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1 also tumor-promoting activities (enhancer of mitotic entry).
2 ise in mitotic kinase activity that triggers mitotic entry.
3 ed expression of cdc25a, a key controller of mitotic entry.
4 es of a dose-dependent 'sizer' that controls mitotic entry.
5 as shown that Wee1 inhibition of Cdk1 blocks mitotic entry.
6 nucleus- and centrosome-associated forces in mitotic entry.
7 B and Cdc25C accumulation, a requirement for mitotic entry.
8 ke protein that contributes to the timing of mitotic entry.
9 ation by Cdc25 phosphatase are essential for mitotic entry.
10 w components of novel mechanisms controlling mitotic entry.
11 e H3, in infected cells suggested a block to mitotic entry.
12 hosphorylation at centrosomes increases with mitotic entry.
13 nt role in DNA damage checkpoint control and mitotic entry.
14 separation are linked to the cell cycle and mitotic entry.
15 sphorylation of PP2A-B55 substrates promoted mitotic entry.
16 nization of the nucleus and the cytoplasm at mitotic entry.
17 ughter pair of tightly engaged centrioles at mitotic entry.
18 se-enriched population that result in faster mitotic entry.
19 reorganization of the cell is coordinated at mitotic entry.
20 ediated degradation, thereby ensuring timely mitotic entry.
21 links the disassembly of Rad51 complexes to mitotic entry.
22 d further uncoupling of DNA replication with mitotic entry.
23 vels decrease at the cell middle, leading to mitotic entry.
24 fails to bind Rad51, associated with faster mitotic entry.
25 g network that contributes to the control of mitotic entry.
26 activation of cyclin-dependent kinase 1 and mitotic entry.
27 tor of protein kinase A that normally blocks mitotic entry.
28 C/C substrates crucial for DNA synthesis and mitotic entry.
29 s, and is believed to be required for proper mitotic entry.
30 spindle in the compartmentalized nucleus on mitotic entry.
31 is activated at G2-M and required for timely mitotic entry.
32 onal relevance for active p38 protein during mitotic entry.
33 tors significantly accelerated the timing of mitotic entry.
34 couple centrosome maturation to NEBD during mitotic entry.
35 se (SCFNIPA) implicated in the regulation of mitotic entry.
36 but also accumulate in G(2)-M due to blocked mitotic entry.
37 active Aur-A accelerates cdc2 activation and mitotic entry.
38 mote full activation of Cdc25 at the time of mitotic entry.
39 onopolar spindles, delays but does not block mitotic entry.
40 reby accelerating S287 dephosphorylation and mitotic entry.
41 ms, including Drosophila, leads to premature mitotic entry.
42 phase entry while centrosome migration marks mitotic entry.
43 5C are not required for mouse development or mitotic entry.
44 cells that was related to the inhibition of mitotic entry.
45 y reported requirement for Cdk2 in promoting mitotic entry.
46 uld ensure that all DNA is replicated before mitotic entry.
47 d for proper activation of cdk1/cyclin B and mitotic entry.
48 into the role of PP1 in Cdc2 activation and mitotic entry.
49 C that we have termed Tome-1, for trigger of mitotic entry.
50 gillus nidulans NIMA kinase is essential for mitotic entry.
51 osphorylated just before cdc2 activation and mitotic entry.
52 ion of proteasomes all abolish this delay in mitotic entry.
53 able to cooperate with cyclin B in promoting mitotic entry.
54 nti-GRASP65 antibody alleviated the block in mitotic entry.
55 ciously and cells overexpressing Clp1p delay mitotic entry.
56 Loss of cyclin A in G2-phase prevents mitotic entry.
57 in B1/CDK1 complex function, thus preventing mitotic entry.
58 PPP1R3B facilitates mitotic exit and blocks mitotic entry.
59 actomyosin cortex and for cell rounding upon mitotic entry.
60 clin B1/CDK1 complex functions necessary for mitotic entry.
61 pression is cell cycle dependent, peaking at mitotic entry.
62 for partitioning or is merely an outcome of mitotic entry.
63 Moreover, knockdown of RUNX3 delays mitotic entry.
64 lly followed by rapid neurite retraction and mitotic entry.
65 tion is therefore a regulatory mechanism for mitotic entry.
66 st solution for irreversible and switch-like mitotic entry.
67 redistribution is precisely coordinated with mitotic entry.
68 Here we show that TopBP1 forms foci upon mitotic entry.
69 that inhibits Cdk1 activation thus blocking mitotic entry.
70 of the cell cycle is a critical regulator of mitotic entry.
71 orm a feedforward regulatory loop to promote mitotic entry.
72 manifested in a cell cycle delay before the mitotic entry.
73 overt premature CDK1 activation and S-phase mitotic entry.
74 undergo specific translational regulation at mitotic entry.
75 eraction between CDK1 and PP2A in regulating mitotic entry.
76 tional function of Oct4 in the regulation of mitotic entry.
77 tially deleterious consequences of premature mitotic entry.
79 signaling by the centrally placed nucleus at mitotic entry [2-4]: the cell geometry network (CGN), co
81 , identified 18 genes that act negatively at mitotic entry, 7 of which have not been previously descr
87 aracterized gene that is required to prevent mitotic entry after treatment with ionizing radiation.
89 phosphorylation on Ser(219) potently induces mitotic entry and apoptosis and increases radiation hype
90 rmore, up-regulation of Pin2 or TRF1 induces mitotic entry and apoptosis, a phenotype similar to that
91 cate monitoring of spindle orientation after mitotic entry and before commitment to mitotic exit.
92 wed increased apoptosis as a result of early mitotic entry and catastrophe compared to DDR-D cells.
97 gree of Plk1 depletion significantly delayed mitotic entry and completely blocked cells at mitosis.
100 progress through mitosis; they round up upon mitotic entry and elongate during chromosome segregation
101 ts that show E2F regulates genes involved in mitotic entry and exit and allow the suggestion that mit
102 changes in Cdk1 activity are permissive for mitotic entry and exit but that the changes in PP2A-B55
103 erization and depolymerization that occur at mitotic entry and exit in Xenopus egg extracts back to t
107 y recruitment of MPS1 to kinetochores during mitotic entry and for sustained spindle checkpoint arres
108 of nuclear-associated GFP diminishes during mitotic entry and GFP progressively re-associates with c
109 ed in cycling Xenopus egg extracts prevented mitotic entry and induced phosphorylation of ATM and its
110 FkappaB at G2-M phases substantially delayed mitotic entry and inhibited transcription of G2-M-specif
111 between the cell-cycle machinery that drives mitotic entry and its accompanying actin remodeling.
114 ltured embryonic fibroblasts causes impaired mitotic entry and mitotic arrest with a profound defect
120 n and Clb2p/cyclin B1, a delay or failure in mitotic entry and progression, and faulty chromosome tra
127 complexes through diverse approaches delays mitotic entry and promotes inhibitory phosphorylation of
129 We conclude that the nucleus accelerates mitotic entry and propose that it acts as a pacemaker fo
131 Moreover, knockdown of PinX1 caused delayed mitotic entry and reduced the accumulation of TRF1 on te
133 r the disassembly of the nuclear envelope at mitotic entry and the accumulation of Mud at the spindle
137 activity) bipolar spindle formation, timely mitotic entry, and formation of a cytokinesis cleavage f
139 Greatwall kinase is a conserved regulator of mitotic entry, and new work in Xenopus egg extracts show
141 ying centrosome maturation and separation at mitotic entry, and thereby increases the frequency of mi
142 ndent kinase (Cdk1) activity is required for mitotic entry, and this event is restrained by an inhibi
143 (Cdk1) phosphorylates septin 9 (SEPT9) upon mitotic entry, and this phosphorylation controls associa
144 Cdc25 catalytic activation, the precision of mitotic entry, and unvarying cell length but not Cdc25 l
147 occludin regulates centrosome separation and mitotic entry as the nonphosphorylatable alanine mutatio
148 ltiprotein clusters at the cortex to promote mitotic entry at a cell size that can be modified by nut
149 otential target of CYLD in the regulation of mitotic entry, based on their physical interaction and s
150 ers a G(2) checkpoint response, which delays mitotic entry because of insufficient decatenation of da
151 e shattering (chromothripsis) is produced by mitotic entry before completion of DNA replication withi
152 One mechanism that triggers these errors is mitotic entry before the completion of DNA replication.
153 and time through the concerted action of key mitotic entry biochemical regulators, including protein
155 tinct manner from checkpoint signaling after mitotic entry but employing a common molecular mechanism
156 s inhibiting the ERK pathway interferes with mitotic entry but has little effect on cdc2 activation a
157 d cyclin-dependent protein kinase 1 promotes mitotic entry but is held in check, in part, by Wee1 pro
158 maining cyclin is sufficient to induce early mitotic entry, but reversal of the S-phase checkpoint is
159 th Aurora A and Plk1 was sufficient to delay mitotic entry by 4 h, while inhibiting either kinase alo
161 DNA damage checkpoint responses and promotes mitotic entry by accelerating claspin degradation throug
166 d to the model that checkpoint kinases block mitotic entry by inhibiting cdc25C through phosphorylati
168 l cycle checkpoint kinase prevents premature mitotic entry by inhibiting cyclin-dependent kinases.
169 nase Cdr1 is a mitotic inducer that promotes mitotic entry by phosphorylating and inhibiting Wee1.
170 he Cdk1 inhibitor Wee1 is inactivated during mitotic entry by proteolysis, translational regulation,
171 ion about cell size and coordinate this with mitotic entry by regulating Cdk1 through Pom1, Cdr2, Cdr
173 e way that CDK regulates spindle assembly at mitotic entry: CDK phosphorylates the Alp7-Alp14 complex
176 nal protein kinase involved in regulation of mitotic entry, chromosome segregation, centrosome matura
177 ted to centrosome maturation and separation, mitotic entry, chromosome segregation, mitotic exit, and
180 ose that high Polo-kinase activity following mitotic entry directs the RZZ complex to minimize premat
181 the release of Pbl/Ect2 from the nucleus at mitotic entry drives Rho-dependent activation of Myosin-
182 is dispensable for irreversible, switch-like mitotic entry due to a second mechanism, whereby Cdk1:Cy
184 f YTHDF2 in HeLa cells leads to the delay of mitotic entry due to overaccumulation of negative regula
186 r signals are required for the activation of mitotic entry during de novo meristem formation from G2
187 via phosphorylation of tyrosine 15 and times mitotic entry during the cortical nuclear cycles of sync
188 Immunodepletion of endogenous Aven allowed mitotic entry even in the presence of damaged DNA, and R
190 onclude that KLF4 is essential in preventing mitotic entry following gamma-irradiation and does so by
195 nation, which relies on apical constriction, mitotic entry in an artificially contractile ectoderm in
197 Thr 104 had an increased capacity to inhibit mitotic entry in cyclin B-treated interphase extracts, a
198 te its interaction with PLK-1 and to trigger mitotic entry in early Caenorhabditis elegans embryos.
200 At high concentrations, GSK461364A delays mitotic entry in G(2) followed by gradual progression in
201 s a protein kinase that negatively regulates mitotic entry in G2 phase by suppressing cyclin B-Cdc2 a
206 litates, but is not absolutely required for, mitotic entry in murine embryonic fibroblasts and is ess
207 characterized Ser/Thr kinase, is involved in mitotic entry in several systems; however, the targets o
212 toplasmic sequestration of Cdc25B/C to block mitotic entry in the presence of unrepaired DNA damage.
213 on of cyclin function does not directly time mitotic entry in these early embryonic cycles and that c
214 d demonstrate that Wee1 kinases can regulate mitotic entry in vivo during metazoan development even i
216 either activator cyclins A or B, stimulates mitotic entry, in part, by phosphorylating the nuclear l
217 PP2A-B55/SUR-6 regulates nuclear size before mitotic entry, in turn affecting nuclear envelope-based
218 with the ubiquitin-proteasome system ensures mitotic entry independent of cell cycle checkpoint.
220 ise temporal depletion of TopBP1 just before mitotic entry induced formation of 53BP1 NBs in the next
227 the fission yeast Schizosaccharomyces pombe, mitotic entry is orchestrated by a geometry-sensing mech
228 he ability of Vpr to block the cell cycle at mitotic entry is well known, but the importance of this
229 in-dependent kinase activation and premature mitotic entry, leading to both p53-dependent and indepen
230 ELK and indicate that MELK inhibition delays mitotic entry, likely via transient G(2)/M checkpoint ac
231 in PLK-1 binding in vitro present delays in mitotic entry, mimicking embryos lacking SPAT-1 or PLK-1
232 cells and tumor xenografts induces premature mitotic entry, mitotic catastrophe, and reduction of tum
235 n of S phase, showing that activation of the mitotic entry network does not depend on protein accumul
237 s suggests that Msh2 primarily acts to delay mitotic entry of cells already in G2, that is, DNA damag
239 ese data demonstrate that stathmin regulates mitotic entry, partially via MTs, to control localizatio
240 Here, we show that besides the premature mitotic entry phenotype, Wee1 mutant murine cells fail t
241 nstead, the inhibitory effect of SP600125 on mitotic entry predominantly occurs upstream of Aurora A
242 Many nuclear proteins are inactivated during mitotic entry, presumably as a prerequisite to chromatin
244 ation, until it reaches a threshold allowing mitotic entry regardless of remaining checkpoint signal
246 tive live-cell imaging, we demonstrated that mitotic entry reverses apical contractility by interferi
252 totic events, such as centrosome maturation, mitotic entry, spindle formation, sister chromatid cohes
253 ive in mitosis, is involved in regulation of mitotic entry, spindle pole assembly, mitotic exit, and
255 h the timely progression through S-phase and mitotic entry, suggesting that CYB-3 is both an S-phase-
256 ering RNA attenuated FdUrd-induced premature mitotic entry, suggesting that progression of HT29 cells
257 bit replication yet were still able to allow mitotic entry, suggesting that these are separate functi
258 letion in neural stem cells results in early mitotic entry that distracts cell division mode, leading
259 tial centrosome clustering step can occur at mitotic entry, the establishment of kinetochore-microtub
262 t degradation of CDC25C phosphatase to block mitotic entry, thereby preventing telomere dysfunction-d
263 nuclear export of Wee1 is not essential for mitotic entry though an important functional role remain
267 e G2 DNA damage checkpoint inhibits Cdc2 and mitotic entry through the dual regulation of Wee1 and Cd
270 X3 disrupts RUNX DNA binding activity during mitotic entry to facilitate the recruitment of RUNX prot
274 Gwl) kinase activity inactivates PP2A-B55 at mitotic entry to promote the phosphorylation of cyclin B
276 ive to prevent premature CDK1 activation and mitotic entry until DNA is properly replicated or repair
280 opriate cell cycle progression and premature mitotic entry via dysregulation of cyclin-dependent kina
281 Wee1 tyrosine kinases are known to regulate mitotic entry via inhibitory phosphorylation of Cdk1.
282 ngs suggest that p38 regulates the timing of mitotic entry via modulation of Cdc25B activity under no
285 s recruited to the nuclear pore complex upon mitotic entry, where it acts with Cdk1 to hyperphosphory
286 expression of FoxM1 target genes and impairs mitotic entry, whereas ectopic VprBP expression strongly
287 h cdc2 activation, cyclin B1 expression, and mitotic entry, whereas inhibiting the ERK pathway interf
288 ts strongly delays cyclin B accumulation and mitotic entry, whereas nondestructible Emi1 stabilizes A
289 Zds1/Zds2 promote Cdc55-PP2A function for mitotic entry, whereas Zds1/Zds2 inhibit Cdc55-PP2A func
290 ve threonine residues (T7, T183 and T407) at mitotic entry, which elicits PLK1-dependent suppression
291 ell-cell adhesion cannot be sustained during mitotic entry, which leads to trophectoderm rupture and
293 ing, we observed that MELK inhibition delays mitotic entry, which was associated with delayed activat
294 ropose that this increases the likelihood of mitotic entry, while molecular noise in its expression a
295 een previously shown to occur in response to mitotic entry with DNA damage or incompletely replicated
296 me nondisjunction occurs as a consequence of mitotic entry with unfinished replication despite intact
298 n contrast, reducing Cdk1 expression delayed mitotic entry without markedly impairing Cdc25B or Cdc25
299 n of FOXC2 in CSC-enriched TNBC cells delays mitotic entry without significantly affecting the overal