ライフサイエンスコーパス: modulator

1 ound to an agonist and a positive allosteric modulator.

2 that is increasingly recognized as an immune modulator.

3 utumoral T(reg) cells as a central metabolic modulator.

4 ctivity, a clear need exists for an improved modulator.

5 ither to a positive or a negative allosteric modulator.

6 fold) affinity selectivity and is a positive modulator.

7 ssing phosphatases, and alteration in immune modulators.

8 isease, and to screen for small-molecule MPC modulators.

9 of our assay for detection of actin-binding modulators.

10 h to monitoring biological responses to CFTR modulators.

11 ld for developing G protein-coupled receptor modulators.

12 ere clinical characteristics are significant modulators.

13 ynergistic pathways and identify their novel modulators.

14 echanisms of activation, and pharmacological modulators.

15 peptides and their inhibition by aggregation modulators.

16 small GTPase proteins are regulated by m(6)A modulators.

17 by fatty acids and small-molecule allosteric modulators.

18 ics for DSB repair induced by small-molecule modulators.

19 toward the development of new PXR-regulating modulators.

20 an avenue for the development of ion-channel modulators.

21 h has made it difficult to develop selective modulators.

22 anaesthetics, benzodiazepines and inhibitory modulators.

23 interleukins, checkpoints, and other immune modulators.

24 tudies of mGlu5 receptor negative allosteric modulators.

25 rojections have been recognized: drivers and modulators.

26 ng the development of direct pharmacological modulators.

27 n will be beneficial for testing other Hsp70 modulators.

28 ructure mimetics as an emerging class of PPI modulators.

29 class of drugs known as selective PPARgamma modulators.

30 mune response by increasing pro-inflammatory modulators.

31 focused on the development of small molecule modulators.

32 , we introduce a bifunctional supramolecular modulator, 1,2,4,5-tetrafluoro-3,6-diiodobenzene, which

33 s for controlling the SPL via small-molecule modulators able to tackle splicing-associated diseases b

34 f a novel CB(1) receptor (CB(1)R) allosteric modulator, ABM300, to ameliorate these dysregulated beha

35 e of the field of subtype-selective GABA(A)R modulators acting via the BZD binding site and their pot

36 LUF7244 as a negative allosteric modulator/activator in combination with dofetilide corre

37 fetilide plus LUF7244, a K(v)11.1 allosteric modulator/activator, to rescue K(v)11.1 trafficking and

38 set of glycosides were screened for positive modulator activity at human P2X7 using a YO-PRO-1 dye up

39 The highest positive modulator activity was with ginsenoside-compound K (CK),

40 ose-glucose) at carbon-3, displayed positive modulator activity with a reduced EC(50) for ATP and inc

41 In the search for highly effective modulators addressing ABCG2-mediated MDR, 23 pyrimidines

42 form a ternary complex, where the allosteric modulator affects the binding affinity and operational e

43 eat, mechanical stretch, and pharmacological modulators alter TREK1 channel activity and overlaps wit

44 An allosteric modulator and an orthosteric agonist bind simultaneously

45 ofitted with a reverse fill/flush (RFF) flow modulator and equipped with dual-channel detection using

46 ts major role as a microRNA (miRNA) activity modulator and its association with various diseases incl

47 PDGFR-beta gene promoter are transcriptional modulators and amenable to small molecule targeting.

48 Most GPCR AAs are allosteric modulators and exhibit a broad range of pharmacological

49 cycle conformation in the less-potent AgrC-I modulators and in the native AIP-I itself.

50 ic unit consisting of 8 high-speed microdisk modulators and operating at 20 GHz.

51 high-throughput screening of small molecule modulators and structure-based drug discovery.

52 extensive research has been performed on TLR modulators and their therapeutic implication under sever

53 previously published as a "silent allosteric modulator" and an antagonist of alpha7 allosteric activa

54 e-earth-ion-doped laser, a silicon microdisk modulator, and a germanium photodetector integrated on a

55 ials are testing antiviral therapies, immune modulators, and anticoagulants.

56 peutic effect of their natural and synthetic modulators, and it will discuss insights for the future

57 They behaved as negative allosteric modulators, and molecular modeling studies suggested an

58 which are functionally active as allosteric modulators, and solved co-crystal structures of the prok

59 o analyze the biological relevance, reported modulators, and structural features of GPR18.

60 tween subunits, for the design of allosteric modulators, appears as a privileged structure for the ph

61 Allosteric modulators are an intensively studied group of receptor

62 Heat shock protein (Hsp) 70 modulators are being developed to enhance the removal of

63 Spatial light modulators are essential optical elements in application

64 LRH-1 and SF-1 modulators are highly sought as treatments for metabolic

65 pies, the beneficial effects of selective GR modulators are now being explored.

66 ediones or identification of novel PPARgamma modulators are potential strategies to treat non-diabeti

67 ase (AD), have paved the way to consider MMP modulators as promising therapeutic strategies.

68 mplications in the development of epigenetic modulators as therapies for HD.

69 with the measured reflection spectra of the modulator at different gate voltages.

70 ating the effects of agonists and allosteric modulators at receptors where agonist binding follows hy

71 The KP modulator AV-101 (4-chlorokynurenine, 4-Cl-KYN), an oral

72 velopment of a second generation of utrophin modulators, based on the bioisosteric replacement of the

73 tform, reporting high-speed LN electro-optic modulators, based upon photonic crystal nanobeam resonat

74 de (dmac) with acetic acid or formic acid as modulators: [Bi(2)(cpb)(acetato)(2)(dmf)(2)].2dmf CTH-6

75 Allosteric modulators bind to sites that are remote from the neurot

76 state is stabilized by a positive allosteric modulator binding at the transmembrane dimerization inte

77 c acetylcholine receptor-negative allosteric modulator, BNC210, to 24 individuals (3 male subjects) w

78 ntified small-molecule NR4A nuclear receptor modulators, but it remains unclear if these ligands affe

79 a region, NADH acts as a positive allosteric modulator by enhancing both the affinity of the inhibito

80 ated effects of the ryanodine receptor (RyR) modulator caffeine on Na(+) current (I(Na)) activation a

81 We conclude that a pharmacological modulator can elicit opposite regulatory effects on Kv4

82 tants, promoter variants, and small molecule modulators can be extremely valuable tools.

83 enhanced network susceptibility, where (ii) modulators can both increase or decrease the threshold t

84 ept of the applicability of the microfluidic modulator chip is demonstrated in a heart-cut multidimen

85 dings suggest that SGE-301, or similar NMDAR modulators, could potentially serve as complementary tre

86 caftor/ivacaftor and/or the alternative CFTR modulator cysteamine.

87 intratumor heterogeneity of Wnt/beta-catenin modulator delta-catenin controls individual cell behavio

88 Avadomide, a CRL4CRBN E3 ubiquitin ligase modulator, demonstrated clinical activity in relapsed/re

89 Lastly, we show the positive allosteric modulator diazepam enhanced GABA-A currents on dopaminer

90 stimulation, the guanine-nucleotide exchange modulator dissociates Galphai*betagamma trimers, scaffol

91 Thus combining the epigenetic modulators DNMTi and HDAC6i increases anti-tumor immune

92 Here we show that CFTR modulators down regulate this exaggerated proinflammator

93 The spliceosome modulator, E7107, reverses cancer aggressiveness and inh

94 of Lypd6, an endogenous nicotinic signaling modulator, enhances ocular dominance plasticity in the a

95 rt that LXA4 interacts with a host chromatin modulator, especially SMARCB1, which upregulates the KSH

96 aling (RGS) proteins are signal transduction modulators, expressed widely in various tissues, includi

97 d standard" system utilizing a spatial light modulator for beam shaping is used to benchmark our impl

98 r translational development of selective UPR modulators for human disease.

99 amaterials and next-generation spatial light modulators for light-shaping.

100 future development and optimization of TASK modulators for the treatment of heart, lung and sleep di

101 le for development of more-specific receptor modulators for therapeutic use of MS.

102 mportant for defining how these unusual GPCR modulators function in disease, but also provides insigh

103 om RO6800020 (1), our former gamma-secretase modulator (GSM) lead compound, we utilized sequential st

104 used our recently developed gamma-secretase modulators (GSMs) and synthesized our GSM-based imaging

105 structurally differentiated gamma-secretase modulators (GSMs) based on an oxadiazine scaffold.

106 The lack of specific autophagy modulators has limited the utility of autophagy inhibiti

107 Redox modulators have been developed as an attractive approach

108 CFTR modulators have been reported to address the basic defec

109 he past decade, various N-methyl-D-aspartate modulators have failed in clinical trials, underscoring

110 Single-agent immune modulators have thus far proven clinically ineffective,

111 an clockwork and T2D and proposes that clock modulators hold promise as putative therapeutic agents f

112 , selective sphingosine 1-phosphate receptor modulator in development for immune-mediated inflammator

113 We implicate MPO as an inflammatory modulator in humans that regulates protease activity and

114 essing endothelium and identifies a novel RA modulator in lung development.

115 revealed that miR-1291 acts as a metabolism modulator in pancreatic carcinoma cells through the regu

116 prescribed selective estrogen receptor (ER) modulator in patients with ER-positive breast cancers.

117 COASY is a novel radiotherapy response modulator in rectal cancer that regulates PI3K activatio

118 Ozanimod, another S1P receptor modulator in the approval stage that also targets S1PR1

119 ntial role of specific PCs as gut microbiome modulators in either the pathogenesis or prevention of h

120 insights for the future exploitation of TLR modulators in human health.

121 re of biological properties of potential FAO modulators in the mammalian system.

122 much interest concerning the development of modulators in the mid- to long-wave infrared, based on e

123 pared with abatacept, a T-cell costimulation modulator, in patients with rheumatoid arthritis refract

124 he macrocycles of the two most potent AgrC-I modulators, in both an agonist and an antagonist, which

125 in other organs, and S1P(1) (S1P receptor-1) modulators including fingolimod show promise for the tre

126 rtially overlap with those of small molecule modulators, including a vestibule binding site that is n

127 tion can be augmented by positive allosteric modulators, including endogenous compounds, such as chol

128 ein are well suited to analyzing agonist and modulator interactions at receptors that bind multiple o

129 distribution of parent drug nuclear receptor modulators into the CNS while masking them as functional

130 disease (HD), and treatment with epigenetic modulators is beneficial in several HD animal models.

131 sively investigated, a large fraction of its modulators is yet to be characterized.

132 l dopamine D(1) receptor positive allosteric modulator, is being evaluated for the treatment of cogni

133 row due to the highly resonant electro-optic modulator, it is not fundamentally limited and can be br

134 alpha5-GABA(A) receptor negative allosteric modulator, L-655,708, reproduces the sustained antidepre

135 e, shared between three structurally diverse modulators (LY-3130481, JNJ-55511118, and JNJ-61432059)

136 st that targeting ChIs with channel-specific modulators may provide therapeutic approaches for allevi

137 feration and angiogenesis), as well as other modulators (micro-RNAs [miRNAs] and proteins).

138 The ability of the excitation/inhibition modulator N-acetyl cysteine (NAC) and the 5-HT(1B/1D/1F)

139 an ultra-light-sensitive optogenetic Ca(2+) modulator, named monSTIM1 encompassing engineered crypto

140 Negative allosteric modulators (NAMs) have shown promising results in precli

141 al studies, many mGlu(5) negative allosteric modulators (NAMs) that have reached clinical trials fail

142 AMs) and alpha5-GABA(A)R negative allosteric modulators (NAMs), which were originally developed as no

143 NF-kappaB essential modulator (NEMO) is a key regulatory protein that functi

144 ved epithalamic structure that is a powerful modulator of anxiety- and depressive-like behavior.

145 with well-documented cytoplasmic roles as a modulator of ATP-dependent DEAD-box RNA helicases involv

146 ese data reveal that MDK acts as an internal modulator of autocrine and paracrine signals that mainta

147 Alzheimer's disease (AD), as a potential key modulator of axon guidance, a neuronal process that depe

148 in alpha-subunit (Galpha(z)) is an important modulator of beta-cell function.

149 n-1, a very potent vasoconstrictor, is a key modulator of blood flow and pressure during in health an

150 r alpha (TNFalpha) has emerged as a critical modulator of blood pressure and neural plasticity; howev

151 eptor kinase 2 (GRK2), an important negative modulator of both G protein-coupled receptors (GPCRs) an

152 on, we have shown that GPBAR1 is an upstream modulator of CCL2/CCR2 axis at the sinusoidal cell/macro

153 ts AMP-activated kinase (AMPK), an important modulator of cellular energy-conserving mechanisms, and

154 ental evidence that GAT1508 is an allosteric modulator of channel-phosphatidylinositol 4,5-bisphospha

155 tes tonic inhibition that acts as a powerful modulator of cortical network activity.

156 was enhanced by down-regulating FLIP, a key modulator of death receptor-mediated activation of caspa

157 we show that overexpression of SNAI1, a key modulator of EMT, is a pathologically relevant event in

158 regulator of cancer metabolism and indirect modulator of epigenetic regulation in GBM.

159 icromolar, highly selective, and cell-active modulator of ERAP1.

160 As stressful environment is a potent modulator of feeding, we seek in the present work to dec

161 the loss of alcohol as a positive allosteric modulator of GABA(A) receptors, a decrease in dopamine f

162 udies identified the BIN1 locus as a leading modulator of genetic risk in Alzheimer's disease (AD).

163 se findings identify macroH2A1 splicing as a modulator of genome maintenance that ensures Xi integrit

164 the human natural killer-1 (HNK-1) glycan, a modulator of GluK2/3 function.

165 s that it is a selective positive allosteric modulator of glutamate-gated chloride channels found in

166 dy identifies fatty acids as a physiological modulator of HIF, defining a mechanism for lipoprotein r

167 vidence implicates autophagy as an important modulator of human disease.

168 st a novel mechanism for SP-A in asthma as a modulator of IL-13-induced inflammation via mediating do

169 sion of heme oxygenase 1 (HO-1), a potential modulator of immune function, was increased in whole blo

170 The ATP-adenosine pathway functions as a key modulator of innate and adaptive immunity within the tum

171 tions, ivermectin also acts as an allosteric modulator of ion channels found in host central nervous

172 cells enabled the identification of MafK as modulator of IRF8 silencing, affecting chromatin archite

173 E NINJA (LNJ), a microProtein that acts as a modulator of jasmonic acid (JA) signaling.

174 affect motors and unveil MAP9 as a positive modulator of kinesin-3 motility.

175 (miRNA) cluster including miR181ab1 is a key modulator of KRAS-driven oncogenesis.

176 Physical exercise is a powerful modulator of learning and memory.

177 In addition, we found that an allosteric modulator of many class A GPCRs, Na(+), synergistically

178 Thus, our work shows that ILK is a central modulator of melanosome movements in primary epidermal m

179 We demonstrate that PMX is a master modulator of merozoite invasion and direct maturation of

180 Serotonin (5-HT) is a modulator of neural circuitry underlying motor patternin

181 that has preliminarily been identified as a modulator of nuclear receptors involved in beta-amyloid

182 ly essential for myogenesis and is instead a modulator of optimal differentiation of skeletal myoblas

183 kinases and glycogen synthase kinase 3, as a modulator of parkin recruitment.

184 ectrometry, given the importance of TIM as a modulator of PER function in the pacemaker.

185 identify the E3 ligase RFWD3 as an essential modulator of stalled fork stability in BRCA2-deficient c

186 We propose that LSH is a major chromatin modulator of the histone variant macroH2A and that its a

187 ion in C. rodentium Arginine is an important modulator of the host immune response to pathogens.

188 signed small molecule ZCM-I-1 as a selective modulator of the production of reactive oxygen species f

189 Our work shows that PARP14 is an important modulator of the response to ATR-CHK1 pathway inhibitors

190 It is well established that fingolimod, a modulator of the sphingosine-1-phosphate pathway, restra

191 Meayamycin B is currently the most potent modulator of the splicing factor 3b subunit 1 and used b

192 lity control through the SMAD2 transcription modulator of the transforming growth factor beta pathway

193 d ultrasound (FUS) has recently emerged as a modulator of the tumor microenvironment, paving the way

194 Thus, we identified IL26 as a novel key modulator of TNBC metastasis and a potential therapeutic

195 However, the role of ARID2 as a modulator of tumor immunity remains unclear.

196 e responses and places this channel as a key modulator of type I IFN production, the hallmark functio

197 neuroanatomical evidence for serotonin as a modulator of vocal-acoustic circuitry and behavior in mi

198 Cannabinoids are notorious and profound modulators of behavioral state.

199 stage to screen large compound libraries for modulators of beta-III-spectrin, or disease-linked spect

200 B cells have been increasingly recognized as modulators of both adaptive and innate immune responses,

201 16,243 and that its expression is induced by modulators of cAMP levels in isolated adipocytes.

202 grade several ECM components and are crucial modulators of cell invasion and tissue organization.

203 Thus, RGSs 4, 6, 9, and 10 are critical modulators of cell signaling pathways that promote SNc D

204 ucts as signaling molecules, antibiotics, or modulators of cellular processes that may be applied in

205 -deficient tumors and identifying epigenetic modulators of chemotherapeutic responses.

206 otransmitters, neuropeptides are emerging as modulators of complex behaviors, including learning and

207 tween histone tails, epigenetic enzymes, and modulators of enzymatic activity.

208 Modulators of epithelial-to-mesenchymal transition (EMT)

209 HAD) superfamily, as previously unrecognized modulators of ferroptosis.

210 s, could unlock new avenues for discovery of modulators of FGF signalling that can slow or stop the p

211 We identified several modulators of Foxp3 expression, including ubiquitin-spec

212 rotein signaling (RGS) proteins are negative modulators of G protein signaling that have emerged as p

213 rtant role for environmental risk factors as modulators of genetic risk.

214 e have enormous potential for application as modulators of genome editing tools.

215 tein-coupled receptors (GPCRs) are important modulators of glucose-stimulated insulin secretion, esse

216 rotein signaling (RGS) proteins are critical modulators of GPCR signaling that dampen the activity of

217 ity and metabolism are known to be important modulators of growth signaling.

218 gation of host exosome proteins as important modulators of HCMV replication with antiviral potential.

219 cytosolic translocation but also function as modulators of host immune responses by modulating numero

220 We use gene mapping to identify modulators of HSC biology linked to MPN risk, and show t

221 the results of a gain-of-function screen for modulators of hypotonicity-induced ATP release using HEK

222 Immunity and nutrition are two essential modulators of individual fitness.

223 Purinergic receptors are well-established modulators of inflammatory processes, primarily through

224 on for the rational design of small molecule modulators of LLPS with therapeutic value.

225 Pase proteome regulated by epitranscriptomic modulators of m(6)A, and our study suggests the potentia

226 mechanical pain neurons and uncovered novel modulators of mechanical pain.

227 es and identifies ILK and GSK-3 as important modulators of melanin transfer to keratinocytes, a key p

228 Heterotrimeric G-proteins are key modulators of multiple signaling and development pathway

229 Positive allosteric modulators of NMDARs include an endogenous neurosteroid

230 venleaf) can also act as positive allosteric modulators of P2X7.

231 Steroid hormones are pivotal modulators of pathophysiological processes in many organ

232 ling (RGS) proteins have emerged as critical modulators of PD pathogenesis and/or motor dysfunction a

233 t microbiome, are potent and proregenerative modulators of poststroke neuronal plasticity at various

234 AMP, sodium salt (DB-cAMP) as two phenotypic modulators of progranulin deficiency.

235 discovery based on the design of allosteric modulators of protein-protein interaction.

236 entify the first-known endogenous allosteric modulators of SIRT1 and characterize a LD-nuclear signal

237 There is an intense search for modulators of SIRT6 activity, however, not many specific

238 ) flours were in vitro evaluated as possible modulators of starch digestibility.

239 Hence, novel modulators of TEAD and methods for their identification

240 efficacy partial agonists and novel, nuanced modulators of the A(3)AR, a drug target of growing inter

241 assess various molecular and pharmacological modulators of the FAO pathway in established cell lines,

242 tudies aimed at characterizing high-affinity modulators of the glycine receptor.

243 ted proteins, including secreted factors and modulators of the matrix.

244 ume (EATv) and density (EATd), and potential modulators of these parameters, has not been described.

245 ion and metabolism of the microbiota, act as modulators of transcription factors involved in inflamma

246 ore template for the design of highly potent modulators of TRPM8-mediated activities.

247 nd certain families are clinically important modulators of vasodilation.

248 ntial therapeutics for LQTS because they are modulators of voltage-gated ion channels.

249 Therapeutic targeting of epigenetic modulators offers a novel approach to the treatment of m

250 Here we systematically screened 39 Na(V) modulators on a bacterial channel (NaChBac) and characte

251 However, the effects of cholinergic modulators on the function of anxiety-related networks i

252 ovitine are greatest when combined with CFTR modulators or cysteamine, justifying further clinical te

253 c acetylcholine receptor positive allosteric modulator (PAM) 3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-

254 y neurons using an NMDAR positive allosteric modulator (PAM) elevates spiking activity of inhibitory

255 binds IDO1 and acts as a positive allosteric modulator (PAM) of the IDO1 enzyme in vitro and in vivo.

256 Application of an mGluR2-positive allosteric modulator (PAM) reduced glutamate neurotransmission in t

257 nistration of the mGluR4 positive allosteric modulator (PAM) VU0155041 (2.5 and 5 mg/kg) rescued soci

258 AGN-241751, an NMDAR positive allosteric modulator (PAM), is currently being tested as an antidep

259 y alpha2/alpha3-GABA(A)R positive allosteric modulators (PAMs) and alpha5-GABA(A)R negative allosteri

260 ntly described 5-HT(2C)R-positive allosteric modulators (PAMs) based on the 4-alkylpiperidine-2-carbo

261 lcholine receptor 4 (M4) positive allosteric modulators (PAMs) for the treatment of symptoms associat

262 choline receptor (mAChR) positive allosteric modulators (PAMs) have been reported to enhance cognitio

263 c derivatives are potent positive allosteric modulators (PAMs) of GABA(A) receptors (GABA(A)Rs) with

264 GluN2C/D-selective NMDAR-positive allosteric modulators (PAMs) with a dihydropyrrolo[1,2-a]pyrazin-3(

265 With a photoelastic modulator (PEM) integrated into an infrared spectrometer

266 preliminary antitumour activity of cereblon modulators plus next-generation anti-CD20 antibodies in

267 into how polynucleotides play the role of a modulator/promoter of LLPS in cells using computational

268 h factor (CTGF), a multifunctional signaling modulator, promotes cancer initiation, progression, and

269 A high-resolution spatial light modulator, referred to as an active optical mapper, perm

270 ogen receptor and mineralocorticoid receptor modulators regulate podocyte injury in experimental mode

271 ing relevant biomolecules and small-molecule modulators regulating them.

272 endothelial cells release the Wnt signaling modulator Rspondin3, which activates beta-catenin signal

273 Here, we characterize the allosteric NTSR1 modulator SBI-553.

274 The selective estrogen receptor modulator (SERM) toremifene was previously identified fr

275 The selective estrogen receptor modulators (SERMs), including 4-hydroxytamoxifen (4OHT),

276 Treatment with a selective GR modulator (sGRm) normalized plasma GC levels and all beh

277 parallel amplifier array and a spatial light modulator (SLM) to actively control the amplitude, polar

278 aphic display is composed of a spatial light modulator (SLM), a volume grating lens, and a microelect

279 solution contamination with a high-affinity modulator such as zinc is most likely to account for the

280 3)H]muscimol binding by allosteric GABAergic modulators such as barbiturates and steroid anesthetics

281 Interestingly, defense modulators such as terpene synthase, papain-like cystein

282 tudies of these three PTCs with various CFTR modulators suggest position-dependent therapeutic strate

283 were more resistant to the estrogen receptor modulator tamoxifen as a result of increased autophagy a

284 However, how these modulators target the receptor complex is currently unkn

285 ia was enhanced by combination with the CFTR modulator tezacaftor/ivacaftor and/or the alternative CF

286 JNJ-56136379 (JNJ-6379), a capsid assembly modulator that blocks hepatitis B virus (HBV) replicatio

287 (ezutromid, 1) is a first-in-class utrophin modulator that has been evaluated in a phase 2 clinical

288 point for the development of selective ERAP1 modulators that have potential for further clinical deve

289 ght the recent development of small-molecule modulators that provide additional biological insight in

290 CF subjects receiving CFTR modulator therapy showed partial restoration of CFTR fun

291 Applying these signaling modulators to human induced pluripotent stem cell-derive

292 We used small molecules and peptide modulators to inhibit BMP, TGF-beta (SMAD), and canonica

293 intercalated small molecules act as "crystal modulators" to modulate the solid-state structures and p

294 that effectively filters small-molecule RyR1 modulators towards clinical relevance.

295 rom ezutromid, the first-generation utrophin modulator, we describe the development of a second gener

296 osteric activity in this class of allosteric modulators were accounted for in our recently developed

297 Nuclear receptor modulators, which often feature carboxylic acid motifs f

298 Ds indicates that subtype-selective GABA(A)R modulators will have novel pharmacological profiles.

299 e design of partial agonists as selective GR modulators with an improved therapeutic index.

300 Pharmacological combination of epigenetic modulators with FGFR-targeted kinase inhibitors may prov

301 New sphingosine-1-phosphate receptor (S1PR) modulators with more specific S1PR target profiles and p