ライフサイエンスコーパス: model of

1 We created a Markov state-transition model of 100 000 adults with TB receiving a novel, fluor

2 Atomic models of 103 of the known human AT1R polymorphisms were

3 induced pluripotent stem cell (iPSC) disease model of a common form of heart disease involving the ao

4 te element method to develop a computational model of a deformable cell that includes subcellular com

5 antitative traits was Fisher's infinitesimal model of a large number of genetic variants, each with v

6 GEMs: (i) obtain or generate a high-quality model of a reference strain; (ii) compare the genome seq

7 in gerbils of both sexes with computational modeling of a single cell.

8 stic snapshots over time to build prediction models of a moving auditory target's trajectory and enab

9 The finite element models of a spider web considering geometric nonlinearit

10 In a xenograft model of acute myeloid leukemia, a single injection of 1

11 In this cohort study, prediction models of acute ovarian failure risk were developed usin

12 can rescue synaptic plasticity in this mouse model of AD (P = 0.007 to untreated APP/PS1).

13 dexamethasone and apomorphine were active in models of AD and PD.

14 ired neurovascular function in several mouse models of AD, including the J20-hAPP mouse.

15 Although animal and theoretical models of addiction emphasize the importance of differen

16 py approach in a canine, rapid atrial pacing model of AF, we demonstrate that NADPH oxidase 2 (NOX2)

17 center B lymphocyte populations as in other models of AID deficiency as well as increased population

18 Our study, using a well-established rat model of alcohol dependence, ex vivo electrophysiology a

19 cts between GDPD1 and retinal enhancers, and modeling of all RP17 SVs was consistent with neo-TADs le

20 I scanner using a transgenic APP/PSEN1 mouse model of Alzheimer's disease.

21 To test this approach, we selected a model of amyotrophic lateral sclerosis (ALS), in which a

22 lation via its application to mouse-specific models of arterial mechanics using an experimentally inf

23 ional logistic regression was used to create models of associations between factors and phenotypes an

24 Conclusion: In a rat model of autoimmune myocarditis, (18)F-FOL shows specifi

25 h these properties fit a recent mathematical model of automatic gradient scaling, that model requires

26 Here we use a model of auxotrophic Salmonella infection in germ-free m

27 The "two-signal" model of B cell activation has long been invoked to expl

28 responses have also been observed in animal models of BDNF deficiency in vivo, and BDNF is a common

29 with CLASSED we developed a context-specific model of beta-adrenergic cardiac hypertrophy.

30 Our results confirm the parallel model of BG function and suggest that the integration an

31 Using a model of binge-eating, we demonstrated that relaxin-3/RX

32 n was quantitatively captured by a continuum model of biofilm growth against substrate friction.

33 malities and mTORC1 hyperactivity in a mouse model of Birt-Hogg-Dube syndrome.

34 tment of CMV viremia in a Cynomolgus macaque model of bone marrow transplantation (BMT) for tolerance

35 e spectral information and in the underlying models of both measurements (bilinear for 3D images and

36 Using murine models of both perinatal and postnatal GBS acquisition,

37 lung growth and prevents PH in two antenatal models of BPD induced by intraamniotic exposure to endot

38 thod was demonstrated in an orthotopic mouse model of breast cancer.

39 use genetically engineered orthotopic mouse models of breast cancer to show that while depletion of

40 RNA sequencing and patient-derived-xenograft models of breast cancer.

41 d active chronic GVHD in a multiorgan system model of bronchiolitis obliterans (BO), driven by germin

42 in vivo biodistribution properties in mouse models of CAIX-positive clear cell renal cell carcinoma

43 ent to induce phenotypes identified in mouse models of cancer cachexia, including muscle fiber atroph

44 biological tissue, and in vivo mouse and rat models of cancer with a thermal camera reveals material

45 herapy in suppressing tumour growth in mouse models of cancer.

46 vivo with an angiotensin II-mediated murine model of cardiac fibrosis in both preventive and therape

47 Conservative management, a multidisciplinary model of care for patients with stage 5 CKD who want to

48 ed palliative care workforce, means that new models of care are needed.

49 increase in knowledge that informs adaptive models of care, with an emphasis on articles published s

50 This paper proposes a novel nonlinear model of cascade failure in weighted complex networks co

51 ction and to develop the first viable animal model of cblC deficiency.

52 Current mouse models of CCHFV infection reliably succumb to virus chal

53 d after deletion of Pdcd10 (Ccm3) in a mouse model of CCM.

54 limiting threshold and a conceptually simple model of CD8(+) T cell Ag recognition, in which Ag dose

55 The findings lend credence to a model of celiac disease where gluten-reactive T cells pr

56 roteome allocation theory and the structural model of cell division.

57 We used a simple whole-cell coarse-grained model of cell physiology that combines the proteome allo

58 the derivatives was evaluated in an in vitro model of cellular injury on cortical neurons.

59 arr and James Albus proposed a computational model of cerebellar cortical function based on the pione

60 Mouse models of cervical cancer were used to evaluate the rela

61 ts at Embryonic Day 20 to simulate antenatal models of chorioamnionitis and preeclampsia, respectivel

62 resistance to therapy has led to a Darwinian model of clonal selection.

63 ate different substitution models, including models of codon selection.

64 at will distill the currently known multiple models of collaboration.

65 Furthermore, using PDX models of colon cancer and resected tumors from colon ca

66 Quantitative linear mixed effects models of color images from a four day porcine burn stud

67 line primordium, an experimentally tractable model of complex self-organized organogenesis.

68 This finding warrants the modeling of concurrent treatment of TB and HIV to potent

69 with histopathological evaluation of a swine model of concussion demonstrated a notably similar patte

70 ts of confidence and propose a computational model of confidence in which metacognitive performance n

71 Boyd and Richerson used models of conformist and anticonformist bias to explain

72 present an infection and transmission animal model of COVID-19 that may facilitate development of SAR

73 An emerging model of COVID-related cardiometabolic syndrome encompas

74 long-term modulation of allergy in a murine model of cow's milk allergy.

75 By developing a general thermodynamic model of CRISPR-Cas binding dynamics, our results unrave

76 e2 expression observed across various murine models of critical illnesses is associated with increase

77 In a rabbit model of CRS, TEMPS was maintained in rabbit sinuses and

78 ak and Reynaud highlight a major omission of models of cumulative technological culture.

79 of the JCI, Auguste et al. generate a mouse model of DCM in which they delete Lmna in cardiomyocytes

80 ergone chronic social defeat stress, a mouse model of depression, at both the level of synaptic funct

81 ronic unpredictable mild stress (CUMS) mouse model of depression.

82 icular value of this construct for informing models of developmental psychopathology and individual d

83 readouts can be obtained in both preclinical models of diabetes mellitus and patients with diabetes m

84 isc1 mutant mice, which could be a promising model of DISC1 haploinsufficiency.

85 enetically ablated miR-133b in the mdx mouse model of DMD.

86 es identified marked heterogeneity in animal models of donor brain death coupled to HTx, with few res

87 t of behavioral deficits in the Ts65Dn mouse model of Down syndrome (DS), translation to human clinic

88 Mouse models of DS, involving trisomy of all or part of human

89 This tool combines profile hidden Markov models of each smORF family and deep learning models tha

90 This limitation has led to models of early life in which the first cells used simpl

91 resents a rich opportunity to sharpen animal models of eating disorders and to identify neural mechan

92 domain, and in fact it applies to simplified models of ecological, neuronal, and traffic networks.

93 nt the current evidence for the two proposed models of EET taxis, "electrokinesis" and flavin-mediate

94 Here we have developed an atomistic spin model of elongated magnetite nanocrystals to specificall

95 Among HIV-infected, model of end-stage liver disease (aHR, 1.04; P < 0.001),

96 mergence of persistence, we consider several models of environmental volatility described by continuo

97 eloped a formalism inspired by the Pacemaker model of evolution that accounts for varying rates of mu

98 basis of these traits is required to assess models of evolution and to develop successful breeding s

99 on provided by HDX-MS experiments and by the model of exchange are sufficient to recover correctly we

100 Studies in models of experimental and clinical nephropathies have d

101 ipolar spindle, we developed a computational model of fission-yeast mitosis.

102 rt a similarly broadly active ancestral ABCE model of floral organ determination in early angiosperms

103 Thermodynamic models of gene regulation can predict transcriptional re

104 d on the coalescent, which assumes a neutral model of genomic evolution, and those are best suited fo

105 . difficile germination and outlines current models of germination regulation.

106 Here, using a native mouse model of glioblastoma, we develop a high-throughput in v

107 ed cell lines, and in vivo, using orthotopic models of glioblastoma.

108 in and illustrate potential limits of murine models of globin gene regulation.

109 te limb continues to serve as an influential model of growth, morphogenesis and pattern formation.

110 As an in vitro model of haematopoietic dysfunction, the BM chip may ser

111 ity that has been established in preclinical models of HCC with the clinical failure of AR antagonist

112 We have developed a new human neuronal cell model of HD, using neural stem cells (ReNcell VM NSCs) s

113 (LLTS) reduces cardiac inflammation in a rat model of heart failure with preserved ejection fraction

114 electron microscopy studies have refined our model of herpesvirus entry into cells, clarifying both t

115 In conclusion, this robust cell culture model of HEV infection provides a powerful tool for stud

116 We used rat models of HFpEF and HFrEF to reveal distinct differences

117 Current ex vivo and animal models of hidradenitis suppurativa (HS) display issues w

118 SP was investigated in primary and cell line models of HIV-1 latency and reactivation.

119 ated the role of PAG1 in a preclinical mouse model of house dust mite (HDM)-induced allergic sensitiz

120 sults not only allow us to propose a revised model of how CDK8 activity is regulated by MED12, but al

121 from studies of patients with MS and animal models of how specific cytokines produced by autoreactiv

122 ctive non-sanguineous, LVR solution in acute models of HS through mechanisms targeting cell swelling-

123 enteric nervous system regeneration in mouse models of HSCR.

124 Utilizing an in vitro model of HSV-1 infection, we found that overexpressed RU

125 or the development of predictive preclinical models of human DILI.

126 Tumor models of human PCa epithelia with CAF expanded similarl

127 In vivo, m-RCT was evaluated in mouse models of hypercholesterolemia that were naturally defic

128 Second, in the streptozotocin model of hyperglycemia-induced renal injury ENaC activit

129 this new culture medium for chronic disease modeling of IL-13-induced airway hyper-responsiveness.

130 ement strategy of the hip, knee and ankle, a model of increasing eccentric load was implemented in th

131 Here, we developed a rat model of incubation of opioid craving after electric bar

132 For example, FastMM can be applied to the modeling of individual cancer metabolic profiles of hund

133 ective at lowering bacterial load in a mouse model of infection.

134 -26 and HENV-32, protected ferrets in lethal models of infection with NiV Bangladesh 3 days after exp

135 Stimulation of the terminals in simulated models of inflammatory or neuropathic hyperexcitability

136 Using a published phylodynamic model of influenza transmission, we identified indicator

137 review, we place risk taking within existing models of information processing in pediatric anxiety di

138 hage biology in different organs and various models of injury and disease.

139 of NC mice, we employed two distinct murine models of iNKT cell over-representation: Vbeta8 TCR cong

140 ts into the requirement for Runx1 in a mouse model of inv(16) acute myeloid leukemia (AML).

141 Here, we employ a sensitized murine model of islet transplantation to test strategies that p

142 rrelate with neuromuscular deficits in mouse models of Kennedy's disease (KD), suggesting that restor

143 o handle kinematic constraints, which enable modeling of kinematic loops (e.g., cycling models) and c

144 we used the well-characterized iSLK.219 cell model of KSHV infection and established a new infection

145 aintaining HSV-1 latency in certain neuronal models of latency.

146 ides and macrocycles, along with the dimeric model of LDH-H, constitute promising pharmacological too

147 examine its safety and efficacy in a murine model of lethal HSV-2 infection.

148 od and also call into question the classical model of lignification, which purports that lignin polym

149 Instead, we rely on well-established genetic models of linkage disequilibrium.

150 ate-of-the-art systems biology approaches to models of liver regeneration, pharmacologically and gene

151 n a highly aggressive, immunocompetent mouse model of lung adenocarcinoma improves long-term survival

152 arrier dysfunction, and mortality in a mouse model of malaria.

153 sts differs from that in our well-understood models of mammalian and yeast cells.

154 Our model of mammary carcinogenesis allowed for the explorat

155 circulating tumor cells (CTCs) in two mouse models of mammary cancer: genetically modified MMTV-PyMT

156 uated the performance of the probes in mouse models of mammary tumours and of metastatic lung cancer,

157 The combination of these results with a model of mass transfer showed that most pheromone molecu

158 Here we utilized a mouse model of maternal immune activation (MIA) with the viral

159 Here, we used a mouse model of maternal obesity to investigate the importance

160 these findings to inform current predictive models of mechanical behaviour in polymer-composite mate

161 major downstream target of RAC1, in a mouse model of melanoma driven by BRAF(V600E);PTEN loss.

162 ngioma, we develop a human cerebral organoid model of meningioma and validate the high ADC marker gen

163 We validated its effects in an in vitro model of MI/IRI in mammalian cardiac cells.

164 Here, we discuss genetic models of mouse DC development and function that have ai

165 A 3D model of MpBgl3 was generated by molecular modeling and

166 ved using a multivariate logistic regression model of MRI parameters after thresholding the data with

167 autoimmune encephalomyelitis (EAE), a murine model of MS, adoptive transfer of IL-10(+) regulatory B

168 Using an animal model of MS, experimental autoimmune encephalomyelitis (

169 detection of demyelinated lesions in rodent models of MS.

170 erimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS).

171 utoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis.

172 uctural-biology approaches, to obtain atomic models of multiple protein complexes implicated in intra

173 We employed a model of murine BSM tissue in which increased expression

174 We have employed varying EMT models of murine breast cancer cells to identify the key

175 rough comprehensive analytical and numerical modeling of myosin V diffusion and stepping.

176 life, have stimulated interest as synthetic models of natural systems and integral components of pho

177 aph theoretical indices and use a generative model of network growth to explore mechanisms underlying

178 he gap between data-driven and theory-driven models of neural dynamics.

179 nderstanding of LPA(1) signaling in the PSNL model of neuropathic pain.

180 demonstrated target engagement in two animal models of neuropathic lysosomal storage diseases (LSDs),

181 suggesting limitations in preclinical animal models of neurotoxicity.

182 ish tail injury and murine acute lung injury models of neutrophilic inflammation, overexpression of S

183 These findings validate a novel animal model of nicotine vapor self-administration in rodents w

184 ncipal goals were: (1) to develop predictive models of NPP and GPP calibrated to source data (1982 to

185 Using a high-fat diet model of obesity in mice and breast tissue from women, w

186 eramides, are selectively reduced in a mouse model of obesity.

187 These results challenge the prevailing model of OSN modulation and highlight opportunities to b

188 Using a murine model of osteomyelitis, we examined survival of S. aureu

189 dence suggests that we construct an implicit model of other people's gaze, which may incorporate phys

190 indings suggest that the capacity to compute models of other agents has deep roots in the strategic s

191 evelop an induced blood-stage malaria (IBSM) model of P. malariae to study parasite biology, diagnost

192 In a hypomorphic murine model of PA, dual mRNAs normalize ammonia similarly to c

193 phenomenologically extended the neural mass model of partial seizures, the Epileptor, by including t

194 istic autoantibody (AT(1) -AA)-induced mouse model of PE.

195 ue primarily to a paucity of relevant animal models of penile HIV infection.

196 earance, consistent with dynamic interactive models of perception.

197 ivity in animals with spared nerve injury, a model of peripheral nerve injury (PNI)-induced neuropath

198 Together, this study presents a new model of peripherin-reactive B lymphocyte-dependent auto

199 In a mouse model of persistent lymphocytic choriomeningitis virus (

200 Some models of phenotypic plasticity conceptualise the respon

201 portunity to test the predictions of current models of planet formation and evolution.

202 address this gap, we adapted an infant mouse model of pneumococcal colonization and transmission to i

203 itored the competence development in a mouse model of pneumonia-derived sepsis.

204 Two mouse models of polymerase exonuclease deficiency shed light o

205 single prolonged stress, a validated rodent model of post-traumatic stress disorder, in combination

206 Such models of preclinical pulmonary hypertension, a disease

207 HV infection and established a new infection model of primary lymphatic endothelial cells (LECs) infe

208 spectrometry to build integrative structural models of protein complexes.

209 better pragmatic and explanatory biological models of psychiatric disorders.

210 Predictive processing models of psychopathologies are not explanatorily consis

211 Preclinical models of psychosis propose that hippocampal glutamaterg

212 This model of psychosocial stress, characterised by an immune

213 in the stress-enhanced fear learning (SEFL) model of PTSD, as well as associated changes in pain sen

214 hibition were studied in the bleomycin mouse model of pulmonary fibrosis.

215 Most previous models of quark nuggets have assumed no intrinsic magnet

216 Furthermore, models of radionuclide transport from disposal boreholes

217 tobiliary function in an in situ and ex situ model of rat donor liver transplantation.

218 This optimization allows for accurate modeling of receptors using templates as low as 20% sequ

219 spaceflight and to establish a comprehensive model of recovery after return to Earth.

220 or the United States and generate predictive models of regional plant taxonomic and phylogenetic dive

221 in order to develop and implement agreeable models of reimbursement while ensuring access to quality

222 ement of cocaine-seeking behavior, an animal model of relapse.

223 functional and structural outcomes in animal models of retinal injury and retinal degenerative diseas

224 addressed this issue in an established mouse model of Retinitis Pigmentosa caused by the P23H mutatio

225 In a genetic mutant model of retinitis pigmentosa, a lead compound, Q525, af

226 onstructions, using linear-nonlinear cascade models of RGC light responses that incorporated measured

227 amined the role of Wnt6 in MeCP2 T158A mouse model of RTT.

228 ns of all 969 genes that comprise the ito977 model of Saccharomyces cerevisiae's metabolic network.

229 meningeal lymphatics are depleted in a mouse model of SAH, the degree of erythrocyte aggregation in C

230 Thus, the K18-hACE2 model of SARS-CoV-2 infection shares many features of se

231 e efficacy of remdesivir in a rhesus macaque model of SARS-CoV-2 infection(9).

232 efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection.

233 ries data from the United States to inform a model of SARS-CoV-2 transmission.

234 ematical modeling, we develop an alternative model of scaling driven by feedback downregulation of Dp

235 r the formation of primary cilia, in a mouse model of SCLC induced by conditional deletion of both Tr

236 MM-TF) method which integrates probabilistic modeling of scRNA-Seq data with the ability to assign TF

237 In an in vivo model of second organ reflow injury, we found that RvD5

238 ite hydrogels can be therefore envisioned as models of secondary plant cell walls prior to lignificat

239 ntials, in keeping with the "dual territory" model of seizure dynamics.

240 ral profiles, we developed a reduced spiking model of sensory cortical circuits that incorporated the

241 tural freely moving behaviors, could advance models of sensory processing.

242 Also, we found that during a murine model of sepsis, P2X7 receptor activity is important for

243 lation and improves animal survival in three models of sepsis (cecal ligation and puncture or bactere

244 utational approaches to develop a structural model of SERCA-PLB interactions to gain a mechanistic un

245 -induced Th2 inflammation and AHR in a mouse model of severe steroid resistant asthma, potentially th

246 The 3-factor model of sexual behavior stigma cut across social contex

247 Here, we build a simple model of sexual reproduction and create a theoretical fr

248 resonance imaging informed by computational models of sign- and goal-tracking.

249 and inhibited disease progression in animal models of SpA.

250 In mouse models of SS, inhibition of BMP6 signaling reduced phosp

251 matory and neuroprotective actions in rodent models of status epilepticus.

252 orms from order Tricladida, are experimental models of stem cell biology and tissue regeneration.

253 asome was confirmed in an experimental mouse model of stroke.

254 A model of structure-based ATP production predicts profoun

255 This protein represents a minimalist model of sufficient complexity to encompass fundamental

256 Delta9-tetrahydrocannabinol (THC) in a mouse model of surgically-induced endometriosis.

257 ges serve to confirm and extend our previous model of SZ and can explain the lack of full efficacy of

258 sessed their therapeutic activity in a mouse model of T cell-mediated autoimmunity that mimics multip

259 umanized NOD-scidIL2Rgamma(null) (NSG) mouse model of T-cell-mediated human islet allograft rejection

260 -infiltrating B lymphocytes in the NOD mouse model of T1D produce Abs directed against the neuronal t

261 We constructed a dynamic transmission model of TB, calibrated to be consistent with an urban s

262 Using the well-established mouse model of TB, our new data provide evidence that the alar

263 report the first description of a humanized model of TBI and show that TBI places significant stress

264 These findings imply a simple phenotypic model of TCR signaling in which multiple T cell response

265 inducible RNA tagging and challenge current models of telomerase maturation.

266 ion between "process" and "representational" models of temporal lobe function is challenged.

267 st human tuberculosis and a validated animal model of the disease, tools to facilitate vaccine develo

268 Here, we present a structural model of the endogenously purified human canonical BAF c

269 hese effects, we implemented a computational model of the hippocampus, performing the same task as th

270 We use a mathematical model of the HIV epidemic in South Africa to simulate CA

271 To create a model of the human intestinal mucus layer and gut microb

272 using a combination of a biophysical network model of the inferior olive and a novel Bayesian model a

273 ry structural elements and produce an atomic model of the intermediate, comprising 120 copies each of

274 hange (HDX-MS) mapped onto a full structural model of the ligase revealed long-range allostery extend

275 s paper, we present a compartmental, logical model of the MEN that is capable of representing spatial

276 We then apply our framework to a stochastic model of the rocky intertidal food web, partitioning emp

277 lar dynamics simulations, yields a molecular model of the transmembrane core signalling unit and enab

278 We developed a compartment model of the United States to simulate different influen

279 ubstituted cyclobutane product via atomistic modeling of the CdSe surface and substrates, determinati

280 ture of the aptamer and enable computational modeling of the docked complex with RT.

281 nting an important step toward comprehensive modeling of the MHC class I pathway.

282 Implementing complex modeling of the relationships between individual dynamic

283 hybrid density functional theory to cluster models of the bimetallic active sites in the heme-copper

284 ene silencing, and a series of computational models of the biological mechanism of the RNA interferen

285 a reformulation that takes current Bayesian models of the brain into account.

286 Detailed molecular models of the odorant transduction process are, however,

287 ng in a naturalistic environment and develop models of their action selection across exploration and

288 e offered by using the temperature-dependent models of thermal conductivity and mass diffusion coeffi

289 e dysregulation and tissue inflammation in a model of TLR7-induced lupus.

290 urotrauma is an urgent priority, yet current models of traumatic brain injury (TBI) inadequately reca

291 he end of this century (2100) by mapping our model of Trichodesmium growth onto inferred global surfa

292 al. defines how genetic variation in a mouse model of type 1 diabetes mellitus (T1DM) affects long-di

293 -avidity autoreactive cells in the NOD mouse model of type 1 diabetes.

294 We used a preclinical model of uropathogenic Escherichia coli-induced acute py

295 In a large animal model of vascular embolization, it is shown that the BEM

296 We propose a dynamic feedback model of vestibular and podokinetic adaptation that can

297 ional component was calculated with a linear model of VF measurements over time.

298 llenge, we previously showed that no classic model of vision, including ffCNNs, can explain human glo

299 In particular, models of water for MD simulations are discussed in deta

300 used ZIKV strains, in two widely used mouse models of ZIKV pathogenesis.