ライフサイエンスコーパス: modulatory

1 e is not homogenous and that it is primarily modulatory.

2 onal data reveal parallels in the underlying modulatory action of two prominent compounds.

3 trate that M2 and M3 receptors have opposing modulatory actions on locomotor circuit output, likely r

4 218 unique chemical entities with documented modulatory activities at homomeric GlyR-alpha1 and -alph

5 Nevertheless, the modulatory activities of these molecules on immune respo

6 or signaling, but molecular details of their modulatory activity are not well understood.

7 llowed by a comprehensive screening for cell-modulatory activity by High-Content Screening (HCS).

8 ts, indicating ClpC may act through the mRNA modulatory activity of MazEF.

9 ne is a tricyclic antidepressant with immune-modulatory activity, whose effects on ligature-induced p

10 ese microbial products have immunoglobulin A-modulatory activity.

11 rings led to significant attenuation of the modulatory activity.

12 and inactive tPA demonstrated similar immune modulatory activity.

13 We evaluated pomalidomide, an oral immune modulatory agent, in patients with symptomatic KS.

14 iew will provide a summary of the epigenetic modulatory agents currently in clinical development and

15 cking parasites that secrete numerous immune-modulatory agents in their saliva to evade host immune r

16 Histamine H4 receptor (H4R) has immune-modulatory and chemotaxic effects in various immune cell

17 ion, owing to the activity of both ascending modulatory and fast-acting corticocortical and subcortic

18 Fourth, DA modulatory and metamoduatory (gating) effects were tailo

19 ction methodology to enrich for functionally modulatory antibodies using a yeast-displayed library of

20 Binding of a modulatory antibody to the cysteine-rich domain liberate

21 ironment, suggesting the potential of immune-modulatory approaches for treating lung cancer with aber

22 In addition to pore-forming Kv4 subunits, modulatory auxiliary subunits called K(+) channel-intera

23 This RNF26 complex represents a new modulatory axis of STING and innate immune signalling at

24 may aid in future development of macrophage-modulatory cancer therapies.

25 pression, localization, and Ca(2+)-dependent modulatory capacities of these isoforms different in fas

26 N terminus is functionally distinct and has modulatory capacities that depend on the muscle type in

27 human Ca(V)2.1 channel, suggesting that this modulatory capacity evolved via changes in channel seque

28 These features are in accordance with the modulatory capacity of G-Neutrophils on regulatory T cel

29 cellular mediators of thrombosis and immune modulatory cells.

30 as a novel subset of induced Treg cells with modulatory characteristics.

31 . elegans thermotaxis behavior by engaging a modulatory circuit whose activity gates the output of th

32 G) is a key structure in the descending pain modulatory circuit.

33 ng molecular mechanisms and binding sites of modulatory compounds, we know just the tip of the iceber

34 nalyses of different Gag constructs revealed modulatory contributions to NA-induced dimerization from

35 generative disorders as a consequence of its modulatory control over diverse neuronal networks requir

36 required to understand its connectivity and modulatory control.

37 Gene expression of interleukin-10, an immune-modulatory cytokine, was significantly (P < 0.05) increa

38 production of immune stimulating and immune modulatory cytokines that drive dysfunctional immune res

39 production of immune stimulating and immune modulatory cytokines.

40 Next, we describe the main modulatory drives of sleep and wakefulness, including ho

41 5-83) years, and had received both an immune modulatory drug (IMiD) and proteasome inhibitor: (35 [73

42 can be reversed using alendronate, an immune modulatory drug.

43 ations and the use of immune suppressive and modulatory drugs for cases of suspected or confirmed aut

44 ry disease are generally treated with immune-modulatory drugs, but daratumumab is also an effective o

45 decline of mGluR5 activity induced the pain modulatory dysfunction with a profound reduction of exci

46 vo, demonstrating a dual, paradoxical immune modulatory effect and supporting the rationale for combi

47 that plasma hyperosmolality exerts a central modulatory effect governing efferent thermoregulatory ac

48 The modulatory effect of adenosine monophosphate (AMP) and a

49 The exact modulatory effect of anionic phospholipids in pLGICs and

50 results establish a splice-variant-dependent modulatory effect of CAPS on catecholamine content in LD

51 usal link between early visual areas and the modulatory effect of exogenous attention on performance.

52 lash suppression (CFS) to assess whether the modulatory effect of gaze direction on emotional face pr

53 cortical atrophy measures, thus suggesting a modulatory effect of iron burden on the disease process.

54 Evaluation of the proposed modulatory effect of irradiation on neuronal activity wi

55 In order to understand the immune modulatory effect of opioids in an unbiased way, here we

56 role of napping and the report of a possible modulatory effect of seasonality in the relation between

57 We find that in the awake macaque the modulatory effect of serotonin is surprisingly uniform:

58 ease of spectral power, and showed a reduced modulatory effect of slow oscillations on higher frequen

59 rther show that standing waves have a strong modulatory effect on activity.

60 ry polyunsaturated fatty acids have a strong modulatory effect on neutrophil homeostasis that may hav

61 lts suggest that attention has a cross-modal modulatory effect on the vestibular cortex during visual

62 In the second experiment, we found that this modulatory effect was explained by participants' assumpt

63 strength with increasing anaplasia implied a modulatory effect.

64 tive populations and to assess its potential modulatory effect.

65 otransmitters act in conjunction with slower modulatory effectors that accumulate in restricted synap

66 ed with HIV also abusing opioids have immune modulatory effects and more severe neurological disease.

67 These modulatory effects assist parasites to establish and sur

68 opulations, with potential to create greater modulatory effects at large.

69 However, the inhibition of MTOR has modulatory effects beyond autophagy that might affect vi

70 Intriguingly, these two modulatory effects by neutrophils are both mediated by r

71 lator of Cav1.2 in neurons, but has distinct modulatory effects compared with its regulation of Cav1.

72 These contrasting patterns of modulatory effects could allow PMd and PMv to play disti

73 basal ganglia interactions, and compared the modulatory effects deep brain stimulation had on differe

74 Most commonly, modulatory effects exerted through cAMP signaling are pe

75 The patterns of modulatory effects from PMd were compared with those fro

76 oncentration was responsible for the maximum modulatory effects observed in all experimental models e

77 The immune-modulatory effects of albumin observed in the Pilot-PREC

78 both pleural cytokine environment and direct modulatory effects of antibiotics.

79 particular, we discuss the off-target immune-modulatory effects of approved cardiovascular therapies,

80 The current study focuses on studying the modulatory effects of b-AP15 on death receptor 5 (DR5) l

81 We hypothesised that if the modulatory effects of gaze on emotional face processing

82 ructural conservation of class B1 GPCRs, the modulatory effects of GM3 and PIP(2) on GCGR may be cons

83 treated patients, and evaluated the putative modulatory effects of HBsAg.We observed that gene expres

84 dative phosphorylation in MDMs prevented the modulatory effects of MSCs.

85 presence of NK cells, governs the net tumor-modulatory effects of neutrophils.

86 Little is known about immune-modulatory effects of nilotinib in vivo, potentially pre

87 that further characterization of the immune modulatory effects of opioid is critical to ensure the s

88 osine 470 and 88 are critical for allosteric modulatory effects of SRI-compounds on the interaction o

89 However, the modulatory effects of stimulation frequency are not only

90 This work provides in vivo evidence for the modulatory effects of subthalamic nucleus deep brain sti

91 Furthermore, we discuss the potential modulatory effects of the gut microbiota on interactions

92 Negative modulatory effects of trait anger on amygdala-dorsolater

93 Here we investigated the allosteric modulatory effects of two allosteric ligands, SRI-20041

94 as suggested that deep brain stimulation has modulatory effects on a number of basal ganglia pathways

95 to evaluate inherent toxicity and potential modulatory effects on Abeta42 toxicity.

96 Several mimics exhibited selective modulatory effects on hUII- and URP-associated vasoconst

97 e effects of GHRH analogs that could involve modulatory effects on monoaminergic signaling, inflammat

98 n(2+) has been shown to have a wide range of modulatory effects on neuronal AMPARs.

99 uring and dissociating multiple time-varying modulatory effects on neuronal responses on the order of

100 at nucleoside derivatives can exhibit varied modulatory effects on P-gp activity, depending on struct

101 We apply the model to investigate daily modulatory effects on pain inhibition, in which response

102 oth the effects of xanomeline per se and its modulatory effects on signals elicited by the NMDA-recep

103 e neurotransmitters that often have opposing modulatory effects on the network.

104 Breastfeeding may have immune modulatory effects that influence the development of chi

105 uced by the blastocyst and has potent immune modulatory effects, especially in relation to T cells.

106 ative cancer treatment, exerts potent immune modulatory effects, inducing tumor-associated antigen (T

107 Individual neurons can exhibit multiple modulatory effects, with considerable variability across

108 connectivity, as well as behaviour-dependent modulatory effects.

109 ANKL levels at baseline predict these immune-modulatory effects.

110 Mb) has been reported to have cardiovascular modulatory effects.

111 complemented by a morphological and pharmaco-modulatory experiment in healthy volunteers.

112 s system (CNS) with fast, transsynaptic, and modulatory extrasynaptic effects being mediated by the i

113 of RAC2 (RAC2(E62K)) involved in recognizing modulatory factors and effectors has been identified in

114 g, identifying the underlying mechanisms and modulatory factors involved, and establishing the most e

115 Modelling the effect of these modulatory factors on sensory responses has proven chall

116 differences in one or more bacterial immune-modulatory factors.

117 Our model requires only the existence of modulatory feedback connections between areas, and short

118 Layer 6 cells provide modulatory feedback input to all thalamic nuclei.

119 se findings define a novel cytokine response modulatory function of MEKi that can be therapeutically

120 d parasites indicate that despite its immune modulatory function, the SNP is neither necessary nor su

121 manner that was largely dependent on its own modulatory function.

122 inflamed tissue is crucial for their immune-modulatory function.

123 of apoptotic cells and also for their immune modulatory functions in the resolution of inflammation.

124 e paralemniscal route is chiefly involved in modulatory functions rather than simply being an informa

125 ntimicrobial defense, MAIT cells have immune-modulatory functions that could enhance dendritic cell (

126 Chemokines have been shown to play immune-modulatory functions unrelated to steering cell migratio

127 ive abundances of bacterial taxa with immune-modulatory functions.

128 th, lung metastasis, and NF-kappaB signaling modulatory functions.

129 s on earth that serve various structural and modulatory functions.

130 trinsic stochastic fractal rate and a global modulatory gain.

131 enriched mushrooms extracts exerts an immune modulatory hepato-protective effect in NASH model.

132 r [GM-CSF], CCL3, CCL5, and CXCL9) or T cell modulatory (IL-4, IL-12, and IL-15) cytokines.

133 of the T-PLL lymphocyte and interrogated the modulatory impact by TCL1A.

134 regulates the adaptive immune response and a modulatory impact on type I allergy is discussed.

135 ons are weaker, slower, and considered to be modulatory, in contrast to fast, high-efficacy feedforwa

136 stimulation (rTMS) and hypothesized that the modulatory influence of PPC over PIVC would be reduced;

137 Considering the modulatory influence of the IL over conditioned fear exp

138 f attitudes and values by exerting a distant modulatory influence on cortical areas and their recipro

139 extend fibers throughout the brain and exert modulatory influence over numerous physiological systems

140 o cortical excitatory input and broaden the "modulatory" influence exerted by corticothalamic synapse

141 t with the idea that the SSN can account for modulatory influences along different stimulus dimension

142 itry and to a more holistic understanding of modulatory influences in sensory processing.

143 We tested for specific patterns of modulatory influences in the domain of motion direction,

144 ested the generality of the SSN by examining modulatory influences in the middle temporal area (MT) o

145 or brain region, we wondered whether similar modulatory influences might be observed for other stimul

146 We sought to assess the modulatory influences of a major neurotransmitter, dopam

147 endothelial dysfunction, including potential modulatory influences of sex, in MDD.

148 been proposed to account for these and other modulatory influences, and tested in V1.

149 ralinear network (SSN), can account for such modulatory influences, using a small set of computationa

150 ng nociceptive signaling and descending pain modulatory information in the affective/emotional pain p

151 rojection neurons convey sensory, motor, and modulatory information to several distinct anatomical re

152 s organization of circadian outflow from and modulatory input to SCN(VIP) cells, and demonstrates a s

153 ion of pauses typically involves synaptic or modulatory input, intrinsic membrane properties may also

154 ENT All sensory systems receive serotonergic modulatory input.

155 idbrain, and hindbrain, in addition to their modulatory inputs from the cortex.

156 ve picture for how L1 transforms sensory and modulatory inputs.

157 f-generated movements and subcortical common modulatory inputs.

158 Our observations suggest a modulatory (instead of a "driver") role of the corticoth

159 ms and point toward future avenues for neuro-modulatory interventions.

160 stal structures of Japanin, an 18 kDa immune-modulatory lipocalin from the Brown Ear Tick (Rhipicepha

161 Here, we identified a conserved immune modulatory mechanism that governs the interaction betwee

162 GlyRs of CGCs support a biphasic modulatory mechanism which enhances AP firing when excit

163 th two stages, each incorporating a divisive modulatory mechanism, reproduces our experimental result

164 e future studies of local and global sensory modulatory mechanisms and their effects on behavior.

165 These results reveal novel modulatory mechanisms for GluN1/GluN3A receptors that fu

166 ogical regulation, the diverse Ca(V) channel modulatory mechanisms may potentially be co-opted or int

167 de it difficult to infer the impact of these modulatory mechanisms on behavioral responses.

168 ther diverse mechanisms, including the small modulatory membrane protein PIRT (phosphoinositide regul

169 These AR-modulatory miRs and targets correlated with AR activity

170 , it is crucial to understand how the innate modulatory molecules are intricately involved in antibac

171 Identifying allosteric modulatory molecules with potential attenuation of cocai

172 e type I interferons (IFNs) and other immune modulatory molecules.

173 ings show that anti-GM-CSF treatment induces modulatory monocytes that act in a CXCL-11-dependent man

174 s that they target, and that even a two cell modulatory network has highly heterogeneous, yet stereot

175 tory immunoreceptors to produce C1q-mediated modulatory networking.

176 ens of molecularly distinct neuropeptidergic modulatory networks that directly interconnect all corti

177 ified connections: reciprocal Kenyon cell to modulatory neuron connections, modulatory neuron to outp

178 stem as a model to establish a framework for modulatory neuron connectivity.

179 Additionally, modulatory neuron output can be stereotyped, yet nonunif

180 r target networks is not well understood, as modulatory neuron populations are heterogeneous in their

181 enyon cell to modulatory neuron connections, modulatory neuron to output neuron connections, and a su

182 The connectivity of individual modulatory neurons can be complex, as they often receive

183 We demonstrate that individual modulatory neurons can integrate neuron class-specific i

184 Our results demonstrate that modulatory neurons do not necessarily provide purely top

185 ttern of connectivity.SIGNIFICANCE STATEMENT Modulatory neurons often project broadly throughout the

186 Modulatory neurons project widely throughout the brain,

187 idating the connectivity logic of individual modulatory neurons provides a ground plan for the seemin

188 However, the connectivity of individual modulatory neurons to their target networks is not well

189 nciples about the connectivity of individual modulatory neurons, we examined a pair of identified neu

190 ationships that underlie network function of modulatory neurons.

191 Rodent models implicate a modulatory pathway centering on the brainstem (i.e., nuc

192 we will be able to distinguish true disease-modulatory pathways from the full range of microglial-re

193 d, these receptors participate in the immune modulatory pathways that contribute to the pathological

194 on of several T lymphocyte-associated immune modulatory pathways, attended by significant upregulatio

195 MVWGP was the most potent immune-modulatory peptide across all cellular assays, which was

196 Contextual effects are attributed to modulatory phenomena, such as stimulus-specific adaption

197 To ascertain the modulatory potential of multiple adrenergic receptor sub

198 ese findings provide novel insights into the modulatory potential of sGAG derivatives on angiogenic p

199 ion with Clostridium difficile and an immune-modulatory probiotic.

200 ly variable across observers and can reflect modulatory processes that are dissociated from perceptua

201 Attention, like other modulatory processes, is also associated with changes in

202 Our results suggest that various modulatory processes, operating at different timescales,

203 nes with potent anti-inflammatory and immune modulatory profiles.

204 l-derived IL1beta in orchestrating an immune-modulatory program that supports pancreatic tumorigenesi

205 troller of ascending brainstem state-setting modulatory projection systems.

206 These modulatory properties depended on MyBP-C's N terminus as

207 We investigated the immune modulatory properties of TEX released upon cell TLR4 act

208 ine is a tetracycline antibiotic with immune-modulatory properties that decreases the severity of EAE

209 This modulatory property of hBD2, unrelated to antibacterial

210 Thus, Shisa7 is a bona-fide AMPAR modulatory protein affecting channel kinetics of AMPARs,

211 This regulation requires the chromatin modulatory protein Alhambra (Alh).

212 The immune modulatory protein herpes virus entry mediator (HVEM) is

213 rane protein 3 (IFITM3) as a gamma-secretase modulatory protein, and establish a mechanism by which i

214 chistosoma eggs), a schistosome-derived host modulatory protein, can ameliorate ifosfamide-related cy

215 Human cytomegalovirus encodes several immune modulatory proteins, including the G protein-coupled rec

216 edial medulla (RVM) and other brainstem pain-modulatory regions, including the ventrolateral periaque

217 ication with vessel patterning might involve modulatory regulatory factors such as R-spondin 1 (Rspo1

218 Additionally, the Th2 modulatory response was evaluated in IL-4 reporter mice.

219 nce of stable network activity, and mediates modulatory responses to the neuropeptide substance P.

220 during low-oxygen growth, saNOS also plays a modulatory role during aerobic respiration.

221 These results reveal a pivotal modulatory role for d-serine in neurodevelopment.

222 These results indicate a modulatory role for TAAR1 in sleep/wake and cortical act

223 Finally, the modulatory role for the functional TLR2-system was sugge

224 We show that Ng plays an important modulatory role in CaMKII phosphorylation following a su

225 bset of mouse FHR proteins have an important modulatory role in complement activation.

226 fer we have discovered that Ulk4 plays a key modulatory role in corticogenesis.

227 Thus, HBL1 plays a modulatory role in fine-tuning human-specific cardiomyoc

228 ast evolution and have only a minor, largely modulatory role in gene regulation under diverse trophic

229 e-related variation of TK is suggestive of a modulatory role in locomotion behavior in C. fortis.

230 -related changes in neuropeptides indicate a modulatory role in sensory input regions and higher orde

231 Intriguingly, the amygdala's modulatory role in such illusory body perceptions is sti

232 Serum vitamin D may play an immune-modulatory role in the development of natural tolerance.

233 c myosin-binding protein C (cMyBP-C) plays a modulatory role in this activation process.

234 p110delta blockade may have a broader immune-modulatory role in types of leukemia that are not sensit

235 Intracellular domains likely play a similar modulatory role in voltage-dependent gating of the relat

236 However, a direct modulatory role of 5-HT in bladder afferent signalling a

237 In this study, we uncovered a novel fusion-modulatory role of a third structurally conserved helica

238 A modulatory role of CAPS in catecholamine loading of vesi

239 However, the modulatory role of ECs in adipose tissue function is not

240 Taken together, we demonstrate a modulatory role of GABA in the murine LSO, rather than a

241 enes other than positional identity, and the modulatory role of Hox genes in fate decisions may offer

242 To confirm a possible modulatory role of IL-6 on MMPs, the relationship betwee

243 These data highlight the modulatory role of NRP1 as MET coreceptor, and they expl

244 Our data emphasize an immune-modulatory role of SCFAs and their importance for cardio

245 The modulatory role of spontaneous brain oscillations on per

246 Specifically, we elucidate the modulatory role of the neuropeptide hormone oxytocin in

247 thereby revealing a tumor-supportive immune-modulatory role of the TRAIL/TRAIL-R system in cancer bi

248 usly unidentified molecular insight into the modulatory role of this protein in cardiac muscle contra

249 o primary visual cortex (V1) that play a key modulatory role on visual function.

250 oreover, although visual stimulation plays a modulatory role, it is neither necessary nor sufficient

251 but also suggests that, in addition to their modulatory role, the family of P2X receptors could have

252 lower temporal precision, consistent with a modulatory role.

253 etwork gain control, an important but purely modulatory role.

254 -AG production and CB1 activation play a key modulatory roles in normal intestinal mucosa permeabilit

255 Our results characterize these novel fusion-modulatory roles of the F HR3, improving our understandi

256 cells and the emerging innate properties and modulatory roles of the fibroblastic mesenchyme.

257 a generative model, whereby a reward-driven modulatory signal gates the impact of the latent model o

258 we investigated the hypothesis that specific modulatory signals shape memory formation into a state t

259 man MondoA requires glucose as well as other modulatory signals to function in transcription.

260 ant sensory neurons can reflect postdecision modulatory signals.SIGNIFICANCE STATEMENT When observers

261 ested that the A-967079 cavity is a positive modulatory site for propofol.

262 tively characterize the contribution of each modulatory source in response generation, mainly due to

263 to quantitatively track the role of multiple modulatory sources over time.

264 ponse to presynaptic stimuli) depends on the modulatory state of inhibition.

265 y, suggesting a maladaptive supraspinal pain modulatory state.

266 ns to define the therapeutic value of immune-modulatory strategies in DS.

267 hese pathways are targeted as part of immune modulatory strategies to treat cancers, referred to gene

268 Individual differences in the modulatory strength of prior belief on insular projectio

269 the LOST model to accommodate changes in the modulatory structure over the duration of the experiment

270 eraction between ks-vFLIP and the IKK kinase modulatory subunit IKKgamma.

271 from its capacity to form a complex with the modulatory subunit of the IkappaB kinase (IKK) kinase, I

272 Thus, these modulatory subunits could be potential drug targets for

273 K(+) channel modulatory subunits KChIP1, KChIP2, and DPP10 are coexpr

274 study is the first to show that K(+) channel modulatory subunits KChIP1, KChIP2, and DPP10 are potent

275 x, this study demonstrates that K(+) channel modulatory subunits KChIP1, KChIP2, and DPP10 participat

276 y (PAG), a key region in the descending pain modulatory system (DPMS) between migraine without aura (

277 pattern of variation of the descending pain modulatory system (DPMS) using a conditioned pain modula

278 ulla (RVM) is a relay in the descending pain modulatory system and an important site of endocannabino

279 The net effects of this modulatory system on locomotor activity can vary between

280 onal connectivities with the descending pain modulatory system, they produced significantly correlate

281 mes chronic with the dysfunction of the pain modulatory system; however, the underlying mechanisms ar

282 nd decreased capacity of intracellular redox modulatory systems are consistent findings in persons wi

283 riod of rapid brain development, before pain modulatory systems reach maturity, will predict pronounc

284 e coordination of multiple neurochemical and modulatory systems.

285 and depend upon the activation of endogenous modulatory systems.

286 n for the seemingly heterogeneous effects of modulatory systems.

287 ary interventions aiming at expanding immune-modulatory taxa could be studied for prevention of aller

288 Despite its importance, there are no modulatory therapeutics.

289 plication, assembly, or secretion and immune modulatory therapies are in development.

290 further build on CANTOS to review the immune-modulatory therapies for atherosclerosis currently in tr

291 s considerable interest in developing immune modulatory therapies for neurodegenerative disorders.

292 th development of novel antiviral and immune modulatory therapies such that approval of new treatment

293 Combination of antiviral and immune modulatory therapies will likely be needed to achieve fu

294 mechanism is likely to benefit future immune-modulatory therapies.

295 tential impact on the optimization of immune-modulatory therapies.

296 ns have centered on the potential for immune modulatory therapy to improve long-term patient outcomes

297 Our findings suggest that modulatory tone may select a subset of rapid activity-de

298 d within the context of SWS-associated neuro-modulatory tone that may reduce feedforward inhibition.

299 nterleukin-10 (IL-10) cytokine, and the down-modulatory tryptophan catabolism.

300 m, dyw implicates a less recognized class of modulatory wake-sleep regulators that primarily function