ライフサイエンスコーパス: mitotic exit

1 promoting complex/cyclosome (APC/C) controls mitotic exit.

2 ved by a proteasome-dependent process during mitotic exit.

3 n of attachment monitoring mechanisms during mitotic exit.

4 B drives the bulk of changes observed during mitotic exit.

5 tes cyclin-dependent kinase 1 (Cdk1) causing mitotic exit.

6 lerated cyclin B1 degradation during induced mitotic exit.

7 osomes, thereby enhancing anaphase onset and mitotic exit.

8 ant, but not wild-type PTEN, caused enhanced mitotic exit.

9 s silenced during mitosis and reactivated at mitotic exit.

10 after mitotic entry and before commitment to mitotic exit.

11 ition checkpoint (SPOC) component to inhibit mitotic exit.

12 ant accumulation of chromatin PTEN, delaying mitotic exit.

13 This creates two cyclin B thresholds during mitotic exit.

14 oval of SS18 and its replacement by CREST at mitotic exit.

15 enable gene expression reestablishment upon mitotic exit.

16 biquitinates the SAC mediator BUB3 to enable mitotic exit.

17 d coordinated daughter cell spreading during mitotic exit.

18 sembly upon mitotic entry and disassembly at mitotic exit.

19 domain of ectopic furrowing when forced into mitotic exit.

20 ited a delay in mitotic entry and an earlier mitotic exit.

21 pling moesin-dependent cell shape changes to mitotic exit.

22 ation of the CDC20 substrate p21, prolonging mitotic exit.

23 es Cdk1 phosphorylation and is important for mitotic exit.

24 On the other hand, nuclear Cdc55 prevents mitotic exit.

25 ient Mcm proteins loading on chromatin after mitotic exit.

26 et and regulates chromosome structure during mitotic exit.

27 the major mitotic regulator Cdk1/Cyclin B or mitotic exit.

28 osome segregation with spindle breakdown and mitotic exit.

29 h plays important roles in mitotic entry and mitotic exit.

30 Cdc14a nor Cdc14b seems to be essential for mitotic exit.

31 vents of nuclear envelope reformation during mitotic exit.

32 Zds1/Zds2 inhibit Cdc55-PP2A function during mitotic exit.

33 anaphase, an event closely coordinated with mitotic exit.

34 nuclear envelope integrity during anaphase B/mitotic exit.

35 Thus p31(comet) is required for timely mitotic exit.

36 educes the length of mitosis and accelerates mitotic exit.

37 vation of Cdc25C and PLK1, leading to faster mitotic exit.

38 on and is then progressively degraded during mitotic exit.

39 rchestrate a complex series of events during mitotic exit.

40 ase reverses Cdk1 phosphorylation to promote mitotic exit.

41 lerates transcription reactivation following mitotic exit.

42 t other phosphatase(s) are also required for mitotic exit.

43 r known mechanism that turns off Cdk1 during mitotic exit.

44 metaphase to allow timely anaphase onset and mitotic exit.

45 mitotic progression and coordinate efficient mitotic exit.

46 contribute to timely Cdc14 activation during mitotic exit.

47 speeding progression through G1/S as well as mitotic exit.

48 on of Chk1 activity with UCN-01 also reduced mitotic exit.

49 esults in defects in cytokinesis, and delays mitotic exit.

50 required for sister-chromatid separation or mitotic exit.

51 ulture cells, high in mitosis and low during mitotic exit.

52 icrotubule-cortex interactions with Lte1 and mitotic exit.

53 B, thus promoting the onset of anaphase and mitotic exit.

54 , suggesting a role of securin in preventing mitotic exit.

55 on of separase and the onset of anaphase and mitotic exit.

56 ly of Cdc5, a Polo-like kinase essential for mitotic exit.

57 s, and appears to be involved in controlling mitotic exit.

58 nly transiently present at centromeres after mitotic exit.

59 c20, targets cyclin B for destruction during mitotic exit.

60 during mitosis and rapidly eliminated during mitotic exit.

61 n of Bub1 by APC/C(Cdh1) is not required for mitotic exit.

62 zing cell survival upon stress by regulating mitotic exit.

63 and subsequent cyclin B destruction triggers mitotic exit.

64 al muscle cells to control proliferation and mitotic exit.

65 tform to test hypotheses about regulation of mitotic exit.

66 ciate with the forming nuclear lamina before mitotic exit.

67 nism of SAC inactivation required for timely mitotic exit.

68 served in interphase is reestablished during mitotic exit.

69 mapping of transcription during mitosis and mitotic exit.

70 tosis and shuttles to the midzone spindle at mitotic exit.

71 wl with a phosphomimetic S883E mutant blocks mitotic exit.

72 erior to the furrow to ensure properly timed mitotic exit.

73 signals are diluted, resulting in premature mitotic exit.

74 migrated to the spindle equator, leading to mitotic exit.

75 cessing complex componentl(2)NC136during the mitotic exit.

76 Ki-67 and RepoMan have key roles during mitotic exit.

77 strates and assigned their temporal order in mitotic exit.

78 the precursors for TAG, in the mutant during mitotic exit.

79 to direct NE recruitment of ESCRT-III during mitotic exit.

80 death or senescence is often triggered after mitotic exit.

81 ase that controls chromosome segregation and mitotic exit.

82 activation and other events occurring during mitotic exit.

83 ity must subsequently be restored to promote mitotic exit.

84 B1, thereby causing inactivation of Cdk1 and mitotic exit.

85 loading of CENP-A to the centromere prior to mitotic exit.

86 anization [14], cell morphogenesis [15], and mitotic exit [16, 17], specifically associates with the

87 n the reforming nuclear envelope (NE) during mitotic exit [2, 3].

88 Disrupting UHRF1 degradation at mitotic exit accelerates G1-phase cell cycle progression

89 budding yeast to prevent anaphase entry and mitotic exit, allowing cells more time to repair damaged

90 Here, we show that mitotic exit also activates pathways that catalyze inhib

91 ivated states occurring exclusively near the mitotic exit and "down" transitions occurring throughout

92 in HEK293 cells causes cell cycle arrest at mitotic exit and apoptotic cell death.

93 tingly, up-regulation of PPP1R3B facilitates mitotic exit and blocks mitotic entry.

94 y of checkpoint inhibitor compounds to drive mitotic exit and cause cells to flatten onto the substra

95 disengagement at anaphase is independent of mitotic exit and Cdk2/cyclin E activity, but requires th

96 atase Cdc14, whose activity is essential for mitotic exit and completion of the cell cycle.

97 er of Cdk substrate dephosphorylation during mitotic exit and contribute to roles in other cellular p

98 sphatases play a conserved role in promoting mitotic exit and cytokinesis by dephosphorylating substr

99 Cdc14 is a phosphatase that controls mitotic exit and cytokinesis in budding yeast.

100 d to regulate DNA damage repair, whereas the mitotic exit and cytokinesis rely on another phosphatase

101 Completion of mitotic exit and cytokinesis requires the inactivation o

102 central spindle by the kinesin MKlp2 during mitotic exit and cytokinesis.

103 nsition and during anaphase but drops during mitotic exit and cytokinesis.

104 al regulation of microtubule function during mitotic exit and cytokinesis.

105 ivision requires strict coordination between mitotic exit and cytokinesis.

106 y APC/C(Cdh1) participates in the control of mitotic exit and cytokinesis.

107 in B, Cdk inhibitors will nonetheless induce mitotic exit and cytokinesis.

108 arase blocked centriole disengagement during mitotic exit and delayed assembly of new centrioles duri

109 ization of DELLAs, which are responsible for mitotic exit and earlier onset of endoreduplication.

110 ssembly machinery in an inactive state until mitotic exit and entry into G1, at which time new CENP-A

111 o pulse-label transcripts during mitosis and mitotic exit and found that many genes exhibit transcrip

112 uitin ligase plays an essential role in both mitotic exit and G1/S transition by targeting key cell-c

113 APC/C(Cdh1) becomes active during mitotic exit and has essential targets in G1 phase.

114 During mitotic exit and interphase, the mitochondrial network r

115 he cohesin complex binds to chromatin during mitotic exit and is converted to a functional form durin

116 rtially prevented kinetochore disassembly at mitotic exit and led to chromosome segregation defects i

117 Mitotic exit and onset of endoreduplication do not corre

118 tion of mitotic progression: it both induces mitotic exit and prevents polarized growth during mitoti

119 the decondensing chromosome mass compact at mitotic exit and promotes a mechanically robust nucleus.

120 machinery, our data support its dual role in mitotic exit and promotion of NHEJ repair in yeast and m

121 factors and centrosome-based regulations in mitotic exit and SPOC control.

122 on and repressing RB1, which is required for mitotic exit and terminal differentiation.

123 is a physiological substrate of APC/C during mitotic exit and that a tight regulation of the CKAP2 pr

124 on switch coordinating E2F8 degradation with mitotic exit and the activation of APC/C(Cdh1).

125 in the formation of a single nucleus during mitotic exit and the maintenance of genomic integrity.

126 Mitotic exit and the re-initiation of transcription are

127 est that, of the many components degraded at mitotic exit and then replenished during the subsequent

128 ols the degradation of substrate proteins at mitotic exit and throughout the G1 phase.

129 ephosphorylates threonine-161 of CDC2 during mitotic exit and we visualize CDC2(pThr-161) at kinetoch

130 RPA2 kinase) also were severely defective in mitotic exit and were unable to support RPA hyperphospho

131 nique dual inhibition profile targeting TTK (mitotic exit) and CLK2 (mRNA splicing).

132 -B is associated with aneuploidy, incomplete mitotic exit, and cell death.

133 cycle processes, including spindle assembly, mitotic exit, and cytokinesis, but the full range of its

134 ion of mitotic entry, spindle pole assembly, mitotic exit, and cytokinesis.

135 NuMA affects chromatin decondensation at the mitotic exit, and nuclear shape in interphase.

136 crotubule array or ectopic furrows following mitotic exit, and recruitment of Aurora B kinase, male g

137 operate to precisely position the CPC during mitotic exit, and that these pathways converge to ensure

138 tion of chromosomes into a single nucleus at mitotic exit, and the formation of micronuclei in vitro

139 potential mechanisms whereby RACK1 regulates mitotic exit are identified: suppression of Src-mediated

140 Chromosome segregation and mitotic exit are initiated by the 1.2-MDa ubiquitin liga

141 the mitotic checkpoint but disappears during mitotic exit at a rate of 31 pM/s.

142 ome deposition occurs in early G1 just after mitotic exit at the time when the CENP-A deposition mach

143 After mitotic exit, BAF53a is replaced by BAF53b, and BAF45a b

144 es not seem to result simply from a delay in mitotic exit, because overexpression of a nondegradable

145 Mitotic exit becomes irreversible only after longer peri

146 C(C) (dh1) ubiquitin ligase mainly regulates mitotic exit but is also implicated in the DNA damage-in

147 destruction of many APC/C substrates during mitotic exit but strongly and specifically stabilize Aur

148 dent kinase (Cdk), is thought to bring about mitotic exit, but how temporal ordering of mitotic exit

149 Additionally, it inhibits mitotic exit by activating the spindle checkpoint.

150 destruction schedule of cyclin types guides mitotic exit by affecting both Cdk1 and APC/C, whose act

151 Rad53 prevents mitotic exit by inhibiting the MEN pathway, whereas the

152 However, precocious mitotic exit by mitotic slippage limits the cytotoxicity

153 Cdc20 through kinetochores also accelerates mitotic exit by promoting its dephosphorylation by kinet

154 ally inhibit APC/C-dependent proteolysis and mitotic exit by simultaneously disrupting two protein-pr

155 tiates the metaphase-anaphase transition and mitotic exit by targeting proteins such as securin and c

156 during G(2)/M and is dephosphorylated during mitotic exit by the phosphatase Cdc14A.

157 cyclosome (APC/C) that triggers anaphase and mitotic exit by ubiquitylating securin and cyclin B1.

158 During mitotic exit, Cdk1 activity initially falls with no obvi

159 On mitotic exit, centrosomes disassemble producing interpha

160 and its inhibitor, alpha-endosulfine, at the mitotic-exit checkpoint.

161 ities have each been independently linked to mitotic exit control in other eukaryotes.

162 ment of the mitotic spindle to kinetochores, mitotic exit, cytokinesis, licensing of DNA replication

163 These defects are distinct from the mitotic-exit defects caused by stabilization of the mito

164 loidy and aneuploidy, spindle defects, and a mitotic exit delay.

165 this reversibility decreases with time after mitotic exit despite the continued presence of the cycli

166 are all delivered to the division site upon mitotic exit even when the AMR is absent.

167 t mitotic exit, but how temporal ordering of mitotic exit events is achieved is poorly understood.

168 ion of Cdk substrates involved in sequential mitotic exit events occurs with ordered timing.

169 totic budding yeast cells efficiently drives mitotic exit events.

170 body (SPB, centrosome equivalent) to control mitotic exit events.

171 formation of an asymmetric Sfi1 filament at mitotic exit followed by Mps1-dependent assembly of a Sp

172 e its importance for temporal control during mitotic exit, how B55 substrates are recognized and diff

173 During mitotic exit, however, centrosomes are deformed and frac

174 Failure to down-regulate Cdc42 during mitotic exit impairs the normal localization of key cyto

175 und that EYA1 is efficiently degraded during mitotic exit in a Cdh1-dependent manner and that these t

176 inated by APC/C in vitro and degraded during mitotic exit in a Cdh1-dependent manner in vivo.

177 ade B-type Cyclins during anaphase prevented mitotic exit in a Cdk1-dependent manner.

178 loss of microtubules from the neck leads to mitotic exit in a majority of checkpoint-activated cells

179 phase of the cell cycle and drop rapidly at mitotic exit in an APC/C- and KEN-box-dependent fashion.

180 ome motion delayed Cyclin B1 degradation and mitotic exit in an Aurora B-dependent manner.

181 events during anaphase and is essential for mitotic exit in budding yeast.

182 he Cdc14 phosphatase, which is essential for mitotic exit in budding yeast.

183 w us to present a new quantitative model for mitotic exit in budding yeast.

184 Cell cycle checkpoints can delay mitotic exit in budding yeast.

185 Mitotic exit in Chk2-deficient cells correlates with red

186 Mitotic exit in neurons is accompanied by an essential s

187 spindle position checkpoint (SPOC) inhibits mitotic exit in response to mispositioned spindles.

188 cts CDK1 activity during anaphase to promote mitotic exit in Saccharomyces cerevisiae Surprisingly, h

189 ect mitotic spindle position before allowing mitotic exit in the budding yeast Saccharomyces cerevisi

190 (SIN) serves to coordinate cytokinesis with mitotic exit in the fission yeast Schizosaccharomyces po

191 signaling pathways regulate cytokinesis and mitotic exit in the yeasts Schizosaccharomyces pombe, an

192 Exit from meiosis I is distinct from mitotic exit, in that replication origins are not licens

193 thaliana) and found that stress causes early mitotic exit, in which cells end their mitotic division

194 but have been observed in cells defective in mitotic exit, including the semidominant cdc5-ad mutatio

195 Deficiencies in RepID, CRL4 or RBBP7 delay mitotic exit, increase genomic instability and enhance s

196 atase required for nucleolar segregation and mitotic exit, inhibits transcription of yeast ribosomal

197 and that the removal of this modification at mitotic exit is a key regulatory event that controls the

198 as cells pass through mitosis, we show that mitotic exit is accompanied by a burst in cytoplasmic ac

199 Because blocking mitotic exit is an effective approach for inducing tumou

200 the budding yeast Saccharomyces cerevisiae, mitotic exit is controlled by the FEAR (for "Cdc-fourtee

201 To prevent genome instability, mitotic exit is delayed until all chromosomes are proper

202 In Saccharomyces cerevisiae, mitotic exit is driven by a protein phosphatase, Cdc14,

203 We determined that this premature mitotic exit is due to defects in spindle assembly check

204 lipids to neutral lipids for storage during mitotic exit is important for proper execution of cytoki

205 gs demonstrate that the unidirectionality of mitotic exit is not the consequence of proteolysis but o

206 associate with segregated kinetochores when mitotic exit is prevented by expression of nondegradable

207 Therefore, temporal order during mitotic exit is promoted by the metazoan BEG pathway.

208 osphatase to kinase ratio over the course of mitotic exit is read out by Cdk substrates that respond

209 The ability of apcin to block mitotic exit is synergistically amplified by co-addition

210 me that counteracts Cdk during budding yeast mitotic exit is the Cdc14 phosphatase.

211 Here, we report that Dbf2, a conserved mitotic exit kinase, localizes to the division site afte

212 ntify Zds1 and Zds2 as new components of the mitotic exit machinery, involved in activation of the Cd

213 Upon mitotic exit, MCPH1 isoforms were degraded by the anapha

214 east, three interdigitated pathways regulate mitotic exit (ME): mitotic cyclin-cyclin-dependent kinas

215 sion cycle protein 20 (CDC20), and ends upon mitotic exit mediated by APC/C bound to CDC20 homolog 1

216 aled that these filaments exhibit a delay in mitotic exit mediated by the checkpoint protein Bub2.

217 During mitotic exit, missegregated chromosomes can recruit thei

218 GSY2 and HAP1, and the mediating TF Hap1; a mitotic exit module featuring four cis-linked genes, AMN

219 have shown that Cdc7-Dbf4 also regulates the mitotic exit network (MEN) and monopolar homolog orienta

220 osis conserved signaling pathways termed the mitotic exit network (MEN) and the septation initiation

221 Release of the mitotic exit network (MEN) component, Cdc14p, from the n

222 eolytic function of separase (Esp1); and the mitotic exit network (MEN) driven by interaction between

223 such signal transduction pathway called the mitotic exit network (MEN) governs the transition from m

224 The mitotic exit network (MEN) is an essential GTPase signal

225 r "Cdc-fourteen early anaphase release") and mitotic exit network (MEN) pathways.

226 s-like GTPase signaling cascade known as the mitotic exit network (MEN) promotes exit from mitosis.

227 In budding yeast, the Mitotic Exit Network (MEN) releases Cdc14 phosphatase fr

228 The septation initiation network (SIN) and mitotic exit network (MEN) signaling pathways regulate c

229 ding yeast, a signaling network known as the mitotic exit network (MEN) triggers exit from mitosis.

230 The Mitotic Exit Network (MEN), a budding yeast Ras-like sig

231 e position and regulates the activity of the mitotic exit network (MEN), a GTPase signaling pathway t

232 The mitotic exit network (MEN), a protein kinase cascade und

233 The Mitotic Exit Network (MEN), a Ras-like GTPase signaling

234 This checkpoint works by inhibiting the mitotic exit network (MEN), a signaling cascade initiate

235 position and, in budding yeast, inhibits the mitotic exit network (MEN), a signaling pathway that pro

236 Components of the mitotic exit network (MEN), a signaling pathway that tri

237 rtment, cells arrest in anaphase because the mitotic exit network (MEN), an essential Ras-like GTPase

238 his order is ensured in budding yeast by the mitotic exit network (MEN), where Cdc14p dephosphorylate

239 eolus, but successful anaphase activates the mitotic exit network (MEN), which triggers dispersal of

240 d that slowing spindle elongation delays the mitotic exit network (MEN)-dependent release of Cdc14, t

241 Cbk1 cannot phosphorylate Ace2 until after mitotic exit network (MEN)-initiated release of the phos

242 regulator of mitotic exit, sitting atop the mitotic exit network (MEN).

243 14 phosphatase, the ultimate effector of the mitotic exit network (MEN).

244 cycle in budding yeast is controlled by the Mitotic Exit Network (MEN).

245 m mitosis by restraining the activity of the mitotic exit network (MEN).

246 prevent exit from mitosis by inhibiting the mitotic exit network (MEN).

247 The mitotic exit network protein Dbf2p binds to SWI5 and CLB

248 of Bfa1, contributing to activation of the "mitotic exit network" that sustains Cdc14 as Cdk activit

249 FEAR (Cdc14 early anaphase release) and MEN (mitotic exit network) activate phosphatase Cdc14 by prom

250 ing activity of the Saccharomyces cerevisiae mitotic exit network.

251 In some cells, however, mitotic exit occurred in the presence of pole-associated

252 HM site phosphorylation prior to mitotic exit occurs in response to activation of the FEA

253 cificity phosphatase plays a key role in the mitotic exit of budding yeast cells.

254 Nearing mitotic exit of neural progenitors, miR-9* and miR-124 r

255 een molecular 'rulers' and 'clocks' licenses mitotic exit only after proper chromosome separation.

256 Mitotic exit pathways are responsible for the inactivati

257 exus between the DNA damage response and the mitotic exit pathways during cell-cycle progression to p

258 hese findings not only show how two distinct mitotic exit phosphatases are recruited to their substra

259 Here we show how Ki-67 and RepoMan form mitotic exit phosphatases by recruiting PP1, how they di

260 After CDK1-CyclinB inactivation upon mitotic exit, PLK4 can bind and phosphorylate STIL in G1

261 During mitotic exit, PP1-dependent dephosphorylation of Gwl Ser

262 ivision site with the septin complex and, as mitotic exit progresses, moves to the actomyosin ring (A

263 dition, analysis of spc72 cells shows that a mitotic-exit-promoting dominant signal, which is trigger

264 In mitotic exit, proteins that were highly phosphorylated a

265 Conversely, mitotic exit requires Cdk1 inactivation and reversal of

266 is, whereas Ser-157 dephosphorylation during mitotic exit restores IRP2 RNA-binding activity and repr

267 Closure of this fenestra during anaphase B/mitotic exit returns the cytoplasmic component to the cy

268 ike protein and is the critical regulator of mitotic exit, sitting atop the mitotic exit network (MEN

269 At mitotic exit, such trapping of Lem2-Nur1 on heterochroma

270 nd Cdc25 that controls the abruptness of the mitotic exit switch.

271 g the early stages of mitosis(8), but during mitotic exit the brushes collapse and Ki-67 promotes chr

272 However, if after mitotic exit, the Cdk1 inhibitor is washed free from cel

273 After forced mitotic exit, the cytoskeleton of monopolar mitotic cell

274 cause Cdk1 activity is at its minimum at the mitotic exit, the ratio of Cdk1/PP1alpha activity change

275 cyclin proteolysis to the irreversibility of mitotic exit, the transition from high mitotic Cdk activ

276 During mitotic exit, they reestablish these adhesions and at th

277 At mitotic exit, this rigid cortex must be dismantled to al

278 icating that yeast cells negatively regulate mitotic exit through two distinct pathways in response t

279 yclosome (APC/C) promotes anaphase onset and mitotic exit through ubiquitinating securin and cyclin B

280 mation of the actomyosin contractile ring at mitotic exit, through the local activation of RhoA.

281 lation in the absence of 14-3-3sigma impairs mitotic exit to generate binucleate cells and provides a

282 We use phosphoproteome analysis of mitotic exit to identify Cdk targets that are dephosphor

283 nal the spindle assembly checkpoint to delay mitotic exit until all chromosomes are attached.

284 the spindle position checkpoint (SPC) delays mitotic exit until the mitotic spindle moves into the ne

285 ositioning errors, relay a signal to inhibit mitotic exit until the spindle is appropriately position

286 for the spindle position checkpoint to delay mitotic exit until the spindle is positioned correctly.

287 associated surveillance mechanism that halts mitotic exit upon spindle mis-orientation.

288 that Cdc14 coordinates cell separation with mitotic exit via FEAR-initiated phosphorylation of the C

289 However, mitotic exit was recently shown to be a function of chro

290 linkages on the same substrates added during mitotic exit were Cdh1-independent.

291 Here we show that Hog1 delays mitotic exit when cells are stressed during metaphase.

292 t of the vertebrate nervous system occurs at mitotic exit when cells lose multipotency and begin to d

293 hosphorylates Aurora B-serine 331 to prevent mitotic exit when most kinetochores are unattached.

294 nteracting machines on chromosomes, restrain mitotic exit when not attached to spindle microtubules b

295 le drugs, Ska3-depleted cells exhibit slower mitotic exit when the spindle checkpoint is silenced by

296 hibition of Aurora kinases, causing abnormal mitotic exit with formation of single cells with aberran

297 n of the MAD2-CDC20 complex, and accelerated mitotic exit with SAC override in the presence of spindl

298 de-induced giant cells revealed a failure in mitotic exit, with the appearance of multinucleated cell

299 The combination of these effects resulted in mitotic exit without chromosome segregation.

300 ivation allows normal nuclear reassembly and mitotic exit without DNA segregation.