ライフサイエンスコーパス: mitotic arrest

1 PTX) paradoxically cause G1 arrest (without mitotic arrest).

2 ack control of APC/C to SAC during prolonged mitotic arrest.

3 totic slippage during prolonged drug-induced mitotic arrest.

4 n cultured cells and suppressed shot-induced mitotic arrest.

5 thesis and caused incomplete proteolysis and mitotic arrest.

6 ing in a progressive weakening of SAC during mitotic arrest.

7 chromosome attachment failures, which led to mitotic arrest.

8 s initiate meiosis and male germ cells enter mitotic arrest.

9 f Mad2 with its binding partners and thereby mitotic arrest.

10 n in the current model describing fate after mitotic arrest.

11 ion and caused cellular microtubule loss and mitotic arrest.

12 ate the checkpoint after a defined period of mitotic arrest.

13 ltinucleated rather than dying directly from mitotic arrest.

14 les and metaphase plate formation and causes mitotic arrest.

15 -) HCT116 cells is frequently accompanied by mitotic arrest.

16 guishes between normal mitosis and prolonged mitotic arrest.

17 uppression results in monopolar spindles and mitotic arrest.

18 ng cancer cells in the apoptotic response to mitotic arrest.

19 formation of aberrant mitotic spindles, and mitotic arrest.

20 locking centrosome maturation and leading to mitotic arrest.

21 mma-tubulin at the centrosomes, rescuing the mitotic arrest.

22 osis in some cell lines at similar levels of mitotic arrest.

23 (PTX) and other microtubule inhibitors cause mitotic arrest.

24 bulin and stabilizes microtubules leading to mitotic arrest.

25 and results in microtubule stabilization and mitotic arrest.

26 paclitaxel-induced microtubule bundling and mitotic arrest.

27 proteins rescues the Chk1 depletion-induced mitotic arrest.

28 20 and induces a spindle-checkpoint-mediated mitotic arrest.

29 r, partial depletion of CCT or Plk1 leads to mitotic arrest.

30 0 or LIS1 cause distinct spindle defects and mitotic arrest.

31 cells by CA-4-P is associated with prolonged mitotic arrest.

32 Blockade of APC activity causes mitotic arrest.

33 nes and increased the population of cells in mitotic arrest.

34 telomeric poly(ADP-ribose) polymerase caused mitotic arrest.

35 s exhibit both proliferative defect(s) and a mitotic arrest.

36 checkpoint, it is insufficient for a robust mitotic arrest.

37 ate a robust checkpoint signal and prolonged mitotic arrest.

38 in human lens epithelial cells resulted in a mitotic arrest.

39 delayed at cell separation upon release from mitotic arrest.

40 ation of FoxM1 and its target genes preceded mitotic arrest.

41 g S or G2-M phases underwent death following mitotic arrest.

42 ure to increase cyclin D1, all indicative of mitotic arrest.

43 and dose-dependent manner, correlating with mitotic arrest.

44 d for mitotic cell cycle factors, leading to mitotic arrest.

45 spindle checkpoint re-activation and lethal mitotic arrest.

46 ta link AR degradation via ubiquitination to mitotic arrest.

47 ing AR into PC3-M cells confers 2-ME-induced mitotic arrest.

48 the apoptosis and adaptation pathways during mitotic arrest.

49 rations of epothilone B, one that induced no mitotic arrest (0.2 nM, 20 h), one that induced one-thir

50 r ability to recover from nocodazole-induced mitotic arrest: a large fraction of +/- cells failed to

51 ecific conditional lethality associated with mitotic arrest, aberrant spindle structures, and chromos

52 congression, and their disruption results in mitotic arrest accompanied by multiple spindle aberratio

53 codynamic experiments demonstrated prolonged mitotic arrest after oral administration of 12c to tumor

54 ces early cell cycle progression followed by mitotic arrest, an event that almost certainly reflects

55 v1 xenografts in mice with docetaxel induced mitotic arrest and a decrease in PSA expression in tumor

56 wn of Aurora A impaired cell growth, induced mitotic arrest and aberrant nuclear division leading to

57 nd inhibits tumor cell proliferation through mitotic arrest and accumulation of monopolar spindles.

58 Paclitaxel stabilizes microtubules, causing mitotic arrest and activating the spindle assembly check

59 We detected DNA damage late in mitotic arrest and also after slippage.

60 ase 1 (CDK1) during antimitotic drug-induced mitotic arrest and also in normal mitosis.

61 ive cell-cycle kinase inhibitor that induces mitotic arrest and apoptosis by targeting Polo-like kina

62 by lentivirus-based RNA interference led to mitotic arrest and apoptosis in cancer cells, whereas no

63 rovide novel insights into the mechanisms of mitotic arrest and apoptosis induced by microtubule-targ

64 might provide a molecular basis for linking mitotic arrest and apoptosis of fibroblasts by C1q tails

65 All three ITCs also induced mitotic arrest and apoptosis with the same order of acti

66 tubule destabilizing agent, led to increased mitotic arrest and apoptosis, consistent with spindle de

67 We found no correlation between levels of mitotic arrest and apoptosis.

68 ibitor has multitargeted activity, promoting mitotic arrest and apoptosis.

69 ghly effective anticancer agent that induces mitotic arrest and apoptosis.

70 r spindle formation that ultimately leads to mitotic arrest and apoptotic cell death.

71 Like Dma1, CK1 accumulates at SPBs during a mitotic arrest and associates stably with SPB components

72 e by hydroxyurea abrogated both AITC-induced mitotic arrest and Bcl-2 phosphorylation.

73 ication identified 'Dosabulin', which causes mitotic arrest and cancer cell death by apoptosis.

74 Here we show that DNA damage-activated mitotic arrest and CDK activation lead to the phosphoryl

75 although it was insufficient to override the mitotic arrest and cell death caused by RABL6A loss.

76 eover, S12 alters spindle formation, causing mitotic arrest and cell death, and inhibits tumor growth

77 d well to their gene ontology association in mitotic arrest and cell death, respectively.

78 kemic cell proliferation in vitro and induce mitotic arrest and cell death.

79 ules and reduces their dynamicity, promoting mitotic arrest and cell death.

80 was accompanied by a synergistic increase in mitotic arrest and cell death.

81 microtubule dynamic instability, leading to mitotic arrest and cell death.

82 heir anticancer effects primarily by causing mitotic arrest and cell death.

83 in defective polyploidization accompanied by mitotic arrest and cell death.

84 pindle assembly checkpoint (SAC) activation, mitotic arrest and cell death.

85 get the microtubule cytoskeleton, leading to mitotic arrest and cell death; however, their clinical e

86 Strong mitotic arrest and chromosome congression failure occurr

87 tured cells, depletion of the protein causes mitotic arrest and complete failure of sister chromatid

88 chanism is independent of paclitaxel-induced mitotic arrest and could provide an alternative mechanis

89 lobal protein synthesis rates and results in mitotic arrest and delayed cell migration.

90 Hence, they bypass mitotic arrest and embark on anaphase in spite of incorr

91 and kidney defects in heterozygotes and with mitotic arrest and embryonic lethality in homozygotes.

92 by Cdk1 is required for checkpoint-mediated mitotic arrest and for recruitment of Plx1 and the check

93 This novel anticancer agent causes mitotic arrest and growth inhibition in several human tu

94 nt inhibitor of KSP, CK0106023, which causes mitotic arrest and growth inhibition in several human tu

95 tion of this protein in vivo causes an early mitotic arrest and increased cytotoxicity when cells are

96 death occurs in premetaphase stage following mitotic arrest and is not a consequence of general toxic

97 MB-435) responded to the same treatment with mitotic arrest and massive apoptosis.

98 e outcome consistent with dual mechanisms of mitotic arrest and mitotic slippage induced by antimitot

99 pus laevis homologue of human KSP, can cause mitotic arrest and monopolar spindle formation.

100 In mice, ablation of Aurora A results in mitotic arrest and pre-implantation lethality, preventin

101 all-molecule inhibitor monastrol resulted in mitotic arrest and rapid caspase activation.

102 repair (HR), resulting in the conundrum how mitotic arrest and repair can be reconciled.

103 ntrations of paclitaxel are too low to cause mitotic arrest and result in multipolar divisions instea

104 l imaging of treated cells demonstrated that mitotic arrest and segregation abnormalities lead to cel

105 ncreased the ratio of cells that died during mitotic arrest and sensitized cancer cells to mitotic po

106 We suggest that under mitotic arrest and starvation, relative CE levels increa

107 ppresses tumorigenesis in part by triggering mitotic arrest and subsequent apoptosis.

108 n-dependent kinase inhibitor p27, leading to mitotic arrest and subsequently cell polyploidy.

109 delayed progression into nocodazole-induced mitotic arrest and was confirmed by a lack of BrdUrd inc

110 tosis induction by AITC depended entirely on mitotic arrest and was mediated via Bcl-2 phosphorylatio

111 ominantly acting cell cycle regulator causes mitotic arrest and, thereby, inviability of male hybrid

112 akinetochore stretch, a checkpoint-dependent mitotic arrest, and accumulation of microtubule attachme

113 d proteasome-dependent survivin degradation, mitotic arrest, and apoptosis, and it blocked the growth

114 Taxanes induce microtubule stabilization, mitotic arrest, and apoptotic cell death, but recent dat

115 y for MT morphology, chromatin condensation, mitotic arrest, and cellular toxicity to identify region

116 cell-cycle progression, increased apoptosis, mitotic arrest, and chemosensitivity, and cooperated wit

117 k model describing cell death control during mitotic arrest, and constrained the model using experime

118 ression prolonged mitosis, caused occasional mitotic arrest, and decreased mitotic spindle movements.

119 govern neural progenitor lineage commitment, mitotic arrest, and differentiation into functional prog

120 d correlation exists between photobleaching, mitotic arrest, and dye oxidation.

121 with pronounced cell proliferation failure, mitotic arrest, and monopolar spindle formation.

122 p between the excitation light intensity and mitotic arrest, and the frequency of mitotic arrest is d

123 assemble K11 linkages in cells released from mitotic arrest, and these are proposed to constitute an

124 d that Plk1 depletion preferentially induced mitotic arrest, aneuploidy, and reduced cell survival in

125 targeting agents (MTAs) cause cell death via mitotic arrest applies to rapidly dividing cells but can

126 all molecules that bind to tubulin and cause mitotic arrest are of immense interest.

127 low nanomolar range and caused apoptosis and mitotic arrest as measured in a high content nuclear mor

128 crotubule organization in cells, and induced mitotic arrest, as well as apoptosis.

129 ed defective chromosome alignment and severe mitotic arrest associated with increased Mad1/Mad2 signa

130 of vihar in the syncytial embryo results in mitotic arrest at late anaphase.

131 Overexpression of RASSF1A induces mitotic arrest at metaphase with aberrant mitotic cells

132 er and the tumor cells survived longer after mitotic arrest, becoming multinucleated rather than dyin

133 s (growth) also occurs in response to G2 and mitotic arrests but not during a G1 arrest.

134 Mitotic arrest by AITC was associated with increased ubi

135 Stabilisation of Mcl-1 during mitotic arrest by mutation of either Thr92 or a D-box de

136 Reducing mitotic arrest by reversin treatment prevented accumulat

137 We hypothesize that epothilones induce mitotic arrest by suppressing microtubule dynamics.

138 ine (MCF-10A) was markedly more resistant to mitotic arrest by WA compared with breast cancer cells.

139 chromatid cohesion defects and the resulting mitotic arrest caused by Naa50 depletion, indicating tha

140 ilencing was sufficient to rescue cells from mitotic arrest caused by PCTAIRE1 silencing.

141 ed in noninfected cells, E4orf3 overcame the mitotic arrest caused by the degradation-resistant R42A

142 spase-2 and suggest that under conditions of mitotic arrest, cdk1-cyclin B1 activity must be overcome

143 of p34(cdc2) activity by purvalanol A caused mitotic-arrested cells to rapidly exit mitosis, suggesti

144 n improper Plk1 recruitment to kinetochores, mitotic arrest, chromosome missegregation, and apoptosis

145 However, how mitotic arrest contributes to tumorigenesis or antimitot

146 apoptosis, suggesting that Cdk activation at mitotic arrest could induce subsequent MCL-1 degradation

147 onents of the spindle checkpoint include the mitotic arrest defective (MAD) genes MAD1-3, and the bud

148 Mitotic arrest deficiency 2 (Mad2) is a component of mit

149 The mitotic arrest deficiency 2 (Mad2) spindle checkpoint pr

150 Mitotic arrest deficiency 2 (Mad2), a critical component

151 Mitotic arrest deficiency protein 1 (Mad1) is associated

152 nclude up-regulation/induction of cyclin D1, mitotic arrest deficient (MAD)1, p21, growth arrest and

153 Mitotic arrest deficient 1 (Mad1) plays a well-character

154 Mitotic arrest deficient 1 (Mad1) plays a well-character

155 Recently, the SAC components Mitotic Arrest Deficient 1 and 2 (MAD1 and MAD2) were fo

156 The checkpoint protein mitotic arrest deficient 2 (Mad2) is an unusual protein

157 We also show that mitotic arrest deficient 2 (Mad2), a member of the spind

158 t is the conformational conversion of "open" mitotic arrest deficient 2 (O-MAD2) into "closed" MAD2 (

159 Structural changes in the mitotic arrest deficient protein 2 (Mad2) have been prop

160 association studies have identified MAD1L1 (mitotic arrest deficient-like 1) as a susceptibility gen

161 by modulating several targets including MAD2 mitotic arrest deficient-like 1, MAD2L1, a component of

162 udding uninhibited by benzimidazole (Bub) 1, mitotic arrest-deficient (Mad) 1, and Mad2 proteins prom

163 nts of the spindle checkpoint pathway (e.g., Mitotic Arrest-Deficient 1 [MAD1], Mitotic Arrest-Defici

164 otic regulation through its interaction with mitotic arrest-deficient 2 (MAD2).

165 ay (e.g., Mitotic Arrest-Deficient 1 [MAD1], Mitotic Arrest-Deficient 2 [MAD2]) and DNA-damage-checkp

166 Mitotic arrest-deficient protein 1 (MAD1) is a component

167 The mitotic arrest-deficient protein Mad1 forms a complex wi

168 the extent of Thr-602 phosphorylation during mitotic arrest dependent on the mechanism of the arresti

169 evailing model suggests that cell fate after mitotic arrest depends on two independent and competing

170 ed microtubule dynamics, and the duration of mitotic arrest dictates the probability, but not the tim

171 transient during mitosis to sustained during mitotic arrest, dramatically increases the extent of Bcl

172 Depletion of cellular Ypi1 induces mitotic arrest due to activation of the spindle checkpoi

173 The failure of cells to maintain mitotic arrest, due to lack of phosphorylation at Ser-11

174 At the IC(50) for mitotic arrest, dynamicity was reduced by 54% by paclita

175 ddition, potent and novel agents that induce mitotic arrest either by directly interfering with tubul

176 The gradual weakening of SAC during mitotic arrest enables APC/C(CDC20) to degrade cyclin B1

177 In contrast, cells made polyploid without mitotic arrest exhibited neither significant structural

178 sult in elimination of human PCa cells via a mitotic arrest followed by apoptosis (1).

179 ependent kinase 1 (Cdc2)/cyclin B 1-mediated mitotic arrest followed by apoptosis.

180 PyST is known to induce mitotic arrest followed by extensive cell death in mamma

181 l of survivin by RNA interference produces a mitotic arrest followed by re-entry into the cell cycle

182 ss of the APC/C in dividing cells results in mitotic arrest, followed by apoptosis.

183 os perturbs the progression of cell cycle by mitotic arrest, followed by apoptotic cell death associa

184 reatment caused spindle assembly defects and mitotic arrest, followed by slippage from mitotic arrest

185 -orientation, and while the SAC can maintain mitotic arrest for extended periods, moderate delays in

186 These two cells enter mitotic arrest for three cycles after the 5th cell cycle

187 g PLK1 inhibition with nocodazole (to induce mitotic arrest) had synergistic antitumor effects in vit

188 CHK2-mediated mitotic arrest has been previously shown to occur in res

189 At the same time, deliberate induction of mitotic arrest has proved clinically useful, as antimito

190 tion of anti-apoptotic Bcl-2 proteins during mitotic arrest; however, it remains unclear how this mec

191 Taxanes are very effective at causing mitotic arrest; however, there is variability among canc

192 that drives widespread genomic instability, mitotic arrest, hyperactivation of autophagy, and cell d

193 M, 20 h), one that induced one-third maximal mitotic arrest (IC(33,) 2 nM, 20 h), and one that induce

194 nM, 20 h), and one that induced half-maximal mitotic arrest (IC(50,) 3.5 nM, 20 h).

195 uman fibroblasts, DNA breaks occurred during mitotic arrest in a p53-independent manner, but p53 was

196 duce prolonged, spindle checkpoint-dependent mitotic arrest in cancer cells.

197 ing Cdc20 mutant restores nocodazole-induced mitotic arrest in cells depleted of Mad2 or BubR1.

198 es, induces microtubule depolymerization and mitotic arrest in cells.

199 capacity of the SAH domain is important for mitotic arrest in conditions of suppressed microtubule d

200 impaired APC/C function also leads to fatal mitotic arrest in diploid RPE1 cells.

201 Furthermore, loss of Foxo3 induced mitotic arrest in erythroid precursor cells, leading to

202 -E17.5, many mutant germ cells fail to enter mitotic arrest in G0 and do not downregulate the pluripo

203 AK301 induced mitotic arrest in HT29 human colon cancer cells with an

204 both pharmacologic and genetic induction of mitotic arrest in human cancer cells.

205 sses structural chromosome instability after mitotic arrest in human cells.

206 ent mechanism for diallyl trisulfide-induced mitotic arrest in human prostate cancer cells.

207 ted, strongly suggesting that DND1 regulates mitotic arrest in male germ cells through translational

208 Telomere fusions triggered mitotic arrest in p53-compromised non-crisis cells, indi

209 Our results suggest that maintenance of mitotic arrest in pregranulosa cells may preclude upregu

210 , an endogenous estrogen metabolite, induces mitotic arrest in prostate cancer cells involving activa

211 on of MT dynamics is critical to maintaining mitotic arrest in response to mispositioned spindles.

212 Both mechanisms are required to sustain mitotic arrest in response to spindle defects.

213 1 in slippage-resistant HT29 or by enforcing mitotic arrest in slippage-prone DLD-1 cells, evokes a s

214 ckdown cells had difficulty in maintaining a mitotic arrest in the presence of nocodazole.

215 hat cells are unable to maintain a prolonged mitotic arrest in the presence of unaligned chromosomes.

216 is whether cells complete mitosis or sustain mitotic arrest in the presence of unaligned chromosomes.

217 intain spindle assembly checkpoint-dependent mitotic arrest in the same cell cycle.

218 larval neuroblasts, leading to a preanaphase mitotic arrest in these cells.

219 Mitotic arrest in wild-type megakaryocytes treated with

220 accompanies paclitaxel-induced, SAC-mediated mitotic arrest, independent of p53 integrity or signalin

221 This response precedes mitotic arrest, indicating coordinated upregulation of p

222 f metaphase chromosome alignment and induced mitotic arrest, indicating that tight binding of CENP-E

223 Mitotic arrest induced by antimitotic drugs can cause ap

224 eficient epithelial cells in vivo escape the mitotic arrest induced by Eg5 suppression.

225 In contrast, CK2 beta does not inhibit the mitotic arrest induced by injection of active Rsk.

226 However, we show here that the mitotic arrest induced by proTAME is due to the inductio

227 dependent kinase 1 (CDK1)/cyclin B catalyzes mitotic-arrest-induced Bcl-x(L)/Bcl-2 phosphorylation.

228 Here, we show that mitotic arrest induces a caspase-dependent DNA damage re

229 on of p53 after cells slipped from prolonged mitotic arrest into G1.

230 pler explanation for why the proTAME-induced mitotic arrest is also dependent on the SAC.

231 Mitotic arrest is ascribable to activation of the Mad2/B

232 gh degradation of cyclin B1 during prolonged mitotic arrest is believed to trigger mitotic slippage,

233 ity and mitotic arrest, and the frequency of mitotic arrest is dependent on the presence of an IFP th

234 ought to test the hypothesis that fate after mitotic arrest is dictated by the robustness of Cdk1/cyc

235 Mitotic arrest is evident in both Magoh haploinsufficien

236 Surprisingly, a robust mitotic arrest is maintained in the majority of bub3 Del

237 tate of the APC changes, indicating that the mitotic arrest is not a static condition.

238 icity of TH588, in line with the notion that mitotic arrest is required for ROS buildup and oxidation

239 efficiency of both chromosome alignment and mitotic arrest, likely through displacement of endogenou

240 However, during mitotic arrest, low level cGAS-dependent IRF3 phosphoryl

241 ssembly; as such, inhibition of Eg5 leads to mitotic arrest making it a potential anticancer target.

242 They also suggest that mitotic arrest may promote tumorigenesis and antimitotic

243 During mitotic arrest, MCL1 protein levels decline markedly, th

244 Rather, it involved a highly specific mitotic arrest mediated by the Mad2 cell cycle checkpoin

245 with human U2OS cells revealed that 1 causes mitotic arrest, micronucleus induction, centrosome ampli

246 We observed aberrant exit of gonocytes from mitotic arrest, migration toward cord periphery, and pre

247 nd mitotic arrest, followed by slippage from mitotic arrest, multinucleation, and apoptosis.

248 The impaired mitotic arrest of BubR1(+/-) MEFs was associated with lo

249 It was reported that taxol-mediated mitotic arrest of cancer cells is associated with surviv

250 bility, cell cycle G2/M phase transition and mitotic arrest of cancer cells.

251 ormal cells in the G1 phase while inducing a mitotic arrest of tumor cells resulting in selective kil

252 ex with Mad2, which is required for imposing mitotic arrest on cells in which the spindle assembly is

253 urora A inhibition that act independently of mitotic arrest or slippage, were assessed in the tumor b

254 will lead to chromosomal segregation errors, mitotic arrest, or aneuploidy.

255 We conclude that prolonged mitotic arrest partially activates the apoptotic pathway

256 Drugs or siRNAs that induce mitotic arrest promote proapoptotic splicing of Bcl-x, M

257 ition of either caspase-3/7 or DNA-PK during mitotic arrest, promotes subsequent cell survival.

258 n of any one of these proteins abolishes the mitotic arrest provoked by depolymerizing microtubules o

259 Mcl-1 destruction during mitotic arrest requires proteasome activity and is depen

260 s (high content screening), we find that the mitotic arrest response shows relatively little variatio

261 The G2 and mitotic arrest resulting from WA exposure in MCF-7, SUM1

262 at human cells in crisis undergo spontaneous mitotic arrest, resulting in death during mitosis or in

263 is pathway wherein chromosome fusions induce mitotic arrest, resulting in mitotic telomere deprotecti

264 Mitotic arrests stop growth independently of arresting m

265 do accumulate Mcd1/Scc1 at centromeres upon mitotic arrest, suggesting that the cyclin-dependent mec

266 , killing cancer cells by inducing prolonged mitotic arrest that activates intrinsic apoptosis.

267 ivation of separase but, instead, triggers a mitotic arrest that depends on Mad2 and Aurora B.

268 Consistently, 17-AAG induced a mitotic arrest that depends on the spindle checkpoint an

269 In cells, proTAME causes a mitotic arrest that is SAC-dependent.

270 t nucleus also undergoes remodeling during a mitotic arrest; the NE continues to expand despite the p

271 Mitotic arrest then drives cohesion fatigue and triggers

272 Prolonged mitotic arrest then led to cell death via mitotic catast

273 ic exit and prevents polarized growth during mitotic arrest, thereby coupling cell cycle progression

274 to the colchicine site of tubulin to induce mitotic arrest through a microtubule cytoskeleton-based

275 l duration and as a functional link coupling mitotic arrest to apoptosis.

276 r cells did not progress through Ptx-induced mitotic arrest, tumor significantly regressed in the mod

277 ed predominantly in those cells that undergo mitotic arrest upon PyST expression.

278 epleted cells, an S112A mutant disrupted the mitotic arrest upon SAC activation.

279 that HR22C16-A1 induces cell death following mitotic arrest via the intrinsic apoptotic pathway.

280 Mitotic arrest was associated with elevated levels of cy

281 ited growth of normal lung fibroblast cells, mitotic arrest was more pronounced in the colon cancer c

282 ontrast to results with 2D culture, observed mitotic arrest was relatively low, suggesting involvemen

283 of Bcl-2 proteins in apoptosis induced after mitotic arrest, we investigated the subcellular location

284 ences the rate and extent of apoptosis after mitotic arrest, we screened a kinase-enriched small inte

285 The morphologies associated with mitotic arrest were dose and time dependent, thereby pro

286 er(216) phosphorylation of Cdc25C as well as mitotic arrest were significantly attenuated by knockdow

287 s of acute leukemia cells have an attenuated mitotic arrest when decatenation is inhibited and that i

288 chromatid exchange but fail to maintain the mitotic arrest when SAC is activated and exhibit a broad

289 aclitaxel has long been recognized to induce mitotic arrest, which leads to cell death in a subset of

290 as aborted cell division without a prolonged mitotic arrest, which ultimately resulted in cell death.

291 mammalian cells can eventually overcome the mitotic arrest while the checkpoint is still activated.

292 ibroblasts causes impaired mitotic entry and mitotic arrest with a profound defect in bipolar spindle

293 This strategy revealed that prolonging mitotic arrest with a small molecule inhibitor of the AP

294 Embryos from nopo females undergo mitotic arrest with barrel-shaped, acentrosomal spindles

295 Embryos from nopo females undergo mitotic arrest with barrel-shaped, acentrosomal spindles

296 utively active kinase results in a prolonged mitotic arrest with continuous turnover of microtubule-k

297 wild-type or a non-degradable CKAP2 led to a mitotic arrest with monopolar spindles containing highly

298 HeLa cells inhibits cell growth and induces mitotic arrest with multiple mitotic defects, which subs

299 utations in Cdc48 and its adaptor Ubx4 cause mitotic arrest with sustained Clb2 and Cdc20 proteins th

300 g slippage and the outcome of taxane-induced mitotic arrest, with potential implications for cancer t