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1 oration across the parent steroid's trienone moiety.
2 ed and isomerized forms of the isoxazole SMX moiety.
3 ependent on the saturation of the phosphanyl moiety.
4 eptide catalysts equipped with an azobenzene moiety.
5 f the cis-2,8-dioxabicyclo[3.3.0]octan-3-one moiety.
6 ng a -CH(2) Br or a -CHO group into a pyrene moiety.
7 n Rossmanns it binds the nucleotide's ribose moiety.
8 es an unusual bicyclic eight-carbon dialdose moiety.
9 receptor with an anti-CD3 T Cell-activating moiety.
10 idate containing a trisubstituted piperidine moiety.
11 L) decorated with a pendent N-methylprolinyl moiety.
12 seminaphthorhodafluor dye with a diselenide moiety.
13 s caspases by involving its O-antigen (O Ag) moiety.
14 ation and hydrogen bond formation via its NH moiety.
15 depending on the substitution of the alkynyl moiety.
16 ng decrease in the basicity of the guanidine moiety.
17 o be an unsymmetrically arranged Cu-S(1)N(3) moiety.
18 -quaterpyridines containing a nicotinic acid moiety.
19 hemoenzymatic attachment of the second sugar moiety.
20 migrate to the alpha-carbon of the acrylate moiety.
21 gnment of the fused pyridine-isothiazolinone moiety.
22 inking agent based on a novel DNA-alkylating moiety.
23 a functionalization and stability providing moiety.
24 rbon stereogenic centers and an alkenylboron moiety.
25 etween the perylene-diimide and the helicene moieties.
26 O-linked beta-N-acetylglucosamine (O-GlcNAc) moieties.
27 and adamantyl groups on the salicylaldehyde moieties.
28 atty acyl substituents and phosphatidic acid moieties.
29 introduction of designed shape-complementary moieties.
30 ng complex crosslinking between nucleophilic moieties.
31 ai-pai stacking interactions between organic moieties.
32 nal changes to accommodate the different cap moieties.
33 e been discerned for HATs involving OH or CH moieties.
34 tes deep defluorination of short fluoroalkyl moieties.
35 old for IEF-focused proteins via photoactive moieties.
36 posttranslational levels of two specific tau moieties.
37 different patterns of N-acetyl and N-sulfate moieties.
38 ance the rigidity and conjugation of the dye moieties.
39 e for solubilizing multiple lipid fatty acid moieties.
40 of functional groups on quinoline and olefin moieties.
41 ion cross-sectional enhancement by phosphate moieties.
42 ymer chains and dehydrating the zwitterionic moieties.
43 groups instead of the rigid polyheterocyclic moieties.
44 a graphitic N dopants surrounding the CoN(4) moieties.
45 u nasal gel for brain delivery of CNS acting moieties.
46 ange of functional groups and heteroaromatic moieties.
47 ive capture via TD NTs with different charge moieties.
49 addition of an alkanethiol to an isonitrile moiety, 5-exo cyclization, followed by nucleophilic addi
50 iscover that the low-valent Cuprous-S(1)N(3) moiety acts as an active center during the oxygen reduct
51 his design, having 1 sulfonate on the indole moiety adjacent to EuK ((99m)Tc-EuK-(SO(3))Cy5-mas(3)) y
52 In hexavinylene-SubPzs, peripheral vinylene moieties adopt a coplanar configuration with the aromati
55 The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers,
57 state with local excitations (LE) on the PTM moiety; also, these nonradiative rates deviate significa
58 6-(F) Mes, in which six tricoordinate borane moieties alternate with short conjugated p-phenylene lin
59 8 approved NDAs were for previously approved moieties, analysis of available NDAs for referent produc
61 MPA monomers with orthogonally complementary moieties and a wisely selected chemical toolbox generate
62 pophilic-lipophilic association of the alkyl moieties and complementary perfect fit of the triangular
63 e dissected IgE responses to specific glycan moieties and found that reactivity to classical CCD epit
64 tions of atoms within the donor and acceptor moieties and is very well described as a simple combinat
65 bles the easy incorporation of morpholino-pS moieties and therapeutically relevant sugar modification
66 iation between the presence of a sulfonamide moiety and a high reporting rate of cutaneous AEs and in
67 ese MALCs, consisting of a dimethylsulfonium moiety and a long alkyl chain (C(18)-SMe(2)(+)), also in
69 rating spiropyran derivatives as the sensing moiety and characterized features that influence photosw
70 and MD2, both of which incorporate a methoxy moiety and exist in cis orientations with respect to the
71 an acetamide substituent on the N-tert-butyl moiety and para-substituted phenyl or naphthlyl moieties
72 ining an NGL consisting of the optimal lipid moiety and the GM1 ganglioside pentasaccharide yielded a
73 as well as protecting groups on the xyloside moiety and the influence of the substituents on the alky
74 ced, the former with a substituted aziridine moiety and the latter with an NCO-alkyl residue (imide o
75 masking units, one is the acyloxybenzyl (AB) moiety and the other is the alkoxycarbonyloxybenzyl (ACB
76 denine molecules, the other with two thymine moieties, and the third containing both adenine and thym
80 n revealed that relatively small hydrophobic moieties are preferred, with 10 being the most potent Sp
83 V)=O intermediates with a terminal metal-oxo moiety are key oxidants in many enzymatic and synthetic
84 spectroscopy revealed the presence of a W=O moiety arising from the in situ reaction of the W=C(t)Bu
86 tated with fragments from carnitine and acyl moieties as well as neutral loss peaks from precursors.
87 ed herein entail the use of the gem-dimethyl moiety as a means of improving the pharmacological activ
90 new structural features, improved structural moiety assignment and use of more sequence-based annotat
91 be has a fast covalent binding with carbonyl moieties at neutral pH to form a stable fluorescent hydr
92 analogs substituted with different chemical moieties at the 2' position suggest a clear role for 2'-
93 rboxamide scaffold, we optimized the undecyl moiety at the 4-position with variations of cyclohexyl-
94 [Ni(IMes)(2)] is essential to install a Bpin moiety at the N-position as a traceless directing group,
97 h are present opposite to the benzodipyrrole moiety, attained ring inversion (inverted sapphyrins), w
98 t possess fully annulated donor and acceptor moieties based on palladium (Pd)-catalyzed [3+2] annulat
99 is based on the electrosynthesis of an amino moiety-bearing polymer layer on the graphene channel.
103 e probe, which contains a cyanimide reactive moiety, binds to the active-site cysteine residue of UCH
104 ular complexity within the inert hydrocarbon moiety, but to date this approach has been met with litt
105 t the 2-electron reduction of heterocumulene moieties can allow access to unusual free carbene coordi
106 or that integrate living cells or bioactive moieties, can respond to a range of environmental stimul
107 w alkynyl benzoxazine and dihydroquinazoline moieties capable of covalent reaction with cysteine.
108 alent drugs, there is a need to identify new moieties capable of cysteine bond formation that are dif
109 ted imidazo[1,2-a]pyridines, an heterocyclic moiety commonly found in medicinal chemistry leads and d
110 he pocket was achieved with a tertiary amide moiety, confirmed by the X-ray co-crystal structure of 2
111 layers and identified its membrane anchoring moiety, consisting of a hydrophobic loop located at the
112 reptozotocin (SZN) contains an N-nitrosourea moiety constructed from N(omega)-methyl-l-arginine (l-NM
113 cterized the photolysis and hydrolysis of NB moieties containing different labile bonds (i.e., ester,
114 and the ability to attach multiple targeting moieties, controlled release, and site-specific targetin
115 olves complementary strands, with azobenzene moieties deliberately staggered between the bases that d
119 to a single alkene product, and unsaturated moieties embedded within linear and heterocyclic biologi
120 ges highly reactive but chemically selective moieties, enabling the use of protein-inert amines for s
121 horylate zidovudine and ganciclovir to toxic moieties, enabling treatment of KSHV-MCD with these drug
123 n Pd-catalysed dearomatization of the benzyl moiety followed by a base-enabled rearomatization throug
126 fic proteases Wss1/SPRTN targets DPC protein moieties for degradation, including stabilized topoisome
128 ourea catalyst features a N-terminal proline moiety for aldehyde activation and a thiourea unit for e
129 phase azide resin that installs a diagnostic moiety for MS/MS-based identification, DIMEN uncovered s
130 peptide may have applications as a targeting moiety for the selective delivery of imaging and therape
131 is revealed the decalin scaffold as the best moiety for the selectivity-enabling subpocket of FBKP51.
132 onsequences of decoupling amino and catechol moieties from each other were compared (that is, incorpo
133 f rare Cu-hemiacetalate and Cu-hemiaminalate moieties from the insertion of an ester or amide into th
134 catalyze the covalent addition of the sugar moiety from a UDP-sugar cofactor to relatively low-molec
135 cto-N-neotetraose (LNnT; Gal-GlcNAc-Gal-Glc) moiety from heptose I (HepI) of the lipooligosaccharide
136 er binding to FGF14, altering the C-terminal moiety from methoxy (21a) to pai bond-containing (23a an
137 , by successively transferring the fructosyl moiety from sucrose to a growing acceptor molecule.
138 at position 8 and deprotection of the sugar moiety gave eight derivatives of pyrazolo-fused deazapur
139 ing the substituents of the trimethoxyphenyl moiety gave rise to an equipotent benzamide analogue M4K
141 l substituents at position 23 of the helical moieties has a negligible impact on the optical properti
142 ated N,O-acetals having a protected cis-diol moiety has been readily achieved in two steps from a kno
144 ngs, and in particular 1,3-disubstituted BCP moieties have become widely adopted in medicinal chemist
145 ytically without denaturing the carbohydrate moiety have enabled the concept of the "lignin-first" bi
146 family, para-substitution with electron-rich moieties (i.e., phenylene or ether) red-shifts both the
150 tuted carbon centers are highly sought-after moieties in pharmaceutical and agrochemical discovery.
151 rivatives in position 9, substituted pyridyl moieties in position 4 and small alkyl groups in positio
152 ry and secondary electron donor and acceptor moieties in the reaction center to control the yield and
153 low from the dissociated heme to the protein moiety in cytochrome c, which we assign to the presence
154 nt with a key role for pegfilgrastim's G-CSF moiety in driving formation of inactive aggregates.
155 y of electrophilicity of the heme superoxide moiety in facilitating the initial indole activation ste
160 decorated with carbohydrate-based targeting moieties including mannose, galactose, dextran, and a mi
162 ABX-GMFET was based on a charge or chemical moiety interaction between the bioprobes and target bact
163 ion involves the incorporation of the active moieties into a shell structure (e.g., protein, polysacc
164 molecule in a micelle, pointing the farnesyl moieties into the hydrophobic center and positioning the
166 hilicity by the transformation of a boronate moiety into a borinic ester with (n)BuLi/trifluoroacetic
167 involves the transformation of the isoxazole moiety into a carboxylic acid group, thus opening access
170 show that the presence of a beta-pyridinium moiety is critical for the desired C-C bond formation.
171 c intermediate in which the 5'-deoxyadenosyl moiety is directly bound to the unique iron of the [4Fe-
172 ionalization of both o,o'-C-H bonds of arene moiety is explicitly viable under the influence of methy
173 via oxygen atom transfer (OAT) to an olefin moiety is mainly derived from the studies on thiolate-he
174 All three parameters suggest that the Bpin moiety is remarkably small, with the planarity of the ox
177 onine and tryptophan as the most susceptible moieties, is mainly monitored by HPLC-MS techniques.
179 dia, it is possible to hydrolyze the oxirane moiety leading to 21 % yield of alpha,beta-dihydroxy aci
180 cts both the mode and rate of cleavage of NB moieties, leading to unpredictable limitations in contro
181 (ASO) with a variety of distinct lipophilic moieties like fatty acids and cholesterol increases ASO
182 ene, beta-pinene and camphene, or two alkene moieties like limonene, valencene, and beta-caryophyllen
183 Composed of a peptide-caged NIR signaling moiety linked with a hydrophilic poly(ethylene glycol) (
184 conductors, which commonly comprise aromatic moieties, may present new opportunities for the understa
185 ntaining residues, 12,13-difluorocyclopropyl moieties, mono- and dimethylated macrolactones, and 1-ke
187 pH-dependent coordination of the ethylamine moiety occurs in the pH range of 6-8 (log K(MnL)(H) = 6.
188 lic framework comprising a cyclooctatetraene moiety, octaphenyltetrabenzocyclooctatetraene, with lith
189 l efficiently substitutes the three carboxyl moieties of Finland trityl with a high rate constant of
190 nteractions between negatively charged sugar moieties of HSPGs and clustered K-T-K motifs in alpha-Sy
192 ective means to confirm the three fatty acid moieties of the TAGs, leading to the rapid and accurate
194 ent RslO5 reductively ring-opens the epoxide moiety of an advanced polycyclic intermediate to form an
196 n catalyze oxidation of a methyl to the acid moiety of dehydroabietic acid in triptolide biosynthesis
197 The total synthesis of the oligosaccharide moiety of disialosyl globopentaosylceramide (DSGb5 Cer),
198 isostere but rather as a readily interacting moiety of drug-like molecules with high potential for in
199 ine the formation of the fully saturated APD moiety of lincomycin versus the unsaturated APD moiety o
200 In eukaryotic cells, the N-terminal amino moiety of many proteins is modified by N-acetyltransfera
203 teins function by binding to the matriglycan moiety of O-mannosyl glycans, we hypothesized that EYS i
204 ety of lincomycin versus the unsaturated APD moiety of PBDs, providing molecules with optimal shapes
205 to C1, the cell-surface anchored C-terminal moiety of PrP generated by natural cellular processing.
210 ocks the key selectivity-inducing cyclohexyl moiety of the ligand in a conformation typical for FKBP5
213 pincer ligands bearing either CF(3) or (t)Bu moieties on the triazole rings along with triphenylpnict
214 e), a thermoresponsive polymer with an amide moiety on its side chain, was studied in aqueous solutio
215 e moment, generated by an N,N-dimethylamino- moiety on one end of the car coupled with a nitro group
217 at loss of the 3-(dichlorophenyl)-isoxazolyl moiety or the aromatic nitrogen heterocycle with nitroge
218 bstituent groups (e.g. heavy atoms, carbonyl moieties) or by the out-of-plane vibrational modes in th
219 ing showed that the oxygens of both hydroxyl moieties originate from molecular oxygen rather than wat
220 increasing availability of beta-cyclodextrin moieties over the surface of the devices and thus the de
221 ng substitutions of the N(6)-(2-phenylethyl) moiety particularly enhanced mA(3)AR affinity by polar i
222 materials, having single or multiple mesogen moieties per molecule, commonly exhibit typical self-org
223 showed a high occurrence of very-long-chain moieties; phytosphingosine and 4-hydroxy-8-sphingenine w
224 ed by benzo[2,1,3]thiadiazole S-N-containing moieties plays a significant role in governing the molec
225 xacontamer, we conclude that while phosphate moieties present in crRNA and ATP molecules enhance IRMP
226 ingolipid long-chain base and the fatty acyl moiety produces many more isobaric species and fragments
227 sults highlight that the N5-alkylamidoindole moiety provides a suitable pharmacophoric scaffold for t
230 orm when the terminal oxygen atom of the NOO moiety reacts with the ortho position of the aromatic ri
231 eaks down into fragments while the pteridine moiety remains intact likely evolving into 6-formylpteri
232 Two neurosteroid analogues with diazirine moieties replacing the 3-hydroxyl (KK148 and KK150) bind
234 n A enediyne payloads through their phenolic moiety represents a novel approach to enediyne ADC creat
235 O(4), but features an extraordinary chemical moiety, rotationally disordered H(4)PO(4)(+) cations, wh
236 ylmethanol, para-substituted with the chiral moiety, shows a propensity for a solid-state sorting phe
237 ct desulfurization reaction of the thiophene moiety strongly improves the molecular anchoring by form
240 gineered through conjugation with fatty acid moieties that are known to exhibit high binding affiniti
241 The beta-lactam ring represents a valuable moiety that can induce covalent binding of an inhibitor
243 nd form of CR8 has a solvent-exposed pyridyl moiety that induces the formation of a complex between C
244 are Wnt proteins, which carry a palmitoleate moiety that is essential for signalling activity(1-3).
245 es indicate the presence of two Fe-(mu-H)-Fe moieties, the structural and electronic features of this
246 he degree of pyramidality of the N(CH(2))(3) moiety-the positive end of the molecular dipole of XS.
247 iggered by a base-sensitive, self-immolative moiety, these precursors show efficient RSSH release and
248 ough these inhibitors each have a nucleoside moiety, they vary dramatically in their core structures,
249 the hydrogen-bond donors of the central urea moiety through an intramolecular interaction led to impr
251 ct steric effects by introducing bulky amido moieties to ortho- or para-positions of the meso-phenyl
255 m the cell as well as the transport of lipid moieties to the outer membrane to establish membrane rig
257 required nucleophilicity of the phosphanido moiety to accomplish the P-C bond formation, the key rol
258 yruvate ratio, suitable for use as a binding moiety to develop a lactate/pyruvate ratio FRET-based ge
260 (3), followed by N-sulfonation of one indole moiety to furnish 6-bromo-3-(6-bromo-1H-indole-3-carbony
262 2 ester-linked lipid from the diacylglycerol moiety to the alpha-amino terminus without forming a cov
264 the consequences of appending the bulky GFP moiety to the protein of interest are rarely investigate
267 Finally, the phytoceramide-1-H-phosphonate moiety was coupled with pseudodisaccharide followed by d
268 The CF(3)Boc-group that caps the P3 amino moiety was discovered to be an essential contributor to
271 MPP* ligands with a P-chirogenic phosphinite moiety was performed by N -> O phosphinyl migration of a
273 n resonance studies revealed that while this moiety was sufficient to confer binding to FGF14, alteri
274 ns with different substituents at the indole moiety was synthesized employing either enzymatic haloge
276 nged, while side-group East, West, and South moieties were altered by introducing different building
278 n which the 12,13-epoxide and macrolactam NH moieties were replaced, the former with a substituted az
280 aminoquinoline and a positively charged tail moiety were potent and had up to nearly 900-fold selecti
281 ) values of all short-chain PFASs (<=5 -CF2- moieties) were similar and varied less (<0.5 log units)
282 ate the need to identify endosome disrupting moieties which retain their activity within poly(acidic)
283 azido- or trifluoromethylphenyl-methanimine moiety, which allowed the selective installation of alph
284 thanides is compensated by the semiconductor moiety, which harvests the optical energy and funnel it
285 n + 1] ring expansion of the tetrahydrofuran moiety, which results in the formation of a medicinally
286 electronic and steric nature of the sulfonyl moiety, which serves as a base-labile protecting group a
287 rease the basicity of the quinolinoquinoline moiety, while the substitution of electron-withdrawing g
288 ol, a thiosemicarbazide or thiosemicarbazone moiety, while VIM-2 by triazole-containing molecules.
289 ed metabolites of microbial origin and lipid moieties with development of ACLF and death as an inpati
290 aring octahedra forming isolated Ru(2) Br(9) moieties with very short Ru-Ru contacts of 2.789 angstro
293 ion-pai interaction of the aromatic triazole moiety with the Arg(356) residue of the receptor is acco
294 membranes by adjusting the number of cyclic moieties within the cores of their glycerol dibiphytanyl
295 the adopted drug design strategy as specific moieties within the ligand structure interacted directly
296 ; intriguingly, the distinct dikeophosphanyl moieties within the macrocycles appear effectively "insu
297 by combining a fluorophore and a recognition moiety within a complex cavity of a multicomponent MOF.
298 of the fluorine residues and the aziridinyl moiety within the structure of the epothilone molecule a