ライフサイエンスコーパス: mole rat

1 furred African mole-rat species (the common mole-rat).

2 insects), and in specialized habitats (naked mole rats).

3 erriding anti-cancer mechanisms of the naked mole rat.

4 considering the small body mass of the naked mole rat.

5 g to the subterranean evolution of the blind mole rat.

6 resistance mechanism identified in the naked mole rat.

7 the remarkable tumor resistance of the naked mole-rat.

8 nization of somatosensory areas in the naked mole-rat.

9 mutated tumor suppressor, TP53, in the naked mole-rat.

10 lmost cancer-proof naked mole rats and blind mole rats.

11 ps, and beetles), snapping shrimp, and naked mole rats.

12 lopmental refinement in naked and Damaraland mole rats.

13 hared similarly between naked and Damaraland mole rats.

14 ge from 4 years in mice to 32 years in naked mole rats.

15 s were under purifying selection in bats and mole-rats.

16 and Natal (Cryptomys hottentotus natalensis) mole-rats.

17 ociality and the unusual physiology of naked mole-rats.

18 tion in outer hair cells isolated from naked mole-rats.

19 entations of oral structures in primates and mole-rats.

20 approximately 15% of somatosensory cortex in mole-rats.

21 ons with differential epigenomic activity in mole-rats.

22 regulation in highly cooperative Damaraland mole-rats.

23 AR/RXR transcription factor binding sites in mole-rats.

24 ectancy of reproductive vs. non-reproductive mole-rats.

25 differed in liver tissue from mice and naked mole-rats.

26 ular nucleus display a greater level in Cape mole-rats.

27 known to occur in species ranging from naked mole rats [1] to owls [2], chimpanzees are the most acco

28 gevity of the longest-lived rodent-the naked mole-rat(1,2).

29 We explore this in the naked mole-rat, a species with the most rigidly organized repr

30 These elements associate with known mole-rat adaptations in metabolic and functional pathway

31 e performance of a recently introduced naked mole-rat algorithm (NMRA), by local optima avoidance, an

32 Here we show that the full-length mole rat alphaB-crystallin intergenic region behaves sim

33 ligonucleotides from the wild-type mouse and mole rat alphaB-crystallin promoter region under study f

34 Our data support the idea that blind mole rats' alphaB-crystallin promoter activity was modif

35 Naked and Damaraland mole rats also showed reduced lateral and medial efferen

36 Naked mole-rats also were completely lacking in cutaneous C-fi

37 Recent studies in naked mole rat and long-lived sea urchins showed that these sp

38 cer-prone mice and almost cancer-proof naked mole rats and blind mole rats.

39 o a growing list of adaptations in the naked mole-rat and provides a plausible proximate mechanism fo

40 ranscriptomic data from 26 bat species, five mole-rats and 38 outgroup species.

41 GF1 axis relates to the longevity of African mole-rats and bats, we compared and analysed the homolog

42 udied in species with reduced vision such as mole-rats and bats.

43 zed, these were highly synchronized in naked mole-rats and likely linked to their use of feeding time

44 nd examined Nrf2-signaling activity in naked mole-rats and nine other rodent species with varying max

45 hearing in naked and the related Damaraland mole-rats and to examine whether these alterations resul

46 mmon, Natal, Mahali, Highveld and Damaraland mole-rats) and evolutionarily divergent mammals (Hottent

47 erested in the genome and genes of the naked mole rat, and also to facilitate further studies on this

48 bonobo/chimpanzee, guinea pig/degu/tuco-tuco/mole rat, and cattle/yak.

49 s induced by oncogenic Ras than mouse, blind mole-rat, and human cells, revealing suppressed Ras sign

50 d genome assemblies of the guinea pig, naked mole-rat, and human.

51 fe spans, including mouse, guinea pig, blind mole-rat, and naked mole-rat, as well as humans.

52 he neurobiology of social hierarchy in naked mole-rats, and add to a growing body of work that links

53 , but several mammals, such as whales, naked mole-rats, and humans, have notably less hair.

54 nments, such as those seen in turtles, naked mole-rats, and several other animals(1).

55 is consistent with the hypothesis that naked mole rats are neotenous, with retention of juvenile char

56 Naked mole rats are the longest-living rodents, whose nervous

57 Naked mole-rats are adapted to living in a low-oxygen and high

58 Senescent cells in naked mole-rats are eliminated by apoptosis.

59 Naked mole-rats are eusocial rodents that live in large subter

60 Naked mole-rats are highly vocal, eusocial, subterranean roden

61 atures of the cutaneous innervation in naked mole-rats are presumably adaptations to their subterrane

62 Cape mole-rats are solitary; they tolerate conspecifics only

63 African mole-rats are subterranean rodents inhabiting undergroun

64 African naked mole-rats are subterranean rodents that have a robust or

65 African mole-rats are subterranean rodents that spend their whol

66 This review aims to present the blind mole rat as an ideal, novel neuroethological model for s

67 ompertz's law 'uniquely identifies the naked mole-rat as a non-aging mammal'.

68 from the brain of the closely related naked mole-rat as well as from epigeic mammals (rat), with a p

69 pain, which would be advantageous for naked mole-rats as they normally live under chronically high l

70 mouse, guinea pig, blind mole-rat, and naked mole-rat, as well as humans.

71 Here we cloned naked mole-rat ASIC3 (nmrASIC3) and used a cell-surface biotin

72 sues (blood, spleen) and thymus of the naked mole-rat at different ages by TCR repertoire profiling a

73 ed in long-lived species including the naked mole-rat, bats, and the bowhead whale, but these adaptat

74 The blind mole rat (BMR), Spalax galili, is an excellent model for

75 On the social scale, the blind mole rat (BMR; Spalax ehrenbergi) is an extreme.

76 Blind mole rats (BMRs) are small rodents, characterized by an

77 In sharp contrast, in the naked mole-rat both Per1 and Per2, as well as Bmal1, peaked at

78 campal and olfactory structures of the naked mole rat brain.

79 resent a comprehensive atlas of the Ansell's mole-rat brain based on Nissl and Kluver-Barrera stained

80 pose that excessive Ca(2+) influx into naked mole-rat brain is buffered by physical storage in large

81 r, hypoxia-mediated Ca(2+) influx into naked mole-rat brain is markedly reduced relative to mice.

82 This is important because naked mole-rat brain is robustly tolerant against in vitro hyp

83 ifically, and relative to mouse brain, naked mole-rat brain mitochondria are larger and have higher c

84 We report that naked mole-rat brain mitochondria buffer >2-fold more exogenou

85 We hypothesized that naked mole-rat brain mitochondria have an enhanced capacity to

86 The ability of naked mole-rat brain mitochondria to safely retain large volum

87 The unique ultrastructure of naked mole-rat brain mitochondria, as a large physical storage

88 We show that in hypoxic naked mole-rat brain, oxidative capacity and mitochondrial mem

89 a(2+) are retarded in hypoxia-tolerant naked mole-rat brain.

90 the hypoxia and ischaemia-tolerance of naked mole-rat brain.

91 e phosphorylation is >2-fold higher in naked mole-rat brain.

92 neuronal migration are not unusual in naked mole rat brains.

93 ongevity mechanism that evolved in the naked mole-rat can be exported to other species, and open new

94 lta1-4 NK-like effector T cells in the naked mole-rat can contribute to tumor immunosurveillance by g

95 HMW-HA triggers hypersensitivity of naked mole rat cells to contact inhibition, which is associate

96 Furthermore, the naked mole-rat cells are more sensitive to HA signalling, as t

97 essing the HA-degrading enzyme, HYAL2, naked mole-rat cells become susceptible to malignant transform

98 In summary, our results show that naked mole-rat cells produce fewer aberrant proteins, supporti

99 robust anchorage-independent growth in naked mole-rat cells, while it readily transforms mouse fibrob

100 f mouse fibroblasts fails to transform naked mole-rat cells.

101 these are unique to the naked mole-rat, the mole-rat clade, or are also present in other mammals.

102 of nonreproductive individuals in Damaraland mole rats closely resembles that found in other cooperat

103 orical lifespan data on more than 3200 naked mole-rats, collected over a total observation period of

104 Multi-year observations of large naked mole-rat colonies did not detect a single incidence of c

105 The discovery of a disperser morph in naked mole-rat colonies has revealed the first possible outbre

106 r innervation in mature and developing naked mole rats compared to mice (Mus musculus), gerbils (Meri

107 However, in mole-rats, concentrated reproduction is also accompanied

108 s that the more stable proteome of the naked mole-rat contributes to its longevity.

109 T(INK4a/b) of the INK4a/b locus in the naked mole rat, contributes to the increased resistance to tum

110 Ca(2+) and examined Ca(2+) handling in naked mole-rat cortical tissue.

111 the diminished function of KCC2, adult naked mole-rats demonstrate a reduced efficacy of inhibition t

112 Naked mole-rats, despite having functional ASICs, are insensit

113 Behaviorally, naked mole-rats did not avoid fumes from moderately high conce

114 ersibly inhibits ASIC-like currents in naked mole-rat dorsal root ganglia neurons.

115 We found that the p53 protein in naked mole-rat embryonic fibroblasts (NEFs) exhibits a half-li

116 Finally, somatosensory cortex in naked mole-rats encompasses virtually all of the neocortex nor

117 at which the level of CRF1 binding in naked mole-rats exceeds that in Cape mole-rats include the bas

118 In addition, the AITC-insensitive highveld mole-rat exhibited overexpression of the leak channel NA

119 pharmacological intervention, in adult naked mole-rats exposed to a simulated hyperthermic surface en

120 in five further members of the Bathyergidae mole-rat family: silvery (Heliophobius argenteocinereus)

121 In cell culture, naked mole-rat fibroblasts arrest at a much lower density than

122 Here we show that naked mole-rat fibroblasts display hypersensitivity to contact

123 We report that naked mole-rat fibroblasts have significantly increased transl

124 We found that naked mole-rat fibroblasts secrete extremely high-molecular-ma

125 ial DNA in the control region and ATP6 in 28 mole rats from basalt and in 14 from chalk habitats.

126 nent of extracellular matrix, protects naked mole rats from cancer and reduces cancer incidence in mi

127 bils (Meriones unguiculatus), and Damaraland mole rats (Fukomys damarensis), another subterranean rod

128 rat (Heterocephalus glaber) and the Ansell's mole-rat (Fukomys anselli) at the molecular level in a c

129 The Ansell's mole-rat (Fukomys anselli) has been the subject of many

130 rats, Heterocephalus glaber, and Damaraland mole rats, Fukomys damarensis) suggest that individual d

131 aked mole-rats was compared to other African mole-rat genera (Cape, Cape dune, Common, Natal, Mahali,

132 ped a freely available web portal, the Naked Mole Rat Genome Resource, featuring the data and results

133 Analysis of the naked mole-rat genome revealed, uniquely among mammals, a hist

134 Using our own TCR annotation in the naked mole-rat genome, we report that the gammadelta TCR reper

135 scriptomes of the eusocial mammal, the naked mole-rat H. glaber, with orthologous A. cephalotes worke

136 aneous saphenous and sural nerves, the naked mole-rat had the lowest C:A-fiber ratio ( approximately

137 In contrast to the furred species, naked mole-rats had a paucity of Abeta-fiber Merkel endings at

138 In contrast, the hairless skin of the naked mole-rats had an exceptional abundance of presumptive Ad

139 However, naked mole-rats had very few VP-ir cells in the bed nucleus of

140 region of the alpha A-cry gene of the mouse, mole rat, hamster, and human, as well as the previously

141 Blind mole rats have degenerated subcutaneous eyes that are vi

142 We speculate that naked mole rats have evolved a higher concentration of HA in t

143 In addition to its longevity, naked mole-rats have an extraordinary resistance to cancer as

144 Although naked mole-rats have been reported to lack natural killer (NK)

145 yroid hormone (TH) concentrations in African mole-rats have revealed a unique TH phenotype, which dev

146 unique evolutionary trajectories in African mole-rat hearing and establishes species members as natu

147 Naked mole-rat hearts show reduced succinate levels during isc

148 The naked mole-rat Heterocephalus glaber is a eusocial mammal exhi

149 The naked mole rat (Heterocephalus glaber) displays exceptional lo

150 The naked mole rat (Heterocephalus glaber) is a long-lived and tum

151 The naked mole rat (Heterocephalus glaber) is an exceptionally lon

152 Compared to many other rodent species, naked mole rats (Heterocephalus glaber) have elevated auditory

153 m of two African mole-rat species, the naked mole-rat (Heterocephalus glaber) and the Ansell's mole-r

154 The naked mole-rat (Heterocephalus glaber) contains abundant high-

155 showed that the saphenous nerve of the naked mole-rat (Heterocephalus glaber) has a C-fiber deficit m

156 ral habitat, the strictly subterranean naked mole-rat (Heterocephalus glaber) has lived in a light-fr

157 The strictly subterranean naked mole-rat (Heterocephalus glaber) has markedly reduced vi

158 The naked mole-rat (Heterocephalus glaber) is a long-lived rodent

159 The naked mole-rat (Heterocephalus glaber) is a subterranean eusoc

160 The naked mole-rat (Heterocephalus glaber) is unusual in numerous

161 n of the guinea pig (Cavia porcellus), naked mole-rat (Heterocephalus glaber), and human.

162 brain atlas was available only for the naked mole-rat (Heterocephalus glaber).

163 ed a Kaplan-Meier survival analysis of naked mole-rats (Heterocephalus glaber) and concluded that the

164 Naked mole-rats (Heterocephalus glaber) have a large cortical

165 Naked mole-rats (Heterocephalus glaber) have numerous anatomic

166 Naked mole-rats (Heterocephalus glaber) live in groups that ar

167 ther long-lived and cancer-resistant African mole rat, Heterocephalus glaber, the naked mole rat in w

168 studies of social mole rats (including naked mole rats, Heterocephalus glaber, and Damaraland mole ra

169 ated a transgenic mouse overexpressing naked mole-rat hyaluronic acid synthase 2 gene (nmrHas2).

170 e molecular changes likely rendered highveld mole-rats immune to the stings of the Natal droptail ant

171 n mole rat, Heterocephalus glaber, the naked mole rat in which cells display hypersensitivity to cont

172 s; in contrast, the level is greater in Cape mole-rats in the shell of the nucleus accumbens and medi

173 ing, the sites with a greater level in naked mole-rats include the basolateral amygdaloid nucleus and

174 ding in naked mole-rats exceeds that in Cape mole-rats include the basolateral amygdaloid nucleus, hi

175 olic and genetic adaptations unique to naked mole-rats including elevated glycogen, thus enabling gly

176 In contrast, some studies of social mole rats (including naked mole rats, Heterocephalus gla

177 Here we show that, in Damaraland mole rats, individual contributions to cooperative behav

178 conspicuously, in both naked and Damaraland mole rats, inner hair cell (IHC) afferent ribbon density

179 est candidate genetic loci that may underlie mole-rat innovations.

180 The blind subterranean mole rat is a model for hypoxia tolerance with the abili

181 Tumor resistance in the naked mole rat is mediated by the extracellular matrix compone

182 sh and amphibians, suggesting that the naked mole-rat is a powerful model for exploring the mechanism

183 The naked mole-rat is a subterranean rodent, approximately the siz

184 contrast, early contact inhibition in naked mole-rat is associated with the induction of p16(Ink4a).

185 e retinogeniculocortical system in the naked mole-rat is considerably smaller than that of rodents th

186 ution of the LG to brain volume in the naked mole-rat is less than a third of that of the rat.

187 t that 28S ribosomal RNA (rRNA) of the naked mole-rat is processed into two smaller fragments of uneq

188 The naked mole-rat is the longest living rodent with a maximum lif

189 ings suggest that altered hearing in African mole-rats is adaptive, perhaps tailoring hearing to euso

190 ber deficit in the cutaneous nerves of naked mole-rats is unlikely to be due primarily to lack of ski

191 odents were found to be more conserved, with mole-rats lacking uniquely conserved amino acid substitu

192 l insects, reproductive division of labor in mole-rats leads to gene regulatory rewiring and extensiv

193 and analyses spanning human, mouse, chicken, mole rat, lemur and sea urchin, genome annotations are o

194 The preternaturally long-lived naked mole-rat, like other long-lived species and experimental

195 Naked mole-rats live in large eusocial colonies that are chara

196 Naked mole-rats live in large, subterranean colonies where bre

197 er, while that of mTORC2 was higher in naked mole-rat livers compared to mice, unlike that of mice wh

198 kely mechanism of altered hearing in African mole-rats, making them the only identified mammals natur

199 neuronal activity, we studied whether naked mole-rats might demonstrate energy savings in GABAergic

200 The ratios of mole rat/mouse promoter activity were 0.01 for lens, 1.7

201 Naked mole rat (MR) Heterocephalus glaber is a rodent model of

202 from the longest-living rodent known, naked mole-rats [MRs; mass 35 g; maximum lifespan (MLSP) > 28.

203 The subterranean-dwelling naked mole-rat (NM-R; Heterocephalus glaber) exhibits prolonge

204 trast, the highly abundant PPGs of the naked mole rat (NMR) exhibited substantial deviation from thei

205 The naked mole rat (NMR), a long-lived and cancer-resistant rodent

206 The naked mole rat (NMR), Heterocephalus glaber, is known as the l

207 The Naked Mole Rat (NMR), Heterocephalus glaber, provides an inter

208 The naked mole rat (NMR), Heterocephalus glaber, the longest-livin

209 monstrated by us and Liang et al. that naked mole-rat (NMR) cells are more resistant to SV40LT and H-

210 In naked mole-rat (NMR) colonies, breeding is monopolized by the

211 The naked mole-rat (NMR) is an exceptionally long-lived rodent tha

212 In the long-lived naked mole-rat (NMR), the entire process of oogenesis occurs p

213 Naked mole-rat (NMR), the longest-living rodent, produces very

214 of HA in the cancer resistance of the naked mole-rat (NMR), we undertook to explore the structural a

215 Naked mole rats (NMRs) are currently one of the most popular n

216 Naked mole rats (NMRs) are the longest-lived rodents yet their

217 Naked mole rats (NMRs) live in sizable colonies where breeding

218 chondria of various tissues from mice, naked mole rats (NMRs), and bats possess two mechanistically s

219 Naked mole-rats (NMRs) (Heterocephalus glaber) are long-lived

220 Naked mole-rats (NMRs) are best known for their extreme longev

221 The blind subterranean mole rat of the Spalax ehrenbergi superspecies is an exc

222 the brains of breeding and subordinate naked mole-rats of both sexes, including several regions linke

223 the brains of subordinate and breeding naked mole-rats of both sexes.

224 When overexpressed in naked mole rat or human cells, pALT(INK4a/b) has stronger abil

225 and human p53, a larger proportion of naked mole-rat p53 protein is constitutively localized in the

226 ermined that the long half-life of the naked mole-rat p53 protein reflects protein-extrinsic regulati

227 l nuclear localization of p53 in NEFs, naked mole-rat p53 retains its canonical tumor suppressive act

228 or cortical remodeling has occurred in naked mole-rats, paralleling the anatomical and behavioral spe

229 Prairie Dog, INFO, Fission Fusion and Naked mole-rat (PIFN) algorithm.

230 Many different species of animals including mole rats, pigeons, and sea turtles are thought to use t

231 The reciprocal mutation in the mole rat promoter fragment ((-272)G-->CA) did not affect

232 e promoter fragment to that of the wild-type mole rat promoter when tested in transgenic mice.

233 For subterranean rodents such as the naked mole-rat, proposed phenotypic adaptations include hypoxi

234 se mammalian species (including mouse, naked mole rat, rabbit, marmoset, cat, sheep, horse, and chimp

235 RF1 binding in the nucleus accumbens of Cape mole-rats reflects their lack of affiliative behavior.

236 These comparative analyses reveal how mole-rat regulatory evolution informs previously reporte

237 To date, the neurobiology of the blind mole rat remains mostly unknown and holds a promising av

238 The excised fragment is unique to the naked mole-rat rRNA and does not show homology to other genomi

239 entify a mechanism responsible for the naked mole rat's cancer resistance.

240 ve contributed to the evolution of the naked mole rat's extraordinary traits, including in regions of

241 The African naked mole-rat's (Heterocephalus glaber) social and subterrane

242 the p53 protein may contribute to the naked mole-rat's remarkable resistance to cancer.

243 er/promoter fragment mimicking the wild-type mole rat sequence functionally converted the mouse promo

244 ce lost binding ability, whereas the mutated mole rat sequence gained the ability to form a complex s

245 Overall, we conclude that naked mole rats show an extremely protracted period of brain m

246 In addition to their longevity, naked mole rats show an unusual resistance to cancer.

247 Damaraland mole rats showed no evidence of postnatal reorganization

248 Developmentally, naked mole rats showed reduced and prolonged postnatal reorgan

249 gh concentration of acetic acid (50%), naked mole-rats showed significant avoidance behavior and incr

250 d low iodide levels in the thyroid and naked mole-rats showed signs of thyroid gland hyperplasia.

251 pite relatively few changes in sequence, the mole rat shsp/alphaB-crystallin promoter/enhancer has se

252 We investigated naked mole-rat somatosensory cortex to determine how brain are

253 Subterranean blind mole rats (Spalacidae) are considered to speciate allopa

254 expression of Flk1 in the blind subterranean mole rat Spalax ehrenbergi.

255 Blind mole rats Spalax (BMR) are small subterranean rodents co

256 tallin enhancer/promoter fragment from blind mole rats (Spalax ehrenbergi), which have nonfunctional

257 pared with that in rats and a furred African mole-rat species (the common mole-rat).

258 tion in the heart and liver from two African mole-rat species and two rodent outgroups using genome-w

259 Most intriguingly, both mole-rat species had low iodide levels in the thyroid an

260 RF and urocortin 3, respectively, in African mole-rat species with diametrically opposed social behav

261 ecific differences in the TH systems of both mole-rat species, although ultimately resulting in simil

262 r characterised the TH system of two African mole-rat species, the naked mole-rat (Heterocephalus gla

263 the long lifespans observed in many bat and mole-rat species.

264 stepwise remodeling during the evolution of mole-rats, such as the insulin and hypoxia response path

265 ein (shsp)/alphaB-crystallin promoter of the mole rat superspecies, Spalax ehrenbergi, with that of t

266 During anoxia, the naked mole-rat switches to anaerobic metabolism fueled by fruc

267 eases Deltapsi(m) is ~4-fold higher in naked mole-rat than mouse brain.

268 In five mole-rats the lower right incisor was extracted on eithe

269 Here, we show that, in the naked mole rat, the INK4a/b locus encodes an additional produc

270 bs, the subterranean tunnel systems of naked mole rats, the intricately decorated bowers of bowerbird

271 s, and whether these are unique to the naked mole-rat, the mole-rat clade, or are also present in oth

272 The exception is the naked mole-rat, the only known vertebrate to show physiologica

273 performed optic nerve injury in adult naked mole-rats, the longest living rodent, with a maximum lif

274 d than that of the extensively studied blind mole-rat; this may facilitate limited responses to visua

275 is present in both cultured cells and naked mole rat tissues but is absent in human and mouse cells.

276 nsistent with exceptional endurance of naked mole rat tissues to various genotoxic stresses.

277 ctose-driven glycolytic respiration in naked mole-rat tissues avoids feedback inhibition of glycolysi

278 ular-mass HA accumulates abundantly in naked mole-rat tissues owing to the decreased activity of HA-d

279 ay reflect a further adaptation of the naked mole-rat to living in an environment with high-carbon di

280 Under experimental conditions, naked mole-rats tolerate hours of extreme hypoxia and survive

281 he thoracic and cervical thymus of the naked mole-rat until adult life.

282 r binding densities in female and male naked mole-rats varying in breeding status.

283 mics and RNAseq of cardiac tissue from naked mole-rats was compared to other African mole-rat genera

284 air follicles, and intervening skin in naked mole-rats was compared with that in rats and a furred Af

285 in other species, its distribution in naked mole-rats was of interest.

286 dinates from reproducing (for example, naked mole-rats, wasps and ants).

287 nderlying the cancer resistance of the naked mole-rat, we investigated the regulation and function of

288 olony behavioral monitoring of captive naked mole-rats, we found a durable nest, characterized by hig

289 vealed that the body hair follicles in naked mole-rats were exceptionally large and well innervated,

290 African naked mole-rats were likely the first mammals to evolve eusoci

291 sponsible for the cancer resistance of naked mole-rats were unknown.

292 African rodent species related to the naked mole-rat with the painful substances capsaicin, acid (hy

293 kedly from this pattern are bats and African mole-rats, with members of both groups being extremely l