ライフサイエンスコーパス: mode of action

1 ence of cross-resistance (new class, target, mode of action).

2 ntly modifies Cys86, must employ a different mode of action.

3 The SL receptor has an unusual mode of action.

4 ompound we call corbomycin-that have a novel mode of action.

5 dies and suggest that they have a dualsteric mode of action.

6 ect of aspirin is related to an antiplatelet mode of action.

7 o underlying biological processes as well as mode of action.

8 ide a foundation for future studies of their mode of action.

9 nstream direct testing of their efficacy and mode of action.

10 son mutant provided unique insights into the mode of action.

11 tion of hemozoin formation as a contributing mode of action.

12 electron microscopy) were used to probe the mode of action.

13 of GEF-H1, supporting a neutrophil-intrinsic mode of action.

14 scherichia coli ClpP and to understand their mode of action.

15 t on phenotype, consistent with its designed mode of action.

16 warrant further investigation of abatacept's mode of action.

17 distinct 22-nt class of miRNAs with a double mode of action.

18 olyene immunosuppressive agents with a novel mode of action.

19 letion attributable to chlorantraniliprole's mode of action.

20 citation, which is consistent with its known mode of action.

21 ther neurotoxicants that may share its toxic mode of action.

22 eness of tACS to stimulate the brain and its mode of action.

23 ain detailed mechanistic insights into their mode of action.

24 studies elucidate the catalyst structure and mode of action.

25 require further elucidation to establish its mode of action.

26 rastuzmab emtansine, given its difference in mode-of-action.

27 bacterial targets and antibiotics with novel modes of action.

28 s challenge, including insecticides with new modes of action.

29 inhibitors of protein kinases have different modes of action.

30 hanced metabolism of herbicides with diverse modes of action.

31 rapy-both effective, yet unspecific in their modes of action.

32 ks (DSBs) induced by genotoxins with various modes of action.

33 protease, and they inhibit RhoA by different modes of action.

34 oss many species and for all major herbicide modes of action.

35 ns is characterized by differing potency and modes of action.

36 Other compounds show a range of potential modes of action.

37 is prevalent only between AMPs with similar modes of action.

38 for the development of treatments with novel modes of action.

39 on of new antimalarial chemotypes with novel modes of action.

40 cal impairments in different NDs via similar modes of action.

41 sociated with post-translationally regulated modes of action.

42 tions, have different toxicity threshold and modes of action.

43 he search for a potential drug with multiple modes of action.

44 convenient for patients, they have different modes of action.

45 res the urgent need for new drugs with novel modes of action.

46 lls for novel classes of inhibitors with new modes of action.

47 lopment of new antimalarial drugs with novel modes of action.

48 ering with nematode ACC is a new nematicidal mode of action addressed by SPT, a well-known systemic i

49 result suggests levesquamide has a different mode of action against M. tuberculosis compared to the t

50 es (NRPSs) that are known to display various modes of action against antibiotic-resistant pathogens.

51 tural architecture, antifungal activity, and modes of action against plant fungal pathogens.

52 Here we have elucidated the mode of action allowing TAT-RasGAP(317-326) to kill cell

53 This mode of action, allowing for controlled reduction and ac

54 cides with similar physiological target site/mode of action also elicit similar behavioral effects on

55 gs predicted to be beneficial based on their mode of action and effects in wild-type or in other neur

56 V-HBsAg-host parameters and to elucidate the mode of action and efficacy of REP 2139-Ca against HDV i

57 prehensive framework for understanding their mode of action and for their possible adaptation as bioc

58 Because of their unique mode of action and high selectivity, plant defensins (PD

59 lexes would greatly help to understand their mode of action and improve them by further engineering,

60 Here, CA's mode of action and its potential as a chemical tool to s

61 loglucan nonspecifically with a dissociative mode of action and relaxed backbone regiospecificity.

62 provided comprehensive understanding of INH mode of action and resistance mechanisms.

63 itors, which displayed a non-ATP-competitive mode of action and stabilized an inactive conformation o

64 important to obtain detailed information on mode of action and substrate specificities of alginate l

65 rther investigation to really understand the mode of action and the origins of stereoselectivity.

66 ve phylogenetic groups, which delineated the mode of action and the regiospecificity of GH74 members.

67 we report further mechanistic insight of the mode of action and translational evidence for an optimiz

68 ied by studies that focus on elucidating the mode of actions and catalytic pathways.

69 The mode-of-action and binding characteristics of ARGX-117 w

70 strengths of both to understand anthelmintic modes of action and mechanisms of resistance.

71 , this demonstrates the need to identify new modes of action and novel herbicides.

72 The different modes of action and pathway connectivities of EDS1 famil

73 e, propranolol, and warfarin) with differing modes of action and physicochemical properties (p K(a),

74 ome-wide approaches to shed new light on the modes of action and the evolution of resistance to anthe

75 d effects of aluminum with fairly well-known modes of actions and indium, an understudied emerging co

76 The binding sites, mode of action, and selectivity were elucidated using cr

77 In most cases their modes of action, and consequences for the whole plant as

78 ease of access, their various antibacterial modes of action, and the proven clinical effectiveness o

79 e therapeutic effects by using pure physical modes of action, and therefore make a difference in pati

80 This review focuses on the mode of action, antimicrobial activity, pharmacokinetics

81 This review focuses on the mode of action, antimicrobial activity, pharmacokinetics

82 This review focuses on the mode of action, antiviral activity, pharmacokinetics, cl

83 The only mode of action appears to be MscL activation.

84 However, efforts to elucidate their modes of action are often impeded by limitations in synt

85 d provide a mechanistic underpinning for its mode of action as an inhibitor of cellular Imp-alpha/bet

86 ere, we present a panel of medium-throughput mode of action assays that enable testing of compounds i

87 mplex; however, structural characterization, mode of action based on sequence of phosphorylation sign

88 ing: W84) were consistent with a competitive mode of action between the fluorescent probes and the al

89 ls from injury and provides insight into its mode of action beyond a basic antibiotic.

90 hysiologic specificity of ATP and a facet of mode-of-action biology we term collateral vulnerability,

91 proteasome inhibition is a relatively common mode of action by cytotoxic compounds containing Michael

92 pellents may primarily exert their olfactory mode of action by decreasing the amount of volatile odor

93 nd the vATPase a1 subunit and demonstrates a mode of action by which drugs may rescue lysosomal dysfu

94 We will discuss the modes of action by those drugs including inducing innate

95 understanding of anthelmintic resistance and modes of action came from the interplay of results from

96 Salmonella Scs machinery has evolved a dual mode of action, capable of transferring reducing power t

97 ent analysis and grouped the pPLA into broad mode-of-action classes.

98 ng specifically nascent blood vessels with a mode-of-action complementary to VEGF-R (vascular endothe

99 Based on this mode of action, computer-aided techniques and structure-

100 between KRAS and its exchange factor SOS1, a mode of action confirmed by a series of biophysical tech

101 common catalytic subunit, they have diverse modes of action determined by associated factors in the

102 s a pleiotropic lipid second messenger whose modes of action differ based on upstream stimulus, biosy

103 of M. tuberculosis, suggesting that PIPD1's mode of action differs from those of most first- and sec

104 Thus, the mode-of-action displayed by compound #7 is different fro

105 The efficacy, safety, and mode of action distinct from other antifungal drugs make

106 oncoding sequence (CNS) 3; this represents a mode of action distinct from that of previously identifi

107 closely related structures, their molecular mode of action diverges, which is reflected in their bio

108 This dual mode of action drives two orthogonal cancer-cell killing

109 during embryonic development, their role and mode of action during eye formation in vertebrate embryo

110 Thus, their modes of action during microtubule nucleation are distin

111 ties and can adopt three distinct hydrolytic modes of action: exo, endo-dissociative, and endo-proces

112 pharmacological validation of an allosteric mode of action for 1, revealing that it is a NAM of dopa

113 Here we report a tumor-suppressive mode of action for growth-differentiation factor 11 (GDF

114 We also uncover a new mode of action for HU and identify potential therapeutic

115 mate are Complex I inhibitors offering a new mode of action for insecticidal malaria vector control.

116 This finding suggests a general mode of action for Lumacaftor through which this correct

117 The mode of action for most mosquito repellents is unknown.

118 The mode of action for oncolytic viruses (OVs) in cancer tre

119 iments revealed iron chelation as a possible mode of action for PGG's activity against CRAB.

120 These findings suggest a potential new mode of action for the novel drug senicapoc which may co

121 algesia, the pig industry is searching for a mode of action for the valorisation of meat with boar ta

122 n, identify a unique interfacial stabilizing mode of action for therapeutic targeting, and aid in the

123 our functional studies corroborate different mode-of-actions for other insecticidal proteins includin

124 ector control, identification of alternative modes of action for future insecticides is paramount.

125 Characterized modes of action for these antibiotics include cell lysis

126 cent experiments have shed light on the many modes of action for these pathways.

127 Its exact mode of action has long been sought after and is still b

128 Their mode of action has not been characterized at the molecul

129 promising leads in AD and PD research, whose mode of action has not been fully established yet.

130 c transcription factors whose structures and modes of action have not been clearly defined.

131 Their modes of action have not yet been explained in a unified

132 The presented distinct modes of action highlight the power of the interplay bet

133 able to discriminate analytes with different modes of action (i.e. CdCl(2) toxicity versus ion pump i

134 , the direct drug target remains unknown and mode of action ill defined.

135 clinical data on domatinostat's efficacy and mode of action in MCC.

136 ing IDO1 expression, we investigated the NAS mode of action in neuroinflammation.

137 sights into its cooperative interactions and mode of action in regulating cholesterogenesis.

138 could function via distinct and synergistic modes of action in encoding and transmitting ancestral t

139 lloproteinases or tyrosine kinases are novel modes of action in the treatment of relapsing multiple s

140 yclic natural products with an extraordinary mode of action, in which they form binary complexes with

141 With new modes of action introduced to the treatment of multiple

142 Its mode of action is distinct from classical CDAs.

143 e maintenance of genome stability, yet their mode of action is not fully understood.

144 rs in the human myeloid compartment, yet its mode of action is poorly understood.

145 The extent of ferroptosis on the mode of action is regulated by simple modifications of t

146 nism, but despite decades of research, their mode of action is still not fully understood.

147 theory of its anthelmintic and insecticidal mode of action is that it is a selective positive allost

148 spite being developed over 70 years ago, its mode of action is unclear.

149 The presumed mode of action is via blockade of axonal voltage gated p

150 ttractive drug leads, and knowledge of their mode-of-action is essential for translation into the cli

151 otational use of insecticides with different modes of action is considered for resistance management.

152 The development of drugs with new modes of action is essential.

153 ular milieu, along with methods to establish modes of action, is required to push this field forward.

154 is discussed to shed light on its innovative mode of action, its potential in treating different dise

155 tibiotics are assumed to have a bactericidal mode of action, killing bacteria, while debridement invo

156 e signal have been identified, nor are their modes of action known.

157 e carbonyl group and the catalyst, and other modes of action like Bronsted acid or iodonium ion catal

158 However, incomplete knowledge of their modes of action limits disease understanding.

159 he inhibition of InhA and that their overall mode of action may differ from that of the original natu

160 Investigation of the mode of action (MoA) demonstrated that activity was driv

161 to narrow down, compare and predict compound mode of action (MoA).

162 for each one of a diverse set of predefined Modes of Action (MOAs) and (2) it reveals data gaps and

163 aluated; this information informed potential modes of action (MOAs) and read-across-like approaches.

164 tify lead therapeutic compounds with unknown modes of action (MoAs), and the resulting uncertainties

165 lization zebrafish with respect to different modes of action (MoAs), we analyzed a set of 18 environm

166 genicity and genotoxicity and characterizing modes of actions (MoAs) using in vitro gene expression a

167 its inhibition of ATP synthase, indicating a mode of action more complex than the isolated reduction

168 obtained in this study exemplify the complex mode of action of "multiaction" Pt(IV) prodrugs.

169 The projected allosteric mode of action of 25 was confirmed by biochemical experi

170 We report the in vivo mode of action of a bromo analog of the drug chloroquine

171 indings provide intriguing insights into the mode of action of a novel class of FabI inhibitors that

172 e phenotypic response of the bacteria to the mode of action of a particular antibiotic, in a 30-minut

173 The intended mode of action of adjuvants is to simultaneously enhance

174 lymer-based anticancer agents that mimic the mode of action of anticancer peptides.

175 pid scrambling must be considered a possible mode of action of antimicrobial peptides and other membr

176 apoptosis, although the former was the main mode of action of beta-phenylethylamine, and the latter

177 ndings provide an in-depth evaluation of the mode of action of CA and its potential as a tool compoun

178 rference of the anti-CD8-PET-tracer with the mode of action of CEA-TCB/CEA-4-1BBL and FOLR1-TCB at re

179 The precise mode of action of curcumin and its impact on system leve

180 ding plausible mechanistic insights into the mode of action of DDIs.

181 Understanding the mode of action of drugs is a challenge with conventional

182 affecting sensory neurons and mimicking the mode of action of insecticides used to control phloem-fe

183 orce microscope (AFM) to identify a possible mode of action of isoprene in improving photochemical ef

184 However, the exact mode of action of itaconate remains unclear.

185 resistance mechanisms in P. falciparum, the mode of action of IZPs remains unknown.

186 h could help provide an understanding of the mode of action of LXA4 and its therapeutic potential aga

187 eviously not been possible to replicate this mode of action of mannitol in isolated airways.

188 , metabolomic and functional approaches, the mode of action of natural biological control agents rela

189 The speculated antifungal mode of action of Ne-TML was related to the decrease in

190 Deeper understanding of the mode of action of P. polymyxa A26 is needed to develop s

191 s advance predictions of the specificity and mode of action of PL6 enzymes.

192 eta-epigenomic data to better understand the mode of action of probiotics, their associated microbiom

193 using PC61 antibody was used to examine the mode of action of propionate.

194 ontent and level of glycation/oxidation, the mode of action of specific lipoproteins can now be decip

195 However, in nematodes the mode of action of SPT and its effect on their developmen

196 To study the mode of action of such compounds, 21 crystal structures

197 l pathogens; however, the identification and mode of action of T6SS effector proteins that mediate th

198 The mode of action of targeted cancer agents (TCAs) differs

199 le cryo-electron microscopy to visualize the mode of action of the advanced INSTIs dolutegravir and b

200 The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-F

201 assembly of Ptch1 and suggests an asymmetric mode of action of the Hh ligands for inhibiting the pote

202 reaction provided detailed insights into the mode of action of the iron-catalyzed C-H alkylation with

203 Here, we elucidate the mode of action of the kalimantacin antibiotics, a novel

204 esis, antimicrobial activity, structure, and mode of action of the lantibiotic salivaricins character

205 It also helps us to understand the mode of action of the numerous allosteric antagonists of

206 e investigated the therapeutic potential and mode of action of the peptidic macrocycle CXCR4 antagoni

207 However, little is known about the exact mode of action of the serotonin metabolite and the possi

208 impacted provide information about the toxic mode of action of the toxin.

209 antibody-dependent cell cytotoxicity-a major mode of action of therapeutic monoclonal antibodies-the

210 abolomics is often applied to understand the mode of action of these chemicals, simple pairwise compa

211 To provide insight into the mode of action of these industrially important enzymes,

212 Understanding the mode of action of these non-protein regulators has been

213 Second, increased understanding of the mode of action of these older drugs might in turn provid

214 that oxidative stress is a key factor in the mode of action of this insecticide at low doses.

215 will have implications in understanding the mode of action of this new class of cancer therapeutics.

216 This trial validates the mode of action of this new class of radioenhancer, which

217 Unravelling the mode of action of this unique biostimulant provides data

218 d transport mechanism of MCTs, elucidate the mode of action of three anti-cancer drug candidates, and

219 ing and discovery and the study of mechanism/mode of action of treatments.

220 ta-phenylethylamine, and the latter the main mode of action of tryptamine.

221 level we provide evidence for non-canonical mode of action of Wnt5a and its regulation over genes as

222 hese results provide valuable insight on the mode-of-action of 2'-FL utilization by Bifidobacterium l

223 ling tool that mechanistically considers the mode-of-action of all available drugs.

224 rget interactions captured uncover the early mode-of-action of NIN-LIKE PROTEIN 7 (NLP7), a master re

225 Here we investigate the mode-of-action of the small, rationally designed synthet

226 Among these, we investigated the modes of action of arbidol, a drug licensed abroad to tr

227 However, broad generalisations on the modes of action of bioinorganic compounds are not conduc

228 zadirachtin were associated with the diverse modes of action of botanicals, for instance NeemAzal and

229 Understanding the modes of action of Bt toxins is important for WCR contro

230 These structures elucidate the modes of action of different Ca(v) ligands and establish

231 es are aiming to investigate the effects and modes of action of engineered nanomaterials (ENMs) in th

232 However, the modes of action of many effectors remain unknown.

233 This observation argues for differential modes of action of neutralizing anti-gB MAbs and suggest

234 The precise modes of action of the PSs vary between viral families,

235 an early increase, underlining the different modes of action of these 2 drugs.

236 Discoveries of the modes of action of these drugs and mechanisms of resista

237 d anesthetics have provided insight into the modes of action of these drugs on the GABA(A) receptor.

238 arch regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited fo

239 lation of kinase signaling in cancer and the modes of actions of cancer-targeting drugs.

240 the molecular binding profile and functional modes-of-action of ligelizumab.

241 at 1.54 angstrom resolution and analyzed its mode of action on COS substrates.

242 discriminate membrane- or receptor-mediated modes-of-action on the basis of the assumption that inte

243 og signaling pathway through a nonsmoothened mode of action, opening new opportunities to combat acqu

244 cts were not related to an anti-inflammatory mode of action or a direct impact on retinal ganglion ce

245 rity since they facilitate the extraction of mode of action, phenotypic, and toxicity information.

246 ot cross-link DNA, suggesting an alternative mode of action potentially involving a protein target.

247 correctly into broad categories according to modes of action previously identified in the literature.

248 c analysis suggested that ES24 has a complex mode of action, probably involving multiple targets.

249 does not offer sterilizing immunity and its mode of action relies on Fcgamma receptor-mediated effec

250 implicated in various cancers, however, its modes of action remain largely enigmatic.

251 to impact the health of biota, although its modes of action remain somewhat unclear.

252 ledge about viral SIE determinants and their modes of actions remain limited.

253 s a known elicitor of plant defenses but its mode of action remains elusive.

254 are important in autophagy, but their exact mode of action remains ill-defined.

255 e accumulation of both PSI and PSII, but its mode of action remains unclear.

256 form pores in target membranes, however, its mode of action remains unknown.

257 cies, although their complex inheritance and modes of action require further characterisation to opti

258 ll [2-6] and taste [7-11], and its olfactory mode of action requires the odorant co-receptor orco [2,

259 ructure-function relationships and revealing modes of action requires the availability of structurall

260 mendous amount of research investigating its mode of action, resistance mechanisms, and biosynthesis

261 emonstrated, many questions related to their mode of action, routes of propagation and integration re

262 To explain their mode of action, seventeen pure betalains were tested in

263 yrase-DNA cleavage complex, a very efficient mode of action shared with the highly successful fluoroq

264 ent modalities that convert occupancy-driven mode of action SMIRNAs into event-driven small molecule

265 otics, which utilize a plethora of different modes of action, some of which are still not fully under

266 se microtubule nucleation pathways and their mode of action still need to be identified.

267 ls-a hallmark feature of AAHC-by independent modes of action, strengthens our proposal that these met

268 Detailed mode of action studies confirm that this compound acts p

269 Mode of action studies showed that compound 1 diffuses a

270 ts confirmed activity of 70 pure samples and mode of action studies, including radioligand binding, i

271 insecticides for bed bug IPM and conducting mode-of-action studies on individual essential oil compo

272 tine complex has a significant effect on the mode of action, suggesting that all three components of

273 nsmission, suggesting its potential as a new mode of action target for future insecticide development

274 dex, and functions through a fungal-specific mode of action, targeting Sec14 of the vesicular traffic

275 sublethal effects of SFX reflect a different mode of action than that of IMD.

276 at the new organometallics display different modes of action than their bioactive components.

277 ient and pH in cancer cell mitochondria is a mode of action that can be targeted in the development o

278 echanisms governing substrate preference and mode of action that has not yet been pieced together.

279 Mupirocin is an antibiotic with a unique mode of action that is active against MRSA, but its clin

280 Molecular dynamics reveal unique modes of action that are distinct from any other insulin

281 s by using therapeutic agents with different modes of action, the use of which is directed by the res

282 When interrogating saRNA mode of action; three saRNA interacting proteins, CTR9,

283 he conjunction between bacterial load as the mode of action, timing of multiplication (pre/post-zygot

284 ental data, render a substantially different mode of action to the allyl boronate congener.

285 velop molecularly targeted drugs with unique modes of action to inhibit JAK-STAT signalling in diseas

286 For instance, a 4-F substituent shifted the mode of action toward both ferroptosis and necroptosis,

287 Two modes of action underlie these effects.

288 g in severe diarrhea and even death, but the mode of action underlying these viral effects remains un

289 Analysis of the mode of action using chemical proteomics revealed severa

290 The dimer's mode of action was then extended from simple binding to

291 Using an algorithm that incorporates this mode of action, we can predict patient-specific response

292 To determine their precise mode of action, we tested whether such neuroadaptive pro

293 Because lncRNA loci can contain multiple modes of action, we wanted to determine which, if any, p

294 Other enzyme inhibitors with different modes of action were tested to investigate the specifici

295 vealed ASM and ceramide-mediated deleterious mode-of-action: when ceramide reduced the number of inte

296 ction, which is consistent with the proposed mode of action, where the SCRs likely inhibit binding be

297 ource to discover novel compounds with novel modes of action, which is essential for the treatment of

298 ern life, but there is uncertainty about its mode of action with a concentration-dependent switch fro

299 ntrol systems by enabling the use of diverse modes of action with a single trait.

300 Two modes of action within the flagellar export apparatus ar