ライフサイエンスコーパス: modification

1 arget accessibility or nature/extent of gene modification).

2 xoguanine, a commonly occurring oxidized DNA modification.

3 is loop, we also assessed the effect of this modification.

4 r analysis due to fragmentation and chemical modification.

5 proteins involved in this post-translational modification.

6 rther experimental investigation of DNA 6 mA modification.

7 gene-drive technologies for field population modification.

8 some basic assumptions about the ordering of modification.

9 es in the anticodon loop of hmtRNAThr to t6A modification.

10 ltaneously and find many cases of incomplete modification.

11 e particular arginine tRNAs destined for m3C modification.

12 strain-specific subsets of posttranslational modifications.

13 position and introduce protein-primary-level modifications.

14 demonstrating direct detection of epigenetic modifications.

15 regulatory function in SAGA-mediated histone modifications.

16 of nanopore sequencing to directly read DNA modifications.

17 ynamic range and modified to study other RNA modifications.

18 perturb ecological processes via behavioral modifications.

19 panding the current toolkit for studying RNA modifications.

20 istribution of data sources triggering these modifications.

21 wing and eye resulted in multiple phenotype modifications.

22 corticoid receptors and post-transcriptional modifications.

23 ty and functions associated with histone UBL modifications.

24 change the reduction potential of NBT after modification, (2) addition of S-nitrosothiols or beta- o

25 neuropsychologically-relevant architectural modifications across systematic reductions in consciousn

26 e importance of physical coupling of histone modification activities to promote epigenetic switching

27 fasciculus underwent additional evolutionary modifications affecting the temporal lobe connectivity p

28 point to distinct modes of potential disease modification: altering the rate of somatic expansion of

29 acid targets, ease of synthesis and chemical modification, amenability to be interfaced with signal a

30 quantitative accuracy for posttranslational modification analysis.

31 fts affirm the changes with surface chemical modification and biomolecular assembly.

32 strated with strategies for >25 types of DNA modification and damage.

33 demonstrated through site-selective protein modification and incorporation into kinase drug scaffold

34 transitional pH depended on both the type of modification and its position within the i-motif forming

35 licing regulation such as post-translational modifications and changes in the expression of splicing

36 While ETD retains modifications and cleaves disulfide bonds-making it attr

37 er microplastics in soil samples, but slight modifications and combinations of methods may prove prom

38 c inheritance via histone post-translational modifications and DNA methylation.

39 These data will guide future modifications and improvements of H129-based anterograde

40 s is directly related to human environmental modifications and is accelerating, having increased seve

41 netic regulators of DNA methylation, histone modifications and RNA methylation in adult F1 male teste

42 f O-GlcNAc and other cotranslational protein modifications and should stimulate an improved understan

43 genes is associated with specific chromatin modifications and transcription factors.

44 capacity of cells to regulate the formation, modification, and dissolution of aggregates.

45 ASIMOV is accessible to inspection, modification, and experiment, is adaptable as an educati

46 including the H2A.Z histone variant, H3K4me3 modification, and nucleosome positioning.

47 ing approaches to external encapsulation and modification, and summarize the most recent biomedical a

48 r in the anticommissural plication, Stanford modification, and Valsalva graft groups.

49 by sea level rise, subsidence, anthropogenic modifications, and changes to water and sediment loads.

50 DNA methylation, histone post-translational modifications, and chromatin structure regulation, are c

51 of the genome by chromatin proteins, histone modifications, and differential compaction is largely su

52 strain-specific structure, posttranslational modifications, and disease phenotype.

53 peptide/protein synthesis, posttranslational modifications, and DNA labeling.

54 odifications, chromatin remodeler-associated modifications, and DNA methylation) that contribute to r

55 ics include coactivator recruitment, histone modifications, and noncoding RNA transcription.

56 iew techniques such as mutagenesis, chemical modifications, and optogenetics that have been used to r

57 ending on redox state, pH, posttranslational modifications, and other factors.

58 including autoregulation, post-translational modifications, and protein compartmentalization.

59 repressive interactions, post-translational modifications, and protein-protein interactions.

60 These include DNA methylation, histone modifications, and regulation of transcription via non-c

61 ferential gene expressions, post-translation modifications, and signaling cascades.

62 al mCIM and eCIM testing methods; additional modifications appear required to differentiate GES-, IMP

63 Aberrant changes in epigenetic modifications are closely involved in drug resistance of

64 es of each step deleted, but also additional modifications are detected, indicating a certain plastic

65 Epigenetic modifications are increasingly recognized to play a role

66 The 3' modifications are modulated by pentatricopeptide repeat

67 er, impact and functional relevance of these modifications are poorly understood.

68 ate list of 34 genes responsible for mt-tRNA modifications are provided.

69 s responsible for regulating protein and DNA modifications are targets of current cancer therapies.

70 in 1 h; but the kinetics and distribution of modification around the DSB are significantly different.

71 bacteria, while phages have evolved covalent modifications as a counterdefense mechanism to protect t

72 We find a widespread increase in cytosine modifications at enhancers in PD neurons, which is partl

73 olecular motors featuring various structural modifications at the central aromatic core are presented

74 the acetyltransferases responsible for this modification belong to the Rim family of proteins.

75 The modification between G and T required the presence of PT

76 using on key approaches - including chemical modification, bioconjugation and the use of nanocarriers

77 as a transcriptionally repressive chromatin modification but the mechanism of repression remains unc

78 Epigenetic analyses reveal that histone modifications, but not DNA methylation, underlie exon-sp

79 We did not find effect modification by HFrEF or HFpEF status.

80 Alternatively, modification by K63-linked polyubiquitylation triggers a

81 We observed no effect measure modification by molecular subtypes (P for interaction =

82 R-MAS (1)H NMR spectroscopy and DNA cytosine modifications by LC/MS, in normal small intestines of C5

83 ins during SI and provide evidence that this modification can affect protein function.

84 This simple modification can dramatically affect the activities and

85 However, behavioral techniques and dietary modifications can be effective in treatment of IBS.

86 These modifications can be made from standard output with no n

87 In conclusion, pathological TDP-43 modifications can be mediated via multiple distinct path

88 ion, replication, DNA repair, and epigenetic modification, chromatin forms the nexus of most nuclear

89 xamined epigenetic mechanisms (e.g., histone modifications, chromatin remodeler-associated modificati

90 re we show that N(6)-methyladenosine (m(6)A) modification, contributing to different aspects of messe

91 erns of nucleosome positioning and chromatin modifications correlate with pA site usage, epigenetic f

92 s additional post-translational and chemical modifications could also be simultaneously detected by t

93 other cell cycle phases suggests that redox modifications could play prominent roles in regulating m

94 As a consequence, both chromatin and RNA modifications could serve as novel targets for the devel

95 ver, it remains elusive how these epigenetic modifications crosstalk.

96 ttle is known about the predominant cytosine modifications, cytosine methylation (5mC) and hydroxymet

97 signalling via different post-translational modifications, denoted as 'oxidative eustress'.

98 By contrast, the m42C modification disrupts the C:G pair and significantly dec

99 3 target genes may involve posttranslational modifications (e.g., phosphorylation and acetylation) an

100 had to be counteracted with further skeletal modifications, e.g. a ventrally curved mid to anterior p

101 for specialized equipment, and highly clear modification effects.

102 ransfer RNAs (tRNAs), tRNA synthetases, tRNA-modification enzymes, translation-initiation and elongat

103 and robust linear regression to quantify the modification extent of peptides.

104 ves with particular reference to its surface modifications, formulations aspects, pharmacokinetic beh

105 grounding to efficiently handle the numerous modifications found on RNA.

106 Loss of tRNA modifications frequently results in severe pathological

107 g the most recent designs being used to make modifications from as small as a single-base-pair change

108 otent than the S diastereomer and N-terminal modification generally lowers TLR2 activity.

109 ly emerged as a mild approach for amino acid modification, generating a sizable toolbox of reactions

110 xygenases that remove the repressive histone modification H3K27me3 and activate differentiation progr

111 The most potent ester modifications harbored unbranched C4 units, which engend

112 ation of the sulfur electrophile for protein modification has been ascribed principally to stabilizat

113 that regulate mRNA fate, covalent nucleotide modification has emerged as a major way of controlling t

114 Chemical modifications have myriad advantages over other treatmen

115 r metabolites to influence posttranslational modifications important to tumorigenesis and cancer cell

116 le stimuli are unable to induce any synaptic modification in 1.3 and 1.5 mM calcium and lead to depre

117 e is the most abundant and best studied mRNA modification in flowering plants.

118 of a hydroxymethylcytosine-like (5hmC-like) modification in P. falciparum asexual blood stages using

119 ulation of R-loops, implying a role for this modification in safeguarding genomic stability.

120 rsity of potential outcomes following Env375 modification in SHIVs.

121 inhibited prokaryote-like post-translational modification in the apicoplast; mimicking its activity a

122 No significant modifications in area parameters could be observed in GA

123 we extend a modular method for labeling base modifications in DNA to recognize all four bases involve

124 We profiled 7 histone modifications in embryonic hearts from each of 9 distinc

125 on of Buta toxicity is linked with favorable modifications in energy flux parameters of photosynthesi

126 on and leaf venation, suggesting substantial modifications in fine-root morphology during transitions

127 avior, we analyzed the circuits' response to modifications in single and multiple intrinsic conductan

128 Through small modifications in two key functional domains, HCNL1 evolu

129 growing number of diverse post-translational modifications including SUMOylation, phosphorylation, pe

130 thway, and for subsequent post-translational modifications including tyrosine sulfation and proline h

131 knowledge on the biogenesis of the RNA m(6)A modification, including the cis-regulatory elements and

132 Epitranscriptomic RNA modifications, including methylation of adenine and cyti

133 We show that feather modifications induced by unfamiliar carotenoids during a

134 ation (SDM) of arginine, a posttranslational modification involved in oncogenesis and embryonic devel

135 The role of post-transcriptional RNA modification is of growing interest.

136 he most prominent feature of microstructural modification is the formation of gas bubbles, which is r

137 The net result of this posttranslational modification is to render a viral protein with diminishe

138 chromatin proteins, DNA sequence and histone modifications is less understood.

139 This indicates that anthropogenic modifications leading to habitat fragmentation and a hig

140 ylation, chromatin accessibility and histone modification level, that can be partially recapitulated

141 shifted by unknown modifications, preventing modification localization and limiting the sensitivity o

142 ss a range of N-terminal posttranscriptional modifications (marks) to histone H3 lysines (H3K4me3, H3

143 s highlight that human induced environmental modifications may enhance genetic connectivity of malari

144 the nucleosome-based recognition and histone-modification mechanisms of NSD2 and NSD3, which could le

145 tly controlled by multiple posttranslational modification mechanisms, including ubiquitination and ph

146 njugation (SUMOylation), a posttranslational modification, modulates almost all major cellular proces

147 eddylation is the post-translational protein modification most closely related to ubiquitination.

148 ked amines with carbon-linked morpholines, a modification motivated by free energy perturbation (FEP+

149 at age-related loss of the posttranslational modification, O-linked beta-N-acetylglucosamine (O-GlcNA

150 Not only are previously established modifications observable by mass spectrometry in strains

151 NA damage responses, this post-translational modification occurs predominantly on serine residues(6-8

152 ut microbiota and human health indicate that modification of bacterial function could be a powerful t

153 is reaction provides a useful method for the modification of biaryl compounds because the nitrile gro

154 aL system as a tool for the precise chemical modification of cellular proteins with spatial and tempo

155 Modification of cellular substrates with linear polyubiq

156 gements, new crop introductions, and genetic modification of crop varieties that are resilient to cli

157 The evolutionary modification of development was fundamental in generatin

158 Both modification of diet in renal disease and Cockcroft-Gaul

159 Cytosine methylation of DNA is a widespread modification of DNA that plays numerous critical roles.

160 essive drugs and available studies reporting modification of drug regimens for specific infections.

161 s involved in multiple reactions, requires a modification of existing compound space ML-concepts.

162 promoter regions, suggesting that epigenetic modification of germ cell DNA may mediate transgeneratio

163 MIA-induced early gut dysfunction, including modification of gut microbiota composition and higher lo

164 ali metal layer presents a promising way for modification of high-capacity Li-rich cathode candidates

165 gacy information-technology infrastructures, modification of laboratory/pathologist workflows, approp

166 ion of proteins has been dominated by random modification of lysines or more site-specific labeling o

167 deiminases (PADI) catalyze posttranslational modification of many target proteins and have been sugge

168 may affect the mucosal immune system through modification of microbiota composition and their interac

169 quisite selectivity, thereby enabling facile modification of NCys-bearing proteins in complex biologi

170 Thus, modification of neuronal cholesterol trafficking and of

171 duals at higher genetic risk of mortality on modification of non-genetic factors.

172 n (S(N)(H)) was first applied for the direct modification of nonaromatic 2H-imidazoles to afford nove

173 Molecular tagging involves the selective modification of particular functional groups, inserting

174 those of other MM therapies and involves the modification of patient or donor T cells to target speci

175 though a myriad of methods now exist for the modification of peptides or proteins, many of these targ

176 stry to bacteriophage allows facile chemical modification of phage libraries, which greatly expands t

177 The late-stage modification of pharmaceuticals by this method was also

178 reasure trove will allow for the intentional modification of plant development for solving future pro

179 ed a previously unreported posttranslational modification of pp71, protein S-nitrosylation.

180 e-step, versatile strategy for the selective modification of protein N-termini with mass boosters.

181 The field of chemical modification of proteins has been dominated by random mo

182 m(5) C) is a post-transcriptional nucleotide modification of RNA found in all kingdoms of life.

183 on that, in many instances, involve chemical modification of samples prior to analysis.

184 n in myocardial repair and to investigate if modification of specific exosome cargo can rescue repara

185 Further, modification of the aloe-emodin with both the ethynyl an

186 single ionic white light emitter by a simple modification of the coordination environment.

187 allow for resynthesis and adaptive chemical modification of the glycocalyx.

188 Modification of the inhibitor with a cell-penetrating en

189 ed on (i) detuning of SPR as a result of the modification of the interfacial refractive index profile

190 d the jaw forward during sleep, and surgical modification of the pharyngeal soft tissues or facial sk

191 oned above were strongly associated with the modification of the secondary structure of shrimp protei

192 reaction allows valuable regioselective C-H modification of these N,O-chelated organoboron chromopho

193 Here, we have used the chemical modification of Trp9, site-directed mutagenesis, and cry

194 Here we report the modification of two peptides that comprise a coiled-coil

195 Finally, we identify specific genes where modification of uORFs likely represents an important dis

196 The m(6)A modification of viral RNAs renders RIG-I signaling less

197 The optimized chemical modifications of adenine base editor mRNA and guide RNA

198 gratory behavior does not require widespread modifications of brain structure, but might be achievabl

199 redox changes can mediate transient covalent modifications of cysteine thiols to modulate the activit

200 Furthermore, 2'F modifications of DNA NANPs significantly enhances RIG-I

201 visual search deficits were associated with modifications of FC between left and right inferior pari

202 inal adaptation, particularly in response to modifications of luminal content, including nutrients.

203 Therefore, genetic modifications of populations can be overwritten with new

204 ly used to characterize post-transcriptional modifications of ribonucleic acids (RNAs).

205 Such transformations are ascribed to modifications of the columnar organization of mushroom b

206 matory cytokines, and exhibit the epigenetic modifications of the FOXP3 gene enhancer CNS2, necessary

207 in interaction sites, and post-translational modifications of the two PA2G4 isoforms and relate these

208 Modifications of this regimen with the addition of novel

209 howed that ALKBH5 is able to erase the m(6)A modification on endogenous hTR.

210 increases its binding to heparan sulphate, a modification on neurexin.

211 ) 98%, P < .0001), but no significant effect modification on the association between asthma and lung

212 ious agents exhibiting the same carbohydrate modification on their surface coat.

213 Epigenetic modifications on chromatin play important roles in regul

214 Moreover, we show that chemical modifications on fungal oxyluciferin can affect the rela

215 molecules without the need for site-directed modifications or bio-orthogonal labels.

216 Without any material modifications or electrolyte optimizations, the gradient

217 nancy, altered maternal behavior, epigenetic modifications, or a combination of mechanisms, but they

218 The high rates of 2 or 3 treatment modifications over the 4-year period suggest an unmet ne

219 ns in the JAK/STAT, MAPK, MYC, and chromatin modification pathways.

220 ethyltransferase substrate specificities and modification patterns in rRNA, and highlight a different

221 RNA modifications play diverse roles in regulating RNA funct

222 Treatments include lifestyle modification, PPI medication, and laparoscopic fundoplic

223 ot consider fragment ions shifted by unknown modifications, preventing modification localization and

224 nefficient drug release, and require complex modification processes.

225 Precise and efficient genome modifications provide powerful tools for biological stud

226 nalyze cell-type-specific post-translational modification (PTM) signaling networks in organoids are a

227 ne methylation is a common posttranslational modification (PTM) throughout the human proteome that pl

228 nature and localization of posttranslational modifications (PTMs) affecting single amino acids and pe

229 nce and identification of post-translational modifications (PTMs) are key elements in protein structu

230 ones, OCN is subjected to post-translational modifications (PTMs) which control its activity.

231 nd recognition of histone post-translational modifications (PTMs).

232 ming, foreign nucleic acids e.g. restriction-modification (R-M) or CRISPR-Cas systems.

233 A phase variable type I restriction-modification (R-M) system (SpnIII) has been linked to a

234 Type I restriction-modification (R-M) systems consist of a DNA endonuclease

235 e CAR-T cell product, time for multiple cell modifications, redosing or combination of CAR T cells di

236 orylation is an essential post-translational modification regulating protein functions and signaling

237 We observed evidence of treatment effect modification resulting in inhibition of treatment effect

238 fies O-glycopeptides via an ion-indexed open modification search and localizes O-glycosites using gra

239 blocks with no post-translational and other modifications, showed predictable activation energy requ

240 Cysteine locks DndCDE-FeS to the modification site with an appropriate protein conformati

241 imination of endogenous NEDD8- and ubiquitin-modification sites by MS after Lys-C digestion and K-eps

242 ten contain multiple ligand binding sites or modification sites, which can operate to create an ultra

243 t into subunit diversity, post-translational modifications, stoichiometry, structural arrangement, st

244 deployment of this technology for population modification strategies.

245 erns and combining these designs with simple modifications such as 2'-OMe to the DNA gap resulted in

246 d by ligand binding or by post-translational modifications such as phosphorylation.

247 e encased DNA strands difficult, or chemical modification, such as covalent crosslinking of DNA stran

248 eir electronic properties through structural modifications, such as heteroatom doping or the incorpor

249 their genomes from R-M cleavage by covalent modifications, such as the hydroxymethylation and glucos

250 p in mapping host-influenced de novo lipid A modifications, such as those associated with antimicrobi

251 Restriction-modification systems are well-studied defense mechanisms

252 ase-variable Type I and Type III restriction-modification systems in multiple human-adapted bacterial

253 nt functions beyond the roles in restriction-modification systems, including the ability of affecting

254 engineered ENHANCE system with various crRNA modifications, target types, reporters, and divalent cat

255 IS's underlying theory and potential surface modification techniques are presented to further demonst

256 acetylation, an important post-translational modification that can regulate protein function.

257 ion kinase (FAK), a HDAC5 post-translational modification that controls its subcellular localization.

258 ion is a reversible post-translational lipid modification that dynamically regulates protein function

259 Thr-2 residue on EsxA, a post-translational modification that is present in mycobacteria but absent

260 s a highly abundant post-transcriptional RNA modification that plays important biological roles throu

261 somes has emerged as a new posttranslational modification that regulates protein synthesis during cel

262 DNA methylation is an epigenetic modification that specifies the basic state of pluripote

263 In addition, we demonstrated epigenetic modifications that might be responsible for the differen

264 Habitat modifications that stabilized resources, either by resou

265 well as prominent associations with histone modifications that typify active genes and enhancer elem

266 , we explored how different types of habitat modifications (that augment or decrease resource availab

267 estigate the effect of soft tissue phenotype modification therapy (PhMT-s) at sites with a tooth or a

268 haviour in response to anthropogenic habitat modification, though caribou data were limited.

269 alysis (TDA) consisting of Topological Image Modification (TIM) and Topological Image Processing (TIP

270 ese compounds are thought to act by cysteine modification to alter the functions of immune-relevant p

271 This finding suggests flagellin modification to reduce NLRC4 activation enhances protect

272 Current efforts mainly focus on surface modification to suppress this unwanted structural transf

273 mbiosis with Medicago spp., and the succinyl modification to this polysaccharide is critical.

274 l production systems based on cost-effective modifications to existing agronomic experiments.

275 uality of life signals, a larger trial, with modifications to improve participation and compliance, w

276 sible for the selective addition of specific modifications to the ascarosides.

277 RNA editing generates modifications to the RNA sequences, thereby increasing p

278 ignificant limitations that force nonoptimal modifications to upstream sample preparation steps, limi

279 tory processes including genome-wide histone modification, transcriptional regulation, and RNA proces

280 uman tRNA, we characterize over 20 different modification types simultaneously and find many cases of

281 Effect measure modification was explored via stratification on individu

282 By leveraging ENCODE data on chromatin modification, we identified features of chromatin enviro

283 genome-wide profiling of the H3K27ac histone modification, we identify neuron-subtype-specific regula

284 of re-writing enhancer-associated chromatin modifications, we show that enCRISPRa and enCRISPRi modu

285 siRNA potency was maintained when these modifications were incorporated at the tested positions

286 Other known posttranslational modifications were near or below our detection limit (e.

287 with a grid method and suggested that medium modifications were required to control regenerant variat

288 ied using the phosphorothioate (PS) backbone modification which enhances stability from nuclease medi

289 ns that span the indirect to direct band-gap modification which exhibit tailorable optical properties

290 ales robustly result in efficient population modification with >=95% of mosquitoes carrying the drive

291 A80-mediated actin N-terminal acetylation, a modification with a major impact on cytoskeletal dynamic

292 ventualities in ways that restore population modification with functional genes, is needed for long-t

293 as a fluorophore in an optical sensor after modification with molecularly imprinted polymers (MIPs)

294 Chemical modification with octenyl succinic anhydride (OSA) helps

295 has been recognized as a post-translational modification with pleiotropic effects that span from reg

296 ch combines structure probing using chemical modifications with direct long-read RNA sequencing and m

297 lular precision without the need for genetic modification, with laser energies lower than a hundred n

298 ch for studying nanoparticle physicochemical modifications within the GIT and the impacts of intentio

299 e reactivity into small molecules or protein modifications without perturbing their biological functi

300 To address this, here we describe a buffer modification workflow (BMW) in which the same sample is