+), and mitogenic signaling were determined in vivo and in vitro
226 uce the maturation of IRA and its associated mitogenic signaling without altering the signals emanati
228 pletion reduces smooth muscle proliferation, mitogenic signaling, and extracellular matrix deposition
229 nic demonstrated RTK blockade, inhibition of mitogenic signaling, and proapoptotic signal induction i
230 in receptor, allowing aberrant activation of mitogenic signaling, promotes aberrant splicing and expr
231 ermal growth factor receptor (EGFR)-mediated mitogenic signaling, promoting tumor cell survival throu
240 late cell proliferation, but how fluctuating mitogenic signals are converted into proliferation-quies
241 hai or Galphas, Akt signaling is suppressed, mitogenic signals are enhanced due to delayed transit ti
242 and implicate tumor-associated DCs and their mitogenic signals as auspicious therapeutic targets.
243 77-eGFP, c-Myc protein expression integrates mitogenic signals downstream of both IL-2 and the TCR, y
245 vels allows effective integration of diverse mitogenic signals in ISCs to adapt their proliferative a
247 alpha(q) and its coupled receptors transduce mitogenic signals is still unclear because of the comple
251 to permeate neurofibroma tissue, mediate key mitogenic signals that contribute to vascular ingrowth,
252 r cells, as well as to normal cells, sending mitogenic signals that greatly enhance tumor growth.
254 tal for oncogenic signaling as it integrates mitogenic signals to amplify production of pro-growth an
255 mature myometrial or leiomyoma cells to send mitogenic signals to neighboring tissue stem cells in re
256 clin D-dependent kinases sense a plethora of mitogenic signals to orchestrate specific transcriptiona
258 cking as to how developing neurons integrate mitogenic signals with microenvironment cues to control
260 We show that Activin directly inhibits the mitogenic sonic hedgehog pathway in a Gli3-dependent man
267 -associated HIV-1 RNA was detected following mitogenic stimulation of peripheral blood CD4(+) T cells
270 e protein complexes that can be activated by mitogenic stimulation to repress mitogen-stimulated targ
276 and temporarily dissociated from mTORC1 upon mitogenic stimulation, suggesting a mechanism underlying
286 f cord blood mononuclear cells to innate and mitogenic stimuli (P = .0009), with an average 1.7- to 2
287 lar B lymphocytes were expanded by providing mitogenic stimuli and then challenged with KSHV-specific
291 hese conditions, hPSC-CMs were refractory to mitogenic stimuli, and we found that key proliferation p
295 irus 8 (HHV-8) is believed to contribute via mitogenic, survival, and angiogenic activities to HHV-8-
296 nd cytokine secretion after stimulation with mitogenic, TLR, and T-cell stimuli by cytometric bead ar
297 ing growth factor-beta1 (TGF-beta1), LRG1 is mitogenic to endothelial cells and promotes angiogenesis