ライフサイエンスコーパス: mitotically

1 apical structures, even if inactivated post-mitotically.

2 without dividing, whereas small cells divide mitotically.

3 show that caspase-2 is required for deleting mitotically aberrant cells.

4 We recently identified a series of mitotically acting piperazine-based compounds that poten

5 s, an event attributed to phosphorylation by mitotically activated aPKC kinase and thought to promote

6 We also demonstrate that mitotically activated ATM phosphorylates Bub1, a critica

7 ence of keratin 16 at the transition between mitotically active and differentiating cells is recapitu

8 ous derepression occasionally occurs in both mitotically active and differentiating cells.

9 Although these cells are mitotically active and do not morphologically differenti

10 l adhesion molecule) immunoreactive NRPs are mitotically active and electrically immature, and they e

11 The anterior PGCs are very mitotically active and exhibit two division patterns wit

12 ical characterization reveals that the FT is mitotically active and its cells express similar markers

13 Spine epidermis is mitotically active and red spherule immunocytes are high

14 f the bulbar conjunctiva near the limbus are mitotically active and yet they are generally immobile i

15 he mammalian forebrain, the subependyma is a mitotically active area that is a source of oligodendroc

16 basonuclin is associated with the nuclei of mitotically active basal cells but not in terminally dif

17 In normal epidermis, a mitotically active basal layer gives rise to terminally

18 Stratified epithelium contains a mitotically active basal layer of cells that cease proli

19 rieved capsules revealed numerous viable and mitotically active BHK cells that continued to secrete h

20 estines were assayed to assess activity in a mitotically active cell type and tissue.

21 a 2 is in a unique position to interact with mitotically active cells (in early retinal development),

22 pproaches can provide curative expression in mitotically active cells and pediatric populations.

23 In the absence of p27(Kip1), mitotically active cells are still observed in the organ

24 Lysates from mitotically active cells did not contain these APC isofo

25 ein-2 showed that the vast majority of these mitotically active cells differentiated into neurons in

26 Mitotically active cells in log growth respond to TNF by

27 ice, using BrdU labeling, and detected fewer mitotically active cells in the cortical plate.

28 n remains elusive, and the function of AR in mitotically active cells is not well understood.

29 an earlier phase of tangential migration of mitotically active cells lays down a widespread periodic

30 ce by positioning the transition zone, where mitotically active cells lose their capacity to divide a

31 ative amacrine cells, nascent cones, and the mitotically active cells of the rod lineage.

32 human ovarian cortical tissue to purify rare mitotically active cells that have a gene expression pro

33 1 was identified as an AR-regulated gene in mitotically active cells that promoted pro-metastatic ph

34 a critical regulator of the transition from mitotically active cells to terminal differentiated neur

35 hymidine analog (EdU), we were able to label mitotically active cells, which revealed that cell proli

36 demonstrated that this activity occurred in mitotically active cells.

37 eak down and dedifferentiate back to single, mitotically active cells.

38 follicular renewal occurs in mammals, and no mitotically active Ddx4-expressing female germline proge

39 rphase and mitosis, only the phosphorylated, mitotically active form of Cdc25 was able to bind Pin1,

40 e women, similar to adult mice, possess rare mitotically active germ cells that can be propagated in

41 hat juvenile and adult mouse ovaries possess mitotically active germ cells that, based on rates of oo

42 c prophase, Tra2b PE deletion spared earlier mitotically active germ cells, even though these still r

43 While basonuclin RNA expression occurs in mitotically active germ cells, protein was not detected

44 atrophy, azoospermia, and reduced numbers of mitotically active germ cells; the remaining mice showed

45 milieu composed of postmitotic neurons, and mitotically active glial and neural progenitor cells.

46 which are quiescent and held in reserve, and mitotically active globose basal cells.

47 epair down-regulation and TNR instability in mitotically active HD cells and offer a proof of princip

48 DNA mutations appears relatively common in a mitotically active human tissue and may provide a method

49 igh degree of silencing is maintained in the mitotically active imaginal cells from mid-embryogenesis

50 Lgr5 marks mitotically active intestinal stem cells (ISCs).

51 Lgr5 marks mitotically active ISCs that exhibit exquisite sensitivi

52 Keratins K5 and K14 are the hallmarks of mitotically active keratinocytes of stratified epithelia

53 ical proliferative zone and appear to become mitotically active late in gestation.

54 pressing tetracycline transactivators in the mitotically active layers of the epidermis, these mice w

55 ger, with longer cells and a larger and more mitotically active meristem.

56 olongs neural proliferation by maintaining a mitotically active neuroblast.

57 Unlike TFs expressed in mitotically active neuroblasts, these TFs do not regulat

58 in vivo of immature postmitotic neurons and mitotically active neuronal precursor cells.

59 the peripheral margin, Vsx-2 is expressed in mitotically active neuronal progenitors and is downregul

60 d that the primate retinal periphery harbors mitotically active neuroprogenitor cells that increase i

61 The recent purification of mitotically active oocyte progenitor cells, termed femal

62 We found that mitotically active pancreatic progenitor cells in mouse

63 a (NG2 glia) are a uniformly distributed and mitotically active pool of cells in the central nervous

64 ained in an undifferentiated state by a less mitotically active population of cells called the quiesc

65 These data suggest that there are mitotically active precursors in the mammalian neural cr

66 cluding effects on both neural crest and DRG mitotically active progenitor cells, in addition to poss

67 nteractions among nascent neurons, glia, and mitotically active progenitor cells.

68 s of MARCKS results in ectopic collection of mitotically active radial progenitors away from the vent

69 Nonetheless, only progenitors that are mitotically active respond to LAMP-inducing signals; onl

70 Concurrently, the loss of Math5 causes mitotically active retinal progenitors to undergo aberra

71 We report the generation of mitotically active Rev3L-/- MEFs on a p53-/- genetic bac

72 imaginal disc culture system, we showed that mitotically active sertraline-treated tissues accumulate

73 The decrease in mitotically active SPG11-NPCs was rescued by GSK3 modula

74 Y15S/Y15S) mice possess abnormal clusters of mitotically active SSC-like cells, but these are eventua

75 rein, we maintained human Sertoli cells in a mitotically active state in vitro, thus enabling transfe

76 cells are functionally heterogeneous with a mitotically active subpopulation lining the lateral doma

77 A subset of mitotically active SVZ precursor cells gives rise to a p

78 Radial glia are mitotically active throughout neurogenesis, and disappea

79 ends even to the germline, which is the only mitotically active tissue in the adult.

80 dent accumulation of mtDNA mutations in this mitotically active tissue.

81 ghest level of purine biosynthesis occurs in mitotically active tissues of the plant.

82 ntly expressed throughout development in all mitotically active tissues, at lower levels in some post

83 without cell division, with similar rates to mitotically active tissues.

84 her, these findings delineate AR function in mitotically active tumor cells, thus providing critical

85 t expressed in the neural progenitors of the mitotically active ventricular zone.

86 icts that throughout neurogenesis almost all mitotically active VZ cells and a substantial percentage

87 hat the majority of VZ cells, and nearly all mitotically active VZ cells during neurogenesis, both ha

88 These differentiated Sertoli cells remained mitotically active when cultured in the presence of 10%

89 e that the human and rodent ONLR possesses a mitotically active, age-depletable neural progenitor cel

90 sal layers of epidermis, but it is absent in mitotically active, basal keratinocytes.

91 e report here that mTECs from adult mice are mitotically active, implying continual turnover, differe

92 The neural crest is a unique population of mitotically active, multipotent progenitors that arise a

93 pancreas, SOX9 expression is restricted to a mitotically active, Notch-responsive subset of PDX1(+) p

94 of a heterogeneous population of cells, some mitotically active, others postmitotic.

95 precursors that, after muscle injury, become mitotically active, proliferate, and fuse together or, t

96 ge of complex forms throughout the EGL while mitotically active.

97 that GFP-positive cells in this region were mitotically active.

98 progression, tumors become vascularized and mitotically active.

99 Ts, are highly vascularized, hemorrhagic and mitotically active.

100 structures and nerves; in addition, they are mitotically active.

101 iated premature differentiation and death of mitotically-active progenitors that express the paired-b

102 Normally, polyploid cells do not divide mitotically after initiating endocycles; hence, little i

103 ain considerable stem cell character as they mitotically amplify prior to differentiation and can be

104 STeS/MMBIR-mediated rearrangements can occur mitotically and can result in duplication or triplicatio

105 s contain exogenous alpha satellite DNA, are mitotically and cytogenetically stable in the absence of

106 Mammalian germ cells divide mitotically and form nests of associated cells just prio

107 wo novel gene functions required to maintain mitotically and meiotically heritable gene silencing ass

108 The weakly expressed Pl' state is mitotically and meiotically stable, yet reversible.

109 ixteen cases of mosaic aneuploidy originated mitotically, and these included four rare trisomies and

110 generated during this process are more sable mitotically, and when reisolated, transform the fungus a

111 TACE (which has alpha-secretase activity) to mitotically arrested adult rat mixed DRG cultures, we de

112 yclosome/anaphase-promoting complex (APC) in mitotically arrested cells but not in interphase cells.

113 Mitotically arrested cells display multipolar spindles a

114 Mitotically arrested cells typically display extensive p

115 cts prepared from logarithmically growing or mitotically arrested cells, we demonstrate that phosphor

116 apoptosis is significantly increased in the mitotically arrested cells.

117 l tails of histone H3 variants purified from mitotically arrested HeLa cells.

118 B, extracted chromosomes were prepared from mitotically-arrested HeLa S3 cells and incubated with re

119 with RZ-1B/1C-mediated retention, creates a mitotically associated PME5 mRNA reservoir in the nucleu

120 Mitotically blocked cells exhibited aberrant spindles, c

121 ure hair cells after gentamicin treatment in mitotically blocked cultures of the bullfrog saccule.

122 with mitotic chromosomes at regions that are mitotically bookmarked by transcription factors and chro

123 nt genome-scale microcompartmentalization of mitotically bookmarked cis-regulatory elements.

124 We then investigate roles of mitotically bookmarked CTCF in prometaphase chromosome o

125 detected in germline micronuclei that divide mitotically but not in somatic macronuclei that divide a

126 eir early radial glial derivatives and their mitotically competent neurogenic daughters.

127 xperiments indicate that an abundant pool of mitotically competent neurogenic progenitor cells reside

128 Thus, the adult human hippocampus contains mitotically competent neuronal progenitors that can be s

129 , the human subcortical white matter harbors mitotically competent progenitor cells, which give rise

130 sufficient for transforming sperm DNA into a mitotically competent pronucleus.

131 canonical modes of cell division to generate mitotically competent resistant daughter cells.

132 unctions in maintaining the pericycle in the mitotically competent state needed for lateral root form

133 es of apoptosis and autophagic cell death in mitotically competent tissues and protein turnover and c

134 that it is the programmed destruction of the mitotically compromised stem cell niche that triggers it

135 erative zone, which includes a population of mitotically cycling cells and cells in meiotic S phase,

136 In mitotically cycling cells, we detect inter-homologue joi

137 hat DHJs are not formed during DSB repair in mitotically cycling cells.

138 Instead, they dedifferentiate back into mitotically cycling germ cells and form rapidly growing

139 d GLP-1 signaling, possibly corresponding to mitotically cycling proliferative zone cells that are di

140 r Ndt80 is sufficient to extend life span in mitotically dividing budding yeast, suggesting that meio

141 Mitotically dividing cells appear to be less dependent o

142 enorhabditis elegans germline is composed of mitotically dividing cells at the distal end that give r

143 ion, a potential mechanism leading to LOH in mitotically dividing cells is DSB repair involving homol

144 Mitotically dividing cells use a surveillance mechanism,

145 The repE gene is not expressed by mitotically dividing cells, and repE mRNA is first detec

146 es that distinguish it from recombination in mitotically dividing cells, and several of these feature

147 rvations that homologous chromosomes pair in mitotically dividing cells, and that chromosome rearrang

148 though the rec14 transcripts were present in mitotically dividing cells, rec14 mutations had no detec

149 uired for the spindle assembly checkpoint in mitotically dividing cells.

150 We show that SMG-1 mainly acts in mitotically dividing germ cells, and during late embryon

151 We find that mitotically dividing germ cells--including germline stem

152 for the phosphorylation of linker histone in mitotically dividing micronuclei.

153 ects in nuclear divisions were restricted to mitotically dividing micronuclei; macronuclei, which are

154 teins (KZFPs), which are highly expressed in mitotically dividing spermatogonia, repress the enhancer

155 ls are maintained in an undifferentiated and mitotically dividing state by Notch signaling and the FB

156 In mitotically dividing vertebrate cells, the primary prote

157 cells that can reside for long periods in a mitotically dormant but reversible cell-cycle arrest sta

158 Small, mitotically dormant cholangiocytes are activated during

159 ng the course of cholestatic liver diseases, mitotically dormant cholangiocytes proliferate and subse

160 dult mammals, NSCs reside predominantly in a mitotically dormant, quiescent state, but they can proli

161 These studies demonstrate that mitotically expanded bone marrow cells can serve as an a

162 moters, which are silenced by methylation or mitotically expressed genes.

163 not in mutants defective in the three known mitotically expressed yeast RecA homologs.

164 Whereas the normally spliced cyclin RNA was mitotically functional, as indicated by its ability to p

165 n stress, MiDAS was detected irrespective of mitotically generated DNA damage.

166 , Rad51D, XRCC2, and XRCC3) are expressed in mitotically growing cells and are thought to play mediat

167 However, in mitotically growing cells this role can be fulfilled by

168 meras indicate that splicing is prevented in mitotically growing cells via inhibition, in contrast to

169 ransposon Ty1 accumulates to a high level in mitotically growing haploid cells, yet transposition occ

170 We also observed that mitotically growing Ku p70 mutants have an anomalously h

171 In mitotically growing yeast cells, five septin subunits ar

172 DNA molecule (xDNA), was analyzed at rDNA in mitotically growing yeast.

173 Epigenetic expression patterns are mitotically heritable and are stably maintained in adult

174 Although mitotically heritable and stable over time, patterns of

175 ptional memory: repressed genes that exhibit mitotically heritable changes in chromatin structure and

176 Mitotically heritable epigenetic or dynamic chromatin st

177 This mitotically heritable mode of regulation is recently evo

178 known for their role in maintaining stable, mitotically heritable silencing of the homeotic (HOX) ge

179 generate thousands of molecularly distinct, mitotically heritable states through the property of mul

180 to interferon-gamma (IFNgamma) results in a mitotically heritable yet reversible state called long-t

181 ion in plant genomes that is meiotically and mitotically heritable, and at times is associated with g

182 omoting cycling and subsequent cell death of mitotically impaired cells.

183 ested in this assay were each able to expand mitotically in concert with the surrounding paraxial mes

184 gates are plated into microdrops seeded with mitotically inactivated feeder cells, and then connected

185 ining the pluripotency of these iPS cells on mitotically inactivated feeder layers prepared from the

186 iopsies were cultured using a combination of mitotically inactivated fibroblasts and Rho-associated p

187 hESCs are conventionally grown on mitotically inactivated mouse embryonic fibroblasts (MEF

188 an be efficiently obtained by cultivation on mitotically inactivated testicular feeders containing CD

189 This included mitotically inactive breast lobular epithelium in additi

190 t meristem of flowering plants is a group of mitotically inactive cells designated the quiescent cent

191 hrough the quiescent center, a population of mitotically inactive cells formerly thought to be undiff

192 en demonstrated to be capable of transducing mitotically inactive cells, including HSCs, and accommod

193 Mitotically inactive feeder layers have been used previo

194 The pathogenic cells were mitotically inactive, but proliferating precursors were

195 These cells are mitotically inactive, differentiated oligodendrocytes an

196 whereupon the buds shrink in size and become mitotically inactive.

197 cell division in the QC, which is generally mitotically inactive.

198 s with reduced EphA4 signaling were rare and mitotically inactive.

199 In conclusion, we found that mitotically incompetent ocular tissue cells contain adul

200 cs can be defined as all the meiotically and mitotically inherited changes in gene expression that ar

201 s, and this chromatin-related memory must be mitotically inherited to maintain cell identity through

202 expression pattern is stably maintained and mitotically inherited.

203 cle formation in skin reconstitution assays, mitotically inhibited cells readily contribute to DP.

204 nick end labeling positive, and they can be mitotically labeled by sustained rather than acute bromo

205 Adenomas appeared to be relatively mitotically old populations, pocketed with occasional ne

206 ations, suggesting that they were relatively mitotically old populations.

207 The mitotically phosphorylated MEK1, upon partial proteolysi

208 retic mobility shifts, we have identified 20 mitotically phosphorylated proteins from Xenopus embryos

209 ody MPM-2 recognizes a significant subset of mitotically phosphorylated S/TP motifs; however, the req

210 The mitotically preserved processing complexes may be essent

211 Some of these mitotically produced cells began to differentiate into h

212 germline genes, and the resolution of SEs in mitotically proliferating cells via SCML2, a germline-sp

213 ns has important functions in cytokinesis in mitotically proliferating cells.

214 proliferate and then differentiate to become mitotically quiescent adipocytes.

215 lea, the greater epithelial ridge (GER) is a mitotically quiescent and transient organ, which has bee

216 Although normal bladder urothelium is a mitotically quiescent barrier epithelium, histologic stu

217 plenishment of the bronchial epithelium from mitotically quiescent cells that have avoided tobacco mu

218 We showed that the mitotically quiescent cells were very significantly more

219 ot meristem has a centrally located group of mitotically quiescent cells, to which current models ass

220 xposure stimulates cellular proliferation in mitotically quiescent cells.

221 CD4+ T cells but significantly decreased in mitotically quiescent cells.

222 mesenchymal cells assembled as aggregates of mitotically quiescent cells.

223 n to a substantially greater degree than did mitotically quiescent cells.

224 For in vitro analysis, mitotically quiescent chondrocytes were exposed to incre

225 and their progenitors with both dividing and mitotically quiescent endothelial cells in restricted re

226 population called satellite cells, which are mitotically quiescent in mature muscle, but can be activ

227 Although mitotically quiescent in mature muscle, satellite cells

228 iated marker negligibly expressed in normal, mitotically quiescent neural tissues.

229 Because the liver is essentially a mitotically quiescent organ, tamoxifen-DNA adduction in

230 eport a previously unrecognized mechanism of mitotically quiescent proximal tubular epithelial cells

231 oughout the body, most of which are found as mitotically quiescent solitary cells.

232 for primitive HPCs, persists in culture in a mitotically quiescent state due to their cytokine-nonres

233 an prostate cancer cell lines, we identified mitotically quiescent subpopulations (<1%), which we com

234 The normally mitotically quiescent supporting cells proliferated afte

235 The healthy liver is mitotically quiescent, but following toxic damage or res

236 ca-1(+)lin(-) engrafting cell as one that is mitotically quiescent, CD43(+), CD49e(+), CD11a(-), CD49

237 ration shows that the placodal epithelium is mitotically quiescent, with few phosphohistone H3-positi

238 m all cells in the basilar papilla, which is mitotically quiescent.

239 rare mononucleate muscle precursor cells are mitotically quiescent.

240 of cells in an epithelium that is otherwise mitotically quiescent.

241 nase inhibitor p27(Kip1), and are presumably mitotically quiescent.

242 NSCs from a proliferatively-active state to mitotically-quiescent state dramatically decreased neuro

243 were shifted from a proliferative state to a mitotically-quiescent state in the demyelinated hippocam

244 We used a mitotically-quiescent, functionally-differentiated model

245 surfaces through trans-oligomerization in a mitotically regulated manner.

246 ties required to bind surfaces together in a mitotically regulated manner.

247 necessary for initiating the division of all mitotically regulated neuroblasts in the brain lobes.

248 ratus during mitosis implicated GRASP65 as a mitotically regulated stacking factor.

249 NA necessary for ribosome biogenesis, is not mitotically regulated.

250 ization and trans-oligomerization but is not mitotically regulated.

251 es to dynamic microtubules, and withstanding mitotically relevant forces.

252 mitosis originated the hypothesis that such mitotically retained molecular signatures could provide

253 Mitotically selected CHO cells were incubated without tr

254 ering by causing a repression of FLC that is mitotically stable after return to warm growing conditio

255 ble in both the prion and the nonprion form, mitotically stable but meiotically unstable, and cured b

256 Results from deletion analysis of mitotically stable chromosome rearrangements and from a

257 es on stable dicentric chromosomes, and also mitotically stable chromosomes lacking alpha-satellite D

258 the induction of potentially deleterious and mitotically stable genic epimutations.

259 e 22 with no detectable CENP-B motifs formed mitotically stable HACs in the absence of drug selection

260 e association of Ring1b and ubH2A with Xi is mitotically stable in non-differentiated TS cells.

261 e active kinetochore protein CENP-E and were mitotically stable in the absence of selection for at le

262 pigenetic phenomenon in the sense that it is mitotically stable in the spring after the inducing sign

263 als, numerous autosomal genes are subject to mitotically stable monoallelic expression (MAE), includi

264 Although artificial chromosomes are mitotically stable over many months in culture, when we

265 t, this process includes degradation of many mitotically stable proteins, followed by their resynthes

266 Mitotically stable random monoallelic gene expression (R

267 ess by which a long period of cold induces a mitotically stable state that leads to accelerated flowe

268 esults in "resetting" of the variegated, but mitotically stable, defects.

269 nducibly convert circular DNA molecules into mitotically stable, linear chromosomes replete with func

270 rrier defects made Whi3(mnem) propagate in a mitotically stable, prion-like manner.

271 jority of or all cells analyzed and appeared mitotically stable, thereby indicating the presence of a

272 nspose into random rDNA repeat units and are mitotically stable.

273 qualize X-linked gene expression through the mitotically-stable transcriptional inactivation of one o

274 embryogenesis and that they may help extrude mitotically stalled nuclei during blastoderm formation.

275 atially uncoupling the nucleus and cytoplasm mitotically, suggesting that centrosomal cyclin-CDK acts

276 Through tandem mass spectrometry analysis of mitotically SUMOylated PARP1, we identified a residue wi

277 When mitotically synchronized cells were treated with the Cdk

278 Analysis of BrdU incorporation in mitotically synchronized HeLa cells suggested that cells

279 h a stem cell population continues to divide mitotically throughout life; hence the cell cycles of th

280 Germ cells can divide mitotically to replenish germline tissue or meiotically

281 contribute to epigenetic functions that are mitotically transmitted by Runx2 in osteoblastic cells.

282 nced version of the floral repressor that is mitotically transmitted to the newly emerging leaves, wh

283 This array is mitotically unstable and can be lost to produce a clone

284 the URA3 negative selectable marker becomes mitotically unstable and is lost at high frequency by di

285 lasmic infection (cytoduction), but which is mitotically unstable in non-selective conditions.

286 ific histone variant CENPA and the HSA17 was mitotically unstable, or alternatively, the centromere w

287 e to reform functional CEN chromatin and was mitotically unstable.

288 are represented as circular elements and are mitotically unstable.

289 , but the prions formed by this variant were mitotically very unstable.

290 Male germ cells arrest mitotically, while female germ cells directly enter meio