ライフサイエンスコーパス: model system

1 ine pancreatic trypsin inhibitor (BPTI) as a model system.

2 umor-immune-system interactions in an animal model system.

3 rate for DHTKD1, but also for OGDH in a cell model system.

4 ction of AQP4, using primary astrocytes as a model system.

5 mproving the physiological relevance of this model system.

6 formation using Brachypodium distachyon as a model system.

7 ntally by using magnons as the Bose-particle model system.

8 first carried out utilizing Drosophila as a model system.

9 edicted in Li(3)RuO(4), making it a valuable model system.

10 and KGN using a high resolution micropellet model system.

11 actions is poorly understood outside of this model system.

12 ld in a neutral electrolyte was studied as a model system.

13 type mesoporous silica nanoparticles as our model system.

14 we used hepatocellular carcinoma (HCC) as a model system.

15 and the bacterium Sodalis pierantonius as a model system.

16 murine induced pluripotent stem cell (miPSC) model system.

17 perception in mice, a genetically tractable model system.

18 go in MGEs, using antibiotic resistance as a model system.

19 was performed using a Xenopus laevis oocyte model system.

20 ence for the CPET oxidation of tyrosine in a model system.

21 pithelial monolayer in an in vitro human gut model system.

22 type IV competence pili in V. cholerae as a model system.

23 in atomic sheets using monolayer MoS(2) as a model system.

24 still lacking due to the lack of a versatile model system.

25 loci and transcriptional network in a mouse model system.

26 e, lipid radicals (PBN adducts) increased in model systems.

27 mains unknown due to a lack of host-specific model systems.

28 mechanistic insights provided by studies in model systems.

29 e hundred-fold lower than common eubacterial model systems.

30 and modelling that can only be performed in model systems.

31 e and mucin production were assessed in both model systems.

32 ficult due to 'cage' and 'legacy' effects in model systems.

33 unknown due, in part, to a paucity of robust model systems.

34 g human specimens, cultured cells, and mouse model systems.

35 or plays a limited role in expansion in many model systems.

36 at P28 or P44/P45 using in vitro and in vivo model systems.

37 e and difluprednate emulsions were chosen as model systems.

38 ains unknown due to a lack of suitable human model systems.

39 mphasizes the power of using defined genetic model systems.

40 ns on how to adapt the approach to different model systems.

41 or continued drug development using improved modeling systems.

42 report the synthesis of substituted forms of model system 1 to study the effects of aryl ring electro

43 Experiments were based on 3 model systems: 1) an in vitro periodontal ligament (PDL)

44 As a model system, 10.9 +/- 1.0 nm Au NPs were analyzed to de

45 g been the subject of speculation in various model systems(2,3), and examples have been found more re

46 t been successful outside of the Arabidopsis model system(7).

47 n homeostasis due to Elongator deficiency in model systems(7-9).

48 A protein model system (8% total protein) with varying casein:whey

49 State (NYS) and its dairy cattle farms as a model system, 87 S. Typhimurium strains isolated from 19

50 ssment of Different Neoplasias in the Adnexa model system, a risk prediction model that has undergone

51 These advantages are not specific to the model system ablated for our demonstration, namely neuri

52 a) summarizing iRLT; (b) contrasting how our model system and others fit this hypothesis and (c) sugg

53 The investigation of our model system and theoretical formulation bring to light

54 ysiological' compressive loads in vitro as a model system and validated findings in an in vivo model

55 hilus, Salmonella, and Mycobacterium) as our model systems and analyzed structural and substrate-bind

56 erse collection of perturbations across many model systems and assay types.

57 Herein, we describe cultured cell model systems and common assays that have been used by i

58 (i) why does repeat behavior differ between model systems and human pedigrees, and (ii) can we use c

59 ces for discovery and validation research in model systems and humans.

60 opment and testing of therapeutics in animal model systems and in humans is provided.

61 x and potentially inconsistent across animal-model systems and in humans.

62 n Polycomb are often restricted to classical model systems and, as such, little is known about the ev

63 e development of new molecular tools, tumour modelling systems and precise instrumentation together w

64 particles assembling into supracrystals as a model system, and pinpoint the key role of surface fluct

65 ell of the marine bivalve Atrina rigida as a model system, and through a combination of multiscale st

66 diseases, describe effective patient-derived model systems, and highlight recent mechanistic insights

67 l annotations associated with perturbations, model systems, and signatures.

68 ence for biaxial binding was obtained in two model systems, and the association strengths increased b

69 to be epigenetically driven tumors for which model systems are lacking.

70 act as a proxy for stress, using a number of model systems (Aspergillus penicillioides; Bacillus subt

71 knowledge gap is largely due to the lack of model systems available to study the toxic potential of

72 ternatively spliced BRCA2 exon 12 (E12) as a model system because its in-frame skipping leads to a po

73 may explain why many LRAs are functional in model systems but relatively ineffective in primary cell

74 s mostly been studied in classical non-human model systems, but to what extent these findings are rec

75 SPR Engineering and hiPSC-Derived 2D Disease Modeling Systems, by Kristina Rehbach, Michael B.

76 Using the in vivo model system Caenorhabditis elegans, we found that the h

77 trigger changes in bone remodeling, and how model systems can be leveraged to identify new therapeut

78 ltant improvements of bottom-up, mechanistic modelling systems can enhance progress towards capturing

79 o-3-phosphocholine (DMPC) liposomes were the model system chosen to mimic the protective phospholipid

80 In this ex vivo modeling system, clinically used valve-sparing aortic ro

81 Here, we develop a model system consisting of chemically tunable, highly lu

82 nalyze signatures of pathogenesis in an MGEP model system consisting of human cells eliciting <3% pro

83 We study a model system consisting of l-aspartic acid (Asp) which w

84 To reduce the complexity, model systems containing starch, gluten and/or water-une

85 Using polycrystalline Pt as a model system, correlative SECCM and electron backscatter

86 Experiments performed on model systems demonstrate that DC tsMSQ properly identif

87 We demonstrate CSCA using a model system designed for EPR analysis: a self-assembled

88 de a historical perspective of this emerging model system, discuss current systems and limitations, a

89 in vitro esophageal epithelial 3-dimensional model system (EPC2-ALI) and murine models of EoE to defi

90 ith the sequence GNNQQNY is widely used as a model system for amyloid fibril formation.

91 important microbial habitat and a tractable model system for asking questions in microbial ecology a

92 udy thus shows the power of gastruloids as a model system for exploring development and somitogenesis

93 tal components, and this approach provides a model system for further exploration in epitaxy systems.

94 tested Drosophila melanogaster, a well-known model system for genetics and human disease.

95 root growth in Arabidopsis, we established a model system for interactions between plants, microorgan

96 The zebrafish has recently emerged as a model system for investigating the developmental roles o

97 ole of the mouse as a genetically accessible model system for mammalian brain circuit analysis we hav

98 ello-oligosaccharides also provides a useful model system for mechanistic studies of LPMO catalysis.

99 can improve the usefulness of zebrafish as a model system for muscle research by providing a rapid an

100 allopolyploid cotton species also provide a model system for polyploid research, of relevance here b

101 bitor, etoricoxib, in vivo and in vitro as a model system for post-surgical pain control.

102 Despite being widely adopted as a model system for stress and anxiety disorders, fear-cond

103 icate with neighboring cells and offer a new model system for studying compartmentalized signaling in

104 ation in Bacillus subtilis provides an ideal model system for studying development in bacteria.

105 r of MNV entry.IMPORTANCE MNV is a prevalent model system for studying human norovirus, which is the

106 bbit subjects used in this work are an ideal model system for studying learning and behavior and are

107 esses and establishes Naegleria as a natural model system for studying microtubule-independent cytosk

108 highly anisotropic superconductor that is a model system for studying the effects of anisotropy.

109 This study establishes a highly robust model system for studying the neural mechanisms of senso

110 yeast Saccharomyces cerevisiae is a powerful model system for systems-wide biology screens and large-

111 ta provide an important proof-of-concept and model system for the potential use of allele-specific sm

112 enide moire heterostructures provide another model system for the study of correlated quantum phenome

113 strate to study chaperone reactions and as a model system for the study of folding of long polypeptid

114 tocarpus has led to it emerging as a general model system for this group, but additional models, such

115 on Daphnia magna has recently been used as a model system for understanding host-microbiota interacti

116 attractive avenue for cancer treatment and a model system for understanding small molecule:RNA recogn

117 (50 degrees C and 90 bar), which serves as a model system for understanding subsurface divalent silic

118 terial Bad enzymes will provide an excellent model system for understanding the biochemical propertie

119 study establishes G. omarorum as a powerful model system for understanding the neuromolecular bases

120 A model system for understanding these dynamics is the mic

121 A leading model system for vertebrate skin patterning is the zebra

122 They are model systems for analyzing RNA-ligand interactions and

123 e suggest that a theory-guided search across model systems for biological mechanisms that enable such

124 ch towards the development of new or adapted model systems for DILI prediction.

125 owing the development of improved infectious model systems for drug discovery and the study of the HB

126 ght the power of clinically relevant in vivo model systems for identifying cancer therapies.

127 as highly accessible and clinically relevant model systems for probing nonclassical, ancestral neuroh

128 Analysis of infection in this model system found that human airway epithelial cell cul

129 tion; to date, however, the validity of this model system has not been empirically determined.

130 ration of axenic (germ-free) and gnotobiotic model systems has been vital to dissecting the role of t

131 testine, has meant that work in many diverse model systems has contributed to our current understandi

132 naling mechanisms in plants beyond these few model systems has opened.

133 The lack of suitable respiratory model systems has precluded understanding of how herpesv

134 Work in model systems has revealed mechanisms controlling commit

135 rganism-specific investigations, a number of model systems have been studied, based upon the conserve

136 Importantly, many model systems have contributed to our understanding of t

137 Studies in classical mouse model systems have provided evidence that balancing of i

138 These model systems have provided the fundamental understandin

139 Its affinity for the model system HER2-DIVMP was found in a nanomolar range.

140 ing confluent monolayer of MDCKII cells as a model system, here we report at single cell resolution t

141 Using DNA nanotubes as a model system, here we show that coupling a generic rever

142 sphere Fc(0/+) process (Fc = ferrocene) as a model system, high boiling point (low vapor pressure) so

143 In this study we employ as a model system HIV-1 TAR RNA and its interaction with the

144 lopropenium organocatalyst was employed as a model system in combination with an arsenal of mechanist

145 ntation in motor cortex (M1) is an important model system in contemporary neuroscience.

146 w how the unique attributes of the zebrafish model system in embryology, imaging, and scalability hav

147 hyon is an annual C3 grass used as a monocot model system in functional genomics research.

148 Thus, we developed an in vitro model system in which B cells expressing vCD200 were uti

149 glucocorticoids using the chicken embryo, a model system in which the effects on the developing hear

150 d it establishes Nematostella as a promising model system in which the functional ramifications of th

151 mental attributes make Senecio an attractive model system in which to address a broad range of questi

152 This work advances S. rosetta as a model system in which to investigate how genes identifie

153 wever, the inherent difficulty to accurately model systems in aqueous solutions, owing to water's hig

154 ic drugs and physiological sleep are used as model systems in experimental studies on consciousness,

155 animal survival in patient-derived xenograft model systems in vivo more potently than single treatmen

156 e, we study interactions within a Drosophila model system, in which Spiroplasma protect their host ag

157 imental handle in the Caenorhabditis elegans model system, in which we uncover the mechanisms that co

158 pathogenesis has historically focused on two model systems, in vitro culture of the human parasite Pl

159 With a few emerging model systems, including the tubeworm Hydroides elegans,

160 we examine lessons learned from a variety of model systems, including yeast, nematode, fruit fly, and

161 s in such an established virulent host-virus model system indicates that temperateness may be more pe

162 r diverse LRAs, latency reversal observed in model systems involves a heat shock factor 1 (HSF1)-medi

163 reenings combined with a clinically relevant model system is a practical approach in identifying synt

164 of endogenous K-PPn of proteins in the yeast model system is that its nonenzymatic nature and its sus

165 ff-target events using personalized iPSC-RPE model systems is warranted.

166 Computational simulations of a model system match the experimental data and show how th

167 g of the viral lifecycles in a more relevant model system may help identify novel therapeutic targets

168 With further characterization, these animal model systems may serve as targets to test psychosis mec

169 These simple model systems not only establish a set of general engine

170 od with a lack of studies using human airway model systems.Objectives: To investigate sphingolipid me

171 ve processes of electronic coherences in the model system of CdSe quantum dots (QDs).

172 Herein, we study a model system of copper nanowires with various degrees of

173 ation (ThFFF) was investigated for a polymer model system of differently branched chain walking polye

174 The first in vitro model system of human trophoblast that could be cultured

175 We report on a model system of hydrophobically driven LLPS induced by h

176 However, in the natural animal model system of Marek's disease alphaherpesvirus (MDV) i

177 typical cross-feeding features of lichen, a model system of mutualism.

178 A model system of two related enzymes with conserved bindi

179 , removal, and replacement, were detected in model systems of lysosomal damage inflicted by proteopat

180 ta support further investigation in clinical model systems of the potential benefit from GDF15 admini

181 Using several model systems of varying complexity, the applicability a

182 Although model systems offer a window into the molecular biology

183 Here, optimized thermal annealing of model system PBDB-TF:Y6 (Y6 = 2,2'-((2Z,2'Z)-((12,13-bis

184 ue of 2.00467 compared with 2.00474 found in model system prepared with zein.

185 Model systems, real juices and wines have been enriched

186 Organoid model systems recapitulate key features of mammalian tis

187 Current model systems require very long incubation times or seve

188 in vitro esophageal epithelial 3-dimensional model system revealed that ANO1 undergoes chromatin modi

189 Our model system reveals cell-intrinsic responses of a key l

190 Research with model systems reveals that environmental conditions can

191 ed a 2D implementation of the Regional Ocean Modeling System (ROMS) to downscale global climate predi

192 e structural information available for three model systems, Sf6, Sf14, and HRP29; we also provide an

193 active deuterium-labeled C-H substrates as a model system, shed light on the underlying mechanistic d

194 ic RNAs is highly complex, even for a simple model system such as the UUCG tetraloop.

195 range of cell self-organization in emerging model systems such as organoids.

196 Simplified model systems suggest that monomers are limited and hete

197 Here, we present an Escherichia coli model system that allows us to probe the structure and f

198 nesses, and therapeutic implications of each model system that are relied upon today.

199 us-removed (SEIR) mathematical compartmental model system that characterizes infections by state and

200 ular system of the hypoxic chicken embryo, a model system that permits the direct effects of pravasta

201 the first time, the establishment of a human model system that recapitulates aspects of IPF-associate

202 le to provide orthogonal support in an algal model system that segregates RanGTP regulation of ciliar

203 Representative in vitro model systems that accurately model response to therapy

204 skin diseases are currently performed using model systems that only partially recapitulate human dis

205 Here, we show in model systems that other than loss of RB1 few gene-copy

206 ng of epithelial tubes in vivo using a novel model system: the extracorporeal vasculature of Botryllu

207 assay using O-GlcNAc transferase (OGT) as a model system through detailed Michaelis-Menten kinetic a

208 id aggregates, which present a more suitable model system to access the impact of membrane physical p

209 We utilized a Drosophila melanogaster model system to assess the effects of sertraline through

210 Here, we used the developing limb as a model system to compare the binding specificity of HOXA1

211 Sr(0.5)Co(1.5)Fe(0.5)O(5+delta) (PBSCF) as a model system to demonstrate enhancing OER activity throu

212 City), we use community garden networks as a model system to demonstrate how biophysical and social f

213 gold-copper alloy NCs and NPs are used as a model system to demonstrate the semiconductive-to-metall

214 switching, we use Borrelia burgdorferi as a model system to determine high-resolution in situ motor

215 pendent membrane-binding protein ANXB12 as a model system to determine the relative contributions of

216 dition, Saccharina japonica has emerged as a model system to directly address applied questions relat

217 ve tetra(tert-butyl)porphyrazine as an ideal model system to elucidate electronic properties of tetra

218 , alpha2delta-2 (Cacna2d2), we used PCs as a model system to examine roles of alpha2delta in excitato

219 systemic changes so we developed an in vitro model system to examine the effects of contractile activ

220 calculations on a sulfoximinoyl-substituted model system to explain the pronounced solvent dependenc

221 e a taste of the power of C. crescentus as a model system to explore a diverse range of topics.

222 catalyzed isomerization of n-heptane as the model system to explore the role of internal diffusion b

223 lic triblock copolymer (Pluronic F-127) as a model system to extract/preconcentrate 2-aminobiphenyl (

224 l fate specification, we used zebrafish as a model system to investigate prdm8 function.

225 zle-shaped pavement cells provide a powerful model system to investigate the cellular and subcellular

226 study represents an experimentally tractable model system to reveal and examine human-specific regula

227 re, we have used the developing cochlea as a model system to show that secreted Wnts regulate PCP thr

228 se thermogenic adipose tissue from mice as a model system to show that T cells, specifically gammadel

229 stom-designed DNA origami nanostructure as a model system to specifically mimic a DNA DSB, enabling u

230 and establishes zebrafish as a valuable new model system to study astrocyte biology in vivo.

231 PC12 cells are a popular model system to study changes driving and accompanying n

232 st that human cerebral organoids represent a model system to study drug-induced neuroinflammation at

233 study used bromeliad landscapes as a natural model system to study how oviposition habitat selection

234 oids have emerged as a biologically relevant model system to study normal human brain development and

235 anne Eaton used the power of Drosophila as a model system to study PCP, but her vision of, and impact

236 established D. melanogaster as an expedient model system to study the effects of radiation-induced d

237 The 2-layer capsid of reovirus provides a model system to study the interactions between capsid pr

238 but also they are an important paradigm and model system to study the intricacies of the defect proc

239 We used matrix metalloprotease-1 (MMP1) as a model system to study the relationship between interdoma

240 terial microcompartments present a promising model system to study this process.

241 terized IGPS enzymes, providing an excellent model system to test the necessity of the decarboxylatio

242 age and ligation, and serves as an important model system to understand RNA catalysis.

243 exposes state-of-the art cellular and animal model systems to 33 sequential beams including 4 proton

244 g the pathogenesis of glaucoma and for using model systems to assess mechanisms and potential interve

245 light the need for cultivation of additional model systems to better capture the diversity of tempera

246 ctive, we outline technological advances and model systems to characterize tumor progression through

247 Here we used DNA G-quadruplex structures as model systems to demonstrate that DNA oligonucleotides a

248 ol and oxidation of 4-aminothiophenol as two model systems to demonstrate the capabilities of these b

249 vacuum (UHV) conditions constitute excellent model systems to determine the activity of step sites in

250 knockout and behavioral approaches in rodent model systems to dissect the role of Gadd45b in dopamine

251 ucture and function and highlight the use of model systems to enable mechanistic understanding of RAD

252 ons, and (iii) draw on studies of cultivated model systems to examine the consequences of lysogeny am

253 ature with gene expression data from diverse model systems to infer a set of molecular regulatory int

254 The authors used mouse and human model systems to show that CFTR dysfunction in platelets

255 man cancer cell lines are frequently used as model systems to study molecular mechanisms and genetic

256 A (mtDNA) is essential for the generation of model systems to study rare mitochondrial diseases but w

257 research, we often rely on well-established model systems to tackle important questions.

258 to use examples of ecological radiations as model systems to understand evolution and ecology.

259 e detailed reaction pathway for this classic model system under considerably simplified reaction cond

260 Following studies of a model system (urea), stochastic differential scanning ca

261 In addition, at least one model system used for experimental evolution studies has

262 l resist microbiome-derived degradation, the model systems used for testing antimicrobial activities

263 To reproduce these responses in vitro, a model system using synthetic lipid vesicles was also dev

264 uted hydrologic models (Precipitation-Runoff Modeling System, Variable Infiltration Capacity, and Dis

265 oxidant activities in gastrointestinal track model system was found for SPC-CHO-0.5%HC.

266 In this study, a simple model system was used to investigate the antibacterial e

267 The model system we have developed now permits the molecular

268 Using fibroblast growth factor 2 (FGF2) as a model system, we addressed this methodological challenge

269 Using this model system, we asked what happens when intrinsic and e

270 Using ZnO as a model system, we combine in situ TEM observations of sin

271 Using the ferromagnetic metal SrRuO(3) as a model system, we demonstrate an efficient and reversible

272 Exploiting LCMV as a model system, we demonstrate that TRIM21 uses anti-N ant

273 hibitor (BETi) resistant leukemia cells as a model system, we demonstrated herein that genome-wide en

274 ng the NTF2-like structural superfamily as a model system, we developed an enumerative algorithm for

275 As a model system, we examined the kinetics of nonfaradaic Pd

276 Using Flock House virus (FHV) as a model system, we identified highly consistent and signif

277 e drug target in an in vivo disease-relevant model system, we introduced a C181S mutation into a cond

278 orhabditis elegans chemosensory neurons as a model system, we provide proof-of-principle that aberran

279 rosine kinase (BTK) as a clinically relevant model system, we show efficient degradation by noncovale

280 Using a cultured keratinocyte model system, we show that depletion of alpha-catenin pe

281 ke, clotting protease thrombin as a relevant model system, we show that its conformation is quite dif

282 transactivation response (TAR) element as a model system, we show that Nm preferentially stabilizes

283 ophaga baltica crAss-like phage phi14:2 as a model system, we show that this protein is a DNA-depende

284 ustrial thermoset polydicyclopentadiene as a model system, we show that when a small number of cleava

285 D (CRAF RAS binding domain) interaction as a model system, we showed that MAFI alone is not sufficien

286 iral infection in a physiologically relevant model system, we showed that RSV infects and spreads mor

287 ased in part on experiments in a sea-anemone model system, we targeted the gene encoding Heat Shock T

288 Using Arabidopsis as a model system, we tested our approach to identify regulat

289 After testing both methods using simple model systems, we apply the two assays to investigate a

290 ted parallel carbon nanotube (CNT) arrays as model systems, we developed a rinsing-after-fixing appro

291 Model systems were incubated at temperatures up to 190 d

292 sional electron gas in a magnetic field is a model system where optical transitions between Landau le

293 network properties or by finding alternative model systems where their co-expression is conserved.

294 TS) systems provide an in vitro cell culture model system which mimics many of the complexities of an

295 ons and analysis on physiologically relevant model systems, which suggest that it is not positively c

296 strate a DNA origami technique designed as a model system with which to explore the mechanism of asse

297 Initially tested with model systems with solid conductive inclusions, this the

298 ylene chromophores were connected into dimer model systems with the chromophores either projected out

299 -220 enabled muscle relaxation, in human and model systems, without cardiovascular side effects and i

300 molecular details for many years in cultured model systems, yielding a plethora of knowledge on how v