ライフサイエンスコーパス: mitotic chromosome

1 ts with spindle checkpoint signaling on each mitotic chromosome.

2 lls, a fraction of separase localizes to the mitotic chromosome.

3 ions in homeodomain lose the ability to bind mitotic chromosomes.

4 tion and axial contraction to properly shape mitotic chromosomes.

5 P-D3 acts to limit condensin II binding onto mitotic chromosomes.

6 nsin II play non-redundant roles controlling mitotic chromosomes.

7 ensin complex plays a key role in organizing mitotic chromosomes.

8 n complex, a key component of interphase and mitotic chromosomes.

9 ic chromosomes, Cbx2 overwhelmingly binds to mitotic chromosomes.

10 nd Cbx2 is needed to recruit PRC1 complex to mitotic chromosomes.

11 s no effect on the immobilization of Cbx2 on mitotic chromosomes.

12 G2 and M-phase is truly required for shaping mitotic chromosomes.

13 ther Cbx-family proteins dynamically bind to mitotic chromosomes.

14 proteins had weaker association to condensed mitotic chromosomes.

15 ammalian cells reduces RCC1 association with mitotic chromosomes.

16 region did not independently associate with mitotic chromosomes.

17 itosis and is necessary for the formation of mitotic chromosomes.

18 ET in spatial proximity to and far away from mitotic chromosomes.

19 l LANA binds TR DNA and also associates with mitotic chromosomes.

20 mentally increasing the levels of cohesin on mitotic chromosomes.

21 e it has never been observed directly within mitotic chromosomes.

22 mately 4,000 proteins identified in isolated mitotic chromosomes.

23 vent resulted in the removal of PR-Set7 from mitotic chromosomes.

24 ith gene promoters packaged within condensed mitotic chromosomes.

25 een lasers are used to induce alterations in mitotic chromosomes.

26 n-mediated compaction to fold chromatin into mitotic chromosomes.

27 topological organization of chromatin inside mitotic chromosomes.

28 constraints on chromatin, ATP alone relaxes mitotic chromosomes.

29 processes occur only in the vicinity of the mitotic chromosomes.

30 and increased SRp20 and ASF/SF2 retention on mitotic chromosomes.

31 transcription, and the assembly of condensed mitotic chromosomes.

32 ecessary and sufficient for interaction with mitotic chromosomes.

33 lex is a major constituent of interphase and mitotic chromosomes.

34 l imaging indicated that they are present in mitotic chromosomes.

35 rotein targets the short arms of acrocentric mitotic chromosomes.

36 a novel interaction with specific regions of mitotic chromosomes.

37 ude that TOP2A is crucial for maintenance of mitotic chromosomes.

38 f-associates to specifically bind TR DNA and mitotic chromosomes.

39 Widerborst subunit led to scattering of all mitotic chromosomes.

40 rus type 1 E2 and viral genomes to host cell mitotic chromosomes.

41 viruses (HPV) for anchoring viral genomes to mitotic chromosomes.

42 s appear to bind to more specific regions of mitotic chromosomes.

43 tion is insufficient for E2 association with mitotic chromosomes.

44 illomavirus type 1 links the viral genome to mitotic chromosomes.

45 lR1 significantly reduced E2 localization to mitotic chromosomes.

46 tion with LANA and the KSHV episomes on host mitotic chromosomes.

47 is interaction to efficiently associate with mitotic chromosomes.

48 e arms as well as the centromeric regions of mitotic chromosomes.

49 n (LANA) mediates viral genome attachment to mitotic chromosomes.

50 and correspondingly does not associate with mitotic chromosomes.

51 teins AKAP95 and HA95, which are targeted to mitotic chromosomes.

52 he BPV1 E2 protein has been shown to bind to mitotic chromosomes.

53 DNA, either HPV-16 or -31, is displaced from mitotic chromosomes.

54 modeling of the large-scale organization of mitotic chromosomes.

55 t represent a condensed form akin to that of mitotic chromosomes.

56 8 decorated the inter-chromatid axial DNA on mitotic chromosomes.

57 d from the TGN, followed by association with mitotic chromosomes.

58 to 120- and 300- to 700-nanometer fibers and mitotic chromosomes.

59 tubule attachments formed at kinetochores of mitotic chromosomes.

60 on of the kinase to the centromere region of mitotic chromosomes.

61 al chromatin polymers, megabase domains, and mitotic chromosomes.

62 he distinct appearance of heterochromatin on mitotic chromosomes.

63 nus of p12 is required for tethering to host mitotic chromosomes.

64 PICH specifically disperses SUMO2/3 foci on mitotic chromosomes.

65 ochore proteins CENP-A, CENP-C, and NDC80 to mitotic chromosomes.

66 TFs we tested are significantly enriched on mitotic chromosomes.

67 s ratio is a critical determinant in shaping mitotic chromosomes.

68 independent and cooperative roles in folding mitotic chromosomes.

69 e that alters the ratio of condensin I:II on mitotic chromosomes.

70 We demonstrated that Grh remains bound to mitotic chromosomes, a property shared with other pionee

71 required for the ability of ETAA1 to prevent mitotic chromosome abnormalities following replicative s

72 Duplicated mitotic chromosomes aligned at the metaphase plate maint

73 Astrin/SKAP complex plays important roles in mitotic chromosome alignment and centrosome integrity, b

74 hronic inhibition of DRP1, causes defects in mitotic chromosome alignment and S-phase entry character

75 ave roles in interphase nuclear positioning, mitotic chromosome alignment, and nuclear migration duri

76 ell as defects in centrosomal separation and mitotic chromosome alignment.

77 nanoscopic imaging of interphase nuclei and mitotic chromosomes, allowing a quantitative analysis of

78 d identified bromodomain protein Brd4 as the mitotic chromosome anchor for the bovine papillomavirus

79 nted microtubules (MTs) self-organize around mitotic chromosomes and assemble anastral spindles.

80 tants retained the ability to associate with mitotic chromosomes and bind TR DNA.

81 f KBP disrupts the movement and alignment of mitotic chromosomes and decreases spindle length, a comb

82 on of chromatin in mitosis that form compact mitotic chromosomes and ensure the fidelity of chromosom

83 The spatial organization of mitotic chromosomes and how condensin shapes chromatin a

84 CTCF is partially retained on mitotic chromosomes and immediately resumes full binding

85 erase IIalpha (TOP2A) is a core component of mitotic chromosomes and important for establishing mitot

86 we found that PICH is modified by SUMO2/3 on mitotic chromosomes and in vitro.

87 contrast, cohesin is completely evicted from mitotic chromosomes and regains focal binding at a slowe

88 t topoisomerase II is the major component of mitotic chromosomes and remain attached to the chromosom

89 r loading the papillomavirus E2 protein onto mitotic chromosomes and represents a kinetochore-indepen

90 dividing cells are noncovalent passengers on mitotic chromosomes and require specific viral-encoded a

91 nstable interactions between kinetochores of mitotic chromosomes and spindle microtubules.

92 protein for the carboxyl terminus of LANA on mitotic chromosomes and suggest distinct functional role

93 fold for the efficient assembly of condensed mitotic chromosomes and that tethering of chromosomal ar

94 the molecular mechanism of PAX3s loading on mitotic chromosomes and the importance of this localizat

95 ly visible within small vesicles attached to mitotic chromosomes and to a lesser extent within interp

96 LANA simultaneously binds mitotic chromosomes and TR DNA to segregate virus genome

97 nal LANA binds histones H2A/H2B to attach to mitotic chromosomes, and C-terminal LANA binds TR DNA an

98 ckles, constitutive heterochromatin domains, mitotic chromosomes, and extrachromosomal regions of mit

99 in tethering LANA/viral episomes to the host mitotic chromosomes, and LANA chromosome-binding sites a

100 m both HPV and animal papillomavirus bind to mitotic chromosomes, and there are variations in the spe

101 of transcription, contributes to cytological mitotic chromosome appearance or 'condensation'.

102 Linker histone H1 is required for mitotic chromosome architecture in Xenopus laevis egg ex

103 In addition to establishing mitotic chromosome architecture, condensin-mediated long

104 he condensin complex is a key determinant of mitotic chromosome architecture.

105 enhances the ability of somatic H1 to rescue mitotic chromosome architecture.

106 Mitotic chromosomes are among the most recognizable stru

107 Kinetochores of mitotic chromosomes are coupled to spindle microtubules

108 Mitotic chromosomes are hypercondensed in length, but di

109 undation for thinking about the evolution of mitotic chromosomes as they prepare for anaphase segrega

110 Condensin complexes are essential for mitotic chromosome assembly and segregation during cell

111 Mitotic chromosome assembly remains a big mystery in bio

112 lation of centromere, kinetochore, and other mitotic chromosome-associated proteins is essential for

113 demonstrate that L1 nuclear localization and mitotic chromosome association can occur in vivo in the

114 by electrophoretic mobility shift assay, and mitotic chromosome association, indicating that distinct

115 is interaction is epigenetically retained on mitotic chromosomes at nucleolar organizing regions.

116 8 family member Kif18A is essential to align mitotic chromosomes at the spindle equator during cell d

117 ase, results in a dramatic shortening of the mitotic chromosome axis, and leads to abnormal INCENP lo

118 Cdk1 controls many aspects of mitotic chromosome behavior and spindle microtubule (MT)

119 d Sbf "antiphosphatase" resulted in aberrant mitotic chromosome behavior.

120 tion and found markedly different extents of mitotic chromosome binding.

121 factor FoxA1 exhibits the greatest extent of mitotic chromosome binding.

122 residues within this motif are required for mitotic chromosome binding.

123 2B, and carboxy-terminal LANA contributes to mitotic-chromosome binding.

124 nal amino acid sequences that are similar to mitotic chromosome-binding sequences in the transcriptio

125 er transcription factor FOXA1 is retained at mitotic chromosomes, bookmarking the genome to enable ge

126 PARP1 was robustly conjugated to SUMO-2/3 on mitotic chromosomes but not on interphase chromatin.

127 to KSHV LANA, mLANA broadly associated with mitotic chromosomes but relocalized to concentrated dots

128 thesized to guide directional instability of mitotic chromosomes, but a direct link has never been es

129 functional within Arabidopsis centromeres of mitotic chromosomes, but cannot be loaded onto centromer

130 3 serine 10 phosphorylation is a hallmark of mitotic chromosomes, but its full function remains to be

131 matin, are released from hyperphosphorylated mitotic chromosomes, but reassociate with chromatin late

132 nodepletion of Nap1 decreased H1M binding to mitotic chromosomes by nearly 50%, reduced H1M dynamics

133 topoisomerase IIalpha contributed to shaping mitotic chromosomes by promoting the shortening of the c

134 or the regulation of TopoIIalpha activity on mitotic chromosomes by SUMOylation.

135 o the nuclear periphery, (b) condensation of mitotic chromosomes, (c) nucleolar morphology, and (d) t

136 Here, we report that mitotic chromosomes can acquire DNA breaks during both p

137 A long-standing conundrum is how mitotic chromosomes can compact, as required for clean s

138 ibit variable capacities of association with mitotic chromosomes, Cbx2 overwhelmingly binds to mitoti

139 maintenance, sister chromatid cohesion, and mitotic chromosome compaction, it appears that these com

140 ow that, despite not requiring condensin for mitotic chromosome compaction, post-mitotic neurons expr

141 , which we term 3D-CLEM, to model the entire mitotic chromosome complement at ultra-structural resolu

142 hat is associated with a subsequent delay in mitotic chromosome condensation (DMC).

143 ease mechanism for microcephaly, implicating mitotic chromosome condensation as a key process ensurin

144 Remarkably, defective mitotic chromosome condensation by a condensin mutation,

145 omosome conformation capture (Hi-C) to study mitotic chromosome condensation in the fission yeast Sch

146 The mechanism of mitotic chromosome condensation is poorly understood, bu

147 Mitotic chromosome condensation, sister chromatid cohesi

148 ed for a poorly understood cellular function-mitotic chromosome condensation-and experimentally valid

149 condensin action and to propose a model for mitotic chromosome condensation.

150 at G(2)/M, massive DNA damage, and improper mitotic chromosome condensation.

151 , cessation of transcription is coupled with mitotic chromosome condensation.

152 n that may be the consequence of problems in mitotic chromosome condensation.

153 c chromosomes and important for establishing mitotic chromosome condensation.

154 chronized cell cultures to determine how the mitotic chromosome conformation transforms into the inte

155 sruption with pharmacological agents and for mitotic chromosome congression.

156 l loss of CENP-A protein resulted in shorter mitotic chromosomes, consistent with a role in setting c

157 ads to an increase in the size of individual mitotic chromosomes, consistent with de-condensation.

158 cellular-molecular mechanisms underlying the mitotic/chromosome defects predicated to be early pathog

159 ds to accumulation of SAF-A-RNA complexes on mitotic chromosomes, defects in metaphase chromosome ali

160 ore than 33% of the protein mass of isolated mitotic chromosomes determined by quantitative proteomic

161 ation is pivotal for accurate segregation of mitotic chromosomes during cell division.

162 K1 as a key regulator of NE architecture and mitotic chromosome dynamics in mammalian cells.

163 opoisomerase (topo) II is observed to reduce mitotic chromosome elastic stiffness.

164 of diffuse interphase chromatin into stable mitotic chromosomes enables the segregation of replicate

165 Topo-II localized to the perimeter of mitotic chromosomes, excluded from the centromere region

166 n nuclear organization during interphase and mitotic chromosome folding.

167 e-replication complex assembly by binding to mitotic chromosomes, followed by gradual removal from ch

168 Mitotic chromosome formation involves a relatively minor

169 Together, our data challenge the view that mitotic chromosome formation is an invariant process dur

170 hether topo IIbeta makes any contribution to mitotic chromosome formation.

171 ganization mechanism similar to condensin in mitotic chromosome formation.

172 ogy and structure of both the interphase and mitotic chromosomes from effective energy landscapes con

173 e protein have been used to distinguish real mitotic chromosome functions of topo IIalpha from its mo

174 These observations argue that budding yeast mitotic chromosomes have an intrinsic, geometric bias to

175 ions by tethering papillomavirus episomes to mitotic chromosomes; however, the mechanism remains unre

176 ach, they assayed the protein composition of mitotic chromosomes, identifying 4029 associated protein

177 all maintained the ability to associate with mitotic chromosomes in a wild-type fashion and to bind T

178 As expected, the LANA mutants bound mitotic chromosomes in a wild-type pattern and also boun

179 in concentrates at the kinetochore region of mitotic chromosomes in animals to accelerate spindle mic

180 ive patch mutants concentrated to dots along mitotic chromosomes in cells containing episomes, simila

181 e the E2 protein tethers the viral genome to mitotic chromosomes in complex with the cellular bromodo

182 serves to tether E2 and the viral genomes to mitotic chromosomes in dividing cells, thus ensuring vir

183 for binding of the C-terminal half of Nod to mitotic chromosomes in embryos.

184 hromatid resolution and cohesin release from mitotic chromosomes in human cells and Xenopus egg extra

185 on in vitro, it is largely excluded from the mitotic chromosomes in KSHV-uninfected cells and is part

186 membrane ruffles, intracellular vesicles and mitotic chromosomes in live cells, the microscope curren

187 ictions that occur at centromeres and RDN of mitotic chromosomes in plants and animals.

188 FISH) probes that could differentially label mitotic chromosomes in root tip preparations.

189 ones and has been observed to diffusely coat mitotic chromosomes in several cell types.

190 nscriptional regulatory microenvironments in mitotic chromosomes in which the genes bookmarked for re

191 eins bind to pericentromeric regions of host mitotic chromosomes, including the ribosomal DNA loci.

192 of papillomavirus E2 proteins associate with mitotic chromosomes independently of Brd4 binding.

193 xCep57 inhibition on isolated mitotic chromosomes inhibits kinetochore-microtubule bin

194 s, E2-mediated tethering of viral genomes to mitotic chromosomes is a common strategy of papillomavir

195 The presence of mitotic chromosomes is additionally required and involve

196 We find that RNA associated with mitotic chromosomes is concentrated at pericentric heter

197 The size of mitotic chromosomes is coordinated with cell size in a m

198 The recruitment of Cbx2 to mitotic chromosomes is independent of PRC1 or PRC2, and

199 Deposition onto mitotic chromosomes is L2-mediated.

200 equired to convert interphase chromatin into mitotic chromosomes is limited.

201 in was not required for binding to condensed mitotic chromosomes, its deletion subtly affected the nu

202 across the genome and the proper assembly of mitotic chromosomes, leading to severe defects in chromo

203 Mutant PAX3 proteins that lose mitotic chromosome localization block cell proliferation

204 spore colonies had very high frequencies of mitotic chromosome loss, resulting in genetically divers

205 However, unlike mitotic chromosomes, meiotic chromosomes display weak ge

206 Mitotic chromosome misalignment and micronuclei formatio

207 mal expansion of the primary constriction of mitotic chromosomes, mislocalization and destabilization

208 ts that integrate inputs from DSB repair and mitotic chromosome morphogenesis into the complete meiot

209 Mammalian mitotic chromosome morphogenesis was analyzed by 4D live

210 r determinants in shaping the characteristic mitotic chromosome morphology.

211 Mitotic chromosome motions are driven by microtubules (M

212 hard McIntosh, who studies the mechanisms of mitotic chromosome movement at the University of Colorad

213 ell division is associated with disorganized mitotic chromosome movements and chromosome loss.

214 d-bearing microtubule attachments that drive mitotic chromosome movements.

215 ins that could dimerize were able to bind to mitotic chromosomes much more efficiently than monomeric

216 this sequence maintained the ability to bind mitotic chromosomes or bind and replicate TR DNA.

217 cell cycle-dependent genome organization and mitotic chromosome organization to support faithful chro

218 are essential protein complexes critical for mitotic chromosome organization.

219 te whether 'one-sided' complexes can compact mitotic chromosomes, organize interphase domains, and ju

220 eviously, we showed that Ki-67 organizes the mitotic chromosome periphery and recruits protein phosph

221 kinetochore microtubule dynamics to control mitotic chromosome positioning.

222 es support a model in which the alignment of mitotic chromosomes promotes proper organization of chro

223 Mitotic chromosome reorganization is marked by the gener

224 Moreover, loading of PAX3 on mitotic chromosomes requires arginine methylation, which

225 The initial binding of Orc1 to mitotic chromosomes requires C-terminal amino acid seque

226 condensin are thought to fold interphase and mitotic chromosomes, respectively, into large loop domai

227 Further analysis of mitotic chromosomes revealed that PICH localized to the

228 A proteomic analysis of mitotic chromosome scaffolds led to the identification o

229 Mitotic chromosomes segregate at the ends of shortening

230 ogramming, sequential cleavage divisions and mitotic chromosome segregation and embryonic genome acti

231 ther expand Mps1's significance for faithful mitotic chromosome segregation and emphasize the importa

232 kinetochore-dependent mechanisms that drive mitotic chromosome segregation are well understood, in o

233 The human polo-like kinase PLK1 coordinates mitotic chromosome segregation by phosphorylating multip

234 Accurate mitotic chromosome segregation depends on the formation

235 ments, both of which can be facilitated by a mitotic chromosome segregation error to produce a micron

236 Here we show that treatment with IR leads to mitotic chromosome segregation errors in vivo and long-l

237 aphase tension may be critical in preventing mitotic chromosome segregation errors, however, the natu

238 e we identify a mechanism by which errors in mitotic chromosome segregation generate DNA breaks via t

239 Faithful mitotic chromosome segregation is required for the maint

240 Sister chromatid cohesion essential for mitotic chromosome segregation is thought to involve the

241 e layers of protection from the carryover of mitotic chromosome segregation patterns into meiotic cel

242 Mitotic chromosome segregation requires that kinetochore

243 contribute to sister chromatid cohesion and mitotic chromosome segregation through splicing of soror

244 e Tyr pocket in the human PLK1 PBD regulates mitotic chromosome segregation to preserve genome integr

245 It is now known that IAPs are involved in mitotic chromosome segregation, cellular morphogenesis,

246 These include chromatin remodeling, mitotic chromosome segregation, protein homeostasis, and

247 egg extracts and plays an essential role in mitotic chromosome segregation.

248 rucial roles in homologous recombination and mitotic chromosome segregation.

249 must resist microtubule-mediated forces for mitotic chromosome segregation.

250 ponse, DNA repair, chromatin regulation, and mitotic chromosome segregation.

251 We have recently discovered that mitotic chromosomes sequentially acquire two interesting

252 st to the random association of BPV1 E2 with mitotic chromosomes, several of these proteins appear to

253 element families were used as FISH probes on mitotic chromosome spreads from a "trispecies" hybrid co

254 We demonstrated by immunostaining of mitotic chromosome spreads of preimplantation embryos th

255 ed translation network that is essential for mitotic chromosome stability.

256 ly understood how these modifications affect mitotic chromosome stiffness and structure.

257 lation) and heterochromatin (methylation) on mitotic chromosome stiffness.

258 Despite many decades of study, mitotic chromosome structure and composition remain poor

259 r metaphase cause dramatic loss of compacted mitotic chromosome structure and conclude that TOP2A is

260 Mitotic chromosome structure and pathways of mitotic con

261 elopment and provide evidence that defective mitotic chromosome structure can promote tumorigenesis.

262 ccurring genome reduplication does not alter mitotic chromosome structure in Drosophila papillar cell

263 Mitotic chromosome structure is pivotal to cell division

264 The limited amount of structural data on mitotic chromosome structure makes it impossible to dist

265 is study identifies an activity critical for mitotic chromosome structure that is inactivated by Repo

266 he role of condensin I in the maintenance of mitotic chromosome structure with unprecedented temporal

267 with a topoisomerase II mutant, defective in mitotic chromosome structure, is also due to the retenti

268 us causes genome reduplication, which alters mitotic chromosome structure.

269 hromatid disentanglement, and maintenance of mitotic chromosome structure.

270 ies that a select set of TFs remain bound on mitotic chromosomes suggest a potential mechanism for ma

271 of PARP1 alter the accumulation of PARP1 on mitotic chromosomes, suggesting that SUMOylation regulat

272 The inner centromere is a region on every mitotic chromosome that enables specific biochemical rea

273 The inner centromere is a region on the mitotic chromosome that serves as a platform for mitotic

274 While many nuclear factors dissociate from mitotic chromosomes, the observation that certain nuclea

275 e geometrically uniform folding of eukaryote mitotic chromosomes, through extrusion of pre-programmed

276 Brd4 associates with mitotic chromosomes throughout mitosis and demonstrates

277 o viral DNA genomes and tethers them to host mitotic chromosomes, thus enabling the viral genomes to

278 nomes to daughter cells by tethering them to mitotic chromosomes, thus ensuring equal distribution an

279 g cell division, chromatin is compacted into mitotic chromosomes to aid faithful segregation of the g

280 tein E2 tethers the viral genome to the host mitotic chromosomes to ensure persistent, long-term main

281 al papillomaviruses link the viral genome to mitotic chromosomes to ensure retention and the efficien

282 ein that tethers terminal repeat (TR) DNA to mitotic chromosomes to mediate episome persistence in di

283 A) tethers viral terminal repeat (TR) DNA to mitotic chromosomes to mediate episome persistence.

284 LANA also simultaneously binds to TR DNA and mitotic chromosomes to mediate the segregation of episom

285 -terminal regions of LANA tether episomes to mitotic chromosomes to segregate episomes to progeny cel

286 iate DNA replication and tethers KSHV DNA to mitotic chromosomes to segregate genomes to daughter cel

287 ted roles in mitosis including 1) connecting mitotic chromosomes to spindle microtubules to establish

288 n addition forms numerous foci/aggregates on mitotic chromosomes upon DNA damage.

289 Here, we found that PAX3 loads on mitotic chromosomes using its homeodomain.

290 that lengthwise compaction of chromatin into mitotic chromosomes via loop extrusion underlies the com

291 ine papillomavirus type 1 is tethered to the mitotic chromosomes via the cellular protein Brd4.

292 Within the condensed mitotic chromosomes we find that Runx2 is retained in la

293 in, which tethers the viral episomes to host mitotic chromosomes, we examined whether KSHV LANA inter

294 Mitotic chromosomes were one of the first cell biologica

295 nd in highly proliferative cells showed that mitotic chromosomes were surrounded by steep Ran guanosi

296 ex is recruited to the kinetochore region of mitotic chromosomes, where it initiates spindle checkpoi

297 l18, and Phc1 proteins become immobilized at mitotic chromosomes, whereas other Cbx-family proteins d

298 nus of Cbx2 is needed for its recruitment to mitotic chromosomes, whereas the C-terminus is required

299 LANA binds histones H2A and H2B to attach to mitotic chromosomes, while the C-terminal region binds T

300 h scales, from the 10 nm sized nucleosome to mitotic chromosomes, whilst jostling within the crowded