ライフサイエンスコーパス: model where

1 perimental discovery, we propose a simple 3D model where the dielectric and metallic domains are arra

2 ntal lineFe(IV)-O-Fe(IV)(OH)(L)2](ClO4)3 (4) models (where, L = tris(3,5-dimethyl-4-methoxypyridyl-2-

3 A model where H2O2 mediates the negative regulation of pla

4 A model where power-law fluctuations of the alpha envelope

5 offer a critical missing link and advocate a model where alpha-syn and synapsin cooperate to cluster

6 ed Hsc70-synapsin associations, advocating a model where Hsc70 activity dynamically clusters cytosoli

7 bomian gland (MG) formation is employed as a model where Dkk4 and its Wnt targets are expressed.

8 Building on these findings, we develop a model where increased inhibitory tone on dopamine neuron

9 We develop a model where organisms perform 'leaky' functions that pro

10 Based on this evidence, we envisage a model where this homeostatic circuit maintains a constan

11 We established a model where the TCR repertoire of normal polyclonal Treg

12 Therefore, we explored a model where DNA accessibility is not the result of therm

13 Our data favor a model where the high diversity of the Treg TCR provides

14 ortance of SC:niche interactions and favor a model where youthfulness of the niche microenvironment p

15 t to the electron density is obtained from a model where the structure of the 5- cluster lies close t

16 Our work highlights a model where alpha-CGRP-mediated neuronal signaling is cr

17 lin signaling was characterized further in a model where ADAMTS9 was overexpressed in skeletal muscle

18 In a model where both neuronal populations were connected bi-

19 ith IBD microbiotas exacerbated disease in a model where colitis is induced upon transfer of naive T

20 d castrate-resistant tumor progression, in a model where either ADT or TRC105 alone had little effect

21 by a person's own genotype, as expected in a model where one's height determines the choice of mate h

22 e function for CNS-specific CD8 T-cells in a model where the antigen is exogenously administered in v

23 Together, our data indicate a model where an alteration at position 420 causes a subtl

24 Results indicate a model where DERAA-Mc activates DERAA-directed T cells th

25 However, calibration of a model where a behaviour depends on an intervention intro

26 isease has contributed to the emergence of a model where hyperphosphorylation triggers both tau disas

27 he findings into consideration, we present a model where Nab2/ZC3H14 interacts with spliceosome compo

28 Therefore, we propose a model where a length-dependent disassembly mechanism con

29 Here, we propose a model where a spiking recurrent network of excitatory an

30 We thus propose a model where approach-avoidance conflict resolution in hu

31 We propose a model where bunyaviruses activate Wnt-responsive genes t

32 We thus propose a model where CcmA and MreB promote PG synthesis at positi

33 We propose a model where cigarette smoke exposure increases miR-31 ex

34 Together, we propose a model where coordination of LKB1 farnesylation and kinas

35 We propose a model where CSB facilitates gene expression by helping P

36 From these results, we propose a model where direct coupling of ATP hydrolysis and confor

37 he pathophysiology of migraine and propose a model where dural CGRP-based mechanisms contribute to th

38 We propose a model where dynamic competition between proteins VI and

39 s issue, Twelvetrees et al. (2016) propose a model where dynein is transported by direct-but transien

40 n together, our results lead us to propose a model where elevated KLF4 levels sustains the oncogenic

41 On the basis of these results, we propose a model where GAPDH obtains mitochondrial heme and then fo

42 Based on these observations we propose a model where in the hydrated state the organized rod stru

43 from this and previous studies, we propose a model where KEG mediates the ubiquitination and subseque

44 findings and previous studies, we propose a model where light activates a non-canonical pathway medi

45 We propose a model where macrophage recruitment to and activation at

46 rization of the mutant leads us to propose a model where multiple pyrenoids are favored by an increas

47 We propose a model where NBAS recruits UPF1 to the membrane of the ER

48 We propose a model where PICALM modulates glutamatergic transmission,

49 We propose a model where PLK1 activity elevates in response to misali

50 We propose a model where positive and negative regulatory influences

51 d on our experimental evidence, we propose a model where RepC nicking activity is passive and depende

52 We propose a model where Rgd3 functions to modulate and maintain Rho3

53 We propose a model where Ser(474) phosphorylation is required for max

54 data and pull-down experiments, we propose a model where ST8SiaIV recognizes and docks on an acidic s

55 We propose a model where tetanic stimulation activates Syt1-independe

56 We propose a model where the C terminus of TF modulates the palmitoyl

57 We propose a model where the core planar polarity proteins Celsr1 and

58 Based on these findings, we propose a model where the ER-localized VAP-SCRN1 interactions prov

59 We propose a model where two sequential post-translational modificati

60 On the basis of these findings we propose a model where, in the presence of ethylene, the EIN2 C ter

61 We have previously proposed a model where subcomplexes of vRNA are exported from the n

62 social decision-making may instead reflect a model where higher-order learning processes are dissocia

63 cross-validation model-comparison selected a model where young children usually use the target locati

64 s and DNA footprinting experiments suggest a model where a PC4 dimer accommodates the DNA with one mo

65 Overall our results suggest a model where BAF is critical for timely repair of large r

66 Our data suggest a model where GlcNAc polymers of greater than 20 units bin

67 These correlative observations suggest a model where late-stage BAX oligomers play a functional p

68 Our results suggest a model where multiple alpha-actinin/Z-repeat interactions

69 These data suggest a model where phosphorylation alters LC interaction specif

70 On the basis of these results we suggest a model where salt decreases the free-energy barrier for A

71 Our data suggest a model where SynEtr1 inhibits downstream signaling and et

72 Our results suggest a model where the bivalent IgG acts akin to molecular plie

73 Together, these results suggest a model where the cellular polarity program plays an integ

74 , biophysical and biochemical data suggest a model where transition from the 'initiation' state into

75 Data suggested a model where NC valency plays an opposing role in the two

76 Tentatively, this evidence suggests a model where an elevation in striatal D2/3 receptor avail

77 This suggests a model where key interactions at the vertex and edges are

78 This investigation suggests a model where LtgD produces PG monomers in such a way that

79 This suggests a model where the DELLA1-mediated GA signaling interplays

80 wledge of PRMT crystal structures suggests a model where the size of two distinct subregions in the a

81 These collective results support a model where a FlaG filament capped by a FlaG-FlaF comple

82 Our data support a model where adding AMPA receptors is sufficient to activ

83 The results from our study support a model where altered protein interactions with alanine-ex

84 Our in vitro and in vivo data support a model where an oxidized dNTPs pool together with aberran

85 These data support a model where Arabidopsis CRKs are synthesized upon pathog

86 These data support a model where Asna1 ensures retrograde transport and, henc

87 Our data support a model where Bcd influences chromatin structure to gain a

88 Our data support a model where both an increased expression of Galphaq-coup

89 The data support a model where CHK2 sequesters the AR through direct bindin

90 Our data support a model where clonal epigenetic reprogramming towards redu

91 ical and molecular biology results support a model where ETR1 and ETR2 are indirectly affecting the e

92 n contributes to FXS pathology and support a model where FMRP, by controlling the translation of Dgkk

93 llectively, results presented here support a model where GSK3beta regulates signaling by controlling

94 Our data support a model where H2A.Z in gene bodies has a strong repressive

95 Taken together, our data support a model where IcsA and N-WASP form a tight complex releasi

96 Collectively, these observations support a model where larynx SCC are characterized by slower growt

97 These findings support a model where loss of either component of the cohesin rele

98 Our findings support a model where low-dose IL-2 selectively activates Tregs to

99 Our findings support a model where MN-intrinsic transcriptional programs shape

100 Our data support a model where nutrition is a key environmental factor infl

101 Taken together these data support a model where PDHK4 regulates KRAS signalling and its tumo

102 The results support a model where Pol iota occasionally accesses the replicati

103 Collectively, our data support a model where proproliferative activities of LMP1, LMP2A,

104 These results support a model where RIN and ET, via ERFs, are required for full

105 m in vitro and in vivo experiments support a model where RNAs produced during early steps in transcri

106 Our findings support a model where sites of glycosylation for many OGT substrat

107 Our observations support a model where specificity is generated through conformatio

108 Together, these findings support a model where spontaneous control of HCV such as sometimes

109 Our data support a model where the balance of activating and inhibitory rec

110 H1 in vivo Collectively these data support a model where the combined action of RhoA and an enhancer

111 Our data support a model where the density of shared RNA binding sites arou

112 Findings reported here support a model where the developmental timing of estrogen signali

113 Altogether, these results support a model where the eVP30-eNP interaction plays a critical r

114 These data support a model where the genomic integrity of human gamma-herpesv

115 These findings support a model where UK-5099 inhibits the MPC complex by binding

116 gions of a budding Gag lattice, supporting a model where direct interactions and/or steric corralling

117 genetic values among partners, supporting a model where partners assort for risk factors to some ext

118 nction in motor neurons or muscle supports a model where presynaptic miR-34 inhibits Nrx-IV to influe

119 Our findings lend to a model where different nuclear pores bind different types

120 high-affinity binding regions, leading to a model where Hox proteins derive binding selectivity thro

121 These results lead to a model where protein and small-molecule ligands synergist

122 These results point to a model where roughly half the mRNA for certain translatio

123 homodimeric cis-PTase structures leads to a model where the elongating isoprene chain extends beyond

124 This points to a model where the in vivo influence on protein behavior is

125 We studied the RCAS/Tv-a model where RCAS-Cre, RCAS-PDGFB, and RCAS-H3.3K27M were

126 with the OOA dispersal, particularly under a model where deleterious mutations are recessive.

127 Under a model where selection is inversely related to dominance,

128 Our results are consistent with a model where altered risk at neighboring bases is linked

129 These results are consistent with a model where C(4) evolution in Neurachninae initially occ

130 We explain these results with a model where different allosteric mechanisms in the CNBD

131 These results are consistent with a model where direct interaction between HmpF and the T4P

132 These data are consistent with a model where filoviral VP35 proteins are the major suppre

133 ecovered in under an hour, consistent with a model where loop extrusion is rapid.

134 Our data are compatible with a model where multiple mRNA closed-loop complexes form wit

135 and residence time of POA consistent with a model where resistance occurs by destabilizing the close

136 Results are consistent with a model where SFPQ*NONO promotes sequence-independent pair

137 laser light scattering are consistent with a model where the DNA undergoes a conformational change to

138 at these results quantitatively agree with a model where the dynamics is governed by the competition

139 ous" behavior would not be consistent with a model where the electron and proton tunnel from a common

140 on of structural states is consistent with a model where the increased activity results from an incre

141 The findings are consistent with a model where the N terminus acts as a lever to support am

142 We propose a model, where DHX34 acts to couple RUVBL1-RUVBL2 ATPase a

143 These data lead to a signal activation model, where Arrow is required to localize Dsh to the me

144 However, new data suggest an alternative model where THEMIS enhances TCR signaling enabling thymo

145 but reveals attenuated effects in the animal model where adiposity is reduced naturally independent o

146 ing in a genetically tractable, whole-animal model where cannabinoid signaling at the molecular/neuro

147 terial system of a pre-clinical ovine animal model, where they endothelialized within one month and r

148 Studies in animal models where a single copy of the syntenic 16p11.2 regio

149 ions are often studied in cellular or animal models where their relative concentrations are not easil

150 upport viral replication in vivo, the animal models where macrophage-mediated replication of SIV is t

151 We tested our HLCs in animal models, where the presence of HAMEC in the clusters show

152 ity in a collagen antibody-induced arthritis model, where it showed biologic-like in vivo efficacy, w

153 These data support an assembly model where staged binding events cooperate to yield hig

154 We developed a mechanistic individual-based model where stigmergy-the deposition of signals into the

155 These findings support an RPA-based model where dissociation and re-association of individua

156 e quantitatively characterized by a Bayesian model where agents ignore expectancy violations that do

157 lymer microspheres were used as a biomimetic model where MNPs and MNP-decorated polymer conjugates we

158 ng algorithm based on the bag-of-words (BoW) model, where, by learning and recognizing the stimulus-d

159 seen in a long-term estrogen-deprived breast model, where significant downregulation of ERalpha prote

160 t of complex patient-specific cardiovascular models, where relative pressures into previously inacces

161 n growth rate dynamics, but that a carryover model where 'epigenetic' memory is imperfectly transmitt

162 We establish a RAS mutant cancer cell model where the autophagy gene ATG5 is dispensable in A5

163 ke a traditional international collaboration model, where individual-level patient DNA are physically

164 compulsive participants using computational models, where these enable a segregation between metacog

165 Our results lead to a conceptual model where Tau stabilizes the MT lattice by strengtheni

166 In Pavlovian conditioning models, where cues predict reinforcer delivery at a diff

167 oach can be extended to other animal disease models where macrophages are implicated and has potentia

168 In those Repeat Expansion Disease models where it has been examined, expansion is dependen

169 ee text] under the edit and Hamming distance models, where w is the size of the computer word; as suc

170 ian framework for specifying diversification models-where rates are constant, vary continuously, or c

171 We propose a population dynamical model where immunity can be both acquired and lost.

172 Here, we devise an opinion dynamics model where individuals are connected through a social n

173 ingful integration of viruses into ecosystem models where they act as key players in nutrient cycling

174 s was also revealed in a CRISPR gene-editing model where we demonstrate that the efficiency of gene i

175 ures allows us to construct a semi-empirical model where protocells are able to reproduce and undergo

176 approach in neuroscience relies on encoding models where brain responses are related to different st

177 umption in the literature on epidemiological models, where the incidence rate dictating propagation o

178 However, chemical reaction (master equation) models where the transcriptional transactivator and prom

179 ion of multicellularity with an evolutionary model where cells search for resources by chemotaxis in

180 In contrast to existing models, where Rgg2 proteins are transcriptional activato

181 We have developed an experimental model where genetically identical, co-housed Drosophila

182 This is one of very few models where autoimmune thyroid disease and hypothyroidi

183 lyses of population genomic data have fitted models where both these processes act simultaneously, to

184 ve data support a "serial synapse formation" model, where at any time point only 1-2 "synaptogenic" f

185 he transition density function for a general model where the effective population size, selection coe

186 ans is directly mirrored in a murine genetic model, where inbred mouse strains are differentially sus

187 this research into a 'ventrodorsal gradient' model, where frontal cortex engagement along this axis d

188 mat composition resulted in a revised growth model where coccoid cyanobacteria predominate in mat com

189 on spontaneous activity patterns: a Hebbian model, where coincident activity in neighboring populati

190 roposed procedure is based on a hierarchical model, where a structure-based prior distribution is des

191 ensemble of variations of this hierarchical model, where each model has a different configuration of

192 formulation of the classic sleep homeostasis model, where homeostatic pressure rises exclusively in T

193 We propose a homeostatic model where C. albicans disease pressure is balanced by

194 We propose a homeostatic model where genetic damage is automatically and continuo

195 connections between them; and a homeostatic model, where connections are homeostatically regulated t

196 ally for two- or three-dimensional hydraulic modeling, where traditional hydraulic models are infeasi

197 Overall, we put forward a hypothesized model where the similarity in chemical structure between

198 bservations were corroborated in the implant model, where there was decreased dissemination from an h

199 with axons, glial, or inflammatory cells in models where axonal degeneration or inflammation occur a

200 rpretation of mitochondrial perturbations in models where APP is overexpressed, and a potential role

201 many variants functions through independent model, where the pleiotropic variants directly affect lu

202 supported in a Galleria mellonella infection model, where exposure of S. aureus to LL-37 abolished th

203 irement was further observed in inflammatory models where DNA sensing via TLR9 contributes to disease

204 individual channels, we found that a kinetic model where apoCaM associates with channels before their

205 We introduce an Eulerian-Lagrangian model where hemodynamics is solved on a fixed Eulerian g

206 les integration of basecalling into a larger model where other parameters can be incorporated, such a

207 We introduce a social learning model where most participants in a network update their

208 In contrast to linear models where translation is largely limited by initiatio

209 used an experimental murine tail lymphedema model where sustained fluid stasis was generated on disr

210 Our approach is built on a hidden Markov model where the underlying process is a two-locus Wright

211 Our approach is based on a hidden Markov model where the underlying process is a Wright-Fisher di

212 ratory experiments we propose a mathematical model where the c-di-GMP network is analogous to a machi

213 ies have been studied in simple mathematical models where genotypes are represented as binary sequenc

214 We tested a new profit maximization model, where photosynthetic uptake of CO(2) is optimally

215 These findings offer a mechanistic model where during islet autoimmunity miR142-3p/Tet2-med

216 yme kinetics into constraint-based metabolic models, where kinetics have usually been ignored or over

217 a spatially explicit zero-sum metacommunity model where species have an elevation-dependent fitness

218 enhancers using a xenograft tumor metastasis model, where mutations are induced naturally via CRISPR/

219 We developed a mouse model where a congenital loss-of-function allele of Grin

220 ed tau-mediated neurodegeneration in a mouse model where activated microglia play a deleterious role.

221 Using a mouse model where encephalopathy of prematurity is induced by

222 Therefore, we developed a mouse model where ERalpha is reintroduced to be exclusively ex

223 Here we have developed a mouse model where light improves cognitive function, which pro

224 ME and thyroid cancer progression in a mouse model where thyroid-specific expression of oncogenic BRA

225 breast cancer, we generated a knock-in mouse model where binding of Pygo2 to H3K4me(2/3) was rendered

226 keletal muscle-specific Cpt1b knockout mouse model where the inhibition of mitochondrial fatty acid o

227 Here, we present a novel mouse model where the presence of a single autoreactive B cell

228 We generated a time-pregnant mouse model where WT and Dhcr7(+/)(-) embryos were maternally

229 ected hits were assessed in a T. cruzi mouse model, where 6a and 6b reduced parasitemia in animals >9

230 Utilizing the Emu-myc mouse model, where Myc is overexpressed specifically in B cell

231 Herein, we use a novel transgenic mouse model, where doxycycline-induced overexpression of vascu

232 el gut-to-brain alpha-syn transmission mouse model, where pathological alpha-syn preformed fibrils we

233 s, we generated genetically engineered mouse models where we can conditionally delete Stk11 and autop

234 Three independent mouse models, where myonuclear numbers were reduced by 75, 55,

235 iance were tested through a series of nested models where increasingly stringent equality constraints

236 Strikingly, a geometric network model, where distances are not Euclidean, predicts the m

237 cortex and compare it to a recurrent network model, where connectivity can be precisely measured and

238 Data support a new model where an LGP2-MDA5 oligomer shuttles NS3 to the mi

239 dinated sub-second signals, suggesting a new model where cholinergic population synchrony signals rap

240 These findings lead to a new model where inward forces generated by endocytic machine

241 Our measurements are described by a new model where the Poisson ratio drives transverse motion,

242 Our data support a new model where xylan biosynthesis and packaging into secret

243 correlations is predicted by a normalization model where MT units sum V1 inputs that are passed throu

244 these proteins follows a seeding-nucleation model, where a misfolded aggregate or 'seed' promotes th

245 articular injections of lubricin in a rat OA model where the inhibition of systemic inflammatory sign

246 fectious burden, and compared the results of models where pathogen overdispersion either was or was n

247 le Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles

248 ated a medaka (Oryzias latipes) osteoporosis model, where inducible expression of receptor-activator

249 These results support a pathogenic model where vestibular symptoms emanate from the vestibu

250 cal model based on existing network pathways/models, where each node can be interrogated by computati

251 sults suggest a supportive versus permissive model, where patterns of coordinated activity, rather th

252 ced into a target engagement pharmacodynamic model where it exhibited robust reversal of histamine-in

253 ollectively, these data suggest an RNA-poise model, where spatial proximity of RNA and DNA could pois

254 complexity of the one-strand-one-polymerase model where synthesis appears to be largely divided, but

255 lts were fitted to a second-order polynomial model where regression analysis and analysis of variance

256 ctivation, and present a minimal, predictive model where clustering receptors leads to their collecti

257 genetically tractable, mammalian predictive model, where cannabinoid signaling at the molecular/neur

258 size several recent findings into a proposed model where the transcription of lncRNAs can serve as gu

259 analysis in support of a previously proposed model where APOBEC activity is the underlying process th

260 Quantum models where a qubit travels back in time solve these pr

261 s which one is behaviorally manifest: a race model, where action selection and execution are closely

262 table in spinal tap biofluid from an ALS rat model, where its levels change as disease progresses, su

263 good agreement with a translocation ratchet model where binding of chaperones in the periplasm biase

264 We arrive at a comprehensive reaction model where the hydrogen-bond rupture with conserved aro

265 species, such replacement leads to a reduced model, where fast species are eliminated.

266 with shared characteristics; and meta-region models where inter-region transmission is expressed as a

267 gh two modelling approaches: parallel-region models, where epidemics in different regions are assumed

268 ed in the classical extinction-reinstatement model, where reinstatement is induced by reexposure to t

269 We propose an attachment-release model where Mlig-ap2 attaches to the substrate and Mlig-

270 lations are required for comprehensive river modeling, where a system of connected rivers is to be si

271 atomic structure, we propose a local seeding model where the kinked GGA motifs in the stem region of

272 these changes could be explained by a simple model where microstimulation has a stereotyped impact on

273 Such is the case, for example, in a simple model where overlapping particles are each given a small

274 Fungi are simple models, where compatibility is based on the recognition

275 ogical or medical studies: learning a sparse model, where only a subset of a large number of possible

276 roposed for studying collective quantum spin models, where the atomic internal levels mimic a spin de

277 CRs has been described in terms of two-state models where the receptor can achieve only a single acti

278 mages is estimated by first using stochastic modelling where the locations of clusters in the images

279 correlates with MA trimerization, suggesting models where MA lattices regulate CT interactions and/or

280 These findings revisit the model where neovascularization is considered to happen c

281 We consider a dynamic game-theoretic model, where a Nash equilibrium corresponds to a possibl

282 We present a general theoretical model where society is split into subgroups and people c

283 Using this model, where prosthetic and natural vision information a

284 thering front depth with pyrite, contrary to models where weathering fronts are stratified.

285 ent regime is hard to explain by traditional models where either infection numbers grow explosively u

286 izable and generalized pathogen-transferring model where pathogens dwell in and transferring (via con

287 vity are predicted by a concerted transition model where the binding of each GABAergic drug additivel

288 nted for by a formal single-level tunnelling model where the temperature dependence relies on the the

289 We therefore propose an updated model where MinE is brought to the membrane through inte

290 s of a hierarchical Bayesian latent variable model, where inference of differential misclassification

291 locomotion can be described by a random walk model where a fly's movement is described by its speed a

292 er to what we see in the field compared with models where competition is independent of body size.

293 ucleating granule formation, consistent with models where multivalent protein:RNA and protein:protein

294 ogical and genetic studies support a working model where rapsyn, a classic scaffold protein, serves a

295 We propose a working model where tethering orients SNARE domains for parallel

296 se in the estrogen-dependent MCF-7 xenograft model, where this effect was accompanied by a dose-depen

297 ndidates involved in flowering using a yeast model, where prion attributes are well defined and readi

298 ese effects were corroborated in a zebrafish model where fulvestrant inhibited neutrophil- and macrop

299 In contrast to the zebrafish model, where activation of gp130/Jak/Stat is sufficient

300 ation conforms to the classic "tension zone" model, where alleles are lost via reduced hybrid viabili