ライフサイエンスコーパス: modular

1 riflate-catalyzed reaction that allows for a modular access to a diverse collection of nine-membered

2 Here, we describe a modular activation reagent called Expamers, which addres

3 suggests that adaptive mutations are locally modular - affecting a small number of phenotypes that ma

4 c intermediates and motors reported here are modular, allowing for their post-functionalization.

5 eder-free, scalable, chemically defined, and modular alveolosphere culture system for the propagation

6 The application of modular analysis supported our findings and further reve

7 The developed mechanochemical strategy is modular and allows for systematic control of the primary

8 derable misalignment that is evident at both modular and cellular scales.

9 This work shows that a modular and coherent photonic-aided payload is feasible,

10 und for unifying the seemingly contradictory modular and distributed modes of face processing.

11 These small, modular and efficient RNA switches may improve the safet

12 d tissue damage, specifically designed to be modular and extensible to support continuous updating an

13 The pipeline is scalable, modular and flexible.

14 We expect that this modular and multiplexed chemoproteomic platform will be

15 the common assumption that the circuitry is modular and performs stereotyped computations.

16 tational scanning experiments as all code is modular and reusable between protocols.

17 However, it is now clear that modular and reversible PcG function is essential at most

18 the DNA brick strategy has provided a highly modular and scalable approach for the construction of co

19 Here, we introduce a modular and scalable method for creating monodisperse, g

20 This study introduces a modular and tunable S(N)Ar-based reactive group for targ

21 tures, along with their ease of preparation, modular and tunable structures, and often biomimetic att

22 Herein, a modular and versatile approach to multifunctional peptid

23 This modular and versatile biomaterial functionalization plat

24 This efficient, modular, and general method for pai-extension opens acce

25 GoldenBraid is a rapid, modular, and robust cloning system used to assemble and

26 The presented modular approach could be deployed for a range of other

27 This modular approach could be deployed in conventional labor

28 The modular approach is flexible, enabling the introduction

29 Using a novel modular approach that encapsulates a parameter database

30 -coupling is shown to enable a practical and modular approach to the catalytic synthesis of enantioen

31 Herein, we disclose the development of a modular approach toward 2,5-diaryltetrazoles compatible

32 This mild modular approach, which does not require employment of e

33 r-sigma-acceptor dyes has been prepared in a modular approach.

34 e are beginning to take hold, suggesting new modular approaches for the design of autonomous molecula

35 Our analysis approaches provide rapid and modular approaches to screen for alterations in CT organ

36 demonstrates that the tandem VWA array has a modular architecture and samples multiple conformations

37 coiled-coil proteins, revealing a conserved modular architecture in primary and motile cilia, but sh

38 Such modular architecture is common among cell-cycle proteins

39 ence, conservation, and novelty underlie the modular architecture of Heliconius color pattern mimicry

40 Using NMR, we mapped the modular architecture of NHERF1, which is composed of two

41 fluctuations is a consequence of the dynamic modular architecture of Pin1.

42 The simple topology and modular architecture of tandem-repeat proteins such as t

43 Thus modular architecture plays an essential role, in additio

44 cal basis of HUSH assembly and find that its modular architecture resembles the yeast RNA-induced tra

45 The MOMA phantom has a modular architecture which includes individual assessmen

46 uctures suggests that GT-C enzymes contain a modular architecture with a conserved module and a varia

47 The novelty of our new DNN method is its modular architecture, which has the capability of combin

48 We found a persistent modular architecture, yet significant reorganisation of

49 mplex folds into an evolutionarily conserved modular architecture.

50 of ecological interaction: e.g., nested and modular architectures would correspond to mutualistic an

51 Its modular arrangement, corresponding with different sensor

52 nelles are required for the assembly of both modular ascarosides and glucosides via ester and amide l

53 (LROs) is required for biosynthesis of most modular ascarosides as well as previously undescribed mo

54 Similar to modular ascarosides, the modular glucosides are derived

55 ion, this radical-based protocol enables the modular assembly of an important class of N-fused indole

56 in 3D hydrogels provides a step towards the modular assembly of soft functional materials with tunab

57 The NPC is a modular assembly of ~500 individual proteins, called nuc

58 ulate cortex, were most abnormal in terms of modular assignment.

59 ues for identification of virions based on a modular atomic force microscopy (AFM).

60 Here we introduce a modular barrel architecture, and demonstrate hierarchica

61 Described is a modular bead-based biosensor design that can be applied

62 Developing reactions to generate complex and modular building blocks in a concise and direct fashion

63 is study, we used natural protein domains as modular building blocks to develop engineered chromatin

64 employ two-dimensional aromatic compounds as modular building blocks to generate richly substituted,

65 igned the ZPF constructs either de novo from modular building blocks, or modified sequences from the

66 The modular building principle of metal-organic frameworks (

67 d matricellular protein SMOC2 (SPARC related modular calcium binding 2) presenting severe oligodontia

68 Our investigations revealed that a modular cascade with a mixture of xylanase and beta-xylo

69 The modular CFM unit fits within a standard benchtop centrif

70 that the combination of rational design and modular chemical synthesis can revitalize classes of ant

71 Herein, we report a modular chemoenzymatic approach to synthesize terpene an

72 Here, we describe a modular chromosomally integrated platform for ectopic ge

73 The modular chromosomally integrated toolkit for ectopic gen

74 nd mixed selectivity, in what we call "mixed modular coding".

75 ion, different modular fingerprint and inter-modular communication, compared to healthy participants.

76 least 1 week after the onset of symptoms and modular components can be exchanged.

77 d behavioral analysis method that identifies modular components of three-dimensional mouse body langu

78 This prodrug system, with modular components that allow for fine-tuning selectivit

79 An exchange of modular components was performed to a lesser extent in t

80 arning can improve target specificity by the modular composition of models from different experimenta

81 patterns among organs are nonrandom, forming modular connections that are reshaped by gene duplicatio

82 In all CHRs, abnormal modular connectome organization at baseline was associat

83 evelop psychosis were found to show abnormal modular connectome organization at baseline, while CHR n

84 35 kDa OCP is structurally and functionally modular, consisting of an N-terminal effector domain (NT

85 Modular construction of an autonomous and programmable m

86 ferritin-MOFs, illustrates the advantage of modular construction strategies in discovering tunable-a

87 s, with their defined compositions, commonly modular construction, and length scales allowing the eng

88 o which strains are immune, are respectively modular (containing groups of hosts and viruses that int

89 ni is inordinately dissociable and under the modular control of two AR paralogs.

90 n human skin explants and, we explore a more modular delivery system that utilizes mRNA added to pre-

91 ata, illustrate the power of a fundamentally modular description of behavior and suggest that behavio

92 Its modular design also enables characterization of non-tumo

93 rst time a versatile ligand platform for the modular design of a collection of highly specific CB(2)R

94 The modular design of the alpha,beta-unsaturated carbonyl sc

95 Moreover, given the modular design of these detergents, we anticipate fine-t

96 The modular design presented herein can be readily adapted t

97 Using a modular design principle, we developed genetically encod

98 We use a modular design strategy to create 27 non-natural and non

99 framework offers multiple advantages: (i) a modular design that is agnostic to coding language(s) an

100 Our modular design utilizes hybrid multi-photon acquisition

101 Taking advantage of FLiCRE's modular design, we expressed an optogenetic channel sele

102 trating that alpha-catenin's C-terminus is a modular detector of F-actin tension.

103 ormation for medicinal chemists, providing a modular disconnection for the rapid diversification of h

104 e multicellular computing systems are highly modular, do not require cell-cell communication channels

105 Dynalogo is optimized for analysis of modular domain-peptide binding experiments but the platf

106 WD40 domain, highlighting the importance of modular domains mechanistically involved in the DNA dama

107 us blue light-responsive photoreceptors into modular domains of the stromal interaction molecule 1 (S

108 es in biochemical activity map to individual modular domains of this polymerase.

109 Layer-by-layer nanoparticles (NPs) are modular drug delivery vehicles that incorporate multiple

110 We found that a modular E3 ubiquitin ligase complex CRL4(DCAF12) binds a

111 t that photonic structures are fundamentally modular: each part of the structure has a role which can

112 A general platform for the modular, efficient assembly of various chondroitin sulfa

113 an example of a developmental mechanism for modular encoding of functional plasticity in the nervous

114 feran affinity to Namapoikia rietoogensis, a modular encrusting construction that is found growing be

115 We find that separate modular enhancers are responsible for dsx expression in

116 We report a previously unassigned modular enoyl-CoA hydratase (mECH) domain and the assemb

117 diiron proteins (FDPs) constitute a group of modular enzymes widespread in Bacteria, Archaea and Euka

118 The resulting code is modular, extensible and legible.

119 We added an oxygenator module to our modular FABRICA bioreactor in order to provide stable ox

120 clization precursors can be synthesized in a modular fashion but also that the cyclization is efficie

121 thogonal transformations can be applied in a modular fashion for multiparty federated mega-analyses w

122 rin") have been effectively constructed in a modular fashion to permit variation of the bridge length

123 witches can be designed in a predictable and modular fashion, through the selection of appropriate gu

124 ng and chewing apparatuses have evolved in a modular fashion.

125 bs, weaker rich club organization, different modular fingerprint and inter-modular communication, com

126 h the merits of delivery controllability and modular flexibility, nanomedicines provide opportunities

127 l, analysis of the FAO superfamily reveals a modular fold with cofactor and substrate-binding domains

128 ause proteins consist of domains that act as modular functional units, we have extended the analysis

129 new molecular nanomaterials with multiple or modular functionality.

130 eneral method for rapid, chemoselective, and modular functionalization of serine residues in native p

131 -containing proteins and thereby exploit the modular functions of these host proteins for various ste

132 unctional enrichment analysis showed that 52 modular genes participated in developmental processes su

133 W) in broilers is associated with functional modular genes.

134 Similar to modular ascarosides, the modular glucosides are derived from highly selective ass

135 itter, and lipid metabolism, suggesting that modular glucosides, like the ascarosides, may serve sign

136 scarosides as well as previously undescribed modular glucosides.

137 Fibrillin-1 is a modular glycoprotein that includes 7 latent transforming

138 Modular gram-scale syntheses of the trimethyl ethers of

139 Our results constrain mechanisms for modular grid firing and provide evidence for inter-anima

140 Developing universal and modular hardware that can be automated using one softwar

141 Moreover, the modular hollow-microcage design allows each unit to be l

142 icient solid-phase synthesis methods and the modular implementation of different functionalities.

143 BOFdat has a modular implementation that divides the BOF definition p

144 ss species while finding no evidence of such modular integration in extant ant groups.

145 colinearity appears to involve direct cross-modular interaction of the reductase with the longer acy

146 tection, was achieved on an Eckert & Ziegler Modular-Lab radiosynthesis platform, affording [(18)F]ol

147 The L protein has a modular layout consisting of a ring-shaped core trailed

148 We present a multi-modular, machine learning-based assessment of autism com

149 protein homeostasis system is organized in a modular manner and aggregation patterns were not correla

150 Targeting circuit excitability in a focal, modular manner may prove to be an effective therapeutic

151 rylic acid) nanogels that were modified in a modular manner with bioactive peptides.

152 ered alkyl boron reagents in a practical and modular manner.

153 zable MRI phantom called the LEGO-compatible Modular Mapping (MOMA) phantom, which not only serves as

154 This work suggests that custom-built modular materials with even better thermal performance c

155 vides a step towards the development of soft modular materials with programmable functionality.

156 The technique is modular, meaning that the co-operative effect of dimeriz

157 Here, we describe a modular mechanophore design platform for molecular relea

158 etween nematodes-so-called 'nematode-derived-modular-metabolites' (NDMMs)-are of major interest becau

159 This modular method avoids potentially hazardous reagents lik

160 Here, we extend a modular method for labeling base modifications in DNA to

161 This mild and modular method proceeds in the absence of stoichiometric

162 gy is used to fabricate a novel miniaturized modular microcage scaffold system, which can be assemble

163 for cryo-electron microscopy (trEM) using a modular microfluidic device, featuring a 3D-mixing unit

164 ctor designed through the arrangement of the modular micronozzles enables the formation of various ty

165 The resulting modular model reproduces hyperactive PI3K-driven cytokin

166 We describe the framework MMSplice (modular modeling of splicing) with which we built the wi

167 These modular models also outperformed alternative models at e

168 -bipyridine)(3) ](NO(3) )(2) , CMOM-1S, is a modular MOF; five new variants in which counterions (BF(

169 ht into maximizing protein expression, using modular mRNA lipoplexes that are more compatible with pr

170 Experiments were based on a simple, modular, multi-chamber platform that permits standardise

171 We developed a modular nanoparticle system capable of encapsulating an

172 candidates for optogenetics because of their modular nature and long-range signaling capabilities.

173 s modular structure and the relevance of its modular nature for its coactivator function in gene regu

174 distinct signaling motifs, highlighting the modular nature of guidance cue receptors and its potenti

175 The modular nature of metabolic pathways is exploited to fac

176 The modular nature of RNA also affords researchers the abili

177 The compact modular nature of the WW domain makes it ideal for media

178 The applicability and modular nature of this novel approach were demonstrated

179 Owing to their crystallinity and modular nature, metal-organic frameworks (MOFs) are an e

180 orks with a high global efficiency, and that modular network structures promote the segregation of in

181 the locomotor central pattern generator is a modular network with speed-dependent recruitment of inte

182 hat chromocenter formation is mediated by a 'modular' network, where associations between two sequenc

183 Thus, while orderly modular networks of orientation preference initially ari

184 Internal activity of modular networks trained with these constraints strongly

185 e how recurrent interactions in a simple and modular neural circuit could create the dynamics needed

186 LabxDB is modular, offering a flexible framework that scientists c

187 tive mass spectrometry (MS) reveals that the modular OGD architecture offers the ability to control p

188 years, the plant-herbivore network was more modular on serpentine than on nonserpentine soils-despit

189 SATurn is a modular, open-source, bioinformatics platform designed t

190 Here, we present the all-fiber modular optical tweezers (AFMOTs), in which an optical t

191 ltiply substituted BCP triazoles on either a modular or a one-pot basis.

192 ts evolve and whether biological systems are modular or are organized such that every gene has the po

193 For highly modular or spatially embedded networks it is better to p

194 of bones, their topological arrangement, and modular organization can discriminate birds from non-avi

195 The polymerase cofactors share a similar modular organization of a soluble N-binding domain and a

196 We identified a new modular organization of erythropoiesis and, for the firs

197 ganize during development makes apparent the modular organization of the cerebral cortex.

198 Such a framework invokes the modular organization well-established for sensory cortic

199 ith system-level changes in brain functional modular organization, accompanied by functional segregat

200 We did not observe changes in modular organization, nodal cartographic assignments, as

201 hin the ventral medial geniculate nucleus, a modular organization, revealed with parvalbumin neuropil

202 n posited that a single, binocularly aligned modular orientation representation develops independent

203 phic conditions reveal correlated nested and modular patterns.

204 rnal stimuli (temperature and pressure), the modular perovskite structure evolves to construct crysta

205 OrgDyn is an open-source and modular pipeline to quantify organoid shape dynamics usi

206 OligoMiner is an open-source and modular pipeline written in Python that introduces a nov

207 lso established the first database of type I modular PKSs, featuring a comprehensive annotation of av

208 The trans-AT family of modular PKSs, whose biosynthetic frameworks diverge sign

209 Our solution is a Modular Platform for Epilepsy Modelling In Vitro (MEMO),

210 metals and cofactors, making this scaffold a modular platform for the design of binding proteins and

211 We use a simple and modular platform that is broadly accessible and yet inco

212 nalizable' hybrid-POMs constitute a valuable modular platform that permits coupling of POM properties

213 assembly-line like megaenzymes of the type 1 modular polyketide synthase (PKS) class.

214 synthetic pathways of the products of type I modular polyketide synthase (PKS) with the focus on prov

215 To harness the synthetic power of modular polyketide synthases (PKSs), many aspects of the

216 The colinearity of canonical modular polyketide synthases, which creates a direct lin

217 We show that PEAMOtecan is a highly modular polymer nanoformulation that protects covalently

218 hibitor, to our proprietary, 'clickable' and modular polyoxetane polymer platform consisting of acety

219 ovalent organic frameworks (COFs) are highly modular porous crystalline polymers that are of interest

220 Herein, we show that a modular, practical, and general palladium-catalyzed, rad

221 Mucin domains are densely O-glycosylated modular protein domains that are found in a wide variety

222 The design of modular protein logic for regulating protein function at

223 The WW domain is a modular protein structure that recognizes the proline-ri

224 Here, we developed LOV2GIVe, an engineered modular protein that allows the activation of heterotrim

225 ntrast, we find an opposite gradient where a modular protein-protein interaction signal is strongest

226 on the structure, dynamics, and function of modular proteins and therefore must be considered for st

227 The structural characterization of modular proteins containing long intrinsically disordere

228 responses, is a prototypical model for such modular proteins.

229 ble command line interface and an underlying modular Python package makes the full power of coevoluti

230 are alpha-helical structures known for their modular recognition of single-stranded RNA sequences wit

231 d resemble the function of RUNX1/ETO through modular recomposition with protein domains from RUNX1, E

232 we introduce a new strategy for transferring modular reconfigurable DNA nanostructures from two-dimen

233 This work reveals modular regulation of erythropoiesis and offers a new st

234 unctional gene analyses were performed using modular repertoires, IPA, Gene Ontology, and NetworkAnal

235 ocular stimulation each yield well-organized modular representations of orientation that display feat

236 ation (PI, abbreviated Pai) reagents for the modular, scalable, and stereospecific synthesis of chira

237 Here, we report modular self-assembly of an engineered protein into four

238 Here, a modular semisynthetic scheme is introduced to govern the

239 ds promise for further development of highly modular, sensitive, selective, and stable electroanalyti

240 d all-carbon macrocycle provides access to a modular series of rotaxanes.

241 Here, we report an inexpensive (<$110) and modular Single-Cell Temperature Controller (SiCTeC) devi

242 The vectors also contain modular sites for hybrid assembly using sequence overlap

243 Key steps in this modular six-step sequence include a DMAP-mediated O- to

244 lts reveal that the tyrannosaur has the most modular skull organization among the amniotes included i

245 encoded protein of interest (POI) through a modular SNAP-Tag/benzylguanine covalent interaction.

246 ploy one class of such geometries to build a modular source of photon pairs that are high-dimensional

247 Mature locomotion involves modular spinal drives generating a set of fundamental pa

248 piNET has been built using a modular Spring-Boot JAVA platform as a fast, versatile a

249 We present COMPSRA, a comprehensive modular stand-alone platform for identifying and quantif

250 ithin a Homeobox (Hox) 5' UTR, we identify a modular stem-loop within this element that binds to a si

251 rug discovery, efficient, atom-economic, and modular strategies for their access are underdeveloped.

252 Our results establish a modular strategy for directing secreted and membrane pro

253 control around the tricyclic skeleton, and a modular strategy that enables analogue generation.

254 perform these essential functions through a modular structural architecture: the N-terminal domain c

255 Flowering plant SEC14L-PITPs often have modular structure and are associated with cell division,

256 years ago, our evolving understanding of its modular structure and the relevance of its modular natur

257 An increasingly complex modular structure of SEC14L-PITPs evolved in land plants

258 hat a recurrent neural network mimicking the modular structure of the anatomical circuit and trained

259 The modular structure of the representation confers the grid

260 to be strongly entangled while also having a modular structure that consists of two distinct groups o

261 We propose a mechanism that produces this modular structure through dynamical self-organization in

262 The inferior colliculus is one such modular structure, containing auditory-recipient matrix

263 et of SEC14L-PITPs with increasingly complex modular structure.

264 connection weights as well as the network's modular structure.

265 complexes, which possess redox activity and modular structures, have arisen as promising candidates.

266 form primitive vascular networks within the modular structures.

267 In combination with a modular substrate synthesis, it allows for rapid access

268 ectral representation is transformed through modular subsystems of successive cortical areas, we unde

269 Here we present a modular supramolecular approach to relay the photoinduce

270 bellar vermis functions could be mediated by modular synaptic connections of distinct fastigial cell

271 endly domino method has been established for modular synthesis of a diverse range of medicinally prom

272 Here, we report a modular synthesis of a suite of oxidized meroterpenoids

273 A highly modular synthesis of BNB- and BOB-doped phenalenyls is p

274 An organocatalytic method for the modular synthesis of diverse N-aryl and N-alkyl azaheter

275 ng (DOC) is a unified click-approach for the modular synthesis of lead-like structures through applic

276 A modular synthesis of Ru(II)-NHC-diamine complexes from r

277 Given their modular synthesis, unique structural features and rich f

278 A modular synthetic approach to degradable metathesis poly

279 We describe here a modular synthetic methodology that can provide libraries

280 Herein, we report a modular synthetic route to linear and branched homoallyl

281 lexible aptamer technology is used to create modular, synthetic mimics of the Large Latent Complex th

282 As a miniature and modular system that creates a reliable and mobile optica

283 t that the Ase1 domains provide cells with a modular system to tune midzone activity and control elon

284 anently fixed to a common board, rendering a modular system where fiber alignments are maintained ove

285 therefore makes possible the development of modular, technology-specific and robust workflows for si

286 data provide insights into the evolution of modular templates for donor and acceptor recognition amo

287 We have demonstrated that small, modular, tetrameric peptides featuring the Lewis-basic r

288 This fully synthetic and modular therapeutic platform could be an important thera

289 N(TM) system: a newly developed non-invasive modular tool which transmits high-resolution Laser Speck

290 A scalable and modular total synthesis of 3-lipid I and 3-lipid II was

291 Here, we show that the modular transcriptional signature in the blood of suscep

292 perationally straightforward, metal-free and modular transformation forms tertiary amines, without st

293 Overall, heteroaromatic sulfones provide modular tunability, shifted chromatographic elution time

294 We used a semisynthetic approach to generate modular ubiquitin-based probe containing a tetrazole-der

295 econvolution of complex regulatory loci into modular units.

296 g H(2) and syngas from remote natural gas in modular units.

297 Overall, we believe that such modular vaccine strategies offer design principles for e

298 The package is extensible and modular, which would facilitate the further development

299 xample of a metameric structure that is both modular, with well-defined morphological regions, and fu

300 We provide eight different modular workflows to be followed in a recommended sequen