ライフサイエンスコーパス: mitotic spindle

1 ures ranging from contractile bundles to the mitotic spindle.

2 and position microtubule arrays such as the mitotic spindle.

3 til chromosomes are correctly aligned on the mitotic spindle.

4 ical NuMA-dynein complexes that position the mitotic spindle.

5 eiotic spindle assembly but is toxic for the mitotic spindle.

6 along astral microtubules to help orient the mitotic spindle.

7 rs that grow out from the poles of the first mitotic spindle.

8 djacent to the spindle poles and orients the mitotic spindle.

9 he chromosomes or their biorientation on the mitotic spindle.

10 tubules at cell-cell adhesions to orient the mitotic spindle.

11 med by a self-organized structure called the mitotic spindle.

12 complex classically known for orienting the mitotic spindle.

13 somal separation and proper formation of the mitotic spindle.

14 ubule cytoskeleton and form the poles of the mitotic spindle.

15 ter chromosomes are properly attached to the mitotic spindle.

16 not properly attached to microtubules of the mitotic spindle.

17 ring positioned and controlled solely by the mitotic spindle.

18 so on the subpellicular microtubules and the mitotic spindle.

19 matically impaired Astrin recruitment to the mitotic spindle.

20 cial role in assembly and maintenance of the mitotic spindle.

21 romoting biorientation of chromosomes on the mitotic spindle.

22 SAC silencing entails proper size scaling of mitotic spindle.

23 n adjacent microtubules and form the bipolar mitotic spindle.

24 pull on astral microtubules to position the mitotic spindle.

25 sembling macromolecular machine known as the mitotic spindle.

26 rtex to facilitate planar orientation of the mitotic spindle.

27 ntil the last chromosome has attached to the mitotic spindle.

28 ch sex chromosomes, to separate on the first mitotic spindle.

29 lum, the subpellicular microtubules, and the mitotic spindle.

30 se until chromosomes attach correctly to the mitotic spindle.

31 most animal cells and form the poles of the mitotic spindle.

32 al organization of microtubules (MTs) in the mitotic spindle.

33 ules, and thereby impacts the density of the mitotic spindle.

34 tion during cell division requires a bipolar mitotic spindle.

35 positioned properly to establish the zygotic mitotic spindle.

36 mble in mitosis to attach chromosomes to the mitotic spindle.

37 les to exert pushing forces that establish a mitotic spindle.

38 microtubules and subsequently aligned on the mitotic spindle.

39 ode positional information that helps orient mitotic spindles.

40 gellum from the cell body, and disruption of mitotic spindles.

41 uitment or centrosome function in organizing mitotic spindles.

42 til all chromosomes are properly attached to mitotic spindles.

43 l microtubule plus end assembly rates within mitotic spindles.

44 tem cells displays randomized orientation of mitotic spindles.

45 and that this network is also a component of mitotic spindles.

46 ification, and formation of nonperpendicular mitotic spindles.

47 c centrosome, a structure that assembles the mitotic spindle [1], is notably large in the zebrafish e

48 velope enables chromosome segregation by the mitotic spindle(1).

49 centromeric chromatin to microtubules of the mitotic spindle(3,4).

50 uch as the nucleus [1, 2], mitochondria [3], mitotic spindle [4, 5], and centrosome [6], exhibit size

51 anical process that requires assembly of the mitotic spindle - a dynamic microtubule-based force-gene

52 Eukaryotic cell division requires the mitotic spindle, a microtubule (MT)-based structure whic

53 ate chromosomes in mitosis, cells assemble a mitotic spindle, a molecular machine with centrosomes at

54 ast two pools of F-actin are associated with mitotic spindles: a relatively stable internal network o

55 FTLD-MAPT in which neurons and glia exhibit mitotic spindle abnormalities, chromosome mis-segregatio

56 n-Eph intercellular signaling in controlling mitotic spindle alignment in Drosophila optic lobe neuro

57 Mitotic spindle alignment with the basal or substrate-co

58 In animals, the mitotic spindle aligns with Par complex polarized fate d

59 cell proliferation, planar alignment of the mitotic spindle allows the daughter cells to stay within

60 ted in part to a preferential orientation of mitotic spindles along the proximal-distal axis [1, 2].

61 rating animal cells are able to orient their mitotic spindles along their interphase cell axis, setti

62 h are mediated by the microtubule (MT)-based mitotic spindle and approximately 200 essential MT-assoc

63 mechanical cues for proper alignment of the mitotic spindle and cell division site.

64 genes encoding proteins that localize to the mitotic spindle and centrosomes have been implicated in

65 n be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, an

66 , which impairs Aurora A localization at the mitotic spindle and induces cell division defects.

67 Although clathrin localizes to the mitotic spindle and kinetochore fiber microtubule bundle

68 During asymmetric cell division, the mitotic spindle and polarized myosin can both determine

69 e polarized orientation of the S. cerevisiae mitotic spindle and primes the invariant inheritance of

70 ical roles in organizing the assembly of the mitotic spindle and templating the formation of primary

71 also uncovered that HPIP associates with the mitotic spindle and that its depletion leads to the form

72 itotic FAs established 3D orientation of the mitotic spindle and the relative positioning of mother a

73 s is regulated by the formation of a bipolar mitotic spindle and the spindle assembly checkpoint, ens

74 required for the assembly of the subsequent mitotic spindle and to phosphorylate a microtubule-assoc

75 tribution and localization of Stu2 along the mitotic spindle and yield defects in spindle morphology

76 trioles organize the microtubule network and mitotic spindle and, as basal bodies, nucleate cilia and

77 Experiments demonstrate allometry of mitotic spindles and a universal scaling relationship be

78 bules during chromosome segregation in human mitotic spindles and Caenorhabditis elegans mitotic and

79 depletion leads to the formation of multiple mitotic spindles and chromosomal abnormalities, results

80 les, leading to the formation of multi-polar mitotic spindles and genomic instability.

81 t nor escape confinement cannot orient their mitotic spindles and more likely undergo apoptosis.

82 We also demonstrate that Dyrk1a localizes to mitotic spindles and that its inhibition leads to decrea

83 gulation between a structural component, the mitotic spindle, and a regulatory component, anaphase-pr

84 ation of microtubules needed to assemble the mitotic spindle apparatus(1).

85 ylation and abrogates EG5 recruitment to the mitotic spindle apparatus, leading to spindle disorganiz

86 Kinetochore fibers (K-fibers) of the mitotic spindle are force-generating units that power ch

87 In animal cells, mitotic spindles are oriented by the dynein/dynactin mot

88 Mitotic spindles are well known to be assembled from and

89 ules, allowing dynein movement to orient the mitotic spindle as astral microtubules depolymerize.

90 exit, ruling out stretching by the elongated mitotic spindle as the cause of breakage.

91 motor proteins that play important roles in mitotic spindle assembly [1].

92 rm the centrosome, a necessary structure for mitotic spindle assembly and cell division.

93 The essential functions required for mitotic spindle assembly and chromosome biorientation an

94 protein that we previously found to control mitotic spindle assembly and chromosome dynamics.

95 tus (NuMA) protein is an essential player in mitotic spindle assembly and maintenance.

96 in that directs nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation.

97 rimary cilia blocks centrosome formation and mitotic spindle assembly and prevents the completion of

98 our study highlight that kindlin-2 regulates mitotic spindle assembly and that this process is pertur

99 g the MAD family of proteins involved in the mitotic spindle assembly checkpoint (SAC) complex.

100 demonstrated that genetic disruptions of the mitotic spindle assembly checkpoint elevate expression o

101 inds to and stabilizes Bub3, a key player in mitotic spindle assembly checkpoint signaling.

102 rse-graining methods by applying them to the mitotic spindle assembly checkpoint.

103 el mechanisms such as abrogation of G2/M and mitotic spindle assembly checkpoints, as well as impaire

104 neuroblasts and human cancer cells to study mitotic spindle assembly in polyploid cells, we found th

105 Normal mitotic spindle assembly is a prerequisite for faithful

106 Accurate mitotic spindle assembly is critical for mitotic fidelit

107 for AURKA-dependent, centrosome-independent mitotic spindle assembly is essential for the survival a

108 Mitotic spindle assembly requires the regulated activiti

109 at range from retrograde axonal transport to mitotic spindle assembly(1,2).

110 ypical example of cytoskeletal remodeling is mitotic spindle assembly, during which microtubules nucl

111 d-bearing attachments to microtubules during mitotic spindle assembly, spindle positioning, and chrom

112 indle matrix has been proposed to facilitate mitotic spindle assembly.

113 microtubule motors that function mainly for mitotic spindle assembly.

114 tion ceases simultaneously with intranuclear mitotic spindle assembly.

115 d by Plk1 and SCFbeta-TrCP to promote proper mitotic spindle assembly.

116 s illustrates how centrosomal Plk1 underlies mitotic spindle assembly.

117 KIF15 and MAD1L1 suggest a possible role of mitotic spindle-assembly genes in IPF susceptibility.

118 The nuclear/mitotic spindle associated protein Ccdc117 interacts wit

119 PLK1 disrupts centrosome separation, causing mitotic spindle asymmetry, merotelic microtubule-kinetoc

120 ides is determined by the orientation of its mitotic spindle at metaphase.

121 egregation during cell division is driven by mitotic spindle attachment to the centromere region on e

122 of cell divisions, which is specified by the mitotic spindle axis.

123 all chromosomes are properly attached to the mitotic spindle by the spindle assembly checkpoint (SAC)

124 Kinesin-5 motors organize mitotic spindles by sliding apart microtubules.

125 is extensively reorganized so that a bipolar mitotic spindle can be correctly assembled.

126 re, the tether impacts full extension of the mitotic spindle, causing abrupt shrinkage or bending of

127 ion defects strictly depends on a functional mitotic spindle checkpoint as well as on intact microtub

128 In this study, we develop evidence that the mitotic spindle checkpoint molecule BUB1B may offer a pr

129 leads to morphological defects, disoriented mitotic spindles, chromosome congression defects and del

130 We found that cabazitaxel induced mitotic spindle collapse and multinucleation by targetin

131 e inhibitory complexes are restricted to the mitotic spindle compartment or are diffusible throughout

132 able to diffuse outside the confines of the mitotic spindle compartment.

133 The mitotic spindle consists of microtubules (MTs), which ar

134 (mgr), leading to monopolar and disorganized mitotic spindles containing few MTs.

135 es, including polarized displacements of the mitotic spindle, contributions from the shape of the mot

136 Subsequently, mitotic spindle cues establish a Myosin gradient at the

137 lls and found that they cause aneuploidy and mitotic spindle defects that then result in apoptosis.

138 The position of the mitotic spindle determines the cleavage plane in animal

139 Correct orientation of the mitotic spindle determines the plane of cellular cleavag

140 Microtubules of the mitotic spindle direct cytokinesis in metazoans but this

141 ockdown showed elevated TGF-beta expression, mitotic spindle disorientation, increased lumenization,

142 tex of the mitotic cell and we show that the mitotic spindle does not reach equilibrium before chromo

143 quired for lumen continuity by orienting the mitotic spindle during cell division.

144 al roles in establishing and maintaining the mitotic spindle during cell division.

145 erface between centromeric chromatin and the mitotic spindle during chromosome segregation.

146 ically modified GR species accumulate at the mitotic spindle during mitosis in a distribution that ov

147 tracked the position and orientation of the mitotic spindle during the first cell division with high

148 Kar9 positions mitotic spindles during budding yeast cell division.

149 atment leads to disorientation of Plasmodium mitotic spindles during the asexual reproduction and res

150 acking software and apply it to characterize mitotic spindle dynamics in the Xenopus laevis embryonic

151 show that the lack of Swe1 causes premature mitotic spindle elongation and that high levels of Swe1

152 longation and that high levels of Swe1 block mitotic spindle elongation, indicating that Swe1 inhibit

153 evidence that it is involved in controlling mitotic spindle elongation.

154 centromeric chromatin to microtubules of the mitotic spindle, enabling sister chromatid segregation i

155 Centrosomes together with the mitotic spindle ensure the faithful distribution of chro

156 The mitotic spindle ensures the faithful segregation of chro

157 CDC2 localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner.

158 outer kinetochore to link centromeres to the mitotic spindle for chromosome segregation.

159 rimary cilium, which inhibits centrosome and mitotic spindle formation and consequently prevents the

160 tion of MCAK and HURP, two key regulators of mitotic spindle formation and known substrates of Aurora

161 gets the FOXM1-KIF20A axis to drive abnormal mitotic spindle formation and mitotic catastrophe and th

162 TOG5-microtubule binding maintained mitotic spindle formation as deleting or mutating TOG5 c

163 ged DNA, but also regulates RNA splicing and mitotic spindle formation in its integral capacity as a

164 membrane morphology, chromosome segregation, mitotic spindle formation, and cell cycle progression.

165 the emergence of cellular phenomena, such as mitotic spindle formation, from component parts.

166 microtubule-associated protein important for mitotic spindle formation.

167 logous possibility that centromeres regulate mitotic spindle formation.

168 cation and assembly is necessary for bipolar mitotic spindle formation.

169 sible and active outside the confines of the mitotic spindle from which they are derived.

170 microtubule cross-linker Shortstop (Shot) in mitotic spindle function in Drosophila Shot localizes to

171 rates that affect chromosome instability and mitotic spindle function, but the manner by which cellul

172 bule-associated protein that is required for mitotic spindle function.

173 growth, which may sensitize ECs to impaired mitotic spindle function.

174 heme decreases GATA1, GATA1-target gene, and mitotic spindle gene expression.

175 The dogma is that the mitotic spindle governs the assembly and constriction of

176 tin) are required for or are even present in mitotic spindles has long been controversial.

177 Mitotic spindle imaging suggests para-tangential pronucl

178 r organizing the microtubule network and the mitotic spindle in animals.

179 origins of diversity in the structure of the mitotic spindle in nematode embryos, at timescales spann

180 stic explanation for variations in the first mitotic spindle in nematodes.

181 The proper positioning of mitotic spindle in the single-cell Caenorhabditis elegan

182 ge-scale serial electron tomography of whole mitotic spindles in early C. elegans embryos with live-c

183 trate that F-actin is indeed associated with mitotic spindles in intact Xenopus laevis embryonic epit

184 d dynamics of the actin cytoskeleton to keep mitotic spindles in syncytial embryos from colliding.

185 ed to resolve telomere cohesion and maintain mitotic spindle integrity.

186 Asymmetric positioning of the mitotic spindle is a fundamental process responsible for

187 Chromosome alignment at the equator of the mitotic spindle is a highly conserved step during cell d

188 The mitotic spindle is a microtubular assembly required for

189 rect bipolar attachment of chromatids to the mitotic spindle is achieved.

190 The mitotic spindle is an ensemble of microtubules responsib

191 The formation of a bipolar mitotic spindle is an essential process for the equal se

192 Yet, a mechanistic understanding of how the mitotic spindle is assembled and achieves chromosome seg

193 The mitotic spindle is composed of dynamic microtubules and

194 oper assembly and orientation of the bipolar mitotic spindle is critical to the fidelity of cell divi

195 During each cell cycle, the mitotic spindle is efficiently assembled to achieve chro

196 The mechanisms by which the mammalian mitotic spindle is guided to a predefined orientation th

197 Precise positioning of the mitotic spindle is important for specifying the plane of

198 Proper organization of the mitotic spindle is key to genetic stability, but molecul

199 ons of the cortex can thus determine how the mitotic spindle is oriented.

200 The position and orientation of the mitotic spindle is precisely regulated to ensure the acc

201 Architectural integrity of the mitotic spindle is required for efficient chromosome con

202 The position of the mitotic spindle is tightly controlled in animal cells as

203 Orientation of mitotic spindles is believed to be a fundamental morphog

204 isolated adherent cells, the orientation of mitotic spindles is sensitive to interphase cell shape a

205 A characteristic feature of mitotic spindles is the congression of chromosomes near

206 only structure linking the two halves of the mitotic spindle, it is under mechanical tension from dyn

207 aphorin ligands fail to correctly orient the mitotic spindle, leading to severe defects in epithelial

208 tubules and caused the formation of abnormal mitotic spindles, leading to mitotic accumulation.

209 olymerization, emphasizing its importance in mitotic spindle length control.

210 e we show that in a range of metazoan phyla, mitotic spindle length decreased with cell size across a

211 Mitotic spindle length, for example, varies several-fold

212 The tail is essential for mitotic spindle localization, which becomes severely red

213 nesis by coupling juxtamembrane signaling to mitotic spindle machinery.

214 TSE1 binds preferentially to the most stable mitotic spindle microtubules and promotes their turnover

215 Microtubule turnover varies among different mitotic spindle microtubules, dictated by their spatial

216 These proteins distinguish cortical from mitotic spindle microtubules, even though the assembly o

217 n when a single kinetochore is unattached to mitotic spindle microtubules.

218 with an increase in the proportion of stable mitotic spindle microtubules.

219 ls exposed to AurkinA mislocalise AURKA from mitotic spindle microtubules.

220 ochores connect centromeric nucleosomes with mitotic-spindle microtubules through conserved, cross-in

221 mplexes that link chromosomal centromeres to mitotic-spindle microtubules.

222 astic cells to proliferative stimuli, causes mitotic spindle misalignment, and expands the pool of ce

223 le in the function and dynamic regulation of mitotic spindles, mitotic progression, and chromosome se

224 FOXM1 and KIF20A similarly promotes abnormal mitotic spindle morphology and chromosome alignment, whi

225 n kinetochore pushing movements and tripolar mitotic spindles occurred in cells lacking Klp5 but not

226 uch as cell cycle progression, chromatin and mitotic spindle organization may also be regulated throu

227 re of many cells, best known for its role in mitotic spindle organization.

228 quired for correct centrosome clustering and mitotic spindle organization.

229 Defects in mitotic spindle orientation (MSO) disrupt the organizati

230 in1-ARHGAP21 interactions, Cdc42 activation, mitotic spindle orientation and 3D glandular morphogenes

231 ation of ACD regulators, leading to aberrant mitotic spindle orientation and defects in the generatio

232 ication via ciliary GTPase signaling directs mitotic spindle orientation and PCP signaling, processes

233 describe multiple distinct functions for the mitotic spindle orientation gene LGN (Gpsm2) in promotin

234 larity in lgl mutants but reveals defects in mitotic spindle orientation in epithelia.

235 y the miR-34/449 family as key regulators of mitotic spindle orientation in the developing cerebral c

236 indicate that miRNA-dependent regulation of mitotic spindle orientation is crucial for cell fate spe

237 e environment, but how those signals control mitotic spindle orientation is not fully understood.

238 Mitotic spindle orientation is used to generate cell fat

239 e show that conserved core components of the mitotic spindle orientation machinery, including Discs L

240 Mitotic spindle orientation must be tightly regulated du

241 ate that ciliary GTPase Arl3 is required for mitotic spindle orientation of mouse basal stem cells du

242 Absence of stathmin induced alterations in mitotic spindle orientation, accumulation of mitotic def

243 rafficking of vesicles to the apical domain, mitotic spindle orientation, and midbody position, consi

244 nein motor function/localization that alters mitotic spindle orientation, chromosomal segregation, an

245 One deletion impairs mitotic spindle orientation, leading to premature cell c

246 shaping keratinocyte mechanics, rather than mitotic spindle orientation.

247 The microtubules that form the mitotic spindle originate from microtubule-organizing ce

248 s a previously unidentified component of the mitotic spindle pole and the centrosome.

249 Importantly, restoring mitotic spindle pole integrity following centromere inac

250 perturbation of centromere function impacts mitotic spindle pole integrity.

251 tained association of each centrosome with a mitotic spindle pole.

252 Instead, MAPKBP1 is recruited to mitotic spindle poles (MSPs) during the early phases of

253 The interaction between centrosomes and mitotic spindle poles is important for efficient spindle

254 ng yeast to mammals, Wts kinase localizes to mitotic spindle poles, a prominent site of Mud localizat

255 dle function in Drosophila Shot localizes to mitotic spindle poles, and its knockdown results in an u

256 (PLK1), facilitates the assembly of the two mitotic spindle poles, which are required for the format

257 Factors that regulate mitotic spindle positioning remain unclear within the co

258 dditional and direct function of NuMA during mitotic spindle positioning, as well as a reiterative us

259 complex as an astral microtubule mediator of mitotic spindle positioning.

260 h sites leads to a defect in centrosomes and mitotic spindles positioning during metaphase and delays

261 chores that are not attached properly to the mitotic spindle produce an inhibitory signal that preven

262 and its binding affinity to centrosomes and mitotic spindles, promoting G2-to-M transition.

263 Sperm-associated Antigen 5 (SPAG5) is a mitotic spindle protein.

264 OCLN interacted with mitotic spindle regulators, NuMA and RAN, while full-len

265 issues, multicellular organisms orient their mitotic spindles relative to neighboring cells.

266 The interphase nucleus and mitotic spindle scale with cell size through both physic

267 Microtubule-based structures such as mitotic spindles scale with cell size, but less is known

268 The length of the mitotic spindle scales with cell size in a wide range of

269 An investigation of how mitotic spindle size scales with cell size in early zebr

270 Mitotic spindles specify cleavage planes in early embryo

271 Clathrin ensures mitotic spindle stability and efficient chromosome align

272 nterplay between PTEN and EG5 in controlling mitotic spindle structure and chromosome behaviour durin

273 potent microtubule polymerases, critical for mitotic spindle structure and dynamics.

274 in the construction of the three-dimensional mitotic spindle structure, Eg5 also plays a distinct rol

275 quired to prevent premature extension of the mitotic spindle that assembles during a HU-extended S ph

276 elies on a membranous system surrounding the mitotic spindle that defines an organelle-exclusion zone

277 ensures the alignment of chromosomes on the mitotic spindle that is required for their proper segreg

278 ch may explain why it has the smallest known mitotic spindle that still manifests the classic congres

279 ction of the centrosome, the assembly of the mitotic spindle, the function of the primary cilium and

280 (MTOC), orchestrating microtubules into the mitotic spindle through its pericentriolar material (PCM

281 The KSP inhibitor targets the mitotic spindle through mechanisms independent of microt

282 ular functions including organization of the mitotic spindle to ensure faithful chromosome segregatio

283 es that couple eukaryotic chromosomes to the mitotic spindle to ensure proper segregation.

284 generators to fine-tune the position of the mitotic spindle to facilitate asymmetric division.

285 cell cycle, regulating the attachment of the mitotic spindle to kinetochores, mitotic exit, cytokines

286 binding that optimally positions Stu2 on the mitotic spindle to promote proper spindle structure and

287 In budding yeast, dynein moves the mitotic spindle to the predetermined site of cytokinesis

288 es, AURKA is allosterically activated on the mitotic spindle via binding to the microtubule-associate

289 ing mitosis, chromosomes are attached to the mitotic spindle via large protein complexes called kinet

290 ein best known for its essential role in the mitotic spindle, where it limits the rate at which faste

291 During mitosis, Tm1J localizes to the mitotic spindle, where it promotes chromosome segregatio

292 k6 facilitates association of Hsp72 with the mitotic spindle, where it promotes stable K-fiber assemb

293 -tubule dynamics is achieved in the smallest mitotic spindles, where the noisiness of microtubule ass

294 siRNA stably decreases MT assembly rates in mitotic spindles, whereas depletion of Kif18A stably inc

295 variations in morphology and dynamics of the mitotic spindle, which orchestrates chromosome segregati

296 MTs nucleate from preexisting MTs within the mitotic spindle, which requires the protein TPX2, but th

297 ment of sister chromatid kinetochores to the mitotic spindle with activation of the anaphase-promotin

298 These cells displayed an aberrant mitotic spindle with disorganized, tangle-shaped microtu

299 ge of MTOCs and contributes to orienting the mitotic spindle within the cell.

300 ations to ensure precise localization of the mitotic spindle, yet compliant enough to allow molecular