ライフサイエンスコーパス: modification enzyme

1 g both as a transcription factor and an rRNA-modification enzyme.

2 to the complete bifunctional restriction and modification enzyme.

3 ain (TRD) of EcoKI, a type I restriction and modification enzyme.

4 when a target site is recognised by the core modification enzyme.

5 ification and confirm ZCCHC4 as the 28S rRNA modification enzyme.

6 in part, through SUMOylation of a chromatin modification enzyme.

7 or enhancers associated with various histone modification enzymes.

8 s has a family of phase-variable restriction-modification enzymes.

9 etic diseases map to genes encoding for tRNA modification enzymes.

10 resulfated heparin and revealed the critical modification enzymes.

11 A binding site of type I DNA restriction and modification enzymes.

12 tent inhibitor of type I DNA restriction and modification enzymes.

13 -binding domains associated with DNA and RNA modification enzymes.

14 at were largely due to disruption of the LOS modification enzymes.

15 omeostasis and disease are controlled by RNA modification enzymes.

16 0a, showcasing a functional redundancy among modification enzymes.

17 from that of other ATP-dependent restriction-modification enzymes.

18 hed the Ae. aegypti genome for candidate DNA modification enzymes.

19 f target recognition by Type ISP restriction-modification enzymes.

20 on changes with charge alterations caused by modification enzymes.

21 rbohydrate in conjunction with several sugar-modification enzymes.

22 chaperones, foldases, and post-translational modification enzymes.

23 g three novel targets for type I restriction/modification enzymes.

24 DNA-binding groove of Type I DNA restriction/modification enzymes.

25 ing multiple hematopoietic TFs and chromatin-modification enzymes.

26 by regulation of cell envelope synthesis and modification enzymes.

27 sitive to the relative composition of the HS modification enzymes.

28 ctivities of other protein posttranslational modification enzymes.

29 rough a dynamic interplay with other histone-modification enzymes.

30 ng enzymatic corepressors, including histone modification enzymes.

31 gulation mediated by G9a and other chromatin modification enzymes.

32 omain that is found in several tRNA and rRNA modification enzymes.

33 ription, and in the action of DNA repair and modification enzymes.

34 es gene activation via coupling with histone modifications enzymes.

35 Using the EcoR124I restriction-modification enzyme, a 3'-5' double-strand DNA (dsDNA) t

36 itude lower than that of other purified tRNA modification enzymes, a Kmapp (DMAPP) = 632 nM, and a kc

37 may serve as a functional paradigm for other modification enzymes acting late in 30S biogenesis.

38 Here we test the hypothesis that RNA modification enzymes also act as RNA chaperones.

39 text of substrate competition between La and modification enzymes, also highlighting subcellular loca

40 te, and the ksgA gene, which encodes an rRNA modification enzyme and is partly cotranscribed with pdx

41 nderstanding of ribosome recognition by rRNA modification enzymes and present a more complete structu

42 ns for recognition of tRNA by processing and modification enzymes and quality control of tRNA in cell

43 that connects RNA polymerase I with ribosome modification enzymes and remodels the translational prog

44 transcription factors and this family of RNA modification enzymes and that h-mtTFB may perform dual f

45 quires the sequential recruitment of histone modification enzymes and the general transcription facto

46 e complexity of substrate recognition by RNA modification enzymes and the potential for direct involv

47 e in vivo interactions between the chromatin modification enzymes and their actual nucleosomal substr

48 a of chromatin-remodeling complexes, histone-modification enzymes and transcription elongation factor

49 target sequence and which is present on the modification enzyme, and a region on each DNA cleavage s

50 to an F-box protein and recognition by early modification enzymes, and the effect of binding is dimin

51 nes had homology to putative DNA restriction-modification enzymes, and two had homology to putative m

52 d auxiliary metabolic functions, restriction modification enzymes, and virion structural proteins, al

53 I3K/Akt, Hippo, Wnt, and multiple epigenetic modification enzymes are also detected.

54 We discuss the likelihood that other RNA modification enzymes are also RNA chaperones.

55 Type I restriction-modification enzymes are differentiated from type II and

56 very similar, although the overall levels of modification enzymes are higher.

57 model organism Escherichia coli not all tRNA modification enzymes are known.

58 Lipid A modification enzymes are reporters for lipopolysaccharid

59 The S subunits of type I DNA restriction/modification enzymes are responsible for recognising the

60 The prokaryotic Type ISP restriction-modification enzymes are single-chain proteins comprisin

61 the key roles of tRNA modifications and tRNA modification enzymes as checkpoints for tRNA integrity a

62 o-EM) structures of the Type IIB restriction-modification enzyme BsaXI.

63 ying disruptions in genes encoding chromatin modification enzymes, but are not significantly expresse

64 d linker (i) makes pentapeptide available to modification enzymes by separation from the helical rece

65 ly, evidence has emerged that bacterial tRNA modification enzymes can act as tRNA chaperones to guide

66 nctional data indicate that specific histone modification enzymes can be key to longevity in Caenorha

67 was unaffected by the presence of the methyl-modification enzymes, CheB and CheR, or the coupling pro

68 imilarity between the two companion receptor modification enzymes, CheB and CheR, suggests an evoluti

69 The Type I restriction-modification enzymes comprise three protein subunits; Hs

70 rize the impact of the loss of specific tRNA modification enzymes, confirming the hypomodification-as

71 of both type I and type III restriction and modification enzymes contains motifs characteristic of D

72 The type I restriction and modification enzymes do not possess obvious DNA-binding

73 the result of differential expression of key modification enzymes during oligodendrocyte differentiat

74 subunit of the bacterial Type I restriction-modification enzyme EcoKI during restriction alleviation

75 tivity of a helicase, the Type I restriction modification enzyme EcoR124I.

76 Likewise some tRNA modification enzymes either require iron-sulfur clusters

77 LlaGI is a single polypeptide restriction-modification enzyme encoded on the naturally-occurring p

78 f Mycoplasma pulmonis encode restriction and modification enzymes exhibiting a high degree of sequenc

79 As histone modification enzymes, EZH2 mediates H3K27 trimethylation

80 s unclear is how specific members of histone modification enzyme families, such as histone methyltran

81 equires the sequential production of the new modification enzyme followed by the restriction activity

82 We screened mutants of several RNA modification enzymes for an effect on RpoS expression an

83 w the genes encoding the terminal structural modification enzyme GSL-OH evolved across the Brassicace

84 alA1 and HalA2 are processed by the purified modification enzymes HalM1 and HalM2 in an in vitro reco

85 A long-term goal in the field of restriction-modification enzymes has been to generate restriction en

86 Only 48% of the candidate cytosolic tRNA modification enzymes have been experimentally validated

87 indicating that most, if not all, of the end modification enzymes have been identified.

88 Pathogenic variants in tRNA-modification enzymes have been implicated in a wide rang

89 nnections between these proteins and histone modification enzymes have emerged as a common theme, imp

90 Small molecule inhibitors of RNA modification enzymes have shown potent anti-proliferativ

91 Additional gene products, such as chromatin modification enzymes, have unanticipated effects on pre-

92 ed that SUPT16H-BRD4 associates with histone modification enzymes (HDAC1, EZH2), and further regulate

93 lar RNAs are chemically modified by many RNA modification enzymes; however, often the functions of mo

94 nce that exposure to an inhibitor of histone modification enzymes implicated in epigenetic control of

95 G37) methyltransferase) is an essential tRNA modification enzyme in bacteria that prevents +1 errors

96 nthase 1 (Pus1p) is an unusual site-specific modification enzyme in that it can modify a number of po

97 titative rate analysis for posttranslational modification enzymes in complex milieus for native subst

98 on and thereby extend the list of known tRNA modification enzymes in E. coli.

99 for the role of haploinsufficency of histone-modification enzymes in multiple-congenital-anomaly synd

100 These data implicate histone modification enzymes in suppressing DC-derived IL-12, wh

101 lmost all of the genes coding for the t+rRNA modification enzymes in the mesophilic moderate halophil

102 than for the minimal system of receptor and modification enzymes in vitro.

103 was linked to increased transcription of LOS modification enzymes, including the product of the crypt

104 Because the modification enzyme is not present in prokaryotes, no na

105 Targeting of protein modification enzymes is a key biochemical step to achiev

106 sion of two translocating Type I Restriction-Modification enzymes is not fully understood.

107 s facilitate enzymatic activities of histone modification enzymes is unclear.

108 is study demonstrates that levels of histone modification enzyme KDM5B determine hyperactivation of P

109 eave DNA, the single polypeptide restriction-modification enzyme LlaGI must communicate between a pai

110 domain of the single polypeptide restriction-modification enzyme LlaGI reveals amino acid motifs char

111 strate that the related Type ISP Restriction-Modification enzymes LlaGI and LlaBIII can cooperate to

112 Heterologous expression of lipid A modification enzymes may enable the development of new v

113 We suggest that histone modification enzymes may re-establish the histone code o

114 oteins, transcription factors (TFs), histone modification enzymes, Mediator, and factors involved in

115 subcellular distribution of Mod5p-I, a tRNA modification enzyme, member of the sorting isozyme famil

116 connecting the intracellular localization of modification enzymes, metabolites and tRNAs to codon sel

117 ygfZ reduced the activities of the Fe/S tRNA modification enzyme MiaB and certain other Fe/S enzymes,

118 Although not required for growth, the modification enzymes modulate virulence of some gram-neg

119 e of a new sub-classification of Restriction-Modification enzymes, named Type I SP (for Single Polype

120 s of cell stress, the type I restriction and modification enzymes of bacteria show reduced, but not z

121 The type I DNA restriction and modification enzymes of prokaryotes are multimeric enzym

122 NA element that regulates downstream encoded modification enzymes of queuosine biosynthesis.

123 trast, is a 1105-aa Type IIC restriction-and-modification enzyme, one of a family of Thermus homologs

124 rategy by which many poorly understood lipid modification enzymes operate.

125 cids, are performed using post-translational modification enzymes or incorporation of unnatural amino

126 be reported that encodes a posttranslational modification enzyme, palmitoyltransferase.

127 r (TF) binding motifs, and several chromatin modification enzymes preferentially interact with these

128 em couples three different posttranslational modification enzymes, prohormone convertases (PCs), carb

129 Type I DNA restriction/modification enzymes protect the bacterial cell from vir

130 downstream of the gene encoding its putative modification enzyme, RamC.

131 some biogenesis requires the presence of the modification enzyme rather than its RNA-modifying cataly

132 acteriophage DNA by the Type III restriction-modification enzymes requires long-range interaction bet

133 of synthetic interactions with several tRNA modification enzymes, resulting in temperature-sensitive

134 or how the biophysical properties of histone modification enzyme-RNA interactions impact chromatin fu

135 mutant strains and those lacking diphthamide modification enzymes showed increased -1 frameshifting.

136 A global survey of tRNA modification enzymes shows that the functional constrain

137 search unifying parameters such as variable modifications, enzyme specificity, number of allowed mis

138 ein-protein interactions, post-translational modifications, enzyme-substrate relationships and diseas

139 tein-protein interactions, posttranslational modifications, enzyme/substrate relationships, disease a

140 hen a mutation in TRM6, which encodes a tRNA modification enzyme subunit, was combined with the delet

141 Acps also include modification enzymes such as proteases and their inhibit

142 eshold, in opposite direction to that of the modification enzymes suggesting that the latter reduce S

143 eudouridine synthase PUS7 is a versatile RNA modification enzyme targeting many RNAs thereby playing

144 lusters by genes encoding post-translational modification enzymes that carry out lantibiotic-type deh

145 hese results support the hypothesis for tRNA modification enzymes that combine catalytic and noncatal

146 dentify a new subgroup of Type I Restriction-Modification enzymes that modify cytosine in one DNA str

147 e to DNA methyltransferases and to epigenome modification enzymes that typically operate in active ch

148 identified a binding site for the chromatin modification enzyme, the SET Domain Bifurcated Histone L

149 nction as a substrate for post-translational modification enzymes, the largest family being the poly-

150 f the hexa-acylated lipid A species, several modification enzymes then function to produce the major

151 binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of

152 The tRNA modification enzymes ThiI (in bacteria and archaea) and

153 th the role of At1g24340 as a benzenoid ring modification enzyme, this metabolic blockage could not b

154 o employed by various maturation factors and modification enzymes to assure the selection, recognitio

155 resent the first natural pair of restriction-modification enzymes to be characterized in atomic detai

156 ng the interaction site for the adaptational-modification enzymes to the carboxyl terminus of induced

157 DNA-modifying homolog of a tRNA-deazapurine modification enzyme, together with four 7-cyano-7-deazag

158 tein, denoting the strict specificity of the modification enzymes toward the substrate protein.

159 ransfer RNAs (tRNAs), tRNA synthetases, tRNA-modification enzymes, translation-initiation and elongat

160 Generally, modification enzymes use substrates derived from intrace

161 in peptides and extends the paradigm of RiPP modification enzymes using not only unstructured peptide

162 several HS core proteins, biosynthesis, and modification enzymes was increased in OA cartilage, wher

163 base-pairs, almost identical to that of the modification enzyme which makes up the core of EcoKI.

164 gene cassettes encode several aminoglycoside modification enzymes, which correlate with most of the a

165 A type I restriction-modification enzyme will bind to an unmethylated target

166 othesized that HpyIII, a type II restriction/modification enzyme with sequence homology to MboI, medi

167 to encode a 49-amino-acid peptide (YydF), a modification enzyme (YydG), a membrane-embedded protease