ライフサイエンスコーパス: mixed-lineage leukemia

1 tients harbor a translocation involving MLL (mixed lineage leukemia).

2 sociated with infant acute lymphoblastic and mixed lineage leukemia.

3 s cytogenetics in acute myeloid leukemia and mixed lineage leukemia.

4 an inv(8)(p11q13) from a patient with acute mixed lineage leukemia.

5 ole and is a potential therapeutic target in mixed lineage leukemia.

6 ing response to therapy, of 35 patients with mixed-lineage leukemia.

7 methyltranferases (H3K4MTs) MLL3 and MLL4 in mixed-lineage leukemia.

8 -CSF pathway, that resemble a B cell/myeloid mixed-lineage leukemia.

9 F23, and NUP98-TOP1 physically interact with mixed lineage leukemia 1 (MLL1) and the non-specific let

10 Acute myeloid leukemia (AML) with mixed lineage leukemia 1 (MLL1) gene rearrangement is ch

11 Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4

12 Mixed lineage leukemia 1 (MLL1) is a histone methyltrans

13 The epigenetic activator Mixed lineage leukemia 1 (MLL1) is paramount for embryon

14 rotein-protein interaction between menin and mixed lineage leukemia 1 (MLL1) plays a critical role in

15 We show that the mixed lineage leukemia 1 (MLL1) protein, a histone methy

16 Mixed lineage leukemia 1 (MLL1), a histone H3 lysine 4 (

17 Menin is an essential oncogenic cofactor for mixed lineage leukemia 1 (MLL1)-mediated leukemogenesis

18 identify that the histone methyltransferase mixed lineage leukemia 1 (MLL1/KMT2A) is an important re

19 ulated by MOZ, mixed lineage leukemia 1, and mixed lineage leukemia 1 cofactor menin.

20 leukemia cell lines harboring the rearranged mixed lineage leukemia 1 gene.

21 of acute leukemias arise from fusion of the mixed lineage leukemia 1 protein (MLL) N terminus to a v

22 oregulators such as histone methylases MLL1 (mixed lineage leukemia 1) and MLL3 and CREB-binding prot

23 The MLL1 (mixed lineage leukemia 1) protein, which is often disrup

24 gnificant overlap in genes regulated by MOZ, mixed lineage leukemia 1, and mixed lineage leukemia 1 c

25 down (KD) of a writer, the methyltransferase mixed-lineage leukemia 1 (Mll1) (n = 26), and an eraser,

26 We find that the histone methyltransferase Mixed-Lineage Leukemia 1 (MLL1) controls 3D cell migrati

27 tivators CREB-binding protein (CBP)/p300 and mixed-lineage leukemia 1 (MLL1) critically regulate circ

28 Mixed-lineage leukemia 1 (MLL1) forms a complex with WD-

29 Chromosomal translocations of the Mixed-lineage leukemia 1 (MLL1) gene generate MLL chimer

30 Mixed-lineage leukemia 1 (MLL1) is a transcription activ

31 Further, using a myeloid-specific mixed-lineage leukemia 1 (MLL1) knockout (Mll1(f/f)Lyz2(

32 Here, we show that mixed-lineage leukemia 1 (MLL1) protein is a key determi

33 ity for a truncated, lacZ knock-in allele of mixed-lineage leukemia 1 (Mll1), a histone methyltransfe

34 Ash1l cooperated functionally with mixed-lineage leukemia 1 (Mll1), as combined loss of Ash

35 f the H3K4-specific methyltransferase, Kmt2a/Mixed-lineage leukemia 1 (Mll1), in mouse postnatal fore

36 expression of the histone methyltransferase, mixed-lineage leukemia 1 (MLL1), which specifically trim

37 onal identity in the murine brain requires a mixed-lineage leukemia 1 (Mll1)-dependent epigenetic mem

38 ultiprotein complex essential for activating mixed-lineage leukemia 1 (MLL1).

39 he histone methyltransferases Set1 and MLL1 (mixed-lineage leukemia 1), leading to histone H3K4 trime

40 The human Mixed Lineage Leukemia-1 (MLL1) complex methylates histo

41 The mixed lineage leukemia-1 (MLL1) core complex predominant

42 The mixed lineage leukemia-1 (MLL1) enzyme is a histone H3 l

43 Translocations and amplifications of the mixed lineage leukemia-1 (MLL1) gene are associated with

44 q23 chromosomal translocations involving the mixed lineage leukemia-1 (MLL1) gene, a key player in hi

45 Mixed-lineage leukemia-1 (MLL1) has been shown to direct

46 MT2A lysine methyltransferase (also known as mixed-lineage leukemia-1), and produce in-frame fusions

47 Lpt) is the N-terminal homolog of mammalian Mixed Lineage Leukemia 2 (MLL2/ALR), a core component of

48 transferases such as enhancer of zeste 2 and mixed lineage leukemia 2, histone demethylases including

49 istone-methyltransferase myeloid/lymphoid or mixed-lineage leukemia 2 (mll2/kmt2b) gene in adult fore

50 ximately 50% reduction in gene dosage of the mixed lineage leukemia 3 (MLL3) gene, located on 7q36.1,

51 and the histone monomethyltransferase, MLL3 (mixed lineage leukemia 3) form altogether a macromolecul

52 The MLL3 (mixed lineage leukemia 3) protein is a member of the hum

53 s identified were all of the subunits of the mixed-lineage leukemia 3 (Mll3) and 4 (Mll4) complexes,

54 The histone H3-lysine-4 methyltransferase mixed-lineage leukemia 3 (MLL3) and its closest homolog,

55 Although PTIP is a unique component of the mixed-lineage leukemia 3 (MLL3)/MLL4 chromatin-modifying

56 deficient in the PTIP component of the MLL3 (mixed-lineage leukemia 3)-MLL4 complex display impaired

57 umonji C family of proteins, associates with mixed-lineage leukemia 3/4 complexes.

58 e report that histone mono-methyltransferase mixed lineage leukemia 4 (MLL4), a key enhancer regulato

59 r is equipped with a 14-residue Win motif of mixed lineage leukemia 4 methyltransferase (MLL4(Win)),

60 Mixed-lineage leukemia 4 (MLL4/KMT2D) is a major enhance

61 Mixed-lineage leukemia 4 (MLL4; also called MLL2 and ALR

62 The histone methyltransferase mixed-lineage leukemia-4 (MLL4) is a transcriptional coa

63 H3.3 is repressed by mixed lineage leukemia 5 (MLL5) in self-renewing GBM cel

64 The human mixed-lineage leukemia 5 (MLL5) protein mediates hematop

65 eptor NKp44 (NKp44L), a novel isoform of the mixed-lineage leukemia-5 protein, as a cellular ligand f

66 lso suppresses proliferation of leukemogenic mixed lineage leukemia-AF9 fusion-protein-transformed my

67 Taspase1, the mixed lineage leukemia and TFIIAalpha-beta cleaving prot

68 mia (ALL), acute myelogenous leukemia (AML), mixed lineage leukemia, and also in therapy AML (t-AML)

69 ragile sites, and breakpoints, including the mixed-lineage leukemia breakpoint cluster region (MLL BC

70 at containing protein 5), a component of the mixed lineage leukemia complex of histone 3 lysine 4 met

71 y, although PTIP and PA1 associate with MLL (mixed lineage leukemia) complexes and participate in tra

72 effectively treats aggressive AML, including mixed-lineage leukemia-driven AML, and outperforms stand

73 f conditional transformation by an inducible mixed lineage leukemia-eleven-nineteen leukemia (MLL-ENL

74 issense and nonsense mutations targeting the mixed lineage leukemia family member 3 (MLL3, encoded by

75 A murine retroviral transduction model of mixed lineage leukemia fused to CREB binding protein suc

76 rmined that minimally, the amino terminus of mixed lineage leukemia fused to the bromodomain and hist

77 upport of this idea, we showed recently that mixed lineage leukemia fusion oncoproteins can convert c

78 ex with MLLT10, which cooperatively regulate mixed lineage leukemia fusion protein (MLL-FP) target ge

79 ses the transcriptional activity of a common mixed-lineage leukemia fusion partner, AF9.

80 The AF1q gene, a mixed-lineage leukemia fusion partner, is highly express

81 ort that hDOT1L interacts with AF10, an MLL (mixed lineage leukemia) fusion partner involved in acute

82 ves as a critical oncogenic cofactor of MLL (mixed lineage leukemia) fusion proteins in acute leukemi

83 in leukemogenesis driven by a subset of MLL (mixed-lineage leukemia) fusion proteins raises the possi

84 Mixed lineage leukemia-fusion proteins (MLL-FPs) are bel

85 ias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique biologi

86 Mixed lineage leukemia gene (MLL) rearrangements (MLL-r)

87 Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukem

88 Translocations involving the mixed lineage leukemia gene (MLL), the human homolog of

89 The mixed lineage leukemia gene (MLL, also known as HRX, ALL

90 Histone methyltransferase, mixed lineage leukemia gene 3 (MLL3) was reported to be

91 Rearrangements of the mixed lineage leukemia gene MLL are associated with aggr

92 Chromosome translocations involving the mixed lineage leukemia gene MLL are associated with aggr

93 Chromosome rearrangements involving the mixed-lineage leukemia gene (MLL) create MLL-fusion prot

94 adults as a result of rearrangements to the mixed-lineage leukemia gene (MLL) located on chromosome

95 atient-derived xenografts (PDX) of pediatric mixed-lineage leukemia gene (MLL)-rearranged ALL were es

96 The mixed-lineage leukemia gene (MLL, ALL1, HRX) encodes a 3

97 ng a chromosomal translocation involving the mixed-lineage leukemia gene (MLL, ALL1, HRX) have a part

98 The Mixed-Lineage Leukemia gene (MLL/HRX/ALL1) encodes a lar

99 or acute myelogenous leukemia), and MLL AML (mixed-lineage leukemia gene) in comparison to control su

100 The MLL (Mixed Lineage Leukemia) gene is a common target for chro

101 e a drug target for acute leukemia with MLL (mixed lineage leukemia) gene translocations.

102 The MLL (mixed-lineage leukemia) gene is involved in many chromos

103 ene involved in translocations with the MLL (mixed-lineage leukemia) gene, was 631 bp away in a head-

104 to as MLL to denote the gene associated with mixed-lineage leukemia) generate MLL fusion proteins tha

105 MEN1 and its coactivator, the mixed-lineage leukemia histone methyltransferase, are re

106 iginally identified as a fusion partner with mixed-lineage leukemia in a patient with acute myeloid l

107 ize the biology and optimal therapy of acute mixed-lineage leukemia in children, we reviewed the path

108 key roles of ERs in the recruitment of these mixed lineage leukemias into the HOXC6 promoter.

109 MLL (mixed-lineage leukemia) is a histone H3 Lys-4 specific m

110 MLL (for mixed-lineage leukemia) is a proto-oncogene that is muta

111 ing translocation t(11;16) (q23;p13.3), MLL (mixed-lineage leukemia) is fused in frame to CBP (CREB b

112 horax family member MLL (myeloid/lymphoid or mixed-lineage leukemia) is presumed to activate Hox expr

113 tool for understanding the biologic basis of mixed lineage leukemia leukemogenesis and for developing

114 One such gene is MLL (myeloid-lymphoid or mixed lineage leukemia) located at chromosome band 11q23

115 5 (WDR5) is a common component of mammalian mixed lineage leukemia methyltransferase family members

116 WDR5 is a component of the mixed lineage leukemia MLL/SET complex and localizes MYC

117 in 5 (WDR5) and its various partners such as mixed lineage leukemia (MLL) and c-MYC are essential for

118 Mixed lineage leukemia (MLL) and its metazoan Trithorax

119 c-Myb, GATA-3, Menin, and mixed lineage leukemia (MLL) bound to CGRE in human prim

120 e II (TOP2)-mediated DNA cleavage within the mixed lineage leukemia (MLL) breakpoint cluster region (

121 nic fusions of the Trithorax-related protein mixed lineage leukemia (MLL) can initiate aggressive leu

122 allosteric changes that transcription factor mixed lineage leukemia (MLL) causes to the interactions

123 WDR5 is a component of the mixed lineage leukemia (MLL) complex, which methylates l

124 ated by epigenetic changes controlled by the mixed lineage leukemia (MLL) family because treatment wi

125 Mixed lineage leukemia (MLL) family histone methyltransf

126 The oncoprotein Ash2L is a component of the mixed lineage leukemia (MLL) family members 1-4, Setd1A,

127 The Mixed lineage leukemia (MLL) family of enzymes deposit H

128 Enzymes of the mixed lineage leukemia (MLL) family of histone H3 lysine

129 Although misregulation of mixed lineage leukemia (MLL) family proteins has been as

130 in, the MEN1 protein product, interacts with mixed lineage leukemia (MLL) family proteins in a histon

131 Mixed lineage leukemia (MLL) fusion genes arise from chr

132 Identification of the targets of mixed lineage leukemia (MLL) fusion genes will assist in

133 ne 79 (K79) on histone H3 and is involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; howe

134 unctions and in leukemogenesis driven by the mixed lineage leukemia (MLL) fusion oncogene MLL-AF9.

135 ough menin acts as an oncogenic cofactor for mixed lineage leukemia (MLL) fusion protein-mediated his

136 polymerase-associated factor complex (PAFc), mixed lineage leukemia (MLL) fusion proteins activate ge

137 unctions as a critical oncogenic cofactor of mixed lineage leukemia (MLL) fusion proteins in the deve

138 The interaction between menin and oncogenic mixed lineage leukemia (MLL) fusion proteins is required

139 Mixed lineage leukemia (MLL) fusion-driven acute leukemi

140 Chromosomal translocations of the mixed lineage leukemia (MLL) gene are a common cause of

141 Chromosomal translocations involving the mixed lineage leukemia (MLL) gene are associated with ag

142 Chromosomal translocations involving the mixed lineage leukemia (MLL) gene are often observed in

143 ith chromosomal translocations involving the mixed lineage leukemia (MLL) gene are usually associated

144 The mixed lineage leukemia (MLL) gene at chromosome band 11q

145 Chromosome translocations involving the mixed lineage leukemia (MLL) gene fuse it in frame with

146 o distinctive origins of human AML driven by Mixed Lineage Leukemia (MLL) gene fusions (MLL-AML).

147 first identified as a fusion partner of the mixed lineage leukemia (MLL) gene in acute myeloid leuke

148 The mixed lineage leukemia (MLL) gene is also frequently inv

149 The Mixed Lineage Leukemia (MLL) gene is commonly involved i

150 A partial nontandem duplication (PNTD) of mixed lineage leukemia (MLL) gene is described in B-cell

151 Translocations of the mixed lineage leukemia (MLL) gene occur in 60% to 80% of

152 Chromosomal rearrangements of the mixed lineage leukemia (MLL) gene occur in ~10% of B-cel

153 en mutated in ALLs with rearrangement of the mixed lineage leukemia (MLL) gene on chromosome 11q23.

154 The mixed lineage leukemia (MLL) gene plays a critical role

155 Chromosomal translocations involving the Mixed Lineage Leukemia (MLL) gene produce chimeric prote

156 Mixed lineage leukemia (MLL) gene rearrangements cause ~

157 of infants with ALL, particularly those with mixed lineage leukemia (MLL) gene rearrangements, is onl

158 Chromosomal translocations disrupting the Mixed lineage leukemia (Mll) gene result in leukemia, wi

159 Chromosomal translocations targeting the mixed lineage leukemia (MLL) gene result in MLL fusion p

160 to be a drug target for acute leukemia with mixed lineage leukemia (MLL) gene translocations.

161 The mixed lineage leukemia (MLL) gene undergoes fusions with

162 kemia (B-ALL) harboring rearrangement of the mixed lineage leukemia (MLL) gene with CD19 CAR-T cells.

163 Chromosomal translocations that fuse the mixed lineage leukemia (MLL) gene with multiple partners

164 L) is characterized by rearrangements of the mixed lineage leukemia (MLL) gene with one of its >50 pa

165 lso interacts with translocation partners of Mixed Lineage Leukemia (MLL) gene, which is commonly tra

166 receptors (ERs) and ER coregulators such as mixed lineage leukemia (MLL) histone methylases (MLL2 an

167 ights into the role of the Trithorax protein mixed lineage leukemia (MLL) in maintaining cancer stem

168 Mixed lineage leukemia (MLL) is a key epigenetic regulat

169 The histone methyltransferase Mixed Lineage Leukemia (MLL) is essential to maintain he

170 Mixed lineage leukemia (MLL) is frequently involved in c

171 A critical unanswered question about mixed lineage leukemia (MLL) is how specific MLL fusion

172 ome translocations, most often involving the mixed lineage leukemia (MLL) locus at 11q23.

173 plex (DotCom), which includes several of the mixed lineage leukemia (MLL) partners in leukemia such a

174 -protein interaction (PPI) between menin and mixed lineage leukemia (MLL) plays a critical role in ac

175 The mixed lineage leukemia (MLL) protein and its Drosophila

176 e Men1 gene product menin interacts with the mixed lineage leukemia (MLL) protein, a histone H3 lysin

177 Inhibition of the menin-mixed lineage leukemia (MLL) protein-protein interaction

178 WD repeat domain 5 (WDR5) and block the WDR5-mixed lineage leukemia (MLL) protein-protein interaction

179 ultiple transcription factors, including the mixed lineage leukemia (MLL) protein.

180 ENL, and AF9, is recruited by HIV-1 Tat and mixed lineage leukemia (MLL) proteins to activate the ex

181 Aven stimulates the mRNA translation of the mixed lineage leukemia (MLL) proto-oncogene in an argini

182 The mixed lineage leukemia (MLL) proto-oncogene is a recurre

183 third plant homeodomain (PHD3) finger of the mixed lineage leukemia (MLL) proto-oncoprotein and a pol

184 loid leukemias (AMLs) with the NUP98-NSD1 or mixed lineage leukemia (MLL) rearrangement (MLL-r) share

185 Mixed lineage leukemia (MLL) represents a genetically di

186 sents the most common leukemogenic fusion of mixed lineage leukemia (MLL) to a cytoplasmic partner pr

187 ing of activation domains from the c-Myb and mixed lineage leukemia (MLL) transcription factors to th

188 regulator in the expression of HOX genes in mixed lineage leukemia (MLL)-based hematological maligna

189 d the miRNAs are aberrantly overexpressed in mixed lineage leukemia (MLL)-rearranged acute leukemias.

190 regulator CDK6 as a promising new target in mixed lineage leukemia (MLL)-rearranged acute myeloid le

191 hylation (H3K27me3/2) and inhibits growth of mixed lineage leukemia (MLL)-rearranged leukemia cells.

192 rates for pediatric patients suffering from mixed lineage leukemia (MLL)-rearranged leukemia remain

193 ranslocations, that approximately 43% of all mixed lineage leukemia (MLL)-rearranged leukemias are EV

194 partner of both de novo and therapy-induced mixed lineage leukemia (MLL).

195 the c-Myb/GATA-3 complex contained Menin and mixed lineage leukemia (MLL).

196 , we identify the histone-remodelling enzyme mixed lineage leukemia (MLL)3 as a clock-controlled fact

197 gulated in the pathophysiology of rearranged mixed lineage leukemia (MLL-r).

198 Moreover, UTX associates with mixed-lineage leukemia (MLL) 2/3 complexes, and during r

199 impaired reconstitution of stem cell-derived mixed-lineage leukemia (MLL) AML, which represents an ag

200 isordered transcription factors, such as the mixed-lineage leukemia (MLL) and c-Myb peptides, at isol

201 more, we observed that SALL4 interacted with mixed-lineage leukemia (MLL) and co-occupied the HOXA9 p

202 t multiple MLL-fusion proteins implicated in mixed-lineage leukemia (MLL) associate with AFF4, ELLs,

203 g to a single surface of the KIX domain, the mixed-lineage leukemia (MLL) binding surface.

204 ate maintenance of target gene expression by mixed-lineage leukemia (MLL) chimeras may result from th

205 his targeting strategy does not affect other mixed-lineage leukemia (MLL) family histone methyltransf

206 as the threonine endopeptidase that cleaves mixed-lineage leukemia (MLL) for proper Hox gene express

207 A subgroup of leukemogenic mixed-lineage leukemia (MLL) fusion proteins (MFPs) incl

208 LEDGF associates with mixed-lineage leukemia (MLL) fusion proteins and menin a

209 Mixed-lineage leukemia (MLL) fusion proteins are potent

210 Mixed-lineage leukemia (MLL) fusions are potent oncogene

211 ary acute myelogenous leukemia involving the mixed-lineage leukemia (MLL) gene (11q23) translocations

212 We previously identified a rearrangement of mixed-lineage leukemia (MLL) gene (also known as ALL-1,

213 A fragment of the mixed-lineage leukemia (MLL) gene (Mll, HRX, ALL-1) was

214 hromosomal translocation that juxtaposes the mixed-lineage leukemia (MLL) gene and the AF4 gene.

215 The Mixed-Lineage Leukemia (MLL) gene encodes a Trithorax-re

216 OF REVIEW: Leukemia carrying mutation of the mixed-lineage leukemia (MLL) gene is particularly refrac

217 Chromosomal rearrangements involving the mixed-lineage leukemia (MLL) gene occur in primary and t

218 The mixed-lineage leukemia (MLL) gene often fuses with ENL a

219 r acute lymphoblastic leukemia patients with Mixed-Lineage Leukemia (MLL) gene rearrangements (MLLr B

220 Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner g

221 t B-ALL is chromosomal rearrangements of the mixed-lineage leukemia (MLL) gene.

222 The mixed-lineage leukemia (MLL) H3K4 methyltransferase prot

223 ost cell factor 1 (HCF1), a component of the mixed-lineage leukemia (MLL) histone methyltransferase c

224 AF4 gene, frequently translocated with mixed-lineage leukemia (MLL) in childhood acute leukemia

225 It is fused to mixed-lineage leukemia (MLL) in leukemia, and missense m

226 Mixed-lineage leukemia (MLL) is a proto-oncogene frequen

227 Chromosomal translocations involving the mixed-lineage leukemia (MLL) locus generate potent oncog

228 d Hoxa9, is a feature of leukemias harboring mixed-lineage leukemia (MLL) mutations.

229 t mutations such as FLT3 internal-tandem and mixed-lineage leukemia (MLL) partial-tandem duplications

230 ax binds KIX at the previously characterized mixed-lineage leukemia (MLL) protein interaction surface

231 The Mixed-Lineage Leukemia (MLL) protein is a histone methyl

232 Histone lysine methylation, mediated by mixed-lineage leukemia (MLL) proteins, is now known to b

233 determined that MSI2 directly maintains the mixed-lineage leukemia (MLL) self-renewal program by int

234 The t(4;11)(q21;q23) fuses mixed-lineage leukemia (MLL) to AF4, the most common MLL

235 gements involving the H3K4 methyltransferase mixed-lineage leukemia (MLL) trigger aberrant gene expre

236 Mixed-lineage leukemia (MLL), an epigenetic regulator, p

237 omal aberrations and abnormalities involving mixed-lineage leukemia (MLL), an upstream regulator of H

238 Mixed-lineage leukemia (MLL)-AF4 fusion arises prenatall

239 Myeloid/lymphoid or mixed-lineage leukemia (MLL)-family genes encode histone

240 t to chromatin as an effective treatment for mixed-lineage leukemia (MLL)-fusion leukemia' by Dawson

241 nance in acute leukemias, in particular, the mixed-lineage leukemia (MLL)-rearranged leukemia.

242 k the progression of certain cancers such as mixed-lineage leukemia (MLL)-rearranged leukemias.

243 alignancies, including Hodgkin, myeloma, and mixed-lineage leukemia (MLL)-translocated cell lines.

244 to the discovery of KMT2A translocations in mixed-lineage leukemia (MLL).

245 In contrast, leukemia driven by mixed-lineage leukemia (MLL, encoded by KMT2A) fusions w

246 Mixed-lineage leukemia (MLL; also known as myeloid/lymph

247 llite markers located at the ATM (D11S2179), mixed-lineage leukemia (MLL; D11S1356), and BCL1 (D11S98

248 They demonstrate that the mixed lineage leukemia (MLL1) gene acts independently fr

249 Mixed Lineage Leukemia (MLL1) translocations encode fusi

250 The mixed-lineage leukemia (MLL1/ALL-1/HRX) histone methyltr

251 ation domain associates with TRRAP/TIP60 and mixed-lineage-leukemia (MLL1/MLL2) SET1-type chromatin-m

252 Mixed lineage leukemias (MLLs) are human histone H3 lysi

253 The human MLL (mixed-lineage leukemia or myeloid-lymphoid leukemia) gen

254 h an aberrant histone methyltransferase, the mixed lineage leukemia partial tandem duplication (MLL-P

255 vation domain of the trithorax group protein mixed lineage leukemia protein (MLL), together with eith

256 th the human transcription factors c-Jun and mixed lineage leukemia protein (MLL).

257 Several lines of evidence suggest that the mixed lineage leukemia protein (MLL, ALL-1, HRX) plays a

258 ct the WD repeat-containing protein 5 (WDR5)-mixed lineage leukemia protein 1 (MLL1) complex across t

259 The mixed lineage leukemia protein MLL1 contains four highly

260 The mixed lineage leukemia protein-1 (MLL1) belongs to the S

261 The mixed lineage leukemia protein-1 (MLL1) catalyzes histon

262 The mixed lineage leukemia protein-1 (MLL1) is a member of t

263 Mixed lineage leukemia protein-1 (MLL1) is a member of t

264 DPY-30), a complex that is part of the MLL1 (mixed lineage leukemia protein-1) core complex but that

265 Here we demonstrate that the mixed-lineage leukemia protein (MLL) complex, a well-kno

266 he Trithorax histone H3K4 methyltransferase, mixed-lineage leukemia protein 3 (MLL3) within Complex P

267 its promoter, and p300, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL4), and RNA polymer

268 ith the transcriptional activation domain of mixed-lineage leukemia protein leads to an enhancement o

269 The mixed-lineage leukemia protein MLL1 is a transcriptional

270 lysine 4 (H3K4) methyltransferases including mixed lineage leukemia proteins to regulate homeobox (Ho

271 The MLL (mixed-lineage leukemia) proto-oncogene encodes a histone

272 3 (IGF2BP3) is specifically overexpressed in mixed lineage leukemia-rearranged (MLL-rearranged) B-acu

273 nd its receptor (IL-17RB) in human and mouse mixed lineage leukemia-rearranged AML cells, which were

274 A notable exception is mixed lineage leukemia-rearranged infant ALL, where vene

275 ogenesis in acute leukemias, particularly in mixed-lineage leukemia-rearranged (MLL-r) leukemia.

276 t extremely high levels in ALL patients with mixed lineage leukemia rearrangements or hyperdiploidy a

277 AMLs bearing MLL (mixed lineage leukemia) rearrangements are associated wi

278 Collectively, the MLL/SET1 (mixed lineage leukemia/SET domain-containing 1, histone

279 The in-frame fusion of mixed lineage leukemia to CREB binding protein has been

280 eport a role for Mllt11 (Myeloid/lymphoid or mixed-lineage leukemia; translocated to chromosome 11/Al

281 sented with acute myeloid leukemia, one with mixed-lineage leukemia, two with acute lymphoblastic leu