ライフサイエンスコーパス: model in which

1 The investigators developed a surgical mouse model in which 2 subsequent MIs affected different left

2 Our data are consistent with a model in which 3B copy number expansion within the FMDV

3 ted with earlier observations into a unified model in which a core mechanism, the variable physical c

4 We propose a model in which a CRB2S-CRB2TM interaction promotes the p

5 Our results lead to a model in which a full ERE is required for ER recruitment

6 The results support a model in which a locus first duplicates, resulting in a

7 e periprotein lipidome of Lyp1 support a new model in which a narrow band of lipids immediately surro

8 This shift entails a model in which a reduction of bioactive leptin levels in

9 Our data supports a model in which a single C-terminal tail tethers XLF to K

10 Our presented data support a model in which a two-authentication system mobilizes a g

11 d survey data informed a Bayesian prevalence model, in which a flexible incidence-to-prevalence relat

12 formation and rules in the DMS and suggest a model in which abnormally specific and persistent repres

13 The mechanics are well-captured by a model in which actin filaments are dynamically connected

14 Site-directed mutagenesis supports a model in which adenosine 5'-triphosphate (ATP)-powered m

15 These observations call for new models in which all components of the cytoplasm comprise

16 development of CD; these findings support a model in which altered intestinal barrier function contr

17 ion of altruism and identify 43 evolutionary models in which altruism evolves and where the authors a

18 ylation of RAPTOR in a new Raptor (AA) mouse model, in which AMPK phospho-serine sites Ser722 and Ser

19 Collectively, our findings fit a model in which AMPKalpha1 in B cells supports recall fun

20 Our findings suggest a dual guidance model, in which an autonomous system, involving interact

21 ulating SRSF6 levels in Huntington's disease models in which an expanded CAG repeat had been knocked

22 Our data support a model in which ANKRD26 initiates a centriole-derived sig

23 Our objective was to develop a mouse model in which antibiotic treatment during pregnancy res

24 assemblies on the nuclear envelope support a model in which arachidonic acid is generated by cPLA(2)

25 itro, and heterologous studies have fueled a model in which ARF dimers bind with high affinity to dis

26 Our data suggest a model in which ARF nucleo-cytoplasmic partitioning regul

27 Nevertheless, our data are consistent with a model in which, at the scales probed, the human genome i

28 monstrates promising results in many disease models, in which autophagy upregulation is able to reduc

29 the dorsal spinal tract provides a realistic model in which axonal disruption and demyelination occur

30 Thus, we propose a model in which B12 and FA blunt the effect of natural Ah

31 These findings have led to a new model in which BbOhmm affects ROS homeostasis in combina

32 ent of IBS should include an integrated care model in which behavioral interventions, dietary modific

33 and structural equation modeling suggested a model in which BF integrates contextual information that

34 Our findings support a model in which binding of the PSL to the WD40 domain sta

35 morigenesis by using a newly generated mouse model in which both murine Met transgene and stabilized

36 In a mouse model in which both pathways are activated in stem and p

37 The results of these studies support a model in which bound PNAG is weakly associated with a sh

38 Our results point to a model in which BuGZ stabilizes Bub3 and promotes Bub3 lo

39 We propose a model in which bZIP60 and bZIP17 synergistically induce

40 PDAC progression, we generated a PDAC mouse model in which CAF plasticity is modulated by genetic de

41 We propose a model in which CAMSAP2 anchors KIFC3 at microtubule minu

42 Our analyses support a model in which cell-cell mechanical communication is suf

43 science has relied on a node-centric network model in which cells, populations and regions are linked

44 These results support a model in which centriole amplification occurs during a t

45 Recent evidence also supports a model in which certain aspects of the wall itself may ac

46 ependent effects of probiotics and suggest a model in which changes in host behavior and downstream m

47 These data support a model in which cholesterol passes through the cores of N

48 We used a novel rat model in which cholinergic stimulation of PFC produced w

49 The study supports a model in which circulating fetal ILC1-like NKPs travel t

50 These kinetic data fit well to a model in which ClpXP and substrate form an initial recog

51 We propose an alternative "eroded strata model" in which clusters of conserved trans-species SNPs

52 re, we demonstrate a nonadhesive gap closure model in which collective cell migration, large-scale ac

53 We propose a general model in which conditional disorder-the partial unfoldin

54 Our data support a model in which confined diffusion of open Lck results in

55 invasion, we developed a zebrafish melanoma model in which constitutive activation of ribosomal prot

56 We suggest a novel model in which coordinated regulation of VASP ubiquitina

57 ese in vitro targeting experiments support a model in which Cpn60 captures and then releases insertio

58 Altogether, our data support a new model in which cristae within the same mitochondrion beh

59 These results suggest a model in which critical interactions between inflammator

60 We propose a structure-based model in which cross-talk between PTMs influences tau fi

61 iochemical analysis, we propose a structural model in which CSN9 binding triggers CSN to adopt a conf

62 Our findings support a model in which cues that emanate from intermediate and f

63 Our findings are consistent with a model in which cytotoxic CD4 T cells contribute to CVD i

64 Cosmological models in which dark matter consists of cold elementary

65 These results support a model in which DDR genes are uniquely susceptible to CDK

66 guanabenz was administered in the cuprizone model, in which demyelination is less dependent upon imm

67 ovide evidence for the differential adhesion model in which differences in intercellular adhesion med

68 These results support a model in which differences in pilus electrostatics affec

69 ic and pharmacological experiments uncover a model in which direct periplasmic sensing of LPS by PbgA

70 We look at variants of the model in which directed edges are added to the new verte

71 we developed a 3D mammary epithelial culture model, in which dissemination is induced by overexpressi

72 itiators in origin recognition and support a model in which DNA geometry and bendability contribute t

73 Our data suggest a model in which during neural development, ADR-2 levels o

74 The data suggest a DDB activation model in which dynactin p150 enhances dynein processivit

75 ortical hierarchy were instead captured by a model in which each region maintains a temporal context

76 of population genetics, or similar types of models, in which each individual can produce only small

77 Together, these data support a model in which EFTUD2 haploinsufficiency leads to the mi

78 Here, we report a novel mouse model, in which elevated transgenic AR expression and Tr

79 ed in time and space, supporting a multi-hit model in which emergence of autoreactive T cells is a pi

80 Consistent with a model in which endogenous Gal-9 controls epithelial grow

81 Using a mouse model in which endothelial Dhh is inducibly deleted, we

82 We propose a model in which EphA7 expression on differentiated myocyt

83 Our data are consistent with a model in which eS25 facilitates initial binding of the C

84 Our data additionally proposes a model in which evolutionarily conserved network motifs,

85 al N. meningitidis, providing evidence for a model in which expression of these pumps in the female u

86 To test this hypothesis, we used a mouse model in which F1 generation animals were exposed prenat

87 These results are consistent with a model in which FakB1 primarily functions in the recyclin

88 Our results support a model in which features of the ITS itself, such as the p

89 Our data support a model in which flotillins are required for direct contro

90 nitiation of collagen assembly and suggest a model in which FN matrix and associated heparan sulfate

91 Our results support a model in which full-length HIV-1 Env trimers are capture

92 combined these approaches with experimental models in which gck was genetically deleted in a populat

93 Together, our findings support a model in which GCNA provides genome maintenance function

94 view these recent publications and propose a model in which genes that confer ASD risk operate in sig

95 Here, we provide a formal model in which genetic contributions to complex traits a

96 hematopoietic differentiation, and support a model in which genome-wide methylation changes are trans

97 BFs, we generated a conditional mutant mouse model in which granulosa cell expression of Runx2 and Cb

98 ogether, these data point toward a potential model in which H/ACA snoRNAs are specifically regulated

99 These quantitative results support a model in which hCP exists in its heterodimeric form and

100 Overall, this suggests a model in which HCV directly regulates the lipid environm

101 on mode between TBK1 and STING and support a model in which high-order oligomerization of STING and T

102 Here, we introduce a computational model in which hippocampus subserves place and MB learni

103 Our data support a model in which HPr transfers a phosphate to an unidentif

104 We therefore propose an Fe(3+)-heme transfer model in which HRM-bound heme is readily transferred to

105 ears more consistent with a mental workspace model in which implied serial order is mapped within a s

106 These findings are consistent with a model in which incomplete agonist occupancy at the four

107 sequencing, these data are consistent with a model in which increased drive from M2 leads to excessiv

108 These results support a model in which increased level of kaempferol in the late

109 Our results speak to a model in which independent states of local desynchroniza

110 nd selection, we developed matrix population models in which individuals are jointly classified by ag

111 These results support a model in which integrins are an upstream component of th

112 We offer a complementary model in which "interoceptive self-inference" guides the

113 These findings support a model in which iRhom2 and ADAM17 are obligate binding pa

114 at the T6' ring in the closed/resting-state model, in which it shows perfect space complementarity a

115 tudies suggest a revised microtubule-sliding model, in which kinesin-5 tails stabilize motor domains

116 We present a model in which KV mitotic cells strategically place thei

117 We propose a model in which Kv2.1 function varies with sex: in males,

118 Altogether, our results support a model in which L6CTs modulate first- and higher-order th

119 This suggests a model in which large doses of risk variants cause illnes

120 Our results support a model in which LetB establishes a physical link between

121 These data support a model in which LGMDD1 mutations in DNAJB6 are a gain-of-

122 a nonproto-oncogene, in T-ALL and support a model in which Lmo2-induced T-ALL results from failure t

123 These results support a model in which localized synthesis of RBOHC and flavonol

124 These results support a tumor progression model in which loss of NF1 in Schwann cells drives plexi

125 These data are consistent with a model in which low iron in the marrow environment affect

126 We propose a model in which Lso2 facilitates rapid translation reacti

127 Our results support a model in which LTP generates synaptic slots, which captu

128 From these findings, we propose a model in which LuxR serves as a counter-silencer at H-NS

129 Our findings support a model in which LuxR/HapR bind proximally to RNA polymera

130 Our results support a model in which mature pneumococcal peptidoglycan is synt

131 o fill the gap, we develop a population game model in which migrants are allowed to be heterogeneous

132 The depth dependency is consistent with a model in which mixing intensity decreases linearly or ex

133 production, which would be consistent with a model in which MK2/3 regulate IL-6 and IL-13 via mTORC1

134 Overall, our results support a model in which MltG functions as a terminase for both cl

135 Our data are consistent with a working model in which monomeric XPA bends DNA, displays episodi

136 observed in a delayed-type hypersensitivity model in which mTORC2 was absent in cutaneous DCs.

137 We propose a model in which multiple body size factors are controlled

138 kevych et al. and Hill et al. of this simple model in which multiple reactivation events can occur, e

139 ce measurements supported a bivalent binding model in which multiple sites on PAI-1 and uPA:PAI-1 com

140 In this study, we developed a mouse model, in which murine IL-6 is overexpressed in a CD11c-

141 established and characterized a skin cancer model, in which Mus musculus papillomavirus 1 (MmuPV1) i

142 We suggest a model in which myelination contributes to sustained stim

143 nover of soil organic N (SON) and consider a model in which N fertilizer augments ongoing SON turnove

144 this hypothesis, we devised a purely visual model in which neurons tuned to letter shape respond to

145 as been hampered by a paucity of preclinical models in which new drugs could be tested for target eng

146 scaffold protein SUFD enabled us to build a model in which NFU1 receives its Fe-S cluster from the S

147 These data support a model in which non-rhythmic Treg cells are driven to rhy

148 Based on our results, we propose a model in which nonimmune cells can discriminate between

149 These findings contribute to a model in which NP and its interactions with VP35 link th

150 Here we present data supporting a model in which NPA associates with PINs in a more direct

151 We propose a model in which NPC biogenesis is carefully controlled to

152 ements support a structure-based mechanistic model in which O(2) and NO movements and conserved amino

153 Our results suggest a parsimonious model in which odor-activated octopamine release excites

154 bination, exemplifying a duplicate retention model in which one copy tends to have more sub-functions

155 her proteins that can dimerize, suggesting a model in which one Microprocessor recruits another Micro

156 The data support a model in which only one RNA-binding mode is critical for

157 Based on this, we suggest a model in which organelles and force generators (motors a

158 This suggests a model in which osmotically obliged water flows through t

159 cts of Trem2 deletion in the PS2APP mouse AD model, in which overproduction of Abeta peptide leads to

160 Together, these data support a model in which parallel OFF channels generated in the re

161 best explained by a trial-by-trial learning model in which participants estimate the reward rate wit

162 l observer model and an approximate Bayesian model in which participants were assumed to attend (and

163 ynamic stochastic general equilibrium (DSGE) model in which past aggregate consumption impacts the co

164 These data support a model in which pathogen effector transcriptional polymor

165 tiated antiretroviral therapy (ART) delivery models, in which patients are provided with care relevan

166 Our results suggest a secretion model in which PE35/PPE68_1 determines the system-specif

167 stributions, but in the way predicted by the model in which people must economize on environmental in

168 The data are best fit by models in which people incorporate their trial-to-trial

169 From these studies we propose a working model in which perturbed photoreceptor states cause micr

170 his was modeled with a 4-parameter sigmoidal model in which PFC and ACC TSPO V(T) accounted for 84% a

171 This article describes models in which physician groups or health systems are p

172 These results support a model in which phytochromes control PhAPG expression thr

173 In summary, our findings support a model in which PI16 promotes neuropathic pain by mediati

174 replication initiation factors, suggesting a model in which Pim1 acts similarly with the Mrx6 complex

175 Our data are consistent with a model in which PNP-dependent inhibition of the GCV syste

176 Together, these data support a model in which Pol delta promotes Alt-NHEJ in human cell

177 Here, we used a MIA rodent model in which polyinosinic: polycytidylic acid (poly (I

178 in unclear and include a sequential addition model, in which polyubiquitin chains are built unit by u

179 t by unit on the substrate, or a preassembly model, in which polyubiquitin chains are preformed on th

180 Taken together, these results support a model in which PPP2R5 degradation and global changes in

181 Our data support a model in which PQM-1 controls a trade-off between lipid

182 Our results support a model in which presynaptic Ca(v) channels serve both as

183 Using a model in which prices for wind turbines and solar PV sys

184 This is consistent with models in which prion propagation and toxicity can be me

185 solve this paradox we propose a two-process model in which probabilistic knowledge initially biases

186 This novel work supports a model in which protein S-nitrosylation may be an additio

187 Our results suggest a model in which protein S-nitrosylation may function as a

188 odels of grid firing but is accounted for by models in which pure grid cells integrate inputs from co

189 Our results support a model in which R-DPRs interfere with cargo loading on ka

190 Altogether, our data support a model in which Rab18 regulates kinectin-1 transport towa

191 Recently, we developed an operant model in which rats press a lever for rewarding social i

192 Our results are consistent with a model in which Rca transiently threads the Rubisco large

193 ed for their behaviour using a Hidden Markov Model, in which recent observations are integrated with

194 Our work supports a model in which regulation of CO position early in meioti

195 We established a mouse model in which repeated systemic vincristine treatment r

196 Using the adult-onset HLH mouse model in which repeated treatments of the TLR9 agonist,

197 oV-2 can be studied in detail only in animal models, in which repeated sampling and tissue collection

198 tructures that suggest a radically different model in which RI binds to T irrespective of superinfect

199 tend previous findings and propose a refined model in which RIM and Munc13-1 act in overlapping and i

200 onditionally in SCs, to create a novel mouse model in which SCs are NMDA-R-deficient (GluN1- mice).

201 Taken together, these data support a model in which SNAP23 plays a crucial function as a scaf

202 We propose a theoretical model in which social processes (both social cognition a

203 meiotic clade relative Vps4, and supports a model in which spastin utilizes a hand-over-hand mechani

204 Our data suggest a model in which spatial segregation of membrane protein c

205 Our results reveal a model in which species are forming faster in environment

206 A model in which speed affects the binding rate and torque

207 Together, our findings support a model in which splicing recruits transcription machinery

208 Our data support a model in which SpoIIIE is anchored at the edge of a sept

209 Our data support a model in which STR length in eukaryotic genomes results

210 his finding is consistent with a source-sink model in which strains emerging in warm climates can per

211 ed two models for this: a "discrete encoding model" in which striatal neurons facilitate movements wi

212 end of movements, and a "continuous encoding model," in which striatal neurons encode the sensory or

213 Our experimental data support a model in which SurA binds uOMPs in a groove formed betwe

214 oxygen consumption or redox state support a model in which surfactin-mediated membrane depolarizatio

215 Thus, contrary to the model in which SWRs arise 'spontaneously' in the hippoca

216 We delineate a working conceptual model in which synaptic plasticity deficits described in

217 These results support a model in which synonymous codon substitutions can impair

218 of MS pathogenesis, away from the classical model in which T cells were the sole central actors and

219 Based on these results, we propose a model in which T. cruzi senses intracellular heme and re

220 Our findings support a model in which target-specific cortical subnetworks form

221 n response to biotic elicitors and support a model in which TARK1 regulates stomatal opening postelic

222 Based on these results, we propose a model in which TGF-beta regulates Scleraxis via ERK1/2 a

223 This is consistent with a model in which the 3' terminus of the vRNA template bind

224 NMR and biochemical experiments support a model in which the 5'UTR can transition between at least

225 Overall, our work establishes a model in which the activity of a sigma factor of group E

226 These observations are consistent with a model in which the assembly of Abeta oligomers is driven

227 ions led us to propose an integral-threshold model in which the cell cycle is controlled by a licensi

228 Overall, our results are consistent with a model in which the cell elongation and division systems

229 structure are discussed within a qualitative model in which the chromatin is highly heterogeneous, ea

230 The data are explained by a model in which the chromosomal structure is driven by dy

231 Here we develop a mouse model in which the consequences of stretching on skin ep

232 This strongly supports a model in which the CTD acts as a key bridging interface

233 er afferents within the corpuscle supports a model in which the extent of lamellar cell wrappings of

234 We propose a model in which the fold-switching dynamics constitute a

235 s associated with each hotspot, supporting a model in which the hotspots apply nonlinearities at a la

236 Our data support a model in which the hydration of the uppermost lower mant

237 Our data support a model in which the identified pathogenic variants operat

238 arginine couples ISCs function and favours a model in which the ISCs niche couples the nutrient level

239 Our results support a model in which the isoform-specific N-terminal extension

240 ontrast, they support a cooperative-assembly model in which the main role of complex III in SCs is to

241 These data support a model in which the modulation of PP-InsPs influence the

242 We previously proposed a two-hit model in which the mouse gastrointestinal Chlamydia migh

243 We propose a model in which the newly identified functions of Mps2 an

244 Together, our data support a model in which the nucleoplasmic HAL-2/HAL-3 protein com

245 phenomena can be described by a theoretical model in which the periodic moire potential is much stro

246 Clone dynamics were consistent with a simple model in which the proliferative advantage conferred by

247 ic and biochemical approaches that support a model in which the PTS proteins HPr and Enzyme I (EI) ar

248 Taken together, our findings support a model in which the PVT1-214/Lin28/let-7 axis serves as a

249 These findings support a model in which the relative binding sites of Rad54 and R

250 The structures allow development of a model in which the sequential hydrolysis of ATP is coupl

251 scribe the assembly of a hybrid mathematical model in which the spatial spread of inflammatory mediat

252 ures of ClpXP bound to substrates, support a model in which the ssrA degron initially binds in the to

253 We propose a multistep model in which the ssRNA phage binds to the F-pilus and

254 Our solution structural data support a model in which the substrate is directly translocated fr

255 Our findings lead to a model in which the torque generator rotates in response

256 cal data, our structure is consistent with a model in which the two-helix finger and clamp cooperate

257 These findings suggest a model in which the ZSWIM8 ubiquitin ligase mediates TDMD

258 e well accounted for by a Bayesian heuristic model, in which the agent continues sampling until uncer

259 This "modulated rate" model, in which the clock signal is integrated over time

260 Bardet-Biedl syndrome type 17 (BBS17) mouse model, in which the gene-trap that suppresses Bbs17 (als

261 wo-step nucleosome destabilization-depletion model, in which the same intrinsic DNA properties of HNA

262 To overcome this limitation, we devised cell models in which the AML1-ETO protein could be quickly de

263 d curve at various [ATP]s and discuss rotary models in which the archaellum has characteristics of bo

264 the nuclear membrane that are comparable to models in which the cytosol is treated as an open, empty

265 ved xenografts (PDXs) are preclinical cancer models in which the tissue or cells from a patient's tum

266 idence in the literature supports activation models in which the VanS protein binds either vancomycin

267 ng the period before a flare and suggested a model in which these cells become activated by B cells i

268 We propose a model in which these cooperative electrostatic interacti

269 B1/VRK signaling coregulation and support a model in which these enzymes modulate B12 in a phosphory

270 nsive data from studies in rodents support a model in which theta oscillations fulfill this role, but

271 These data support a model in which this new regulator of iron homeostasis li

272 blastomeres and provides strong support for models in which this asymmetry is established early in t

273 We provide an update to this model in which three receptors, IL-7R, pre-BCR, and CXCR

274 Our findings support a model in which tightly-intertwined biological dependenci

275 ponse, making it an interesting and relevant model in which to examine long-term function and integri

276 nctional criteria, and has become a powerful model in which to study glia and their neuronal interact

277 Drosophila provides a powerful model in which to study inflammation in vivo, and previo

278 Patient derived neurons are a promising model in which to study pathogenic mechanisms and therap

279 Specifically, cFLIP-deficiency provides a model in which to study the mechanisms regulating CASP8-

280 Xenopus thus provides a vertebrate model in which to study vocal communication at many leve

281 Our findings support a model in which topoisomerases participate in Pol II prom

282 are embedded in the TORC2 network suggests a model in which TORC2-dependent signals control both plas

283 In this article, we develop a microfluidic model in which tumor spheroids are embedded within 3D co

284 stablished an EMT lineage tracing (Tri-PyMT) model, in which tumor cells undergoing EMT would irrever

285 We examine a simple computational model in which tutor exposure imprints the correct numbe

286 differentiation and supports a developmental model in which Type-I and Type-II hair cells develop in

287 We propose a model in which UBAP2L is an essential SG nucleator that

288 econd major protective TI epitope supports a model in which uncleaved HA trimers exist on the surface

289 We propose a model in which uniquely large zebrafish embryonic centro

290 We suggest a model in which viral attachment and infection involves h

291 ce are a previously developed BCR-transgenic model in which virtually all B lymphocytes express the H

292 ted with visual responsiveness, supporting a model in which visual speech enhances the efficiency of

293 Taken together, these data support a model in which VtlR indirectly regulates hundreds of gen

294 Together, these results support a model in which WDR-48 binds and stabilizes USP-46 protei

295 cribe an ex vivo cultured human skin explant model in which we have characterized pathological tissue

296 seizure, we implemented a modified kindling model in which we induced a seizure through amygdala sti

297 ed an estimated CNS from a linear regression model in which we regressed the observed CNS on predicto

298 aturation transfer experiments, we propose a model in which weak, multimodal collagen I-beta(2)m inte

299 Our results are consistent with a model in which X4 HIV strains infect and potentially est

300 Together, our findings suggest a model in which ZZEF1 binds to histone H3 tail and promot