ライフサイエンスコーパス: modify

1 , whereas cleavage by ADAM proteases was not modified.

2 ically, around 40% of susceptible motifs are modified.

3 ermined by the specific lysine residue being modified.

4 Finally, we modified a proximity ligation assay for tissue sections

5 To address this question, we modified a regulatable fluorescent secretory cargo by ad

6 olchicine alkaloids and their analogues with modified A, B, and C rings, as well as hybrid compounds

7 nd binding, covalent inhibitors irreversibly modify a proximal nucleophilic residue on the protein vi

8 h careful chemical design, it is possible to modify a psychedelic compound to produce a safer, non-ha

9 The new polymer was utilized for modifying a GCE to generate a new electrochemical sensor

10 s poorly understood, and whether its histone-modifying activities are required for transcriptional re

11 While m(6)A-modified adenoviral RNAs have been previously detected,

12 ocurement and Transplantation Network (OPTN) modified adult heart allocation to better stratify candi

13 adhesion force of a positively polarized PDA-modified AFM-SECM probe was 6.2 +/- 2.2 nN, and it was a

14 y of CRT with a defibrillator (CRT-D) may be modified after the development of the first hospitalizat

15 tions, accounting for 9% of heritability and modifying age of diagnosis as well as aggressiveness; 18

16 tage disease should not be treated with bone-modifying agents to prevent recurrence, but could still

17 ng a sizable toolbox of reactions capable of modifying almost all of the canonical amino acids.

18 ystal structures of inactive MCR lacking the modified amino acids were indistinguishable from the ful

19 Our results illustrate that an extrinsic cue modifies an intrinsic temporal program to increase neuro

20 We modify an ocean model to simulate submarine iceberg melt

21 1T-MoS(2) and single-atom modified analogues represent a highly promising class of

22 s the primarily cytosolic sirtuin Sirt2, are modified and inhibited by cysteine S-nitrosation in resp

23 volved in such an event has been genetically modified and, if modified, to infer from its genetic seq

24 By modifying and calibrating an active vertex model to expe

25 By modifying Arioc's implementation to exploit this GPU mem

26 Acid-base conditions modify artery tone and tissue perfusion but the involved

27 e that previous conservation units should be modified, as clear genetic breaks do not exist beyond th

28 X-ray crystal structures of variously modified ASL(Arg1)(ICG) and ASL(Arg2)(ICG) constructs bo

29 lyses reveal that HIPK2 is at least O-GlcNAc modified at S852, T1009, and S1147 residues.

30 detection ranging from 1 to 50 nM, the AuNPs modified Au chip was proven to clearly be a better analy

31 recruits organelle-associated reads using a modified "baiting and iterative mapping" approach, condu

32 ostere of CF(3) and Et (BITE) in a series of modified barbiturate inhibitors.

33 since teeth penetrate the oral epithelium, a modified barrier has evolved, called the junctional epit

34 in vitro, suggesting that PPR65 cannot bind modified bases due to differences in the structure of th

35 t of the inhibitory synapse, in the NAc that modifies behavioral coping mechanisms and stress resilie

36 LPMOs modify biomass by oxidatively cleaving polysaccharides,

37 The modified biosensor also offered its credibility towards

38 nding of LBL-lipid interactions and create a modified BoNT/B with improved therapeutic efficacy.

39 w report that (1) S-nitrosothiols covalently modify both NBT and TNBT, but only change the reduction

40 The association of LA LGE with voltage is modified by ablation.

41 ons between enteric pathogens and death were modified by acute malnutrition.

42 charges on each end of the bridge and can be modified by altering these charges.

43 The effect was modified by CD4 cell count with protection conferred if

44 e, we tested whether these associations were modified by cerebral white matter hyperintensity (WMH) b

45 mple, and whether any such associations were modified by current asthma, current hay fever, pollen se

46 t that the microbiome-gut-immune axis can be modified by DEHP and emphasize the value of multiomics a

47 The SAM Au chip was sequentially modified by EDC-NHS crosslinkers, grafting of protein-A

48 hat the association between 9p21.3 and MI is modified by glucose homeostasis and lifestyle.

49 ical interventions, and information is often modified by individuals before being forwarded.

50 However, the neurophysiological processes modified by nesting remain poorly understood.

51 al representations of external stimuli to be modified by previous experience is critical for efficien

52 The effect of rs10830963 was not modified by shift work schedules.

53 , in which the gamma-phosphate is covalently modified by two different biodegradable masking units, o

54 vidence that its analgesic efficacy might be modified by variants of the catechol-O-methyltransferase

55 and organophosphorus hydrolase (OPH) enzyme-modified carbon paste (CP) microneedle electrodes for sq

56 gets, while enzymatic suppressors covalently modify Cas ribonucleoprotein complexes or degrade immune

57 n into Ir-H, the reaction proceeds through a modified Chalk-Harrod mechanism, starting with selectivi

58 h using a Cre-dependent virus in genetically modified ChAT::Cre rats, a species used for this manipul

59 gene expression by chemically and physically modifying chromatin.

60 The modified cleaning procedure is environmentally friendly

61 ssociated with secondary vaccine failure and modified clinical illness, is emerging in Victoria with

62 tify the lineage output and dynamics of gene-modified clones; this is usually challenging because of

63 , or Ph arm substituents are obtained, and a modified condensation method produced alpha-Me beta-Me c

64 e results demonstrate that ClpXP degradation modifies conformational assemblies of MinD in vitro and

65 ribute to disease heritability by tending to modify constrained functional sequence.

66 seeking and taking during abstinence using a modified context-induced reinstatement procedure, a rat

67 e important in future studies of genetically modified crickets for improved food production, includin

68 cetamide (alphaCA) compounds that covalently modify cysteine-54 (C54) of the MPC2 subunit of the mito

69 OGT is the only glycosyltransferase that modifies cytoplasmic and nuclear protein by transfer of

70 nal activity-regulated role for microglia in modifying developmental myelin targeting by oligodendroc

71 on of the subthalamic nucleus differentially modifies different oscillatory activities in a widesprea

72 Thus, there is an unmet need for disease-modifying drugs.

73 , when synaptic connectivity is continuously modified due to noise or storage of other patterns, simi

74 E increases the diagnostic capability of the modified Duke criteria.

75 Two symptom-medication scores were used: the modified EAACI CSMS score and the MASK control score for

76 Secondary endpoints were: hemispheric space-modifying edema, infarct growth between per-occlusion an

77 ates protease activity and NET formation and modifies efferocytosis.

78 The high stability observed with the modified electrode for prolonging period indicated that

79 A-MWCNT/Hyalu/l-Cys and A-MWCNT/Hyalu/l-Ser modified electrodes.

80 acids were indistinguishable from the fully modified enzyme, suggesting that interactions between th

81 ated the role of sphingolipids and the lipid-modifying enzyme sphingomyelin phosphodiesterase acid-li

82 Recently, DNA-modifying enzymes (Taq DNA polymerase, Phi29 DNA polymer

83 Histone-modifying enzymes are implicated in the control of diver

84 egation 3-9 homolog 2 (SUV39H2), key histone-modifying enzymes involved in promoting reduced chromati

85 zygous loss-of-function mutations in histone-modifying enzymes may cause severe neurodevelopmental di

86 of two computationally selected and cysteine modified epitopes of neuron specific enolase (NSE), as-s

87 Indeed, O-glycopeptides modified exclusively at the N-terminus would enable O-gl

88 ns and developmental processes can evolve by modifying existing genes or creating novel genes.

89 tailed understanding is required to engineer modified FA production in oilseeds and suggest that phos

90 The study confirms that using GO modified fiber optic probe, the sensitivity is enhanced

91 velop phosphorylated hCT analogs that showed modified fibrillation that depended on phosphorylation s

92 ine functions at controlled positions in the modifying film, strong CO(2) adsorption and hydrogenatio

93 antitatively on admission CT scans using the modified Fisher scale (grades: 0, no radiographic hemorr

94 (-1) and 128.3 ug L(-1), respectively in the modified flask basal broth (MFBB) under shaking conditio

95 crobiome might be used for CRC screening and modified for chemoprevention and treatment.

96 ese problems can be resolved with a slightly modified form of the MM rate law, based on the total qua

97 y sniffers, after migration assay, with high modified frequency (between 50 and 78%), what could chan

98 The morphology of silicon particles is modified from massive polygonal and plate-like to a mixt

99 that in vivo AtN conversion may be a disease-modifying gene therapy to treat HD and other neurodegene

100 opportunity for transposons to mobilize and modify genomes, driving evolutionary change without subs

101 mic inflammatory response as measured by the modified Glasgow prognostic score (mGPS) and the neutrop

102 /background ratio compared to a common epoxy-modified glass substrate.

103 costs on the production side of genetically modified (GM) and organic corn systems in Minnesota, USA

104 ic agents that combine an optimized affinity-modifying group and optimized albumin binders to maximiz

105 When the modified Haigis-L formula considering spherical aberrati

106 duced in 4 out of 17 (23.5%) patients in the modified high-dosage group.

107 m regulates the DNA damage response (DDR) by modifying histone H2A at Lys15 (H2AK15ub) and triggering

108 in) that dock to DNA or post-translationally modified histones and a caspase activation and recruitme

109 the protein PARP1 and its paralogue PARP2 to modify histones and other substrates through the additio

110 arly acting, renoprotective injury response, modifying immune cell actions.

111 During the Delphi process, most items were modified in order to reach consensus.

112 MS analysis revealed that Pif1 was modified in several domains throughout the protein's seq

113 uid and even the microfluidic channel can be modified in this model.

114 lymerases, nucleases, and other enzymes that modify incompatible DNA ends to allow their ligation.

115 the preparation and use of a thin metal film modified Indium Tin Oxide (ITO) electrode as a highly co

116 Treatment of mice with an ATXN2 ASO also modified innate immunity, the complement system and lyso

117 treated with axi-cel and were included in a modified intent-to-treat (mITT) analysis.

118 We performed a modified intention-to-treat analysis on 231 patients (11

119 included 159 randomized participants in the modified intention-to-treat analysis, with 80 allocated

120 [86%] in 400 mg group) were included in the modified intention-to-treat maintenance phase population

121 Activity and safety were assessed in the modified intention-to-treat population (ie, patients who

122 [100%] in 400 mg group) were included in the modified intention-to-treat population, and 397 (102 [94

123 Safety was assessed in the modified intention-to-treat population.

124 A conventional DnCNN was modified into a guided DnCNN, which uses the low b-value

125 ied fin and a lower portion with rays highly modified into specialized filaments.

126 the p(HEMA-GMA) cryogels were systematically modified into strong and weak cationic groups.

127 and most pronuclei were defined, which were modified into the definitive nuclear configuration throu

128 while their synergistic actions successfully modified its structure reflecting in lowered viscosity.

129 imal residual disease (MRD) negativity using modified ITT was 70% according to next-generation sequen

130 We used a modified Kaplan-Meier analysis, accounting for the compe

131 In highly modified landscapes, spatial nutrient transport theory s

132 The design of the azobenzene-modified linking DNA is critical and involves complement

133 he targeting liposomes containing 10 mol% GM-modified lipids increased the accumulation of the conjug

134 xemplified by faster accumulation of glycine-modified lipopolysaccharide (LPS) and depletion of outer

135 (S) and C'EK(S)K(S) (K(S) = S-aroylthiooxime-modified lysine, C' = citrulline, and E = glutamic acid)

136 The structure of DslA reveals a modified lysozyme superfamily fold, with several adaptat

137 ped next-generation viscosifiers-organically modified magnesium silicates (MSils)-for reservoir drill

138 the immunomagnetic separation with antiCD81 modified magnetic particles and the labeling based on CD

139 Modifying material properties at the nanoscale is crucia

140 n 58 adults with active mild-to-moderate UC (modified Mayo scores 4-10, endoscopic subscores >=1).

141 observed when the assay was performed on Ab-modified MBs, and E. coli could be quantified in tap wat

142 essed TGF-beta signaling as a shared seizure-modifying mechanism.

143 Here, using a modified method of single-cell analysis for somatic L1 i

144 The modified method was validated and met the performance cr

145 nt endpoints for each infection type) in the modified microbiologic intent-to-treat (mMITT) populatio

146 ature of this study is the use of chemically modified micromodels such that the pore surfaces are rep

147 mouse models of mammary cancer: genetically modified MMTV-PyMT mice and orthotopically grafted 4T1 t

148 erminal thiocarbonylthio moiety with a diene-modified model protein.

149 d nanoparticle (LNP)-encapsulated nucleoside-modified mRNA encoding full-length gB.

150 e data suggest that the use of gB nucleoside-modified mRNA-LNP vaccines is a viable strategy for impr

151 action was developed for the analysis of 41 (modified) mycotoxins in beer.

152 lve the epigenetic control of enhancers that modify neuronal functions.

153 e, we demonstrate that RNA labeling with the modified, nontoxic uridine analog 5-ethynyl uridine (5-E

154 PS-modified nucleic acid therapeutics show improved metabol

155 ic acids, iminonucleosides, and C2'- and C4'-modified nucleoside analogs.

156 Modified nucleotides in tRNA are critical components of

157 s to overcome the limitations of introducing modifying nucleotides, often required to derive phasing

158 chno-functional properties of unmodified and modified okara under optimal condition were performed.

159 this syndrome and consider how they might be modified or inhibited.

160 We designed a novel digital therapeutic that modifies patient-selected cinematic content in real-time

161 es are a broad class of macrocyclic, heavily modified peptide natural products that are unified by th

162 The caveat is that modified peptides would need to reliably contain only a

163 earch strategy for comprehensive analysis of modified peptides.

164 e assessed by both PERCIST and immunotherapy-modified PERCIST, PET-based response maintained prognost

165 ity to create artificial drive constructs to modify pest populations has exacerbated our need to unde

166 No disease-modifying pharmacologic treatments are available.

167 e synthesis and characterization of P-phenyl modified phosphorus- and nitrogen-containing phosphaquin

168 days was recently reported using genetically modified pigs and a clinically applicable drug treatment

169 Modified Poisson regression estimated perinatal mental i

170 ians and their patients was examined using a modified Poisson regression model.

171 lectively, the evidence is consistent with a modified polymicrobial synergy and dysbiosis model for b

172 spension of either positively charged (amine-modified polystyrene; a-PS) or negatively charged (polys

173 nd in vitro assays to measure drugs' bilayer-modifying potency.

174 g signaling events that post-translationally modify pre-existing components of intercellular junction

175 nge electron step correction algorithm and a modified PRESTA boundary crossing algorithm are employed

176 ural and CF(2)-labelled post-translationally modified protein substrates via simultaneous sensing of

177 anding the potential allergenicity of new or modified proteins is crucial to ensure public health pro

178 Receptor activity-modifying proteins (RAMPs) interact with G-protein-coupl

179 FiTAc-seq is a modified protocol that replaces the proteinase K digesti

180 ion chest radiographs, measured by using the modified Radiographic Assessment of Lung Edema (mRALE) s

181 Here we used a modified Ramsay assay to quantify the impact of Malpigha

182 ral-Infarction 2b-3), good clinical outcome (modified Rankin Scale 0-2), complications rates, procedu

183 al hemorrhage (sICH), and favorable outcome (modified Rankin Scale score 0-2) at 3 months.

184 vourable functional outcome was defined as a modified Rankin Scale score of 0-2 or a Glasgow Outcome

185 performed to predict grave outcomes (3-month modified Rankin Scale score of 5-6).

186 ped by functional outcome, determined by the modified Rankin Scale.

187 Tissue was stained with a modified rapid Golgi technique.

188 e represents a reasonable compromise between modified reference genomes and de novo assembled genomes

189 response system to oral trimetazidine 35 mg modified-release twice daily or matching placebo.

190 interactions between the posttranslationally modified residues do not exert a major influence on the

191 glycosyl acceptor for the installation of a modified ring I.

192 sequencing and will enable studies of 2'OMe modified RNA with new levels of detail.

193 hromosomal tracts previously not possible to modify seamlessly due to their recurrence in the genome

194 omputational model to data (n = 1754) from a modified serial dictator game, to explore whether pre-ex

195 lar changes in seawater composition may have modified serpentinization-driven H(2) fluxes, remain poo

196 lational prenylation processing pathway that modifies several oncogenic proteins, including RAS.

197 d a high degree of variability in display of modified Sia between different species.

198 f chitin into complex glycosides, such as C5-modified sialosides, through the use of highly selective

199 nvestigated one-year toxicity of non-surface modified silica nanoparticles (SNPs) with variations in

200 hesis, properties and applications of dually modified starches were discussed.

201 The gelatinization temperatures of the modified starches were similar to those of the isolated

202 with ionic liquid stationary phases using a modified static coating technique and demonstrated the n

203 e preparation procedure which involves (1) a modified substrate cleaning procedure and (2) prebake at

204 ractions Motifs (SIMs) required to bind SUMO modified substrates.

205 9 case data with mobility data to estimate a modified susceptible-infected-recovered (SIR) model in t

206 those using chimeric antigen receptor (CAR)-modified T cells, to solid tumors requires combinatorial

207 tions (IMIs) after chimeric antigen receptor-modified T-cell (CAR-T-cell) therapy are limited.

208 have assessed whether rotavirus vaccination modifies T1D development, finding null or protective ass

209 rmore, rotavirus infection has been shown to modify T1D risk in T1D-prone mice.

210 are marked by the accumulation of aberrantly modified tau proteins.

211 Results showed acceptance of the modified technique with the majority feeling safer and c

212 ypothyroid Symptoms score or Tiredness score modified the effects of L-thyroxine versus placebo (P fo

213 Finally, paternal diet modified the expression profiles of central epigenetic r

214 We modified the QVOA to reflect pressure from low concentra

215 During landing, pulsed retrorockets modified the surface to reveal a near surface stratigrap

216 might facilitate the t(11;14)(q13;32), which modifies the 3-dimensional structure of the involved reg

217 tudy, we assessed whether acute malnutrition modifies the association between common enteric pathogen

218 and end-product of the digestion process and modifies the carbonate equilibrium.

219 Flavonoid intake modifies the composition of the gut microbiome, which co

220 We show that ORP2 knock-down modifies the distribution of cholesterol accessible to a

221 This charge redistribution modifies the Li(+) substructure causing Li(+) ions to bi

222 ease in the number and size of lysosomes and modifies the pH of these organelles from ~4.5-5 to ~6.1

223 e Schottky junction under the direct current modifies the space-charge distribution in the electric d

224 e out-of-plane magnetic field is expected to modify the exciton-phonon interactions by quantizing exc

225 ns with auxiliary subunits and other factors modify the intrinsic kinetic mechanism to result in new

226 e challenge to health systems to prevent and modify the major risk factors related to non-communicabl

227 ncy department showed no findings that would modify the management of the patient.

228 ept of preventive antiepileptic treatment to modify the natural history of epilepsy has been proposed

229 es, the breakdown of which can significantly modify the net volume change of fluid-mediated reactions

230 ed ODC activity and elevated putrescine that modify the phenotype in this developmental Tsc2-RG model

231 tervention can act upon the immune system to modify the process of aging.

232 FLG loss-of-function mutations modify the relationship between allergen exposure and se

233 arasite transmission, community assembly can modify the relationship between host and parasite richne

234 supporting the idea that DNA methylation may modify the risk of environmental factors on health outco

235 Baseline SBP did not modify the treatment effect of sacubitril/valsartan, and

236 uce a novel pharmaceutical strategy based on modifying the activity of heparan sulfate, an important

237 In this work, modifying the defective surface of perovskite films with

238 ous heat exposure plays a beneficial role in modifying the exaggeration of the exercise pressor refle

239 e coupling strength between dynamical units (modifying the level of synchronization) and what are the

240 Our method works by passively modifying the phase relationships among the different fr

241 (proteins, lipids, nucleic acids) to either modify their activity or, when released in excess, infli

242 with G-protein-coupled receptors (GPCRs) to modify their functions, imparting significant implicatio

243 ndeed, functional 3D printable materials can modify their surfaces, structures, properties or even sh

244 genetic heterogeneity of patients that might modify their vulnerability to disease.

245 in metazoan CCDs, opening the possibility of modifying their activity through rational chemical or ge

246 improve the binding affinity of aptamers by modifying their sequences upon their G-quadruplex and se

247 healthcare system for the advent of disease-modifying therapies against AD is imperative.

248 ere is no cure for MS, but available disease-modifying therapies can lessen severity and delay progre

249 ncreasing number of highly effective disease-modifying therapies for people with multiple sclerosis (

250 betes-induced dementia, there are no disease-modifying therapies that are able to prevent or block di

251 Concomitant disease-modifying therapies were allowed.

252 ineffective predictor of response to disease-modifying therapies.

253 e treatment effects of comprehensive disease-modifying therapy versus conventional therapy on the pri

254 sess if the presence of cardio-renal disease modifies these relationships.

255 oid the host immune response (by genetically modifying these components), as well as optimize the lar

256 , and whether treatment (TMVr or GDMT alone) modified this association was tested.

257 We have further modified this compound via a structure-based approach an

258 Addition of UBA I seed crystals modified this pathway such that only UBA I was observed

259 While in animals, O-GlcNAc transferase (OGT) modifies thousands of intracellular proteins, the human

260 SR was defined as modified thrombolysis in cerebral ischemia 2b to 3.

261 There was no difference in recanalization (modified Thrombolysis-In-Cerebral-Infarction 2b-3), good

262 ivessel thrombosis, stent thrombosis, higher modified thrombus grade post first device with consequen

263 n of proteolytic peptides of proteins, which modifies Tn by glycosyltransferase C1GalT1 with isotopic

264 the design and analysis methods were further modified to allow estimation of rate ratios or to allow

265 These ligands are then modified to develop low nanomolar inhibitors of SIRT2.

266 This model can be modified to reflect updated transmission characteristics

267 mber of sites with a broad dynamic range and modified to study other RNA modifications.

268 event has been genetically modified and, if modified, to infer from its genetic sequence its likely

269 ential to shape urban life and significantly modify travel behaviors.

270 e multiple sclerosis who were not on disease-modifying treatment and who had an Expanded Disability S

271 tion, disease course, disability, or disease-modifying treatments.

272 Bempedoic acid did not significantly modify triglyceride level (MD -1.51%; 95% CI -3.75%, 0.7

273 We further modified tumor gemcitabine levels with injectable PEGyla

274 A standard or modified two-tiered testing algorithm is used to enhance

275 t Physical Performance Battery), loneliness (modified UCLA Loneliness Scale), and isolation considere

276 o acids were detected using focused-ion-beam-modified ultrashort cantilevers.

277 processes (natural or artificial) might have modified underlying neural structure to support species-

278 Therapeutic oligonucleotides are often modified using the phosphorothioate (PS) backbone modifi

279 ere longer but peak magnitudes were lower in Modified Vaccinia Ankara (MVA)-boosted regimens.

280 loned into nonhuman Great Ape Adenoviral and Modified Vaccinia Ankara vectors to generate a viral-vec

281 nist prime, intramuscular (i.m.) recombinant Modified Vaccinia Ankara Virus (MVA)-gag pol-IL-4R antag

282 riplex is a recombinant attenuated poxvirus (modified vaccinia Ankara) expressing immunodominant CMV

283 vanted HBV S and core antigen, followed by a modified Vaccinia virus Ankara vector to induce HBV-spec

284 In this Protocol Extension, we describe a modified version of our original protocol (published in

285 We argue that modified versions of the standard bases, some with featu

286 were delivered to the lungs of rats using a modified vibrating mesh aerosol drug delivery system.

287 cetate buffer and in solvent with the buffer modified with (15)NH(3)-formate.

288 nerate nanoscopic polymersomes that are then modified with a hemispherical gold nanocoat.

289 ngus on multi-walled carbon nanotube surface modified with a naphthalene group.

290 eromones, known as the ascarosides, that are modified with a variety of groups derived from primary m

291 branching promotes degradation of substrates modified with branched chains under multi-turnover condi

292 f mediators on biocompatible gold electrodes modified with carbon ink or fumed silica can compete wit

293 decorated on a glassy carbon electrode (GCE) modified with Fe-based metal-organic frameworks, MIL-101

294 etration enhancer-containing vesicles (PEVs) modified with glucidex, a dextrin, and a biopolymer obta

295 nsor based on a glassy carbon electrode (GC) modified with graphene quantum dots (GQDs) and Nafion (N

296 s were covalently attached to a gold surface modified with N-hydroxysuccinimide/1-ethyl-3-(3-dimethyl

297 on, we confirmed that the S-layer protein is modified with the same heptameric glycan, suggesting a c

298 Nanogels were modified with up to 15 wt% peptide without significantly

299 esign, durable woods and properly treated or modified woods will be paramount.

300 rison of association studies using Z-scores, modified Z'-scores, p-values and Jaccard indices.