ライフサイエンスコーパス: mitotic progression

1 rate, inhibiting CDH1 activity and promoting mitotic progression.

2 ial role in genome integrity maintenance and mitotic progression.

3 R signaling in a pathway to promote faithful mitotic progression.

4 accelerated entry into mitosis, but delayed mitotic progression.

5 modifications at Ser635 had little effect on mitotic progression.

6 r Mad2 and promotes silencing of the SAC and mitotic progression.

7 chestrates accurate chromosome alignment and mitotic progression.

8 SUN proteins in bipolar spindle assembly and mitotic progression.

9 nal activity of SRSF1 is required for normal mitotic progression.

10 d is crucial for proper spindle assembly and mitotic progression.

11 NP-T homolog, that are required for accurate mitotic progression.

12 e loading of Bub3, chromosome alignment, and mitotic progression.

13 APC(Cdc20)) plays pivotal roles in governing mitotic progression.

14 mpletely eliminated Nuf2 binding and blocked mitotic progression.

15 mposed by TIF1gamma knockdown and allows for mitotic progression.

16 genomic oxidized nucleotides with disturbed mitotic progression.

17 dle assembly, pole splitting, and a delay in mitotic progression.

18 essary for locating NIMA back to SPBs during mitotic progression.

19 80 complex formation, and adversely affected mitotic progression.

20 eostat to fine-tune Aurora B activity during mitotic progression.

21 r SMC proliferation via direct regulation of mitotic progression.

22 dissolution of sister chromatid cohesion and mitotic progression.

23 f stable KT-MT fibers (K-fibers), disrupting mitotic progression.

24 me, and the outer nuclear membrane to direct mitotic progression.

25 plicated in playing an important role during mitotic progression.

26 ncomitant increases in apoptosis and altered mitotic progression.

27 mporal regulation of miR159 by APC/C ensures mitotic progression.

28 et), a Mad2-binding protein, is required for mitotic progression.

29 f early mitotic spindle poles and the timely mitotic progression.

30 e regulation of PP2A localization for proper mitotic progression.

31 ylation of KIBRA on Ser(539) plays a role in mitotic progression.

32 omplish normal bipolar spindle formation and mitotic progression.

33 hestrated regulation is important for normal mitotic progression.

34 ation of these pathways results in defective mitotic progression.

35 r at stalled replication forks, facilitating mitotic progression.

36 res, defects in spindle assembly and blocked mitotic progression.

37 on, neither trap had a discernable effect on mitotic progression.

38 to be required in smaller amounts for normal mitotic progression.

39 he genes essential for G(1)/S transition and mitotic progression.

40 re NIMA-related kinases essential for proper mitotic progression.

41 t prolong interphase but instead interrupted mitotic progression.

42 is degraded during G(2) and mitosis to allow mitotic progression.

43 dissolution of sister chromatid cohesion and mitotic progression.

44 ation of Aurora kinase B, a key regulator of mitotic progression.

45 e exosome-independent role in cell cycle and mitotic progression.

46 ssion of the G(2)/M phase genes and impaired mitotic progression.

47 ulatory role for Chk1 phosphorylation during mitotic progression.

48 and another as a factor required for proper mitotic progression.

49 nt translation that is required for accurate mitotic progression.

50 e requirement of S326 phosphorylation during mitotic progression.

51 or NBN did not show a significant slowing of mitotic progression.

52 Both proteins are required for normal mitotic progression.

53 vates the spindle checkpoint, and delays the mitotic progression.

54 oes delay inactivation of Mad2 signaling and mitotic progression.

55 energy sensing to mitochondrial activity for mitotic progression.

56 or of spindle dynamics that is essential for mitotic progression.

57 basic cellular machinery required for robust mitotic progression.

58 rkinetochore tension at metaphase and alters mitotic progression.

59 abrogates the requirement for tankyrase 1 in mitotic progression.

60 crotubule polymerization and cause an extend mitotic progression.

61 hreonine protein kinase essential for normal mitotic progression.

62 AP2 protein level is critical for the normal mitotic progression.

63 is critical for spindle assembly and normal mitotic progression.

64 atwall have previously been shown to disrupt mitotic progression.

65 licing factors and RBPs resulted in aberrant mitotic progression.

66 me (APC/C), a ubiquitin ligase that controls mitotic progression.

67 r spindle assembly, chromosome alignment, or mitotic progression.

68 tant component of this system that regulates mitotic progression.

69 demonstrated that NHK-1 is also required for mitotic progression.

70 me (APC/C), a ubiquitin ligase essential for mitotic progression.

71 ical for G(1)/S transition and essential for mitotic progression.

72 vertebrate Plks, is essential for successful mitotic progression.

73 ulans, dynein is not apparently required for mitotic progression.

74 me (APC/C), a ubiquitin ligase that controls mitotic progression.

75 regulatory proteins to the spindle poles for mitotic progression.

76 tion of hepatocellular metaphase-to-anaphase mitotic progression.

77 , whose activity appears to be essential for mitotic progression.

78 regation relies on the precise regulation of mitotic progression.

79 is an important regulator of hepatocellular mitotic progression.

80 cilitate evasion from apoptosis and aberrant mitotic progression.

81 tion whose degradation is a prerequisite for mitotic progression.

82 hospholigand binding is necessary for proper mitotic progression.

83 that is responsive to DNA damage as well as mitotic progression.

84 ses whose combined function is important for mitotic progression.

85 esent a new signaling pathway that regulates mitotic progression.

86 tants show that both pathways are needed for mitotic progression.

87 organization, as well as in other aspects of mitotic progression.

88 chanisms that regulate Aur-A activity during mitotic progression.

89 elomere elongation, and specifically affects mitotic progression.

90 ted that overexpression of Pin2/TRF1 affects mitotic progression.

91 is known about how Pin2/TRF1 is involved in mitotic progression.

92 multisubunit ubiquitin ligase that mediates mitotic progression.

93 iferative activity due to a potent arrest of mitotic progression.

94 liated cells to promote ciliogenesis without mitotic progression.

95 hugoshins is a fundamental step in mammalian mitotic progression.

96 cells disturbs neither spindle formation nor mitotic progression.

97 s on Cdc55 and Igo2 did not cause defects in mitotic progression.

98 h we show is important for TPX2 function and mitotic progression.

99 , chromosome congression defects and delayed mitotic progression.

100 h chromatin compaction and the regulation of mitotic progression.

101 versatile ubiquitin code is read out during mitotic progression.

102 bule attachment, a condition known to arrest mitotic progression.

103 Delta plays a direct role in the control of mitotic progression.

104 misattached kinetochores to prevent further mitotic progression.

105 SET8 reaccumulation is important for normal mitotic progression.

106 tochore in activating APC/C-Cdc20 for normal mitotic progression.

107 mitotic blockers and agents that accelerate mitotic progression.

108 oss of centromeric cohesion disrupts orderly mitotic progression.

109 ase of the cell cycle, with stable arrest of mitotic progression.

110 atic cells, where DNA damage fails to affect mitotic progression.

111 ers defects in spindle assembly and prevents mitotic progression.

112 otubule spindle function, thereby inhibiting mitotic progression.

113 Aspm-deficient CGNPs show impaired mitotic progression, altered patterns of division orient

114 the yeast Ndc80 tail is required for timely mitotic progression and accurate chromosome segregation.

115 Spindle integrity is critical for efficient mitotic progression and accurate chromosome segregation.

116 -Cyclin A, Cyclin B, and Cyclin B3-influence mitotic progression and are degraded in a stereotyped se

117 with Aurora A to regulate spindle formation, mitotic progression and brain size.

118 applies sophisticated live imaging to assess mitotic progression and cell cycle control in these cell

119 Agents that block mitotic progression and cell proliferation by interferin

120 ponsible for the ability of taxol to inhibit mitotic progression and cell proliferation.

121 rease in Aurora B kinase activity can impair mitotic progression and cell viability.

122 eptide ligands that are largely derived from mitotic progression and cell-cycle proteins.

123 ase 1 (PP1) targeting subunit that regulates mitotic progression and chromatin remodelling.

124 somes and mitotic spindles where it mediates mitotic progression and chromosomal stability.

125 Sgo is thus critical for mitotic progression and chromosome segregation and provi

126 ts by CLASP1, astrin and Kif2b is central to mitotic progression and chromosome segregation fidelity.

127 s once per cell cycle is critical for proper mitotic progression and chromosome segregation.

128 ubule dynamics, perform functions related to mitotic progression and chromosome segregation.

129 These results indicate that mitotic progression and control of mitotic reentry after

130 mitotic apparatus, An-Mlp1 may help monitor mitotic progression and coordinate efficient mitotic exi

131 of the dynein-dynactin complex and regulates mitotic progression and cytokinesis.

132 previously underappreciated role for Ras in mitotic progression and demonstrate a pharmacologically

133 cal link between two important regulators of mitotic progression and demonstrate the critical role of

134 ssential ubiquitin protein ligase, regulates mitotic progression and exit by enhancing degradation of

135 of both PP2A-B55 and PP2A-B56 to coordinate mitotic progression and exit in fission yeast.

136 ent with the established role of Cyclin B in mitotic progression and exit.

137 tion mediated by NDR1 kinase is required for mitotic progression and for Sgo1 binding to mitotic cent

138 of RUNX phosphorylation in regulating proper mitotic progression and genomic integrity.

139 tify a common function for NudE and NudEL in mitotic progression and identify an alternative mechanis

140 role for these proteins in the regulation of mitotic progression and in SAC activation.

141 aging, we show that BET inhibition prolonged mitotic progression and induced mitotic cell death, both

142 a, is a novel anticancer agent that inhibits mitotic progression and induces apoptosis in most cancer

143 oforms of cyclin E (LMW-E) overexpression on mitotic progression and its link to genomic instability

144 TM and DNA damage and is required for proper mitotic progression and maintenance of genomic stability

145 escribed mechanism for interrupting faithful mitotic progression and may ultimately inform the design

146 kinase that plays important roles in normal mitotic progression and mitotic checkpoint signaling, co

147 hat Pak1 is required for cell proliferation, mitotic progression and Plk1 activity in HeLa cells.

148 nd approximately 100 candidate regulators of mitotic progression and proliferation; the availability

149 have shown that pRB inactivation also slows mitotic progression and promotes aneuploidy, but reasons

150 central switch at kinetochores that defines mitotic progression and promotes fidelity by temporally

151 How mitotic progression and quality control might be influen

152 etion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle m

153 ecies during mitosis in cancer by disturbing mitotic progression and simultaneously inhibiting the hy

154 crb mutant embryos have defects in mitotic progression and spindle formation, and exhibit g

155 ion of oncogenic KRAS in regulating accurate mitotic progression and suggest new avenues to therapeut

156 sults emphasize the importance of CENP-C for mitotic progression and suggest that Vmw110 may be inter

157 H2 terminus of human CENP-A is essential for mitotic progression and that localization of CENP-C, ano

158 ight the potential role of EDD in regulating mitotic progression and the cellular response to perturb

159 he fly ATR orthologue), the abnormalities of mitotic progression and the cyclin B protein level were

160 define an essential role for IKK2 in normal mitotic progression and the maintenance of spindle bipol

161 s1 is a protein kinase that regulates normal mitotic progression and the spindle checkpoint in respon

162 human PLK1 PBD trigger cellular anomalies in mitotic progression and timing.

163 evel of Plk1 depletion caused a 2-h delay of mitotic progression, and a high degree of Plk1 depletion

164 quired for kinetochore localization of MAD1, mitotic progression, and activation of the SAC.

165 localization of Bub3 was required for normal mitotic progression, and Bub3 and Cdc20 colocalized at t

166 and dynamic regulation of mitotic spindles, mitotic progression, and chromosome segregation fidelity

167 role for Pak in regulating Plk1 activity and mitotic progression, and connect Pak to the complex prot

168 -like kinase 1 (Plk1) is critical for proper mitotic progression, and its association with the centro

169 y of human AURORA-A kinase (AURKA) regulates mitotic progression, and its frequent overexpression in

170 hat Wdr62 interacts with Aurora A to control mitotic progression, and loss of these interactions lead

171 entrosomal Aurora-A kinase (AURKA) regulates mitotic progression, and overexpression and hyperactivat

172 the importance of ROS scavenging for normal mitotic progression, and provide a reference for judicio

173 ession of many late cell cycle genes, delays mitotic progression, and reduces fitness in budding yeas

174 Spindle pole localization of WDR62 and mitotic progression are defective in patient-derived fib

175 Additionally, hBUBR1 is essential for normal mitotic progression as it prevents cells from prematurel

176 This event is important for proper mitotic progression, as constitutive phosphorylation of

177 activity of Bora is also required for normal mitotic progression, as knockdown of Bora activates the

178 trate that Golgi disassembly is required for mitotic progression because failure to vesiculate the Go

179 tivating enzyme are zygotically required for mitotic progression but are dispensable for cell viabili

180 g of Golgi cisternae, vesicle tethering, and mitotic progression, but their specific functions are un

181 ears to be essential for the coordination of mitotic progression, but which also plays an unexpected

182 reticulum-localized protein FAM134A impairs mitotic progression by affecting metaphase plate alignme

183 A, cyclin B and Greatwall kinase coordinate mitotic progression by increasing levels of Cdk1-depende

184 lar mechanism by which HPV16E7 perturbs host mitotic progression by interfering Mps1-MAP4 signaling c

185 is the primary upstream kinase that directs mitotic progression by phosphorylation of a large number

186 g protein that controls spindle dynamics and mitotic progression by regulating MT depolymerases.

187 In this study, we show that USP2a mediates mitotic progression by regulating the stability of Auror

188 ome pathway ensures the unidirectionality of mitotic progression by removing cell-cycle regulators re

189 hat this physical interaction is crucial for mitotic progression by targeting polo kinase activity to

190 ured E4F(-/-) blastocysts exhibit defects in mitotic progression, chromosomal missegregation, and inc

191 These defects are associated with impaired mitotic progression coupled with abnormal mitotic spindl

192 or CaM-dependent activation cause defects in mitotic progression, cytokinesis, and ciliary resorption

193 well as wild-type siblings, indicating that mitotic progression delays alone do not alter overall gr

194 g spindle assembly renders Eg5 essential for mitotic progression, demonstrated by the lethal effects

195 ese cells initiated anaphase after a delayed mitotic progression due to the presence of unaligned chr

196 /PR55 and LET-92/PP2A-C cooperate to control mitotic progression during early embryogenesis.

197 us, our data implicate mnm as a regulator of mitotic progression during the proliferative phase of ey

198 itor restored taxane sensitivity by inducing mitotic progression errors and apoptosis.

199 ase Cdc28 is a well established regulator of mitotic progression, evidence for a direct role in mitot

200 1 microtubule-binding domain perturbs normal mitotic progression, explaining the critical role of the

201 est for extended periods, moderate delays in mitotic progression have significant effects on the resu

202 Although these defects transiently delayed mitotic progression, HeLa cells initiated anaphase witho

203 over that Magoh deficiency delays progenitor mitotic progression in a dosage-sensitive fashion, with

204 nstrate that several fundamental features of mitotic progression in adult stem and progenitor cells a

205 gradation of cyclin B1, which is crucial for mitotic progression in animal cells.

206 is an indispensable pleiotropic regulator of mitotic progression in Aspergillus.

207 Lte1 is known as a regulator of mitotic progression in budding yeast.

208 ccumulation of genomic 8-oxodG and perturbed mitotic progression in cancer cells, which can be exploi

209 The accumulated PTTG1 impeded mitotic progression in cells expressing PV.

210 result in defective chromosome alignment and mitotic progression in cells using a CRISPR/Cas9-based r

211 enes are required maternally for egg laying, mitotic progression in early embryos, and embryonic surv

212 that changes in organismal physiology affect mitotic progression in germline stem and progenitor cell

213 is a kinesin-like motor protein required for mitotic progression in higher eukaryotes.

214 ncoprotein E7 of HPV16 but not HPV18 retards mitotic progression in host cell by direct binding to th

215 ly abolished E7-binding capacity and rescued mitotic progression in host cells.

216 ntent imaging to identify genes required for mitotic progression in human cancer cells and applied it

217 largely dispensable for rounding and timely mitotic progression in isolated cells, it is needed to d

218 Survivin is induced by OX40 independent of mitotic progression in late G1, and blocking Survivin su

219 Key regulators for the mitotic progression in mammalian cells are the polo-like

220 Using quantitative analyses of mitotic progression in mammalian cells, we show that Hec

221 evel of targeted proteolysis to allow normal mitotic progression in mammalian cells.

222 nk between 3R and 4R-Tau isoform expression, mitotic progression in neuronal progenitors and post-mit

223 e conserved checkpoint kinase Chk1 regulates mitotic progression in response to DNA damage and replic

224 conserved checkpoint kinase, Chk1, regulates mitotic progression in response to DNA damage by blockin

225 Our results offer a revised view of mitotic progression in S. cerevisiae that augments the r

226 anges, such as dietary intake or age, affect mitotic progression in stem and/or progenitor cells is l

227 Low Delta is believed to arrest mitotic progression in taxol-treated cells.

228 Finally, we report that mitotic progression in the absence of MAP kinase signali

229 oesin, is essential for NB proliferation and mitotic progression in the developing brain.

230 hful inheritance of chromosomes by arresting mitotic progression in the presence of kinetochores that

231 ein phosphatases, on different parameters of mitotic progression in the presence or absence of stathm

232 to 14-3-3 may partially modulate hepatocyte mitotic progression, in association with nuclear redistr

233 c kinase responsible for multiple aspects of mitotic progression, including assembly of the outer kin

234 ation of key cell-cycle proteins involved in mitotic progression, including cyclin-dependent kinase 1

235 by inducing cell cycle proteins involved in mitotic progression, including Forkhead Box M1.

236 Cells that fail in mitotic progression indeed activate cell death or cell c

237 re linked at least in part to alterations in mitotic progression induced by defective ARF6 cycling.

238 forces ( approximately 5 nN) that accelerate mitotic progression, intermediate forces where cells res

239 rmation and genomic instability by impairing mitotic progression involving Cdc25C.

240 dy illustrates that such an expert system of mitotic progression is able to highlight the complexity

241 It has been established that mitotic progression is critical for HPV16 infection, but

242 Yet mitotic progression is defined by multiple parameters, w

243 When mitotic progression is delayed, cells sequester the adde

244 In these mutants, mitotic progression is halted attributable to spindle as

245 ol entry into mitosis, but their role during mitotic progression is less well understood.

246 Though mitotic progression is modulated in response to DNA dama

247 Mitotic progression is regulated largely through dynamic

248 Mitotic progression is restored upon centrosome depletio

249 The timing mechanism for mitotic progression is still poorly understood.

250 s, Lte1 has dual functions for regulation of mitotic progression: it both induces mitotic exit and pr

251 elling might have important consequences for mitotic progression: it might contribute to produce stro

252 ent, blocks cell proliferation by inhibiting mitotic progression leading to mitotic and postmitotic a

253 s, uncoupling of replication initiation from mitotic progression led to altered genome ploidy in the

254 addition to the anaphase promoting complex, mitotic progression may involve another E3 ubiquitin lig

255 migration; however, more dramatic defects on mitotic progression, mitotic orientation, and mitotic ch

256 Loss of control over mitotic progression, multipolar spindle formation, and c

257 anomalous segregation of chromosomes during mitotic progression of cancer cells.

258 leucine zipper kinase (MELK) is critical for mitotic progression of cancer cells; however, its mechan

259 , persistent gamma-H2AX foci, and defects in mitotic progression of distal airway progenitors.

260 croscopy, we analyzed the dynamic process of mitotic progression of HeLa(H2B)-GFP cells lacking CENP-

261 NIMA-related kinase 6 (Nek6) is required for mitotic progression of human cells.

262 tic and quantitative single-cell analysis of mitotic progression on an open-source platform.

263 resolution but exerted only minor effects on mitotic progression or SAC function.

264 thought to function in apoptotic regulation, mitotic progression, or possibly both.

265 tion of mitotic CAK activity and to regulate mitotic progression positively.

266 pattern of protein dephosphorylation during mitotic progression, possibly by a drop of PP2A-B55 acti

267 (-/-) mammary mouse tumours, suggesting that mitotic progression promotes PARP-inhibitor-induced cell

268 centrations that are insufficient to inhibit mitotic progression, PTX induced both p53 and p21 causin

269 ly well understood, details of Ran's role in mitotic progression remain obscure.

270 e transcription factors in coordination with mitotic progression remain poorly understood.

271 gulation of their activity in the context of mitotic progression remains less well understood.

272 hanism (or mechanisms) by which they inhibit mitotic progression remains unclear.

273 ulation, rs11556924 alters the regulation of mitotic progression resulting in an extended mitosis.

274 and loss of IRC15 function leads to delayed mitotic progression, resulting from failure to establish

275 of these cells and emphasized the timing of mitotic progression, spindle structure, and chromosome b

276 ndings reveal a role for SETD6 in regulating mitotic progression, suggesting a pathway through which

277 ive effect of PDGF in SMCs without affecting mitotic progression, suppressed neointimal formation in

278 We found that two genes responsible for mitotic progression, SWI5 and CLB2, exhibit a mitosis-de

279 fiber assembly, ch-TOG/TACC3 recruitment and mitotic progression that also resulted from Nek6 depleti

280 icient fibroblasts exhibit a marked delay in mitotic progression that can be rescued by lentiviral tr

281 an aberrant accumulation of PTTG1 disrupting mitotic progression that could contribute to thyroid car

282 ke kinases is important in the regulation of mitotic progression; this work keys on one member, namel

283 role for EGR-1 in regulating hepatocellular mitotic progression through the spindle assembly checkpo

284 Depleting ferritin disrupted CSC mitotic progression, through the STAT3-FoxM1 regulatory

285 hese results suggest that moderate delays in mitotic progression trigger the initiation of centriole

286 ir response to external forces are linked to mitotic progression under conditions of mechanical confi

287 ce revealed that the pathway is required for mitotic progression under normal growth conditions.

288 The spindle assembly checkpoint (SAC) delays mitotic progression until all sister chromatid pairs ach

289 served role of these checkpoints is to block mitotic progression until DNA replication and repair are

290 The spindle assembly checkpoint arrests mitotic progression until each kinetochore secures a sta

291 ary widely in the extent to which they delay mitotic progression upon SAC activation.

292 on fork progression was observed, but rather mitotic progression was impaired and mitotic DNA synthes

293 To study the spatiotemporal control of mitotic progression, we developed a high-content analysi

294 ion of CRL2(ZYG11A/B) has minimal effects on mitotic progression when APC/C is active.

295 The spindle assembly checkpoint (SAC) delays mitotic progression when chromosomes are not properly at

296 Bub1 (KBB) pathway is required during normal mitotic progression when kinetochores are misaligned but

297 fness of the human centromere matures during mitotic progression, which leads to amplified centromere

298 kinase activity might not grossly impact on mitotic progression, while treatment with MRE11A inhibit

299 erase inhibitors by Chk1 siRNA, which showed mitotic progression with 4N DNA content leading to mitot

300 GR was necessary for mitotic progression, with increased time to complete mit