ライフサイエンスコーパス: modulating protein

1 alovirus-encoded viral interleukin-10 immune-modulating protein.

2 crobial factors such as coronaviral membrane-modulating proteins.

3 many cellular constituents, including actin-modulating proteins.

4 These results implicate a role for CypD in modulating protein acetylation.

5 executes a specific strategy targeting actin-modulating proteins, across multiple functionalities, to

6 nd enhancing the activity of the small actin modulating protein, actin depolymerising factor (ADF) in

7 y numerous roles in cell function, including modulating protein activity by changing protein conforma

8 complicated post-translational modification, modulating protein activity in health and disease.

9 e limited or extended complementarity, or by modulating protein activity, in some cases by mimicking

10 eir mechanistic contributions are useful for modulating protein allostery in mechanistic and engineer

11 tion, and cell homeostasis are maintained by modulating protein and lipid flux through the early secr

12 ategories over-represented with MMS-toxicity modulating proteins and demonstrate that, in addition to

13 at YopO phosphorylates a wide range of actin-modulating proteins and located their phosphorylation si

14 ese results support a model in which F-actin modulating proteins and vesicle trafficking proteins coo

15 entified seven highly connected MMS-toxicity modulating proteins associated with translation and mRNA

16 rate can also determine protein targeting by modulating protein binding to specific interacting partn

17 role in cellular signaling, most notably by modulating proteins bound at chromatin and increasingly

18 evelop target-selective neurotherapeutics by modulating protein-channel interactions.

19 ing chimeras (PROTACs), which are capable of modulating protein concentrations at a post-translationa

20 utative Ku helicase activity plays a role in modulating protein conformation under the conditions tes

21 nkeys may alter insulin signaling in vivo by modulating protein content of insulin receptor signaling

22 The apoptosis-modulating protein Daxx functions as a transcriptional r

23 rucial component of the UPS, particularly in modulating protein degradation in response to small-mole

24 We find that modulating protein diffusion with flow, or membrane bind

25 ium may serve as a key regulatory switch for modulating protein-DNA interactions central to nuclear r

26 Importantly, modulating protein-DNA interactions of the fork-proximal

27 Arg49 in Tdx, His49 in Pdx, His56 in Adx) in modulating protein dynamics as a function of oxidation s

28 ted fatty acids regulate lipid metabolism by modulating protein expression at many levels including g

29 n of translation is the primary mechanism of modulating protein expression during mitosis.

30 ript splicing for the purpose of rescuing or modulating protein expression.

31 in1 regulates multiple signaling cascades by modulating protein folding and thereby activity and stab

32 lass of molecular chaperones responsible for modulating protein folding in the cell.

33 it to compare 303, 311 and 288 UVC-toxicity modulating proteins from Escherichia coli, Schizosacchar

34 Protein methylation plays important roles in modulating protein function and thus in optimizing and r

35 up of lysine provides an additional means of modulating protein function and, in particular, enzyme a

36 methyltransferases plays essential roles in modulating protein function in both normal and disease s

37 biquitin conjugation is an essential process modulating protein function in eukaryotic cells.

38 lationship between O-GlcNAc and phosphate in modulating protein function in many cellular processes a

39 tions regulate physiology either by directly modulating protein function or by impacting immune recog

40 also for understanding the role of lipids in modulating protein function or drug binding.

41 an attractive but underexplored approach to modulating protein function with small molecules.

42 al modification (PTM) plays pivotal roles in modulating protein function.

43 other homo-oligomeric proteins as a means of modulating protein function.

44 rted motions suggesting anesthetic action in modulating protein function.

45 or tyrosine (D187Y) in domain 2 of the actin-modulating protein gelsolin causes the neurodegenerative

46 We show that toxicity-modulating proteins have similar topological properties

47 old to Escherichia coli hemolysin expression modulating protein Hha; however, structural differences

48 irus 1 (HSV-1) neurovirulence- and autophagy-modulating protein ICP34.5 interacts with numerous mitoc

49 n during differentiation is downregulated by modulating protein interaction at the site II cell cycle

50 not identified, Ran is known to function by modulating protein interactions for karyopherin (Kap) be

51 o acids in maintaining UVR8 conformation and modulating protein interactions is poorly understood.

52 editing, controlled RNA splicing, reversibly modulating protein interactions, and altering cellular i

53 y can be tuned between these two pathways by modulating protein interactions.

54 th by influencing baseline anthropometry and modulating proteins involved in bone mineralisation and

55 s, and identify a nontransgenic strategy for modulating protein levels in crop species, a trait of gr

56 ations in the efficiency of mRNA translation modulating protein levels in the absence of correspondin

57 re limited for specific applications such as modulating protein levels or specific targeting of a pos

58 AMP in the control of the K(+) machinery, by modulating protein levels through gene transcription and

59 , may play previously unappreciated roles in modulating protein levels via ubiquitination.

60 Our results suggest that modulating protein longevity within the ETC is critical

61 d skeletal muscle atrophy and dysfunction by modulating protein metabolic imbalance, and thus CTSS wa

62 the dynamics of S-thiolation and its role in modulating protein nanomechanics, offering molecular ins

63 ed TMPs containing elevated levels of immune-modulating proteins, one of which is programmed death-li

64 We have also mapped our MMS-toxicity modulating proteins onto an E. coli protein interactome

65 n a pluripotent state by posttranslationally modulating protein PARylation.

66 Camstatin, an analogue of the calcium-modulating protein Pep-19 strongly expressed in CA2 neur

67 and other polynucleotides play a key role in modulating protein phase separation.

68 unctions as a master regulator of mitosis by modulating protein phosphatase 1 (PP1).

69 rylation (P < 0.05) of the Na(+),K(+)-ATPase modulating protein phospholemman at serine residue 63 (S

70 y produced cytokines, chemokines, and immune-modulating proteins present in hAF.

71 Gelsolin is a key actin cytoskeleton-modulating protein primarily regulated by calcium and ph

72 2 enhance shuttling of SRSF5 in P19 cells by modulating protein-protein and protein-RNA interactions.

73 ic function, at least in part, by positively modulating protein-protein interaction between Cdc42 and

74 ing that it is more likely to be involved in modulating protein-protein interaction than in interacti

75 g protein activity and cellular signaling by modulating protein-protein interactions (PPIs).

76 Methionines can play an important role in modulating protein-protein interactions associated with

77 t an array of biological responses including modulating protein-protein interactions in human cancer

78 the biogenesis of secreted agouti protein or modulating protein-protein interactions that contribute

79 However, disrupting or modulating protein-protein interactions with low-molecul

80 These observations suggest that, by modulating protein-protein interactions within homo- and

81 ight the role of the chemical environment in modulating protein-protein interactions, providing a cle

82 yclic drugs offer powerful opportunities for modulating protein-protein interactions, yet their devel

83 lular processes and proteome architecture by modulating protein-protein interactions.

84 at the center of these strategies and act by modulating protein-protein interactions.

85 ly rigid, membrane permeable, and capable of modulating protein-protein interactions.

86 and BRCA1, are attractive targets for drugs modulating protein-protein interactions.

87 ut also for the discovery of small molecules modulating protein-protein interactions.

88 ment and optimization of pharmaceuticals for modulating protein-protein interactions.

89 is known about the role that lipids play in modulating protein-protein interactions.

90 ulations, including a subset of phosphosites modulating protein-RNA interactions.

91 and the GA offers unexpected mechanisms for modulating protein secretion and/or endosome recycling e

92 tructures, they are unexpectedly involved in modulating protein secretion.

93 ight the roles of lipids, membrane curvature-modulating proteins, small G proteins, actin, and dynami

94 Salt plays a vital role in modulating protein solubility during plant protein extra

95 e residues play essential roles in proteins, modulating protein stability, fold and function.

96 rves as the key regulator of p53 function by modulating protein stability.

97 Glycosylation plays a critical role in modulating protein structure, stability, and binding pro

98 scriptional activator, and yhbH, a sigma(54) modulating protein, suggests sigma(54) may be involved i

99 ) pathway is known to play a central role in modulating protein synthesis and autophagy.

100 ess response (ISR) maintains proteostasis by modulating protein synthesis and is important in synapti

101 uggesting that RIP blocks ischemic injury by modulating protein synthesis and nerve activity.

102 evolutionarily conserved function of Myc in modulating protein synthesis control is critical to the

103 w role for PTalpha as a coregulator activity-modulating protein that confers receptor specificity.

104 Exciting new work on autophagy-modulating proteins that are enriched at the synapse has

105 th molecular motors, actin binding and actin modulating proteins, the actin cytoskeleton exhibits a v

106 ondrial K7 protein targets a cellular Ca(2+)-modulating protein to confer resistance to apoptosis, wh

107 cate that PREPL affects neuronal function by modulating protein trafficking and synaptic function, an

108 se study was developed to identify compounds modulating protein translation directed from the interna

109 Modulating protein turnover in ATM-depleted cells also h

110 Seeking novel PKR-modulating proteins we report here that nucleophosmin (N

111 tion to the nucleus, subnetworks of toxicity-modulating proteins were overrepresented in the vacuolar

112 ter immunizations, suggesting that these APC-modulating proteins, when used as poxvirus-encoded adjuv

113 The actin-modulating protein Wiskott-Aldrich syndrome protein verp

114 gh-resolution solution structure of Yersinia modulating protein YmoA is presented.