ライフサイエンスコーパス: modest effect

1 cretagogue effect, while proteins only had a modest effect.

2 ilar treatments with deoxygedunin had only a modest effect.

3 y relatively few genomic regions of small to modest effect.

4 les for diabetic retinopathy appear to be of modest effect.

5 use, the findings suggest that it only has a modest effect.

6 ot and a PPARbeta/delta activator had only a modest effect.

7 he bud neck-associated septin proteins has a modest effect.

8 ing the contribution of multiple variants of modest effect.

9 r treatment of the KB1050 biofilm had only a modest effect.

10 decreases in cholesterol levels have only a modest effect.

11 nitude of the average improvement suggests a modest effect.

12 er, but rather was due to the lack of even a modest effect.

13 dels, whereas loss of Akt1 or Akt2 have more modest effects.

14 een tested in the treatment of epilepsy with modest effects.

15 control) effects, whereas CO2 and N only had modest effects.

16 as agents administered individually had only modest effects.

17 es; brassinosteroid and gibberellin had only modest effects.

18 oving O(2) from the templating base had more modest effects.

19 large sample size requirements for detecting modest effects.

20 a shortened side chain for Leu-531 had only modest effects.

21 ositions -4, -9, and -11 for M-MuLV had more modest effects.

22 d to preserve the helical structure had more modest effects.

23 beta cell in adult mice reportedly has more modest effects.

24 valent mutations at the NBD1 socket had only modest effects.

25 We show here that loss of a c-Myb allele had modest effects (20%-28% decrease) on colony formation of

26 ected that risk involves multiple genes with modest effects acting independently or interacting.

27 wth of HR(+) cancer cells but exhibited only modest effects against tumor cells residing in the ECM n

28 redominant role played by common variants of modest effect and the diversity of biological mechanisms

29 verse outcomes, whereas Kineret exerted only modest effects and no benefit for gestation length, neon

30 risk variants likely to include hundreds of modest effects and possibly thousands of very small effe

31 olecules targeting these pathways have shown modest effects as monotherapies in patients.

32 o confer disease susceptibility, with only a modest effect at each locus.

33 t of extracted soy isoflavones, except for a modest effect at the femoral neck.

34 to investigate the presence of common allele modest effects at autosomal and chromosome X variants th

35 clic beta-sheets 1a and 1b only exhibit more modest effects at equimolar or greater concentrations.

36 Interventions that have even quite modest effects at the individual level could drastically

37 ured children and their parents have shown a modest effect, but additional research is needed to refi

38 prove adherence rates have demonstrated only modest effects, but lessons from these initial intervent

39 Most medical interventions have modest effects, but occasionally some clinical trials ma

40 s exist to identify susceptibility loci with modest effect by meta-analyzing together multiple studie

41 nd showed higher GSH than HSC(control), with modest effects by AA.

42 Whereas blocking either pathway triggers modest effects, combining a ?-secretase inhibitor to blo

43 While ICI alone had modest effects, DAC followed by either of ICI therapies

44 ng hexosamine biosynthetic pathway, but this modest effect did not fully account for the change in N-

45 ction in theta, alpha, and beta ranges, with modest effects during rule maintenance.

46 back pain, and duloxetine is associated with modest effects for chronic low back pain.

47 remains limited to short-term trials showing modest effects for chronic low back pain; trials were no

48 Further, the modest effects from several mutations suggest that there

49 Modest effects have been reported in some studies of old

50 ependent (CTL) levels, whereas having a more modest effect in decreasing ethanol consumption in CTL m

51 Thus, despite only having a modest effect in in vitro assays, opsonizing Ab had a dr

52 yridamole plus aspirin had a significant but modest effect in reducing the risk of stenosis and impro

53 ting the hypothesis that fructose has only a modest effect in relieving repression of frtA by FrtR.

54 opsis thaliana) deficient in phyB, but had a modest effect in the wild type.

55 not have any effect; TL2 mutation has only a modest effect in translation, but translation is reduced

56 Inhibiting single cytokines produced modest effects in clinical trials, in part because the c

57 iors in H-Agg animals, however yielding more modest effects in L-Agg animals; while high-dose DPAT ef

58 ny formation in methylcellulose but had only modest effects in liquid culture.

59 There were also only modest effects in reducing the progression of diabetic k

60 py with either bexarotene or DHA resulted in modest effects in vitro and in vivo, combined treatment

61 tribute to disease risk, each with generally modest effects independently.

62 Multiple common genetic variants of modest effect influence IL-6 concentration.

63 The relatively modest effect may reflect 50% dose reduction for each al

64 alleles: rs1800693 is a common variant with modest effect (odds ratio = 1.2), whereas rs4149584 is a

65 thioflavin-S positive tangles, suggesting a modest effect of anti-amyloid-beta immunization on tangl

66 Except for a modest effect of cystatin-C, no biomarker was associated

67 A modest effect of DHA + aspirin on Porphyromonas gingival

68 Despite the modest effect of FASN inhibition on tumor growth in xeno

69 with a sedentary lifestyle, we report a very modest effect of HIT and no effect of resistance trainin

70 There was no effect of surgeon volume and a modest effect of hospital volume (odds ratio for highest

71 Our findings show a modest effect of influenza vaccination on disease severi

72 randomized clinical trial (n = 663) found a modest effect of intensive dietary counseling for a low-

73 No or only a modest effect of local realignment was detected on the t

74 pol III repression by MAF1 and demonstrate a modest effect of MAF1 on global translation via reduced

75 s and suggests a molecular mechanism for the modest effect of myristoylation on binding, wherein the

76 Clinical trials have suggested a modest effect of naltrexone as a pharmacotherapy for alc

77 We here confirm a modest effect of purifying selection on the mtDNA coding

78 Despite the modest effect of survivin knockdown on tumor growth, red

79 greater than that for UL30 and explains the modest effect of the W780V mutation on foscarnet suscept

80 o the early termination of the trial, or the modest effect of treatment.

81 Coupled with previous reports showing modest effects of BRMS1 on adhesion and invasion, our re

82 ate cancer cell function as we observed only modest effects of chelation strategies on the growth of

83 The modest effects of clinical studies using intracoronary a

84 dox presented by our data by noting that the modest effects of crowding on elemental binding steps ar

85 The sample was too small to rule out modest effects of infliximab and included only patients

86 The bias was larger than expected given the modest effects of reward size on tracking of single targ

87 LS pharmacoresistance could both improve the modest effects of riluzole and set in motion a re-evalua

88 diation and Fe2+-EDTA/H2O2 showed relatively modest effects of sequence context on the proportions of

89 Modest effects of the catalyst nature on regioselectivit

90 Our data indicate that the modest effects of uroguanylin on energy and glucose home

91 the amino acid activation step, with only a modest effect on aminoacyl transfer.

92 circulating antinuclear antibodies and had a modest effect on anti-double-stranded DNA titers but sho

93 w that B-cell-specific deletion of Max has a modest effect on B-cell development but completely abrog

94 XAV939 had a more modest effect on beta-catenin protein, colony forming un

95 5/8S, and C221S, respectively, followed by a modest effect on C242S was observed.

96 Cd5 enhancer deletion also had only a modest effect on CD5 expression in the T lineage.

97 In contrast, Pat1 depletion had a modest effect on cell growth but caused progressive telo

98 Knockdown of OSR1 has only a modest effect on cell survival and does not lead to spin

99 ty expected that such RD&D would have only a modest effect on cost, but would improve performance in

100 anscription at most cellular genes but has a modest effect on cotranscriptional termination.

101 le data, there is evidence that rs4641 has a modest effect on diabetes susceptibility (1.10 [1.04-1.1

102 in digital mammography has a measurable but modest effect on diagnostic accuracy.

103 inheritance, many DNA sequence variants with modest effect on disease risk contribute to the genetic

104 hy descriptors of atherosclerosis had only a modest effect on downstream MFR.

105 Variation within PCLO may have a modest effect on early-onset type 2 diabetes, possibly a

106 as blockade of Hedgehog signaling has only a modest effect on EFT cells.

107 ow here that although T790M alone has only a modest effect on EGFR function, when combined with the c

108 vivo, whereas the loss of Raptor had only a modest effect on endothelial cells (ECs).

109 The mutation has only a modest effect on enzyme activity and on the diversion of

110 relative to alanine, glycine has only a very modest effect on equilibrium loop stability.

111 contrast, in breast CSCs, biguanides have a modest effect on glycolytic and TCA cycle intermediates,

112 tion of either GP2 glycan individually had a modest effect on GP expression and no impact on antibody

113 While siRNA for RhoA had a modest effect on growth inhibition, downregulation of Rh

114 We discovered that ASFV infection had only a modest effect on host miRNAs, with only 6 miRNAs differe

115 a species pairs, the X chromosome has only a modest effect on hybrid male sterility between D. virili

116 uch as Dual Specificity Phosphatase 1, and a modest effect on IL-10 secretion.

117 that of IL-13, but lack of gammac had only a modest effect on IL-4 signaling.

118 oid tissue, and blockade of E-selectin has a modest effect on improving long-term graft survival.

119 r mHS-3.5 in embryonic stem cells has only a modest effect on in vitro erythroid differentiation, whe

120 singly, absence of palmitoylation has only a modest effect on in vitro or in vivo signaling.

121 virus produced in fibroblasts but had only a modest effect on infection by virus from epithelial cell

122 f of the siRNA seed region have a relatively modest effect on knockdown potency.

123 trations (2.5-5 muM) of SFB had a relatively modest effect on LCSC-2 or 293 T cell growth, but damage

124 r results may explain why climate has only a modest effect on leaf economic traits in general.

125 The large amount of food given and the modest effect on linear growth in newborns suggests that

126 ural mechanism for estradiol alone to have a modest effect on mating behavior while setting the stage

127 rs58542926 is a low-frequency variant with a modest effect on NAFLD, suggesting that carriers of the

128 ha and ABT-737 alone or in combination had a modest effect on normal hematopoiesis but each individua

129 eatment, but thus far it has only provided a modest effect on overall survival benefits.

130 and demand--but these differences had only a modest effect on patient outcomes.

131 cate that, in general, mutations of small to modest effect on phenotype were involved.

132 into pretest atherosclerotic CVD risk has a modest effect on post-test atherosclerotic CVD risk.

133 ome quality improvement interventions have a modest effect on process of care measures but not on cli

134 SOCS3 has only a modest effect on promoting Brk degradation, and this req

135 nic perturbation of BARAC's aryl rings has a modest effect on reaction rate, whereas steric hindrance

136 e analyses, preoperative comorbidities had a modest effect on readmission; however, postoperative fac

137 nd new evidence that antioxidants may have a modest effect on reducing the dominant symptom in chroni

138 istration of desmopressin resulted in only a modest effect on renal concentrating ability.

139 duction in resection tract length has only a modest effect on repair of multiple, dirty DSBs in G2-ar

140 ion of the eye, ablation of Stra6 has only a modest effect on retinoid homeostasis and does not impai

141 n in the general population, and most have a modest effect on risk of RA (odds ratio approximately 1.

142 ffects of many alleles, each exerting only a modest effect on risk.

143 nuclease activity of the protein, and have a modest effect on RNA binding.

144 Overall, we propose a model wherein a modest effect on RNA splicing is sufficient to mediate t

145 hibited Akt phosphorylation, they had a very modest effect on S6rp and 4E-BP1 phosphorylation.

146 Heme binding had only a modest effect on SbnI enzymatic activity, suggesting tha

147 TG101348 treatment had modest effect on serum cytokine levels, but greater than

148 Neurobehavioral testing demonstrated a modest effect on spatial learning and memory in SAM-expo

149 creasing it by hyperosmotic shock has only a modest effect on stiffness, whereas defects in the dpy-5

150 th chemotherapy or radiation leads to only a modest effect on survival.

151 ho are homozygous for phe508del CFTR, with a modest effect on sweat chloride concentration.

152 The loss of T-bet had a modest effect on T cell production of IFN-gamma but did

153 ion of regulatory T cells (day 7) and only a modest effect on T-cell proliferation (48 to 96 h) in re

154 notyped for 14 known common gene variants of modest effect on T2D risk.

155 sing influences, ovule oversupply has only a modest effect on the degree to which lifetime seed produ

156 y binding of ligands to exosite I has only a modest effect on the E*-E equilibrium for this mutant.

157 of both RANKL and OPG, and IL-17 had only a modest effect on the expression of RANKL or OPG.

158 IL-1beta treatment showed a modest effect on the expression profile of miRNAs in nor

159 Expression of Miro1(KK) had a modest effect on the frequency of these Ca(2+) spikes bu

160 Our work suggests that EBV has only a modest effect on the GC process, which allows it to acce

161 Interestingly, although flupentixol had a modest effect on the immediate response invigoration pro

162 cine order in the heterologous regimen had a modest effect on the immune response.

163 xposure to silica dust or ox-LDL alone had a modest effect on the induction of foam cell formation an

164 mozygous deletion of Gab2 in mice had only a modest effect on the initiation of Neu-induced mammary t

165 inding constant for RNAP while having only a modest effect on the isomerization rate constant.

166 the enzyme for glycerolipids but had only a modest effect on the K(m).

167 n protein expression appeared to only have a modest effect on the kinetics of propagative IIF, and ev

168 al model, we show that the correlation has a modest effect on the mean evolutionary response and a la

169 In bipolar patients, older age had a modest effect on the metabolic syndrome rate.

170 t affect DNA methylation and only had a very modest effect on the release of transposable elements an

171 of HAdV-C5 in the liver, while it has only a modest effect on the replication of HAdV-C6.

172 Cholesterol has only a modest effect on the repulsive interactions between prot

173 general, genetic factors are known to have a modest effect on the risk of HL; however, familial risk

174 gesting that anti-VEGF injections may have a modest effect on the RNFL thickness after several years

175 kely has no effect on homodimerization and a modest effect on the secondary structure of echinT.

176 presence of the terminal carboxylates has a modest effect on the thermodynamic stability of the comp

177 that the presence of a carbon-rich PRB has a modest effect on the underlying soil microbial community

178 Only a modest effect on the whole-cell responses was observed b

179 With doctors experiencing no more than a modest effect on their work lives, open notes seem worth

180 with trametinib, a MEK inhibitor, had only a modest effect on these cultures.

181 A modest effect on transcript elongation and pausing was s

182 uced lytic replication of EBV but had only a modest effect on transcription activation function.

183 gy rather than infection and may have only a modest effect on transmission.

184 on translocation channel in MdtC has an only modest effect on transport yet in MdtB totally inactivat

185 Cottonseed extracts exhibited modest effect on TTP family gene expression in macrophag

186 y inhibited viral morphogenesis, with only a modest effect on viral gene expression, recapitulating a

187 t virus RNA replication or budding but had a modest effect on virus cell entry, indicating that the a

188 of the virus to promote FFWO, while having a modest effect on virus-cell fusion.

189 dual residues implicated in G4 binding had a modest effect on WRN binding to DNA, decreasing the pref

190 CCC inhibition had modest effects on [Cl(-)](i) and neuronal volume, but su

191 dies (SSGWAS) may fail to identify loci with modest effects on a trait.

192 isingly, absence of the TLR pathway had only modest effects on Ab production in an acute infection wi

193 alizations, whereas methamphetamine had only modest effects on affiliative behaviors.

194 ell self-renewal through deletion of Id1 has modest effects on animal survival, while knockdown of Ol

195 roduces additional stability with relatively modest effects on antigenicity.

196 sion and escape from interleukin-7 have only modest effects on B cell developmental transcriptional a

197 egies, multiple common genetic variants with modest effects on blood pressure (<1 mmHg systolic) have

198 int mutations in this loop have either no or modest effects on catalytic efficiency.

199 g and immunogenicity of PE-III but have only modest effects on CD4+ T-cell priming in mice.

200 Modest effects on cell viability and mitochondrial DNA w

201 We find that this additional term has modest effects on coarsening dynamics, but alters the st

202 , positions in the Fru-1,6-BP site exhibited modest effects on coupling between Ala and PEP binding.

203 nomodulatory therapies exist, they have only modest effects on disease progression.

204 The drug had modest effects on DNA fragmentation as a single agent at

205 ischemia around the probe tracks it had only modest effects on dopamine no-net-flux results.

206 productive transcription, while having only modest effects on either RNAP promoter association or th

207 ntrast, mutation of the Asn-67 site had only modest effects on enzyme stability and processing.

208 ing, and improved lung function but had only modest effects on eosinophilia.

209 urements to numerous mutants revealed fairly modest effects on gating kinetics despite significant ch

210 anslation, and the nonprotective IgM mAb had modest effects on gene expression.

211 However, there were modest effects on genes regulated by 'super-enhancers'.

212 A marked enteric neuronal loss with modest effects on GI function is found after buserelin t

213 terminal structure, the disulfides have only modest effects on global thermodynamic stability, and th

214 proteinuria and tubular injury but had more modest effects on glomerular pathology and podocyte numb

215 ctive concentrations of agonist but only had modest effects on glutamate and glycine EC50.

216 ll, and even severe alterations lead to only modest effects on growth proficiency.

217 nexpectedly, the switch I mutations had only modest effects on GTP binding and on GTPase activity and

218 SS20 had only modest effects on heart failure and this tracked with on

219 knockdown in nonphlebotomized mice had only modest effects on hepatic ferritin subunit levels and no

220 only minor defects in blood homeostasis and modest effects on HSC self-renewal.

221 DNMAML expression had modest effects on in vivo proliferation but preserved ov

222 Vitamin C had only modest effects on intracellular ROS and a more general c

223 Val131 or Val135 and glycine for Pro132 had modest effects on kinase activity, the introduction of b

224 continued expression of mutant Kras produced modest effects on life extension, whereas simultaneous d

225 However, mutation of Glu214 to Gln had only modest effects on ligand binding and catalysis.

226 A2 activity, PLA2G7 variants associated with modest effects on Lp-PLA2 activity were not associated w

227 eneficially affect abdominal AT loss and has modest effects on markers of MetS.

228 disturbance of the circadian clock had only modest effects on metabolic parameters.

229 Treatment with inhaled corticosteroids had modest effects on miRNA expression in steroid-naive asth

230 The results indicate that flooding has modest effects on mobility that are most visible at mode

231 IQ in the analysis, and the CNV only confers modest effects on other cognitive traits.

232 anergy in lymphocytes) in CD4+ T cells, with modest effects on other E3 ubiquitin ligases such as c-C

233 tein convertase subtilisin/kexin type 1 with modest effects on PC1/3 in vitro have been associated wi

234 PB1-F2 expression had modest effects on polymerase activity, PB1 accumulation,

235 HbA1C has modest effects on predicted atherosclerotic CVD risk whe

236 SFK blockade alone had modest effects on proliferation, but significantly enhan

237 yperactivation of transposable elements with modest effects on protein-coding gene expression.

238 anner; protein also stimulates insulin, with modest effects on reducing blood glucose.

239 y affect the compaction of chromatin and has modest effects on remodeling by SWI/SNF and RSC.

240 pression of pax6 in the eye anlage, but only modest effects on retinal cell survival.

241 Although each individual mutation has only modest effects on RPA activity, a form combining both ph

242 TOXCAT is insensitive to mutations that have modest effects on self-association in detergents but rea

243 rotocol dramatically altered SREBP-1 but had modest effects on SREBP-2 levels.

244 ound that checkpoint blockade alone had only modest effects on survival.

245 , but even high non-physiological doses have modest effects on synapses.

246 eas where bird numbers are highest will have modest effects on the availability of locations for powe

247 By contrast, ligand binding has only modest effects on the conformation and dynamics of the e

248 erythrocytic variants in aggregate had only modest effects on the diagnostic accuracy of HbA1c.

249 re state-managed invertebrate fisheries, but modest effects on the groundfish fishery because individ

250 kinetics of l-leucine inhibition, with some modest effects on the kinetic parameters of catalysis.

251 etion of either of the BRD4 bromodomains had modest effects on the metastatic suppression ability of

252 In contrast, these ASIC antagonists had only modest effects on the reflex in rats with freely perfuse

253 motor neurons in an SMA mouse model had only modest effects on the SMA phenotype and survival.

254 Dicer ablation had modest effects on the steady-state levels of spliced Xis

255 reveal that this lipid modification has only modest effects on the structure and hydration of S1-S4 d

256 loid formation, (the lag time), while having modest effects on the total amount of amyloid fibrils pr

257 eproduction of the angle of knee flexion had modest effects on the trajectory of pain and physical fu

258 Preculturing islets with ANXA1 had modest effects on their capacity to regulate blood gluco

259 e clock protein Period (PER) as well as more modest effects on Timeless (TIM).

260 '-fluoro substitutions in the mRNA have only modest effects on tRNA selection.

261 ough leading to genome instability, has only modest effects on V(D)J recombination or lymphocyte deve

262 RS2-dependent decay, ARS2 knockdown has only modest effects on viral gene expression 24 h after lytic

263 o not incorporate to full occupancy and have modest effects on virus replication and pathogenesis.

264 We show that CTD deletion has modest effects on yeast growth, but poly-SUMO conjugates

265 the guide+PAM region had measurable (albeit modest) effects on cleavage.

266 signal was largely due to multiple genes of modest effects (P = 4 x 10(-4), after removing known loc

267 n NSAIDs but not NSAID-like drugs, with more modest effects persisting after adjustment for potential

268 dnCNVs are found likely to contain multiple modest-effect risk genes.

269 To detect variants with modest effect size and discriminate among false positive

270 is not broadly generalisable, but must be of modest effect size and only observable in limited situat

271 Many different genetic variants of modest effect size are likely to contribute to the regul

272 (50%); however, multiple genetic variants of modest effect size are likely to contribute to this heri

273 ts is hampered by genetic heterogeneity, the modest effect size of many alleles, and the likely invol

274 oci from the GWA studies, that confer only a modest effect size, could harbour a significantly greate

275 o multiple genetic variants, each exerting a modest effect size.

276 es (GWAS) have identified common variants of modest-effect size at hundreds of loci for common autoim

277 ange (IQR) 21%-53%] and were associated with modest effect sizes [median odds ratio (OR) 1.33, IQR 1.

278 r thousands of associations characterized by modest effect sizes and miniscule P values.

279 s scepticism arises from such aspects as the modest effect sizes of associated variants and their unc

280 Despite the modest effect sizes of current GPS, quantile analyses il

281 e show that type 2 diabetes risk variants of modest effect sizes reduce the age at diagnosis in HNF1A

282 Due to modest effect sizes, large sample sizes of tens to hundr

283 With reasonable power to detect even modest effect sizes, the absence of genome-wide signific

284 Many signals identified by GWAS have modest effect sizes, useful for identifying novel biolog

285 with depression either are rare or have very modest effect sizes.

286 M disease susceptibility, although with more modest effect sizes.

287 large patient collections powered to detect modest effect sizes.

288 s and the mean squared error, especially for modest effect sizes.

289 nes affect BP in the general population with modest effects sizes (<0.05 standard deviation units), a

290 QTL exhibit modest effects that are mostly additive.

291 /b4 deletion) and a single common variant of modest effect (the gr/gr deletion) are largely responsib

292 tionally identify several previously unknown modest-effect trans-acting QTL (quantitative trait loci)

293 strongly enhanced (10- to 50-fold), while a modest effect (two- to threefold) is also observed for t

294 As LPS exerts modest effects upon IL10 mRNA stability, we hypothesized

295 of substituents to the phenyl ring has only modest effects upon the S...O bond strength.

296 had limited power to identify variants with modest effects, we carried out meta-analysis of three T2

297 Modest effects were observed in PDE4AKO mouse embryonic

298 More modest effects were observed in the other lobes, includi

299 treatments studied have produced minimal or modest effects, which are not sustained when the therapy

300 (2+) has no effect with 100 nm liposomes and modest effect with giant unilamellar vesicles.